JP2015522286A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015522286A5 JP2015522286A5 JP2015522101A JP2015522101A JP2015522286A5 JP 2015522286 A5 JP2015522286 A5 JP 2015522286A5 JP 2015522101 A JP2015522101 A JP 2015522101A JP 2015522101 A JP2015522101 A JP 2015522101A JP 2015522286 A5 JP2015522286 A5 JP 2015522286A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- sequence
- host cell
- binding
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261673144P | 2012-07-18 | 2012-07-18 | |
| US61/673,144 | 2012-07-18 | ||
| EP12178529.9 | 2012-07-30 | ||
| EP12178529.9A EP2692865B1 (en) | 2012-07-30 | 2012-07-30 | Transposition-mediated identification of specific binding or functional proteins |
| PCT/EP2013/065214 WO2014013026A1 (en) | 2012-07-18 | 2013-07-18 | Transposition-mediated identification of specific binding or functional proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522286A JP2015522286A (ja) | 2015-08-06 |
| JP2015522286A5 true JP2015522286A5 (https=) | 2016-02-04 |
| JP6043431B2 JP6043431B2 (ja) | 2016-12-14 |
Family
ID=49775745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015522101A Active JP6043431B2 (ja) | 2012-07-18 | 2013-07-18 | 特異的な結合タンパク質または機能性タンパク質の遺伝子転位を利用した同定 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10174309B2 (https=) |
| EP (2) | EP2692865B1 (https=) |
| JP (1) | JP6043431B2 (https=) |
| CN (1) | CN104640985B (https=) |
| AU (1) | AU2013291971B2 (https=) |
| BR (1) | BR112015000836B1 (https=) |
| CA (1) | CA2878982C (https=) |
| DK (1) | DK2692865T3 (https=) |
| ES (1) | ES2528892T3 (https=) |
| IL (1) | IL236771A (https=) |
| IN (1) | IN2015DN01301A (https=) |
| MX (1) | MX338911B (https=) |
| NZ (1) | NZ705074A (https=) |
| PT (1) | PT2692865E (https=) |
| SG (1) | SG11201500280XA (https=) |
| SI (1) | SI2692865T1 (https=) |
| WO (1) | WO2014013026A1 (https=) |
| ZA (1) | ZA201500203B (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201407852D0 (en) | 2014-05-02 | 2014-06-18 | Iontas Ltd | Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules |
| SG11201803098VA (en) | 2015-10-30 | 2018-05-30 | Nbe Therapeutics Ag | Anti-ror1 antibodies |
| UA125718C2 (uk) | 2016-01-20 | 2022-05-25 | Зе Скріппс Ресеарч Інстітьют | Композиції антитіл до ror1 і пов'язані з ними способи |
| SG11201806121PA (en) | 2016-01-20 | 2018-08-30 | Scripps Research Inst | Ror2 antibody compositions and related methods |
| JP2019513415A (ja) * | 2016-04-04 | 2019-05-30 | イーティーエッチ チューリッヒ | タンパク質産生及びライブラリー生成のための哺乳類細胞株 |
| CN110022898B (zh) | 2016-12-09 | 2023-07-04 | 格利克尼克股份有限公司 | 用多价Fc化合物治疗炎性疾病的方法 |
| MX2019006573A (es) | 2016-12-09 | 2019-11-18 | Gliknik Inc | Optimizacion de fabricacion de gl-2045 un stradomer multimerizante. |
| US11278570B2 (en) | 2016-12-16 | 2022-03-22 | B-Mogen Biotechnologies, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
| JP7275043B2 (ja) | 2016-12-16 | 2023-05-17 | ビー－モーゲン・バイオテクノロジーズ，インコーポレーテッド | 増大したｈＡＴファミリートランスポゾン媒介遺伝子導入ならびに関連する組成物、システムおよび方法 |
| US11447546B2 (en) | 2017-07-20 | 2022-09-20 | Nbe-Therapeutics Ag | Human antibodies binding to ROR2 |
| KR20230008269A (ko) | 2017-08-07 | 2023-01-13 | 엔비이-테라퓨틱스 아게 | 생체 내 내성이 높은 항체 약물 결합체 |
| JP7407425B2 (ja) * | 2018-05-18 | 2024-01-04 | ソルボンヌ・ユニヴェルシテ | 導入遺伝子組込みおよびそれらの転位依存性発現のための分子ツールおよび方法 |
| CA3104288A1 (en) | 2018-06-21 | 2019-12-26 | B-Mogen Biotechnologies, Inc. | Enhanced hat family transposon-mediated gene transfer and associated compositions, systems, and methods |
| WO2020084034A1 (en) | 2018-10-26 | 2020-04-30 | F. Hoffmann-La Roche Ag | Multispecific antibody screening method using recombinase mediated cassette exchange |
| JP2020146014A (ja) * | 2019-03-15 | 2020-09-17 | 株式会社東芝 | トランスポゼース活性測定用ベクター、トランスポゼース活性測定用キット、トランスポゼース活性測定方法及び細胞分離方法 |
| BR112022001632A2 (pt) * | 2019-07-30 | 2022-04-19 | Akeso Biopharma Inc | Anticorpos, polipeptídeo, polinucleotídeo, vetor, célula hospedeira, conjugado de anticorpo, proteína de fusão, kit, usos do anticorpo, composição farmacêutica, métodos in vivo ou in vitro, para preparar o anticorpo e para prevenção, tratamento, tratamento adjuvante e/ou de diagnóstico de doenças autoimunes |
| CN114981409A (zh) | 2019-09-03 | 2022-08-30 | 美洛德生物医药公司 | 用于基因组整合的方法和组合物 |
| CN111139264B (zh) * | 2020-01-20 | 2021-07-06 | 天津达济科技有限公司 | 一种基于线性双链dna分子在哺乳动物细胞系内构建单域抗体库的方法 |
| MX2022012005A (es) * | 2020-03-27 | 2022-10-21 | Ddbio Co Ltd Shang Hai | Metodo para el despliegue de anticuerpo biespecifico en la superficie de celula de mamifero y vector. |
| CN111471714A (zh) * | 2020-05-07 | 2020-07-31 | 西南大学 | Minos转座子系统介导的真核生物转基因细胞系及构建方法 |
| EP4271817A2 (en) | 2020-12-30 | 2023-11-08 | Alaunos Therapeutics, Inc. | Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof |
| WO2022183167A1 (en) | 2021-02-25 | 2022-09-01 | Alaunos Therapeutics, Inc. | Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof |
| US20240360436A1 (en) * | 2021-03-31 | 2024-10-31 | DDBio. Co., Ltd. | Vector and method for screening functional antigen-binding protein |
| BR112023023642A2 (pt) | 2021-05-11 | 2024-01-30 | Myeloid Therapeutics Inc | Métodos e composições para integração genômica |
| US20250145950A1 (en) | 2022-02-01 | 2025-05-08 | Alaunos Therapeutics, Inc. | Methods for Activation and Expansion of T Cells |
| WO2024102954A1 (en) | 2022-11-10 | 2024-05-16 | Massachusetts Institute Of Technology | Activation induced clipping system (aics) |
| WO2025158420A1 (en) | 2024-01-25 | 2025-07-31 | Nanocell Therapeutics Holdings B.V. | Methods and composition for inducing activation and dna expression in t-cells |
| WO2025169168A1 (en) | 2024-02-09 | 2025-08-14 | Nanocell Therapeutics Holdings B.V. | Extracorporeal transfection of immune effector cells |
| WO2025216732A1 (en) * | 2024-04-10 | 2025-10-16 | Duke University | Methods and compositions relating to ecdna biogenesis |
| WO2025235862A1 (en) | 2024-05-10 | 2025-11-13 | Inndura Therapeutics Inc. | A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5667988A (en) * | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| US6218185B1 (en) | 1996-04-19 | 2001-04-17 | The United States Of America As Represented By The Secretary Of Agriculture | Piggybac transposon-based genetic transformation system for insects |
| ATE466948T1 (de) | 1997-03-11 | 2010-05-15 | Univ Minnesota | Dns-basiertes transposon-system für die einführung von nucleinsäure in die dns einer zelle |
| US7160682B2 (en) | 1998-11-13 | 2007-01-09 | Regents Of The University Of Minnesota | Nucleic acid transfer vector for the introduction of nucleic acid into the DNA of a cell |
| US6962810B2 (en) | 2000-10-31 | 2005-11-08 | University Of Notre Dame Du Lac | Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector piggyBac |
| US7105343B1 (en) | 2000-10-31 | 2006-09-12 | University Of Notre Dame Du Lac | Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector Piggybac |
| CA2446453A1 (en) | 2001-06-14 | 2002-12-27 | Basf Corporation | Light-stabilized polymers comprising light-stabilizing moieties, articles therefrom and a method of making the same |
| WO2003089618A2 (en) | 2002-04-22 | 2003-10-30 | Regents Of The University Of Minnesota | Transposon system and methods of use |
| DE60319259T2 (de) * | 2002-06-14 | 2009-03-05 | Dyax Corp., Cambridge | Rekombination von nukleinsäurebibliotheksmitgliedern |
| AU2003274897A1 (en) | 2002-07-10 | 2004-01-23 | Stratagene California | Humanized renilla reniformis green fluorescent protein as a scaffold |
| DK1545613T3 (da) | 2002-07-31 | 2011-11-14 | Seattle Genetics Inc | Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom |
| US8071364B2 (en) * | 2003-12-24 | 2011-12-06 | Transgenrx, Inc. | Gene therapy using transposon-based vectors |
| US7932088B1 (en) | 2005-04-25 | 2011-04-26 | University Of Notre Dame Du Lac | High efficiency transformation of Plasmodium falciparum by the lepidopteran transposon, piggyBac |
| US20060252140A1 (en) | 2005-04-29 | 2006-11-09 | Yant Stephen R | Development of a transposon system for site-specific DNA integration in mammalian cells |
| JPWO2007046439A1 (ja) * | 2005-10-18 | 2009-04-23 | 独立行政法人農業生物資源研究所 | 抗体を産生するトランスジェニックカイコとその製造方法 |
| US20090042297A1 (en) * | 2007-06-01 | 2009-02-12 | George Jr Alfred L | Piggybac transposon-based vectors and methods of nucleic acid integration |
| EP2160461B1 (en) | 2007-07-04 | 2012-08-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Hyperactive variants of the transposase protein of the transposon system sleeping beauty |
| JP2010538659A (ja) | 2007-09-17 | 2010-12-16 | アフォミックス コーポレイション | デュアルベイトレポーターを用いてｓｃＦｖスクリーニングにおける特異性を増大させる方法 |
| US7863425B2 (en) * | 2007-09-26 | 2011-01-04 | Cornell University | Compositions and methods for inhibiting Yersinia pestis infection |
| DK2211904T3 (en) | 2007-10-19 | 2016-10-24 | Seattle Genetics Inc | Cd19-binding agents and uses thereof |
| WO2009087230A1 (en) | 2008-01-11 | 2009-07-16 | Morphosys Ag | Display vectors and methods and uses thereof |
| EP2244563B1 (en) * | 2008-02-01 | 2019-08-28 | Bogin, Robert | Methods, compositions, and systems for production of recombinant spider silk polypeptides |
| JP2009225781A (ja) * | 2008-02-29 | 2009-10-08 | Neosilk Co Ltd | カイコを用いた糖鎖構造に特徴を有する糖蛋白質の製造方法 |
| EP2098536A1 (en) * | 2008-03-05 | 2009-09-09 | 4-Antibody AG | Isolation and identification of antigen- or ligand-specific binding proteins |
| ES2410579T5 (es) | 2008-12-16 | 2021-10-04 | Novartis Ag | Sistemas de despliegue de levaduras |
| US20100311116A1 (en) * | 2009-06-04 | 2010-12-09 | Excellgene Sa | Fast generation of high expression stable cell lines expressing recombinant proteins under minimal and short-term selective pressure |
| EP2653540B9 (en) * | 2010-12-15 | 2018-05-16 | Inter-University Research Institute Corporation Research Organization of Information and Systems | Protein production method |
-
2012
- 2012-07-30 PT PT121785299T patent/PT2692865E/pt unknown
- 2012-07-30 ES ES12178529.9T patent/ES2528892T3/es active Active
- 2012-07-30 EP EP12178529.9A patent/EP2692865B1/en active Active
- 2012-07-30 DK DK12178529.9T patent/DK2692865T3/en active
- 2012-07-30 SI SI201230139T patent/SI2692865T1/sl unknown
-
2013
- 2013-07-18 EP EP13177083.6A patent/EP2687599A1/en not_active Withdrawn
- 2013-07-18 JP JP2015522101A patent/JP6043431B2/ja active Active
- 2013-07-18 MX MX2015000885A patent/MX338911B/es active IP Right Grant
- 2013-07-18 NZ NZ705074A patent/NZ705074A/en unknown
- 2013-07-18 CN CN201380048308.7A patent/CN104640985B/zh active Active
- 2013-07-18 CA CA2878982A patent/CA2878982C/en active Active
- 2013-07-18 WO PCT/EP2013/065214 patent/WO2014013026A1/en not_active Ceased
- 2013-07-18 US US14/414,981 patent/US10174309B2/en active Active
- 2013-07-18 SG SG11201500280XA patent/SG11201500280XA/en unknown
- 2013-07-18 BR BR112015000836-4A patent/BR112015000836B1/pt active IP Right Grant
- 2013-07-18 AU AU2013291971A patent/AU2013291971B2/en active Active
-
2015
- 2015-01-13 ZA ZA2015/00203A patent/ZA201500203B/en unknown
- 2015-01-18 IL IL236771A patent/IL236771A/en active IP Right Grant
- 2015-02-17 IN IN1301DEN2015 patent/IN2015DN01301A/en unknown
-
2018
- 2018-10-30 US US16/175,073 patent/US20190153433A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015522286A5 (https=) | ||
| Gohil et al. | Applying high-dimensional single-cell technologies to the analysis of cancer immunotherapy | |
| Jovic et al. | Single‐cell RNA sequencing technologies and applications: a brief overview | |
| Baysoy et al. | The technological landscape and applications of single-cell multi-omics | |
| Zhang et al. | Landscape and dynamics of single immune cells in hepatocellular carcinoma | |
| Zheng et al. | Molecular transitions in early progenitors during human cord blood hematopoiesis | |
| Papalexi et al. | Single-cell RNA sequencing to explore immune cell heterogeneity | |
| Soda et al. | Recent advances in liquid biopsy technologies for cancer biomarker detection | |
| Kim et al. | Single-cell isolation of circulating tumor cells from whole blood by lateral magnetophoretic microseparation and microfluidic dispensing | |
| Georgiou et al. | The promise and challenge of high-throughput sequencing of the antibody repertoire | |
| WO2019113506A1 (en) | Methods and compositions for multiplexing single cell and single nuclei sequencing | |
| US20200283843A1 (en) | Methods and compositions for massively parallel variant and small molecule phenotyping | |
| Gurung et al. | Systematic discovery of neoepitope–HLA pairs for neoantigens shared among patients and tumor types | |
| JP2015536642A5 (https=) | ||
| CN110964796A (zh) | 大规模平行单细胞分析 | |
| HRP20171193T1 (hr) | Proizvodnja vezivnih molekula | |
| JP2018514195A (ja) | 細胞の統合された機能性および分子のプロファイリング | |
| Chen et al. | Single-cell analysis technologies for cancer research: from tumor-specific single cell discovery to cancer therapy | |
| JP2018513187A (ja) | がんのネオエピトープ | |
| JP2013509878A5 (https=) | ||
| EP2260112A2 (en) | Method of screening single cells for the production of biologically active agents | |
| Camp et al. | Human organomics: a fresh approach to understanding human development using single-cell transcriptomics | |
| JP2023518274A (ja) | 単一細胞コンビナトリアルインデクシング式サイトメトリーシークエンシング（Ｓｉｎｇｌｅ－Ｃｅｌｌ Ｃｏｍｂｉｎａｔｏｒｉａｌ Ｉｎｄｅｘｅｄ Ｃｙｔｏｍｅｔｒｙ Ｓｅｑｕｅｎｃｉｎｇ） | |
| De Angelis et al. | Colorectal cancer stem cells: an overview of evolving methods and concepts | |
| Vegh et al. | The impact of single-cell RNA sequencing on understanding the functional organization of the immune system |