JP2015520606A5 - - Google Patents
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- JP2015520606A5 JP2015520606A5 JP2015505034A JP2015505034A JP2015520606A5 JP 2015520606 A5 JP2015520606 A5 JP 2015520606A5 JP 2015505034 A JP2015505034 A JP 2015505034A JP 2015505034 A JP2015505034 A JP 2015505034A JP 2015520606 A5 JP2015520606 A5 JP 2015520606A5
- Authority
- JP
- Japan
- Prior art keywords
- maf
- gene
- breast cancer
- expression level
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102100039189 Transcription factor Maf Human genes 0.000 claims 39
- 108090000623 proteins and genes Proteins 0.000 claims 23
- 238000000034 method Methods 0.000 claims 21
- 230000014509 gene expression Effects 0.000 claims 19
- 210000000988 bone and bone Anatomy 0.000 claims 18
- 206010027476 Metastases Diseases 0.000 claims 15
- 230000009401 metastasis Effects 0.000 claims 15
- 206010006187 Breast cancer Diseases 0.000 claims 12
- 208000026310 Breast neoplasm Diseases 0.000 claims 12
- 238000000338 in vitro Methods 0.000 claims 10
- 239000003112 inhibitor Substances 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 102000014128 RANK Ligand Human genes 0.000 claims 5
- 108010025832 RANK Ligand Proteins 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 201000007281 estrogen-receptor positive breast cancer Diseases 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 238000011282 treatment Methods 0.000 claims 5
- 230000003321 amplification Effects 0.000 claims 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims 4
- 230000015556 catabolic process Effects 0.000 claims 3
- 238000006731 degradation reaction Methods 0.000 claims 3
- 208000026535 luminal A breast carcinoma Diseases 0.000 claims 3
- 208000026534 luminal B breast carcinoma Diseases 0.000 claims 3
- 230000005945 translocation Effects 0.000 claims 3
- 229940122361 Bisphosphonate Drugs 0.000 claims 2
- 102000055006 Calcitonin Human genes 0.000 claims 2
- 108060001064 Calcitonin Proteins 0.000 claims 2
- 229940097000 DKK-1 inhibitor Drugs 0.000 claims 2
- 101001135738 Homo sapiens Parathyroid hormone-related protein Proteins 0.000 claims 2
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 2
- 206010027452 Metastases to bone Diseases 0.000 claims 2
- 108090000445 Parathyroid hormone Proteins 0.000 claims 2
- 102100036899 Parathyroid hormone-related protein Human genes 0.000 claims 2
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 2
- QHLITPHIARVDJI-UHFFFAOYSA-N [1-[4-(2-naphthalenyl)-2-pyrimidinyl]-4-piperidinyl]methanamine Chemical compound C1CC(CN)CCN1C1=NC=CC(C=2C=C3C=CC=CC3=CC=2)=N1 QHLITPHIARVDJI-UHFFFAOYSA-N 0.000 claims 2
- 150000004663 bisphosphonates Chemical class 0.000 claims 2
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims 2
- 229960004015 calcitonin Drugs 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000002834 estrogen receptor modulator Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- HCWPIIXVSYCSAN-OIOBTWANSA-N radium-223 Chemical compound [223Ra] HCWPIIXVSYCSAN-OIOBTWANSA-N 0.000 claims 2
- 229960005562 radium-223 Drugs 0.000 claims 2
- XXUZFRDUEGQHOV-UHFFFAOYSA-J strontium ranelate Chemical compound [Sr+2].[Sr+2].[O-]C(=O)CN(CC([O-])=O)C=1SC(C([O-])=O)=C(CC([O-])=O)C=1C#N XXUZFRDUEGQHOV-UHFFFAOYSA-J 0.000 claims 2
- 229940079488 strontium ranelate Drugs 0.000 claims 2
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 102000004171 Cathepsin K Human genes 0.000 claims 1
- 108090000625 Cathepsin K Proteins 0.000 claims 1
- 229940122156 Cathepsin K inhibitor Drugs 0.000 claims 1
- 230000004544 DNA amplification Effects 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 208000003076 Osteolysis Diseases 0.000 claims 1
- 102000008108 Osteoprotegerin Human genes 0.000 claims 1
- 108010035042 Osteoprotegerin Proteins 0.000 claims 1
- 208000020584 Polyploidy Diseases 0.000 claims 1
- 102000001332 SRC Human genes 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229940111134 coxibs Drugs 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 229940125436 dual inhibitor Drugs 0.000 claims 1
- 238000011337 individualized treatment Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229940043355 kinase inhibitor Drugs 0.000 claims 1
- 208000029791 lytic metastatic bone lesion Diseases 0.000 claims 1
- 229940124302 mTOR inhibitor Drugs 0.000 claims 1
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims 1
- XXUPLYBCNPLTIW-UHFFFAOYSA-N octadec-7-ynoic acid Chemical compound CCCCCCCCCCC#CCCCCCC(O)=O XXUPLYBCNPLTIW-UHFFFAOYSA-N 0.000 claims 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 108010087686 src-Family Kinases Proteins 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000011269 treatment regimen Methods 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261621949P | 2012-04-09 | 2012-04-09 | |
| EP12382139.9A EP2650682A1 (en) | 2012-04-09 | 2012-04-09 | Method for the prognosis and treatment of cancer metastasis |
| EP12382139.9 | 2012-04-09 | ||
| US61/621,949 | 2012-04-09 | ||
| US201261724807P | 2012-11-09 | 2012-11-09 | |
| US61/724,807 | 2012-11-09 | ||
| US201261732175P | 2012-11-30 | 2012-11-30 | |
| US61/732,175 | 2012-11-30 | ||
| PCT/IB2013/001204 WO2013153458A2 (en) | 2012-04-09 | 2013-03-15 | Method for the prognosis and treatment of cancer metastasis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018059907A Division JP6781184B2 (ja) | 2012-04-09 | 2018-03-27 | がん転移の予後診断および処置のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520606A JP2015520606A (ja) | 2015-07-23 |
| JP2015520606A5 true JP2015520606A5 (enExample) | 2016-05-12 |
| JP6381519B2 JP6381519B2 (ja) | 2018-08-29 |
Family
ID=45929479
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505034A Active JP6381519B2 (ja) | 2012-04-09 | 2013-03-15 | がん転移の予後診断および処置のための方法 |
| JP2018059907A Active JP6781184B2 (ja) | 2012-04-09 | 2018-03-27 | がん転移の予後診断および処置のための方法 |
| JP2020174192A Withdrawn JP2021007408A (ja) | 2012-04-09 | 2020-10-15 | がん転移の予後診断および処置のための方法 |
| JP2022099476A Pending JP2022125079A (ja) | 2012-04-09 | 2022-06-21 | がん転移の予後診断および処置のための方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018059907A Active JP6781184B2 (ja) | 2012-04-09 | 2018-03-27 | がん転移の予後診断および処置のための方法 |
| JP2020174192A Withdrawn JP2021007408A (ja) | 2012-04-09 | 2020-10-15 | がん転移の予後診断および処置のための方法 |
| JP2022099476A Pending JP2022125079A (ja) | 2012-04-09 | 2022-06-21 | がん転移の予後診断および処置のための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9702878B2 (enExample) |
| EP (3) | EP2650682A1 (enExample) |
| JP (4) | JP6381519B2 (enExample) |
| KR (2) | KR102252332B1 (enExample) |
| CN (1) | CN104797935B (enExample) |
| AU (1) | AU2013246618B9 (enExample) |
| BR (1) | BR112014025269B1 (enExample) |
| CA (1) | CA2891609C (enExample) |
| DK (2) | DK2836837T3 (enExample) |
| ES (2) | ES2798107T3 (enExample) |
| FI (1) | FI3825692T3 (enExample) |
| MX (1) | MX374827B (enExample) |
| WO (1) | WO2013153458A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2562274T3 (es) | 2010-10-06 | 2016-03-03 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Procedimiento para el diagnóstico, pronóstico y tratamiento de metástasis de cáncer de mama |
| EP2650682A1 (en) | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Method for the prognosis and treatment of cancer metastasis |
| ES2705237T3 (es) | 2012-06-06 | 2019-03-22 | Fundacio Inst De Recerca Biomedica Irb Barcelona | Método para el diagnóstico y el pronóstico de metástasis del cáncer de pulmón |
| US10119171B2 (en) | 2012-10-12 | 2018-11-06 | Inbiomotion S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis |
| DK2906718T3 (da) | 2012-10-12 | 2019-07-01 | Inbiomotion Sl | Fremgangsmåde til diagnose, prognose og behandling af prostatakræftmetastase under anvendelse af c-maf |
| AU2014229505B2 (en) * | 2013-03-15 | 2020-02-27 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the prognosis and treatment of cancer metastasis |
| US20160032399A1 (en) * | 2013-03-15 | 2016-02-04 | Inbiomotion S.L. | Method for the Prognosis and Treatment of Renal Cell Carcinoma Metastasis |
| BR112015023510A2 (pt) | 2013-03-15 | 2017-10-10 | Fundacio Inst De Recerca Biomedica Irb Barcelona | método para o diagnóstico, prognóstico e tratamento de câncer metastático |
| JP6550045B2 (ja) * | 2013-10-09 | 2019-07-24 | フンダシオ、インスティトゥト、デ、レセルカ、ビオメディカ（イエレベ、バルセロナ）Ｆｕｎｄａｃｉｏ Ｉｎｓｔｉｔｕｔ Ｄｅ Ｒｅｃｅｒｃａ Ｂｉｏｍｅｄｉｃａ （Ｉｒｂ Ｂａｒｃｅｌｏｎａ） | 乳がんに由来する骨の転移がんの予後診断および処置のための方法 |
| JP2017538412A (ja) * | 2014-12-11 | 2017-12-28 | インバイオモーション エセ．エレ． | ヒトｃ−ｍａｆに対する結合メンバー |
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| CN105907886A (zh) * | 2016-07-07 | 2016-08-31 | 蔡维泺 | miR-124在乳腺癌骨转移疾病中的应用 |
| JP7108631B2 (ja) | 2017-01-06 | 2022-07-28 | パルヴェラ セラピューティクス、インク． | ｍＴＯＲ阻害剤の無水組成物およびその使用方法 |
| CN108796071A (zh) * | 2017-04-26 | 2018-11-13 | 中国科学院上海生命科学研究院 | 转移性乳腺癌标记物及其在诊断和治疗中的应用 |
| EP3713581A1 (en) * | 2017-11-22 | 2020-09-30 | Inbiomotion S.L. | Therapeutic treatment of breast cancer based on c-maf |
| KR102664243B1 (ko) * | 2018-01-19 | 2024-05-08 | 데루타-후라이 화마 가부시키가이샤 | 암 환자의 치료에 유용한 오줌의 알칼리제 |
| KR102224910B1 (ko) * | 2018-06-26 | 2021-03-05 | 재단법인 의약바이오컨버젼스연구단 | Rna 은 제자리 혼성화 방법을 통한 aimp2-dx2 신호 자동화 검출 방법 |
| CN110656171B (zh) * | 2018-06-28 | 2023-05-05 | 润安医学科技(苏州)有限公司 | 小核仁核糖核酸snord33作为生物标记物用于制备检测试剂盒中的用途 |
| JP2021530463A (ja) | 2018-07-02 | 2021-11-11 | パルヴェラ セラピューティクス、インク． | ｍＴＯＲ阻害剤の無水組成物および使用方法 |
| US12139764B2 (en) | 2018-11-14 | 2024-11-12 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Systems and methods for characterizing and treating breast cancer |
| WO2021062261A1 (en) * | 2019-09-25 | 2021-04-01 | The Trustees Of Columbia University In The City Of New York | Prognostic markers of metastatic cancer |
| CN112662763A (zh) * | 2020-03-10 | 2021-04-16 | 博尔诚（北京）科技有限公司 | 一种检测常见两性癌症的探针组合物 |
| CN112662764A (zh) * | 2020-03-17 | 2021-04-16 | 博尔诚（北京）科技有限公司 | 一种检测11种癌症的探针组合物 |
| JP7607330B2 (ja) * | 2021-04-30 | 2024-12-27 | 国立大学法人金沢大学 | 骨腫瘍の予後診断方法又は予後診断補助方法 |
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| CN115919464B (zh) * | 2023-03-02 | 2023-06-23 | 四川爱麓智能科技有限公司 | 肿瘤定位方法、系统、装置及肿瘤发展预测方法 |
| CN119614707A (zh) * | 2025-01-13 | 2025-03-14 | 中山大学 | ERα生物标志物在ER+乳腺癌骨转移诊断、治疗和预后中的应用 |
| CN119662833B (zh) * | 2025-01-22 | 2025-08-15 | 中山大学孙逸仙纪念医院 | 基于肿瘤小泡中circCCDC50的Luminal型乳腺癌骨转移标记物、预测诊断试剂盒 |
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| US8173825B2 (en) | 2006-12-20 | 2012-05-08 | The United States Of America, As Represented By The Secretary Of Agriculture | Method of making fatty acid ester derivatives |
| WO2008098351A1 (en) | 2007-02-14 | 2008-08-21 | University Health Network | Treatment of d-cyclin mediated proliferative diseases and hemotological malignancies |
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| EP2650682A1 (en) | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Method for the prognosis and treatment of cancer metastasis |
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