ES2745704T3 - Células madre y células pancreáticas útiles para el tratamiento de diabetes mellitus insulinodependiente - Google Patents

Células madre y células pancreáticas útiles para el tratamiento de diabetes mellitus insulinodependiente Download PDF

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ES2745704T3
ES2745704T3 ES13733516T ES13733516T ES2745704T3 ES 2745704 T3 ES2745704 T3 ES 2745704T3 ES 13733516 T ES13733516 T ES 13733516T ES 13733516 T ES13733516 T ES 13733516T ES 2745704 T3 ES2745704 T3 ES 2745704T3
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cells
pancreatic
cell
lineage
reprogrammed
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William Rust
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SERAXIS Inc
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
    • C12N5/0678Stem cells; Progenitor cells; Precursor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37Digestive system
    • A61K35/39Pancreas; Islets of Langerhans
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2500/05Inorganic components
    • C12N2500/10Metals; Metal chelators
    • C12N2500/20Transition metals
    • C12N2500/24Iron; Fe chelators; Transferrin
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/38Hormones with nuclear receptors
    • C12N2501/385Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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    • C12N2501/41Hedgehog proteins; Cyclopamine (inhibitor)
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    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/13Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1329Cardiomyocytes
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    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/22Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells
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    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
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  • Nutrition Science (AREA)
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  • Obesity (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
ES13733516T 2012-06-26 2013-06-24 Células madre y células pancreáticas útiles para el tratamiento de diabetes mellitus insulinodependiente Active ES2745704T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261664259P 2012-06-26 2012-06-26
PCT/US2013/047243 WO2014004341A1 (en) 2012-06-26 2013-06-24 Stem cells and pancreatic cells useful for the treatment of insulin-dependent diabetes mellitus

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ES2745704T3 true ES2745704T3 (es) 2020-03-03

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US (2) US9968639B2 (cg-RX-API-DMAC7.html)
EP (2) EP2864473B1 (cg-RX-API-DMAC7.html)
JP (2) JP6386453B2 (cg-RX-API-DMAC7.html)
KR (2) KR102058259B1 (cg-RX-API-DMAC7.html)
CN (2) CN104640979B (cg-RX-API-DMAC7.html)
AU (2) AU2013280698B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014031676A2 (cg-RX-API-DMAC7.html)
CA (1) CA2876677C (cg-RX-API-DMAC7.html)
DK (1) DK2864473T3 (cg-RX-API-DMAC7.html)
EA (2) EA033954B1 (cg-RX-API-DMAC7.html)
ES (1) ES2745704T3 (cg-RX-API-DMAC7.html)
IL (2) IL236346B (cg-RX-API-DMAC7.html)
IN (1) IN2015DN00281A (cg-RX-API-DMAC7.html)
PT (1) PT2864473T (cg-RX-API-DMAC7.html)
SG (1) SG11201408717XA (cg-RX-API-DMAC7.html)
WO (1) WO2014004341A1 (cg-RX-API-DMAC7.html)

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CN106467918B (zh) * 2015-08-18 2020-07-31 中国科学技术大学先进技术研究院 一种基于人皮肤细胞的胰岛素分泌细胞的诱导方法及应用
CN105434471A (zh) * 2015-11-26 2016-03-30 深圳爱生再生医学科技有限公司 治疗糖尿病的干细胞制剂及其制备方法
US11484554B2 (en) * 2018-02-09 2022-11-01 Seraxis, Inc. Pancreatic cells for treating diabetes and methods of generating the same
CN112888778B (zh) * 2018-10-15 2025-06-03 埃维亚生命科学有限公司 通过低分子化合物由源自内胚层组织或器官的细胞制备干细胞/祖细胞的方法
IL293803A (en) * 2019-12-11 2022-08-01 Univ Tokyo Induction of proliferating pancreatic islet-like germ cells by transient expression of mycl and induction of differentiation into insulin-positive cells
WO2023278382A1 (en) 2021-06-29 2023-01-05 Staffan Holmin Endoluminal delivery cannula
IL316370A (en) 2022-04-15 2024-12-01 Smartcella Solutions Ab COMPOSITIONS AND METHODS FOR EXOSOME-MEDIATED DELIVERY OF mRNA AGENTS
WO2024163938A1 (en) 2023-02-03 2024-08-08 Seraxis, Inc. Therapeutic cells and methods relating to the same
WO2025029826A1 (en) 2023-07-31 2025-02-06 Seraxis, Inc. Modified therapeutics cells and methods relating to the same

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IL236346B (en) 2019-06-30
EA201590088A1 (ru) 2015-04-30
JP6386453B2 (ja) 2018-09-05
PT2864473T (pt) 2019-09-27
JP6856586B2 (ja) 2021-04-07
CA2876677C (en) 2021-09-07
JP2015522281A (ja) 2015-08-06
KR102058259B1 (ko) 2019-12-23
EP2864473B1 (en) 2019-08-21
BR112014031676A2 (pt) 2017-10-31
US20150231181A1 (en) 2015-08-20
EA033954B1 (ru) 2019-12-13
CN113265370A (zh) 2021-08-17
IL236346A0 (en) 2015-02-26
EP3611255A1 (en) 2020-02-19
AU2013280698B2 (en) 2019-01-17
EP2864473A1 (en) 2015-04-29
US20130344594A1 (en) 2013-12-26
CA2876677A1 (en) 2014-01-03
IN2015DN00281A (cg-RX-API-DMAC7.html) 2015-06-12
AU2019202085A1 (en) 2019-04-18
US9474772B2 (en) 2016-10-25
EA201992135A1 (ru) 2020-02-05
KR20190141263A (ko) 2019-12-23
JP2018193394A (ja) 2018-12-06
IL266965A (en) 2019-07-31
DK2864473T3 (da) 2019-09-23
SG11201408717XA (en) 2015-02-27
CN104640979A (zh) 2015-05-20
KR102174581B1 (ko) 2020-11-06
WO2014004341A1 (en) 2014-01-03
AU2013280698A1 (en) 2015-01-22
US9968639B2 (en) 2018-05-15
CN104640979B (zh) 2021-05-04
KR20150036059A (ko) 2015-04-07
IL266965B (en) 2021-08-31

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