JP2015519396A5 - - Google Patents
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- Publication number
- JP2015519396A5 JP2015519396A5 JP2015517311A JP2015517311A JP2015519396A5 JP 2015519396 A5 JP2015519396 A5 JP 2015519396A5 JP 2015517311 A JP2015517311 A JP 2015517311A JP 2015517311 A JP2015517311 A JP 2015517311A JP 2015519396 A5 JP2015519396 A5 JP 2015519396A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- compound
- salt
- inden
- imidazo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 5
- -1 3-methyl-1H-pyrazol-5-yl Chemical group 0.000 claims 3
- CUYKNJBYIJFRCU-UHFFFAOYSA-N 3-aminopyridine Chemical group NC1=CC=CN=C1 CUYKNJBYIJFRCU-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- OXTRVTLULICJAS-UHFFFAOYSA-N pyridin-3-amine;dihydrochloride Chemical compound Cl.Cl.NC1=CC=CN=C1 OXTRVTLULICJAS-UHFFFAOYSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261659679P | 2012-06-14 | 2012-06-14 | |
| US61/659,679 | 2012-06-14 | ||
| PCT/US2013/044211 WO2013188184A1 (en) | 2012-06-14 | 2013-06-05 | Inhibitor of jak1 and jak2 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015519396A JP2015519396A (ja) | 2015-07-09 |
| JP2015519396A5 true JP2015519396A5 (enExample) | 2016-06-30 |
| JP6092376B2 JP6092376B2 (ja) | 2017-03-08 |
Family
ID=48626679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517311A Expired - Fee Related JP6092376B2 (ja) | 2012-06-14 | 2013-06-05 | Ｊａｋ１およびｊａｋ２の阻害剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9062050B2 (enExample) |
| EP (1) | EP2861231B1 (enExample) |
| JP (1) | JP6092376B2 (enExample) |
| KR (1) | KR20150008907A (enExample) |
| CN (1) | CN104349775B (enExample) |
| AU (1) | AU2013274641B2 (enExample) |
| BR (1) | BR112014030651A2 (enExample) |
| CA (1) | CA2871659C (enExample) |
| EA (1) | EA201492104A1 (enExample) |
| ES (1) | ES2605827T3 (enExample) |
| IN (1) | IN2014MN02228A (enExample) |
| MX (1) | MX2014015271A (enExample) |
| WO (1) | WO2013188184A1 (enExample) |
| ZA (1) | ZA201407940B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR105400A1 (es) * | 2015-08-04 | 2017-09-27 | Lilly Co Eli | Inhibidores de jak1 |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| CN110229067A (zh) * | 2019-06-05 | 2019-09-13 | 南京焕然生物科技有限公司 | 一种2-氨基茚制备方法 |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN115141195B (zh) * | 2021-03-03 | 2024-02-06 | 成都先导药物开发股份有限公司 | 一种nuak抑制剂及其用途 |
| WO2023086320A1 (en) * | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of jak2 |
| CN116585312A (zh) * | 2023-04-30 | 2023-08-15 | 兰州大学第二医院 | 含苯氧基丙酸化合物的胰腺癌jak2和stat3双靶向抑制剂及应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006087530A1 (en) | 2005-02-16 | 2006-08-24 | Astrazeneca Ab | Chemical compounds |
| TWI398252B (zh) * | 2006-05-26 | 2013-06-11 | Novartis Ag | 吡咯并嘧啶化合物及其用途 |
| US20100204246A1 (en) * | 2007-04-18 | 2010-08-12 | Astrazeneca Ab | 5-aminopyrazol-3-yl-3h-imidazo (4,5-b) pyridine derivatives and their use for the treatment of cancer |
-
2013
- 2013-06-05 AU AU2013274641A patent/AU2013274641B2/en not_active Ceased
- 2013-06-05 EA EA201492104A patent/EA201492104A1/ru unknown
- 2013-06-05 WO PCT/US2013/044211 patent/WO2013188184A1/en not_active Ceased
- 2013-06-05 KR KR20147034683A patent/KR20150008907A/ko not_active Abandoned
- 2013-06-05 EP EP13729215.7A patent/EP2861231B1/en not_active Not-in-force
- 2013-06-05 CA CA2871659A patent/CA2871659C/en not_active Expired - Fee Related
- 2013-06-05 BR BR112014030651A patent/BR112014030651A2/pt not_active IP Right Cessation
- 2013-06-05 CN CN201380031385.1A patent/CN104349775B/zh not_active Expired - Fee Related
- 2013-06-05 ES ES13729215.7T patent/ES2605827T3/es active Active
- 2013-06-05 JP JP2015517311A patent/JP6092376B2/ja not_active Expired - Fee Related
- 2013-06-05 MX MX2014015271A patent/MX2014015271A/es unknown
- 2013-06-05 IN IN2228MUN2014 patent/IN2014MN02228A/en unknown
- 2013-06-05 US US14/402,146 patent/US9062050B2/en not_active Expired - Fee Related
-
2014
- 2014-10-30 ZA ZA2014/07940A patent/ZA201407940B/en unknown
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