JP2015522286A5 - - Google Patents
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- JP2015522286A5 JP2015522286A5 JP2015522101A JP2015522101A JP2015522286A5 JP 2015522286 A5 JP2015522286 A5 JP 2015522286A5 JP 2015522101 A JP2015522101 A JP 2015522101A JP 2015522101 A JP2015522101 A JP 2015522101A JP 2015522286 A5 JP2015522286 A5 JP 2015522286A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- sequence
- host cell
- binding
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261673144P | 2012-07-18 | 2012-07-18 | |
| US61/673,144 | 2012-07-18 | ||
| EP12178529.9A EP2692865B1 (en) | 2012-07-30 | 2012-07-30 | Transposition-mediated identification of specific binding or functional proteins |
| EP12178529.9 | 2012-07-30 | ||
| PCT/EP2013/065214 WO2014013026A1 (en) | 2012-07-18 | 2013-07-18 | Transposition-mediated identification of specific binding or functional proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522286A JP2015522286A (ja) | 2015-08-06 |
| JP2015522286A5 true JP2015522286A5 (https=) | 2016-02-04 |
| JP6043431B2 JP6043431B2 (ja) | 2016-12-14 |
Family
ID=49775745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015522101A Active JP6043431B2 (ja) | 2012-07-18 | 2013-07-18 | 特異的な結合タンパク質または機能性タンパク質の遺伝子転位を利用した同定 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10174309B2 (https=) |
| EP (2) | EP2692865B1 (https=) |
| JP (1) | JP6043431B2 (https=) |
| CN (1) | CN104640985B (https=) |
| AU (1) | AU2013291971B2 (https=) |
| BR (1) | BR112015000836B1 (https=) |
| CA (1) | CA2878982C (https=) |
| DK (1) | DK2692865T3 (https=) |
| ES (1) | ES2528892T3 (https=) |
| IL (1) | IL236771A (https=) |
| IN (1) | IN2015DN01301A (https=) |
| MX (1) | MX338911B (https=) |
| NZ (1) | NZ705074A (https=) |
| PT (1) | PT2692865E (https=) |
| SG (1) | SG11201500280XA (https=) |
| SI (1) | SI2692865T1 (https=) |
| WO (1) | WO2014013026A1 (https=) |
| ZA (1) | ZA201500203B (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201407852D0 (en) | 2014-05-02 | 2014-06-18 | Iontas Ltd | Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules |
| EA201891066A1 (ru) | 2015-10-30 | 2018-10-31 | ЭнБиИ-ТЕРАПЬЮТИКС АГ | Антитела к ror1 |
| SG11201806120WA (en) | 2016-01-20 | 2018-08-30 | Scripps Research Inst | Ror1 antibody compositions and related methods |
| WO2017127702A1 (en) | 2016-01-20 | 2017-07-27 | The Scripps Research Institute | Ror2 antibody compositions and related methods |
| CN118185874A (zh) | 2016-04-04 | 2024-06-14 | 苏黎世联邦理工学院 | 一种重组哺乳动物b细胞 |
| CA3043251A1 (en) | 2016-12-09 | 2018-06-14 | Gliknik Inc. | Methods of treating inflammatory disorders with multivalent fc compounds |
| CN110177802A (zh) | 2016-12-09 | 2019-08-27 | 格利克尼克股份有限公司 | 多聚化stradomer GL-2045的制造优化 |
| AU2017378482B2 (en) | 2016-12-16 | 2024-06-13 | R&D Systems, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
| US11278570B2 (en) | 2016-12-16 | 2022-03-22 | B-Mogen Biotechnologies, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
| WO2019016392A1 (en) | 2017-07-20 | 2019-01-24 | Nbe-Therapeutics Ag | HUMAN ANTIBODIES BINDING TO ROR2 |
| EP3665193A1 (en) | 2017-08-07 | 2020-06-17 | NBE Therapeutics AG | Anthracycline-based antibody drug conjugates having high in vivo tolerability |
| EP3794128A1 (en) * | 2018-05-18 | 2021-03-24 | Sorbonne Universite | Molecular tools and methods for transgene integration and their transposition dependent expression |
| AU2019288669B2 (en) | 2018-06-21 | 2025-06-26 | R&D Systems, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
| EP3870604B1 (en) | 2018-10-26 | 2022-11-23 | F. Hoffmann-La Roche AG | Multispecific antibody screening method using recombinase mediated cassette exchange |
| JP2020146014A (ja) * | 2019-03-15 | 2020-09-17 | 株式会社東芝 | トランスポゼース活性測定用ベクター、トランスポゼース活性測定用キット、トランスポゼース活性測定方法及び細胞分離方法 |
| CA3145909A1 (en) * | 2019-07-30 | 2021-02-04 | Yu Xia | Anti-human p40 protein domain antibody and use thereof |
| JP7831937B2 (ja) | 2019-09-03 | 2026-03-17 | クリエイト・メディシンズ，インコーポレーテッド | ゲノム組込みのための方法および組成物 |
| CN111139264B (zh) * | 2020-01-20 | 2021-07-06 | 天津达济科技有限公司 | 一种基于线性双链dna分子在哺乳动物细胞系内构建单域抗体库的方法 |
| WO2021190631A1 (zh) * | 2020-03-27 | 2021-09-30 | 泷搌（上海）生物科技有限公司 | 在哺乳动物细胞表面展示双特异性抗体的方法及载体 |
| CN111471714A (zh) * | 2020-05-07 | 2020-07-31 | 西南大学 | Minos转座子系统介导的真核生物转基因细胞系及构建方法 |
| EP4271817A2 (en) | 2020-12-30 | 2023-11-08 | Alaunos Therapeutics, Inc. | Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof |
| IL305393A (en) | 2021-02-25 | 2023-10-01 | Alaunos Therapeutics Inc | Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof |
| EP4317549A4 (en) * | 2021-03-31 | 2025-03-26 | Ddbio. Co, Ltd., (Shang Hai) | Vector and method for screening functional antigen-binding protein |
| AU2022272235A1 (en) | 2021-05-11 | 2023-12-21 | Create Medicines, Inc. | Methods and compositions for genomic integration |
| US20250145950A1 (en) | 2022-02-01 | 2025-05-08 | Alaunos Therapeutics, Inc. | Methods for Activation and Expansion of T Cells |
| WO2024102954A1 (en) | 2022-11-10 | 2024-05-16 | Massachusetts Institute Of Technology | Activation induced clipping system (aics) |
| WO2025158420A1 (en) | 2024-01-25 | 2025-07-31 | Nanocell Therapeutics Holdings B.V. | Methods and composition for inducing activation and dna expression in t-cells |
| WO2025169168A1 (en) | 2024-02-09 | 2025-08-14 | Nanocell Therapeutics Holdings B.V. | Extracorporeal transfection of immune effector cells |
| WO2025216732A1 (en) * | 2024-04-10 | 2025-10-16 | Duke University | Methods and compositions relating to ecdna biogenesis |
| WO2025235862A1 (en) | 2024-05-10 | 2025-11-13 | Inndura Therapeutics Inc. | A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5667988A (en) * | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| US6218185B1 (en) | 1996-04-19 | 2001-04-17 | The United States Of America As Represented By The Secretary Of Agriculture | Piggybac transposon-based genetic transformation system for insects |
| US6489458B2 (en) | 1997-03-11 | 2002-12-03 | Regents Of The University Of Minnesota | DNA-based transposon system for the introduction of nucleic acid into DNA of a cell |
| US7160682B2 (en) | 1998-11-13 | 2007-01-09 | Regents Of The University Of Minnesota | Nucleic acid transfer vector for the introduction of nucleic acid into the DNA of a cell |
| US6962810B2 (en) | 2000-10-31 | 2005-11-08 | University Of Notre Dame Du Lac | Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector piggyBac |
| US7105343B1 (en) | 2000-10-31 | 2006-09-12 | University Of Notre Dame Du Lac | Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector Piggybac |
| HUP0400118A2 (hu) | 2001-06-14 | 2005-02-28 | Basf Corporation | Fénystabilizáló gyököket tartalmazó fénystabilizált polimerek, ezekből készült cikkek és eljárás előállításukra |
| AU2003231048A1 (en) | 2002-04-22 | 2003-11-03 | Regents Of The University Of Minnesota | Transposon system and methods of use |
| DE60319259T2 (de) * | 2002-06-14 | 2009-03-05 | Dyax Corp., Cambridge | Rekombination von nukleinsäurebibliotheksmitgliedern |
| CA2492074A1 (en) | 2002-07-10 | 2004-01-15 | Stratagene | Humanized renilla reniformis green fluorescent protein as a scaffold |
| SI1545613T1 (sl) | 2002-07-31 | 2011-11-30 | Seattle Genetics Inc | Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni |
| WO2005062881A2 (en) * | 2003-12-24 | 2005-07-14 | Transgenrx, Inc. | Gene therapy using transposon-based vectors |
| US7932088B1 (en) | 2005-04-25 | 2011-04-26 | University Of Notre Dame Du Lac | High efficiency transformation of Plasmodium falciparum by the lepidopteran transposon, piggyBac |
| US20060252140A1 (en) | 2005-04-29 | 2006-11-09 | Yant Stephen R | Development of a transposon system for site-specific DNA integration in mammalian cells |
| EP1947180B1 (en) * | 2005-10-18 | 2012-12-05 | National Institute Of Agrobiological Sciences | Antibody producing transgenic silkworms and method for producing the same |
| US20090042297A1 (en) * | 2007-06-01 | 2009-02-12 | George Jr Alfred L | Piggybac transposon-based vectors and methods of nucleic acid integration |
| EP2160461B1 (en) | 2007-07-04 | 2012-08-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Hyperactive variants of the transposase protein of the transposon system sleeping beauty |
| CA2698727A1 (en) | 2007-09-17 | 2009-03-26 | Affomix Corporation | Increasing specificity in a scfv screen using dual bait reporters |
| US7863425B2 (en) * | 2007-09-26 | 2011-01-04 | Cornell University | Compositions and methods for inhibiting Yersinia pestis infection |
| RU2476441C2 (ru) | 2007-10-19 | 2013-02-27 | Сиэтл Дженетикс, Инк. | Cd19-связывающие средства и их применение |
| CA2711806A1 (en) | 2008-01-11 | 2009-07-16 | Morphosys Ag | Display vectors and methods and uses thereof |
| WO2009097540A1 (en) * | 2008-02-01 | 2009-08-06 | Entogenetics, Inc. | Methods, compositions, and systems for production of recombinant spider silk polypeptides |
| JP2009225781A (ja) * | 2008-02-29 | 2009-10-08 | Neosilk Co Ltd | カイコを用いた糖鎖構造に特徴を有する糖蛋白質の製造方法 |
| EP2098536A1 (en) | 2008-03-05 | 2009-09-09 | 4-Antibody AG | Isolation and identification of antigen- or ligand-specific binding proteins |
| US20110275535A1 (en) | 2008-12-16 | 2011-11-10 | Novartis Ag | Yeast Display Systems |
| US20100311116A1 (en) * | 2009-06-04 | 2010-12-09 | Excellgene Sa | Fast generation of high expression stable cell lines expressing recombinant proteins under minimal and short-term selective pressure |
| AU2011342161C1 (en) | 2010-12-15 | 2016-03-17 | Kyowa Kirin Co., Ltd. | Process for production of protein |
-
2012
- 2012-07-30 ES ES12178529.9T patent/ES2528892T3/es active Active
- 2012-07-30 DK DK12178529.9T patent/DK2692865T3/en active
- 2012-07-30 PT PT121785299T patent/PT2692865E/pt unknown
- 2012-07-30 EP EP12178529.9A patent/EP2692865B1/en active Active
- 2012-07-30 SI SI201230139T patent/SI2692865T1/sl unknown
-
2013
- 2013-07-18 CA CA2878982A patent/CA2878982C/en active Active
- 2013-07-18 US US14/414,981 patent/US10174309B2/en active Active
- 2013-07-18 BR BR112015000836-4A patent/BR112015000836B1/pt active IP Right Grant
- 2013-07-18 AU AU2013291971A patent/AU2013291971B2/en active Active
- 2013-07-18 WO PCT/EP2013/065214 patent/WO2014013026A1/en not_active Ceased
- 2013-07-18 NZ NZ705074A patent/NZ705074A/en unknown
- 2013-07-18 SG SG11201500280XA patent/SG11201500280XA/en unknown
- 2013-07-18 JP JP2015522101A patent/JP6043431B2/ja active Active
- 2013-07-18 EP EP13177083.6A patent/EP2687599A1/en not_active Withdrawn
- 2013-07-18 MX MX2015000885A patent/MX338911B/es active IP Right Grant
- 2013-07-18 CN CN201380048308.7A patent/CN104640985B/zh active Active
-
2015
- 2015-01-13 ZA ZA2015/00203A patent/ZA201500203B/en unknown
- 2015-01-18 IL IL236771A patent/IL236771A/en active IP Right Grant
- 2015-02-17 IN IN1301DEN2015 patent/IN2015DN01301A/en unknown
-
2018
- 2018-10-30 US US16/175,073 patent/US20190153433A1/en not_active Abandoned
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