JP2015520197A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015520197A5 JP2015520197A5 JP2015517568A JP2015517568A JP2015520197A5 JP 2015520197 A5 JP2015520197 A5 JP 2015520197A5 JP 2015517568 A JP2015517568 A JP 2015517568A JP 2015517568 A JP2015517568 A JP 2015517568A JP 2015520197 A5 JP2015520197 A5 JP 2015520197A5
- Authority
- JP
- Japan
- Prior art keywords
- less
- composition according
- hydrophobic
- targeting moiety
- hydrophilic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 11
- 239000002105 nanoparticle Substances 0.000 claims 9
- HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical compound OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 claims 7
- 230000002209 hydrophobic effect Effects 0.000 claims 6
- 230000008685 targeting Effects 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 3
- 229920002521 macromolecule Polymers 0.000 claims 3
- 229920000747 poly(lactic acid) Polymers 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 229920002307 Dextran Polymers 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000001268 conjugating effect Effects 0.000 claims 2
- 229920001477 hydrophilic polymer Polymers 0.000 claims 2
- 229920001600 hydrophobic polymer Polymers 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims 1
- 229920000249 biocompatible polymer Polymers 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 229920000359 diblock copolymer Polymers 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261690127P | 2012-06-20 | 2012-06-20 | |
| US61/690,127 | 2012-06-20 | ||
| PCT/CA2013/050475 WO2013188979A1 (en) | 2012-06-20 | 2013-06-20 | Mucoadhesive nanoparticle delivery system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520197A JP2015520197A (ja) | 2015-07-16 |
| JP2015520197A5 true JP2015520197A5 (cg-RX-API-DMAC7.html) | 2016-09-15 |
| JP6275707B2 JP6275707B2 (ja) | 2018-02-07 |
Family
ID=49767986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517568A Active JP6275707B2 (ja) | 2012-06-20 | 2013-06-20 | 粘膜付着性ナノ粒子送達系 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20140005379A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2863892B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6275707B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102177557B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN104507458B (cg-RX-API-DMAC7.html) |
| CA (1) | CA2877051C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2658972T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013188979A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| ES3005233T3 (en) | 2010-10-01 | 2025-03-14 | Modernatx Inc | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| DE12722942T1 (de) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | Freisetzung und formulierung von manipulierten nukleinsäuren |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2648950C2 (ru) | 2011-10-03 | 2018-04-02 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
| AU2012352180A1 (en) | 2011-12-16 | 2014-07-31 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| WO2013151663A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of membrane proteins |
| US20140005379A1 (en) | 2012-06-20 | 2014-01-02 | Frank GU | Nanoparticle delivery system and components thereof |
| US9878000B2 (en) | 2012-06-20 | 2018-01-30 | University Of Waterloo | Mucoadhesive nanoparticle composition comprising immunosuppresant and methods of use thereof |
| HRP20220607T1 (hr) | 2012-11-26 | 2022-06-24 | Modernatx, Inc. | Terminalno modificirana rna |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| EP2971010B1 (en) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| JP2016518388A (ja) | 2013-04-30 | 2016-06-23 | オティトピック インク． | 乾燥粉末配合および使用方法 |
| AU2014321215B2 (en) | 2013-09-23 | 2020-07-16 | Rensselaer Polytechnic Institute | Nanoparticle-mediated gene delivery, genomic editing and ligand-targeted modification in various cell populations |
| EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| WO2016007647A1 (en) * | 2014-07-09 | 2016-01-14 | The Johns Hopkins University | Glutaminase inhibitor discovery and nanoparticle-enhanced delivery for cancer therapy |
| DE102014012675A1 (de) * | 2014-08-26 | 2016-03-03 | Wavelight Gmbh | Vernetzung von Augengewebe |
| JP2017538796A (ja) * | 2014-10-09 | 2017-12-28 | ディストレット テクノロジーコ シシリア ミクロ エ ナノ システミ エス．シー．エー．アール．エル． | 両親媒性共重合体、それらの調製および薬物の送達のための使用 |
| WO2016176768A1 (en) * | 2015-05-04 | 2016-11-10 | University Of Waterloo | Mucoadhesive nanoparticle composition comprising immunosuppresant and methods of use thereof |
| WO2017019792A1 (en) * | 2015-07-27 | 2017-02-02 | The Texas A&M University System | Surface active nanosystems |
| WO2017019773A1 (en) * | 2015-07-28 | 2017-02-02 | Layerbio, Inc. | Sustained-release drug formulations for glaucoma |
| CA2996910C (en) * | 2015-09-01 | 2023-08-22 | Mcmaster University | Micelles for mucoadhesive drug delivery |
| US10765745B2 (en) * | 2015-09-09 | 2020-09-08 | Board Of Regents, The University Of Texas System | Multifunctional nanoparticle systems and methods for cancer diagnosis and combination therapy |
| US10987434B2 (en) * | 2015-10-21 | 2021-04-27 | The Regents Of The University Of Michigan | Detection and treatment of caries and microcavities with nanoparticles |
| KR101721977B1 (ko) * | 2015-11-02 | 2017-03-31 | 영남대학교 산학협력단 | 약물 지속 방출형 나노 입자 및 상기 나노입자로 표면개질된 췌장소도세포를 포함하는 당뇨병 치료용 약학 조성물 |
| CN106680248B (zh) * | 2015-11-05 | 2019-03-05 | 南京理工大学 | 基于金丝桃素与1-芘丁酸作用的dna荧光分析方法 |
| EP3409772B1 (en) | 2016-01-29 | 2023-06-28 | National University Corporation Hokkaido University | Intracellular substance transport system and use thereof |
| JP6703408B2 (ja) * | 2016-01-30 | 2020-06-03 | 国立大学法人 筑波大学 | ポリイオンコンプレックスを有効成分とするドライアイ処置用組成物 |
| WO2017204475A1 (ko) * | 2016-05-24 | 2017-11-30 | 한양대학교 산학협력단 | 항암제 함유 나노입자를 포함하는 뇌질환 치료를 위한 비강 투여용 약제학적 조성물 |
| WO2018045199A2 (en) * | 2016-08-31 | 2018-03-08 | Kansas State University Research Foundation | Nucleic acid-peptide capsule complexes |
| CN106265594B (zh) * | 2016-09-21 | 2019-07-26 | 南京医科大学 | 一种缺血性脑卒中靶向的红细胞膜仿生智能药物载体及其制备方法 |
| US10427194B2 (en) | 2016-09-28 | 2019-10-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Microwave-enabled thermal remediation of organic chemical contaminated soils using dielectric nanomaterials as additives |
| KR102002612B1 (ko) * | 2016-10-25 | 2019-07-22 | 서강대학교 산학협력단 | 녹내장 치료용 안약 제제 |
| CN106581691B (zh) * | 2016-12-04 | 2019-09-10 | 苏州大学 | 还原响应的靶向聚乙二醇-聚碳酸酯美登素前药胶束、其制备方法与应用 |
| KR20240172763A (ko) | 2016-12-14 | 2024-12-10 | 리간달 인코포레이티드 | 핵산 및/또는 단백질 적재물 전달을 위한 조성물 및 방법 |
| US11021529B2 (en) | 2017-03-03 | 2021-06-01 | Massachusetts Institute Of Technology | Antimicrobial constructs and uses thereof |
| JPWO2019004482A1 (ja) * | 2017-06-26 | 2020-08-13 | 国立大学法人 東京大学 | 複素環式ボロン酸誘導体 |
| BR102017016440A2 (pt) | 2017-07-31 | 2019-03-19 | Universidade Federal Do Rio Grande Do Sul | Composição para terapia gênica do sistema nervoso central, processo de obtenção e uso da mesma |
| US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
| AU2017432640B2 (en) | 2017-09-22 | 2023-11-30 | Aspeya US Inc. | Dry powder compositions with magnesium stearate |
| CN107569454B (zh) * | 2017-09-29 | 2018-05-04 | 深圳大佛药业股份有限公司 | 一种盐酸奥洛他定鼻喷雾剂及其制备方法 |
| ES2711669A1 (es) * | 2017-11-02 | 2019-05-06 | Univ Santiago Compostela | Sistemas de liberacion de farmacos de acido polisialico y metodos |
| WO2019126739A1 (en) | 2017-12-21 | 2019-06-27 | Shepherd Therapeutics, Inc. | Pyrvinium pamoate anti-cancer therapies |
| CN108251409B (zh) * | 2018-01-11 | 2020-02-11 | 山东交通学院 | 一种吸附降解油污的复合微生物导弹材料及其制备方法 |
| US10590020B2 (en) | 2018-01-18 | 2020-03-17 | Arizona Board Of Regents On Behalf Of Arizona State University | Additive-amplified microwave pretreatment of wastewater sludge |
| CN108451895A (zh) * | 2018-04-26 | 2018-08-28 | 霍尔果斯汉智医药科技有限公司 | 一种左炔诺孕酮阴道膨胀栓及其制备方法 |
| US20210299218A1 (en) * | 2018-08-01 | 2021-09-30 | Nanoneuron Therapeutics, Inc. | Neuroprotective compositions and use thereof |
| JP7164700B2 (ja) | 2018-09-11 | 2022-11-01 | リードバイオセラピューティクスリミテッド | 粘膜付着性分散ナノ粒子系およびその製造方法 |
| US20210113715A1 (en) * | 2018-09-14 | 2021-04-22 | Cedars-Sinai Medical Center | Targeted nanoparticles for diagnosing, detecting and treating cancer |
| US11000482B2 (en) * | 2018-11-21 | 2021-05-11 | University Of South Carolina | Fabrication of a suramin-loaded nanoparticle and its application |
| US11458092B2 (en) | 2018-12-14 | 2022-10-04 | NuVessl, Inc. | Composition with enhanced passenger molecule loading |
| CN110075345B (zh) * | 2019-04-01 | 2021-12-10 | 杭州英健生物科技有限公司 | 适用于胃窥镜喷涂到胃损伤黏膜表面的双组分自粘性胃黏膜保护胶及其应用 |
| CN109875964B (zh) * | 2019-03-27 | 2021-08-27 | 内江西凯杰成医药科技有限公司 | 一种阿霉素无载体纳米药物的制备及其应用 |
| WO2020210378A1 (en) * | 2019-04-08 | 2020-10-15 | University Of Massachusetts | Localization of payload delivery systems to tumor sites via beacon cell targeting |
| CN111848835B (zh) * | 2019-04-30 | 2023-02-03 | 苏州大学 | 含氟化合物修饰的壳聚糖在透皮给药制剂制备中的应用 |
| CN110200941B (zh) * | 2019-06-24 | 2020-05-15 | 苏州大学 | 作用于小肠的辐射防护纳米药物及其制备方法 |
| CN112274646B (zh) * | 2019-07-12 | 2023-06-02 | 北京茵诺医药科技有限公司 | 用于靶向活化cd44分子的双亲性蛋白质-高分子结合体递送系统、其制备方法和应用 |
| US20220339117A1 (en) | 2019-09-04 | 2022-10-27 | The Trustees Of Princeton University | Comb polymer and block copolymer stabilized nanoparticles encapsulating nucleic acids and other soluble hydrophilic compounds |
| CN110755597B (zh) * | 2019-10-24 | 2023-07-07 | 广州市希丽生物科技服务有限公司 | 用于预防和治疗类风湿性关节炎的外用药物组合物 |
| CN111620924A (zh) * | 2020-06-04 | 2020-09-04 | 华中农业大学 | 基于天然产物的药物设计方法、五环三萜类化合物、其制备方法及应用 |
| WO2022006685A1 (en) * | 2020-07-10 | 2022-01-13 | Nuecology Biomedical Inc. | Injectable high-drug-loaded nanocomposite gels and process for making the same |
| CN112206325B (zh) * | 2020-09-21 | 2022-11-18 | 温州医科大学附属眼视光医院 | 一种长眼表滞留人工泪液及其制备方法 |
| US20240033219A1 (en) * | 2020-12-09 | 2024-02-01 | The Regents Of The University Of California | Compositions and methods for mucosal drug delivery |
| CN112783163A (zh) * | 2020-12-29 | 2021-05-11 | 江西方迪科技有限公司 | 密集架的智能记忆控制系统 |
| CN112691087B (zh) * | 2021-01-25 | 2022-02-25 | 潍坊医学院 | 一种那他霉素纳米粒及其制备方法 |
| CN113077942B (zh) * | 2021-04-12 | 2021-12-17 | 西北工业大学 | 一种基于功率超声制备智能柔性导电薄膜及其应用 |
| WO2022246175A1 (en) * | 2021-05-21 | 2022-11-24 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for treating depression and anxiety |
| CN113876716B (zh) * | 2021-10-14 | 2023-03-10 | 中山大学·深圳 | 一种治疗胃肠道疾病的生物粘附性纳米粒及其制备方法 |
| US20240335575A1 (en) * | 2021-10-20 | 2024-10-10 | Aphios Corporation | Method and apparatus for inactivating pathogens in units of whole blood using superparamagnetic nanoparticles coated with chemiluminescence reagents and broad-spectrum anti-viral therapeutics |
| WO2023092208A1 (pt) * | 2021-11-25 | 2023-06-01 | Universidade Estadual De Campinas | Processo de obtenção de solução polimérica injetável fotoreticulável, solução polimérica injetável fotoreticulável e seus usos |
| EP4447951A2 (en) * | 2021-12-16 | 2024-10-23 | Alveolus Bio, Inc. | Inhalable or ingestible lactic acid compositions for the treatment of chronic lung disease |
| CN119731223A (zh) * | 2022-04-29 | 2025-03-28 | 佛罗里达大学研究基金会 | 超高分子量聚合物及其制备和使用方法 |
| CN115558128B (zh) * | 2022-09-28 | 2024-05-24 | 中国科学院长春应用化学研究所 | 一种具有过氧化物酶活性水凝胶敷料及其制备方法和应用 |
| AU2023366929A1 (en) | 2022-10-25 | 2025-05-08 | Veradermics, Incorporated | Compositions and methods of use for modified release minoxidil |
| US12145890B2 (en) | 2022-12-16 | 2024-11-19 | Raytheon Company | Coated (core-shell) nanoparticles for nanocomposite optical ceramics |
| CN115970066B (zh) * | 2022-12-29 | 2024-09-27 | 成都爱睿康乐医疗器械有限公司 | 基于主客体相互作用的载药纳米凝胶生物润滑剂及其制备方法和应用 |
| WO2024148431A1 (en) * | 2023-01-10 | 2024-07-18 | Nuecology Biomedical Inc. | A pharmaceutical composition in the form of an injectable nanocomposite gel for co-delivery of multiple medicines or drugs |
| WO2024206230A1 (en) * | 2023-03-24 | 2024-10-03 | Trustees Of Tufts College | Tissue targeting lipids and lipid nanoparticles |
| CN116617405A (zh) * | 2023-04-21 | 2023-08-22 | 四川大学 | 具有粘膜粘附性的脂质体药物载体及其制备方法和应用 |
| CN117562870A (zh) * | 2023-11-08 | 2024-02-20 | 浙江大学 | 一种生物相容、装载水不溶性药物的靶向性纳米胶囊及其制备方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4649047A (en) | 1985-03-19 | 1987-03-10 | University Of Georgia Research Foundation, Inc. | Ophthalmic treatment by topical administration of cyclosporin |
| US4839342A (en) | 1987-09-03 | 1989-06-13 | University Of Georgia Research Foundation, Inc. | Method of increasing tear production by topical administration of cyclosporin |
| IT1250421B (it) | 1991-05-30 | 1995-04-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive. |
| JP3412198B2 (ja) | 1993-08-31 | 2003-06-03 | 日本油脂株式会社 | 変性マレイン酸共重合体および用途 |
| US6007845A (en) | 1994-07-22 | 1999-12-28 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
| GB9700624D0 (en) | 1997-01-14 | 1997-03-05 | Danbiosyst Uk | Drug delivery composition |
| ES2220406T3 (es) | 1999-02-19 | 2004-12-16 | Universiteit Utrecht | Hidrogeles estereocomplejos. |
| US6254860B1 (en) | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
| US6525145B2 (en) | 2000-04-18 | 2003-02-25 | Clemson University | Polylactide/dextran graft co-polymers for biomaterial and tissue engineering applications |
| US7803392B2 (en) | 2000-12-27 | 2010-09-28 | University Of Kentucky Research Foundation | pH-Sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules |
| US7354574B2 (en) | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| ES2226567B1 (es) | 2003-06-20 | 2006-07-01 | Universidad De Santiago De Compostela | Nanoparticulas de acido hialuronico. |
| US7083802B2 (en) | 2003-07-31 | 2006-08-01 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| WO2005055945A2 (en) | 2003-12-08 | 2005-06-23 | Gel-Del Technologies, Inc. | Mucoadhesive drug delivery devices and methods of making and using thereof |
| US20090232899A1 (en) | 2004-05-21 | 2009-09-17 | David Allan E | Mucoadhesive nanocomposite delivery system |
| US20050281775A1 (en) | 2004-06-16 | 2005-12-22 | Carrington Stephen D | Mucoadhesive and bioadhesive polymers |
| US8361439B1 (en) | 2005-01-04 | 2013-01-29 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
| US20080145432A1 (en) | 2005-03-09 | 2008-06-19 | Yoshinori Kakizawa | Fine Particle and Pharmaceutical Preparation |
| WO2007124132A2 (en) * | 2006-04-20 | 2007-11-01 | University Of Utah Research Foundation | Polymeric compositions and methods of making and using thereof |
| EP2019691B1 (en) | 2006-05-15 | 2020-08-12 | Massachusetts Institute of Technology | Polymers for functional particles |
| ES2294951B1 (es) | 2006-09-28 | 2008-12-01 | Kelian Gutierrez Ugarte | Maquina para peinar el cabello en forma de largos mechones de pelo entrelazado en rastas. |
| US8242165B2 (en) | 2006-10-26 | 2012-08-14 | Creighton University | Mucoadhesive nanoparticles for cancer treatment |
| US20090074828A1 (en) | 2007-04-04 | 2009-03-19 | Massachusetts Institute Of Technology | Poly(amino acid) targeting moieties |
| EP2167044A1 (en) | 2007-06-11 | 2010-03-31 | BioCure, Inc. | Mucoadhesive vesicles for drug delivery |
| WO2009049089A1 (en) * | 2007-10-09 | 2009-04-16 | Washington University In St. Louis | Ligand directed toroidal nanoparticles for therapy and diagnostic imaging |
| US8603532B2 (en) | 2008-10-20 | 2013-12-10 | Massachusetts Institute Of Technology | Nanostructures for drug delivery |
| US8802075B2 (en) | 2009-02-18 | 2014-08-12 | Eyeon Particle Sciences Llc | Bi-functional co-polymer use for opthalmic and other topical and local applications |
| US20110104069A1 (en) | 2009-10-30 | 2011-05-05 | The Ohio State University | Multi-functional biodegradable particles for selectable targeting, imaging, and therapeutic delivery and use thereof for treating ocular disorders |
| JP5560719B2 (ja) | 2010-01-08 | 2014-07-30 | 東レ株式会社 | 親水性生理活性物質含有微粒子の製造方法 |
| WO2012097049A2 (en) * | 2011-01-11 | 2012-07-19 | The University Of North Carolina At Chapel Hill | Dna repair enzyme inhibitor nanoparticles and uses thereof |
| EP2510930A1 (en) | 2011-04-15 | 2012-10-17 | Bionanoplus, S.L. | Nanoparticles comprising half esters of poly (methyl vinyl ether-co-maleic anhydride) and uses thereof |
| US9101547B2 (en) | 2011-08-04 | 2015-08-11 | Nano And Advanced Materials Institute Limited | Enteric-coated capsule containing cationic nanoparticles for oral insulin delivery |
| US9878000B2 (en) | 2012-06-20 | 2018-01-30 | University Of Waterloo | Mucoadhesive nanoparticle composition comprising immunosuppresant and methods of use thereof |
| US20140005379A1 (en) | 2012-06-20 | 2014-01-02 | Frank GU | Nanoparticle delivery system and components thereof |
-
2013
- 2013-06-20 US US13/923,274 patent/US20140005379A1/en not_active Abandoned
- 2013-06-20 CN CN201380040130.1A patent/CN104507458B/zh active Active
- 2013-06-20 WO PCT/CA2013/050475 patent/WO2013188979A1/en not_active Ceased
- 2013-06-20 EP EP13806729.3A patent/EP2863892B1/en active Active
- 2013-06-20 US US14/410,521 patent/US9993439B2/en active Active
- 2013-06-20 JP JP2015517568A patent/JP6275707B2/ja active Active
- 2013-06-20 ES ES13806729.3T patent/ES2658972T3/es active Active
- 2013-06-20 CA CA2877051A patent/CA2877051C/en active Active
- 2013-06-20 KR KR1020157001443A patent/KR102177557B1/ko not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015520197A5 (cg-RX-API-DMAC7.html) | ||
| Jampilek et al. | Advances in drug delivery nanosystems using graphene-based materials and carbon nanotubes | |
| George et al. | Natural biodegradable polymers based nano-formulations for drug delivery: A review | |
| Kyriakides et al. | Biocompatibility of nanomaterials and their immunological properties | |
| Kanwar et al. | Green nanotechnology-driven drug delivery assemblies | |
| Xu et al. | Smart porous silicon nanoparticles with polymeric coatings for sequential combination therapy | |
| Maurya et al. | Strategic use of nanotechnology in drug targeting and its consequences on human health: A focused review | |
| Neerooa et al. | Development of polymer-assisted nanoparticles and nanogels for cancer therapy: An update | |
| JP2011519932A5 (cg-RX-API-DMAC7.html) | ||
| US20080243113A1 (en) | Modification of stent surfaces to impart functionality | |
| Grumezescu | Nano-and microscale drug delivery systems: design and fabrication | |
| HK1206270A1 (en) | Controlled release formulations for the delivery of hif-1 inhibitors | |
| Michalak et al. | Polymeric nanoparticles–a novel solution for delivery of antimicrobial agents | |
| WO2016193810A8 (en) | Formation of cyclosporin a/cyclodextrin nanoparticles | |
| Mishra et al. | Targeting aspects of nanogels: an overview | |
| RU2018105494A (ru) | Улучшенные системы доставки наночастиц | |
| Cui et al. | Bacillus-shape design of polymer based drug delivery systems with Janus-faced function for synergistic targeted drug delivery and more effective cancer therapy | |
| JP2018503736A5 (cg-RX-API-DMAC7.html) | ||
| Lakkakula et al. | Alginate‐Based Nanosystems for Therapeutic Applications | |
| Bahmani et al. | Fabrication of poly (ϵ‐caprolactone)/paclitaxel (core)/chitosan/zein/multi‐walled carbon nanotubes/doxorubicin (shell) nanofibers against MCF‐7 breast cancer | |
| Clementino et al. | Polysaccharides: New frontiers for nasal administration of medicines | |
| EP3450395A3 (en) | Graphene oxide nanoparticle compositions and methods of making the same | |
| Morad et al. | Bioengineered metallic nanomaterials for nanoscale drug delivery systems | |
| Mortazavian et al. | Preparation, design for optimization and in vitro evaluation of insulin nanoparticles integrating thiolated chitosan derivatives | |
| Pirmoradi et al. | Autophagy and biomaterials: a brief overview of the impact of autophagy in biomaterial applications |