JP2015522281A5 - - Google Patents
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- Publication number
- JP2015522281A5 JP2015522281A5 JP2015520349A JP2015520349A JP2015522281A5 JP 2015522281 A5 JP2015522281 A5 JP 2015522281A5 JP 2015520349 A JP2015520349 A JP 2015520349A JP 2015520349 A JP2015520349 A JP 2015520349A JP 2015522281 A5 JP2015522281 A5 JP 2015522281A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- composition
- reprogrammed
- lineage
- pancreatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 13
- 230000008672 reprogramming Effects 0.000 claims 5
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 101100239628 Danio rerio myca gene Proteins 0.000 claims 1
- 102100028098 Homeobox protein Nkx-6.1 Human genes 0.000 claims 1
- 101000578254 Homo sapiens Homeobox protein Nkx-6.1 Proteins 0.000 claims 1
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 1
- 101150039798 MYC gene Proteins 0.000 claims 1
- 102100032063 Neurogenic differentiation factor 1 Human genes 0.000 claims 1
- 108050000588 Neurogenic differentiation factor 1 Proteins 0.000 claims 1
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims 1
- 101710183548 Pyridoxal 5'-phosphate synthase subunit PdxS Proteins 0.000 claims 1
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 1
- 101100459258 Xenopus laevis myc-a gene Proteins 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 210000004039 endoderm cell Anatomy 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 210000003716 mesoderm Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000004923 pancreatic tissue Anatomy 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261664259P | 2012-06-26 | 2012-06-26 | |
| US61/664,259 | 2012-06-26 | ||
| PCT/US2013/047243 WO2014004341A1 (en) | 2012-06-26 | 2013-06-24 | Stem cells and pancreatic cells useful for the treatment of insulin-dependent diabetes mellitus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018149816A Division JP6856586B2 (ja) | 2012-06-26 | 2018-08-09 | インスリン依存性糖尿病の治療に有用な幹細胞と膵臓細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522281A JP2015522281A (ja) | 2015-08-06 |
| JP2015522281A5 true JP2015522281A5 (cg-RX-API-DMAC7.html) | 2016-08-04 |
| JP6386453B2 JP6386453B2 (ja) | 2018-09-05 |
Family
ID=48746139
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520349A Active JP6386453B2 (ja) | 2012-06-26 | 2013-06-24 | インスリン依存性糖尿病の治療に有用な幹細胞と膵臓細胞 |
| JP2018149816A Active JP6856586B2 (ja) | 2012-06-26 | 2018-08-09 | インスリン依存性糖尿病の治療に有用な幹細胞と膵臓細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018149816A Active JP6856586B2 (ja) | 2012-06-26 | 2018-08-09 | インスリン依存性糖尿病の治療に有用な幹細胞と膵臓細胞 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9968639B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2864473B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6386453B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR102058259B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN104640979B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2013280698B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112014031676A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2876677C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2864473T3 (cg-RX-API-DMAC7.html) |
| EA (2) | EA033954B1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2745704T3 (cg-RX-API-DMAC7.html) |
| IL (2) | IL236346B (cg-RX-API-DMAC7.html) |
| IN (1) | IN2015DN00281A (cg-RX-API-DMAC7.html) |
| PT (1) | PT2864473T (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201408717XA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014004341A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106467918B (zh) * | 2015-08-18 | 2020-07-31 | 中国科学技术大学先进技术研究院 | 一种基于人皮肤细胞的胰岛素分泌细胞的诱导方法及应用 |
| CN105434471A (zh) * | 2015-11-26 | 2016-03-30 | 深圳爱生再生医学科技有限公司 | 治疗糖尿病的干细胞制剂及其制备方法 |
| US11484554B2 (en) * | 2018-02-09 | 2022-11-01 | Seraxis, Inc. | Pancreatic cells for treating diabetes and methods of generating the same |
| CN112888778B (zh) * | 2018-10-15 | 2025-06-03 | 埃维亚生命科学有限公司 | 通过低分子化合物由源自内胚层组织或器官的细胞制备干细胞/祖细胞的方法 |
| IL293803A (en) * | 2019-12-11 | 2022-08-01 | Univ Tokyo | Induction of proliferating pancreatic islet-like germ cells by transient expression of mycl and induction of differentiation into insulin-positive cells |
| WO2023278382A1 (en) | 2021-06-29 | 2023-01-05 | Staffan Holmin | Endoluminal delivery cannula |
| IL316370A (en) | 2022-04-15 | 2024-12-01 | Smartcella Solutions Ab | COMPOSITIONS AND METHODS FOR EXOSOME-MEDIATED DELIVERY OF mRNA AGENTS |
| WO2024163938A1 (en) | 2023-02-03 | 2024-08-08 | Seraxis, Inc. | Therapeutic cells and methods relating to the same |
| WO2025029826A1 (en) | 2023-07-31 | 2025-02-06 | Seraxis, Inc. | Modified therapeutics cells and methods relating to the same |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5861313A (en) * | 1995-06-07 | 1999-01-19 | Ontogeny, Inc. | Method of isolating bile duct progenitor cells |
| AU2376200A (en) | 1999-01-07 | 2000-07-24 | Incyte Pharmaceuticals, Inc. | Insulin-synthesis genes |
| US6815203B1 (en) * | 1999-06-23 | 2004-11-09 | Joslin Diabetes Center, Inc. | Methods of making pancreatic islet cells |
| US20030082155A1 (en) | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| CN100475953C (zh) | 1999-12-06 | 2009-04-08 | 通用医疗公司 | 胰腺干细胞 |
| US6436704B1 (en) * | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
| WO2004023100A2 (en) | 2002-09-06 | 2004-03-18 | Amcyte Inc. | Cd56 positive human adult pancreatic endocrine progenitor cells |
| ATE437941T1 (de) | 2003-06-20 | 2009-08-15 | Vrije Universiteit Brussel Vub | Verfahren zur erzeugung von beta-inselzellen aus exokrinen pankreaszellen |
| CA2581424A1 (en) * | 2004-03-09 | 2005-09-22 | Gang Xu | Methods for generating insulin-producing cells |
| US20060029987A1 (en) | 2004-08-06 | 2006-02-09 | Applera Corporation | Diagnosis of pancreatic cancer by using pancreatic targets |
| US7807459B2 (en) | 2005-09-27 | 2010-10-05 | Reneuron, Inc. | EphA4-positive human adult pancreatic endocrine progenitor cells |
| JP2009543580A (ja) * | 2006-07-19 | 2009-12-10 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイテッド | 細胞の再プログラミング用組成物、及びその用途 |
| US20100204258A1 (en) | 2007-03-12 | 2010-08-12 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for modulating insulin secretion and glucose metabolism |
| US8455251B2 (en) | 2007-11-09 | 2013-06-04 | Rnl Bio Co., Ltd. | Method for isolating and culturing adult stem cells derived from human amniotic epithelium |
| WO2009128533A1 (ja) | 2008-04-18 | 2009-10-22 | 国立大学法人名古屋大学 | 間葉系幹細胞およびその生産方法 |
| CN102083964B (zh) * | 2008-05-09 | 2013-06-12 | 格拉斯哥大学大学行政评议会 | 与基于细胞的疗法相关的材料和方法 |
| US9683215B2 (en) * | 2008-08-22 | 2017-06-20 | President And Fellows Of Harvard College | Methods of reprogramming cells |
| EP2379577A4 (en) * | 2008-12-23 | 2012-08-29 | Vivoscript Inc | COMPOSITIONS AND METHODS FOR CELL REPROGRAMMING WITHOUT GENETIC MODIFICATION |
| WO2011032025A2 (en) * | 2009-09-10 | 2011-03-17 | The Salk Institute For Biological Studies | Adipose-derived induced pluripotent stem cells |
| AU2011250912A1 (en) * | 2010-05-12 | 2012-11-22 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| US9394523B2 (en) * | 2010-08-22 | 2016-07-19 | Ramot At Tel-Aviv University Ltd. | Induced pluripotent stem cells derived from human pancreatic beta cells |
| KR101836855B1 (ko) * | 2010-08-31 | 2018-04-19 | 얀센 바이오테크 인코포레이티드 | 만능 줄기 세포의 분화 |
| CN103210082A (zh) * | 2010-09-15 | 2013-07-17 | 雷蒙特亚特特拉维夫大学有限公司 | 扩增胰岛β细胞和使其再分化的方法 |
| WO2012044486A1 (en) * | 2010-09-28 | 2012-04-05 | Baylor Research Institute | Induction of pancreatic stem cells by transient overexpression of reprogramming factors and pdxi selection |
-
2013
- 2013-06-24 CN CN201380033028.9A patent/CN104640979B/zh active Active
- 2013-06-24 EP EP13733516.2A patent/EP2864473B1/en active Active
- 2013-06-24 KR KR1020157000845A patent/KR102058259B1/ko active Active
- 2013-06-24 JP JP2015520349A patent/JP6386453B2/ja active Active
- 2013-06-24 SG SG11201408717XA patent/SG11201408717XA/en unknown
- 2013-06-24 WO PCT/US2013/047243 patent/WO2014004341A1/en not_active Ceased
- 2013-06-24 EA EA201590088A patent/EA033954B1/ru not_active IP Right Cessation
- 2013-06-24 BR BR112014031676A patent/BR112014031676A2/pt not_active Application Discontinuation
- 2013-06-24 EA EA201992135A patent/EA201992135A1/ru unknown
- 2013-06-24 CN CN202110419726.9A patent/CN113265370A/zh active Pending
- 2013-06-24 KR KR1020197036838A patent/KR102174581B1/ko active Active
- 2013-06-24 DK DK13733516.2T patent/DK2864473T3/da active
- 2013-06-24 EP EP19185702.8A patent/EP3611255A1/en active Pending
- 2013-06-24 CA CA2876677A patent/CA2876677C/en active Active
- 2013-06-24 ES ES13733516T patent/ES2745704T3/es active Active
- 2013-06-24 US US13/925,248 patent/US9968639B2/en active Active
- 2013-06-24 AU AU2013280698A patent/AU2013280698B2/en active Active
- 2013-06-24 PT PT13733516T patent/PT2864473T/pt unknown
-
2014
- 2014-12-18 IL IL236346A patent/IL236346B/en active IP Right Grant
-
2015
- 2015-01-13 IN IN281DEN2015 patent/IN2015DN00281A/en unknown
- 2015-04-22 US US14/693,245 patent/US9474772B2/en active Active
-
2018
- 2018-08-09 JP JP2018149816A patent/JP6856586B2/ja active Active
-
2019
- 2019-03-26 AU AU2019202085A patent/AU2019202085A1/en not_active Abandoned
- 2019-05-28 IL IL266965A patent/IL266965B/en unknown
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