CN104349775B - Jak1和jak2的抑制剂 - Google Patents

Jak1和jak2的抑制剂 Download PDF

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Publication number
CN104349775B
CN104349775B CN201380031385.1A CN201380031385A CN104349775B CN 104349775 B CN104349775 B CN 104349775B CN 201380031385 A CN201380031385 A CN 201380031385A CN 104349775 B CN104349775 B CN 104349775B
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CN
China
Prior art keywords
cells
compound
fluoro
cancer
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201380031385.1A
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English (en)
Chinese (zh)
Other versions
CN104349775A (zh
Inventor
T.P.伯克霍尔德
J.R.克莱顿
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Eli Lilly and Co
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Eli Lilly and Co
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Publication of CN104349775A publication Critical patent/CN104349775A/zh
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Publication of CN104349775B publication Critical patent/CN104349775B/zh
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201380031385.1A 2012-06-14 2013-06-05 Jak1和jak2的抑制剂 Expired - Fee Related CN104349775B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261659679P 2012-06-14 2012-06-14
US61/659679 2012-06-14
PCT/US2013/044211 WO2013188184A1 (en) 2012-06-14 2013-06-05 Inhibitor of jak1 and jak2

Publications (2)

Publication Number Publication Date
CN104349775A CN104349775A (zh) 2015-02-11
CN104349775B true CN104349775B (zh) 2017-06-06

Family

ID=48626679

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380031385.1A Expired - Fee Related CN104349775B (zh) 2012-06-14 2013-06-05 Jak1和jak2的抑制剂

Country Status (14)

Country Link
US (1) US9062050B2 (enExample)
EP (1) EP2861231B1 (enExample)
JP (1) JP6092376B2 (enExample)
KR (1) KR20150008907A (enExample)
CN (1) CN104349775B (enExample)
AU (1) AU2013274641B2 (enExample)
BR (1) BR112014030651A2 (enExample)
CA (1) CA2871659C (enExample)
EA (1) EA201492104A1 (enExample)
ES (1) ES2605827T3 (enExample)
IN (1) IN2014MN02228A (enExample)
MX (1) MX2014015271A (enExample)
WO (1) WO2013188184A1 (enExample)
ZA (1) ZA201407940B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR105400A1 (es) * 2015-08-04 2017-09-27 Lilly Co Eli Inhibidores de jak1
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
CN110229067A (zh) * 2019-06-05 2019-09-13 南京焕然生物科技有限公司 一种2-氨基茚制备方法
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN115141195B (zh) * 2021-03-03 2024-02-06 成都先导药物开发股份有限公司 一种nuak抑制剂及其用途
TW202325289A (zh) * 2021-11-09 2023-07-01 美商雅捷可斯治療公司 Ｊａｋ２抑制劑之形式及組合物
CN116585312A (zh) * 2023-04-30 2023-08-15 兰州大学第二医院 含苯氧基丙酸化合物的胰腺癌jak2和stat3双靶向抑制剂及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007140222A2 (en) * 2006-05-26 2007-12-06 Novartis Ag Pyrrolopyrimidine compounds and their uses
WO2008129255A1 (en) * 2007-04-18 2008-10-30 Astrazeneca Ab 5-aminopyrazol-3-yl-3h-imidazo [4,5-b] pyridine derivatives and their use for the treatment of cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2308731T3 (es) 2005-02-16 2008-12-01 Astrazeneca Ab Compuestos quimicos.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007140222A2 (en) * 2006-05-26 2007-12-06 Novartis Ag Pyrrolopyrimidine compounds and their uses
WO2008129255A1 (en) * 2007-04-18 2008-10-30 Astrazeneca Ab 5-aminopyrazol-3-yl-3h-imidazo [4,5-b] pyridine derivatives and their use for the treatment of cancer

Also Published As

Publication number Publication date
JP2015519396A (ja) 2015-07-09
CA2871659A1 (en) 2013-12-19
BR112014030651A2 (pt) 2017-06-27
IN2014MN02228A (enExample) 2015-07-17
US20150133490A1 (en) 2015-05-14
KR20150008907A (ko) 2015-01-23
EP2861231A1 (en) 2015-04-22
JP6092376B2 (ja) 2017-03-08
AU2013274641A1 (en) 2014-11-20
EP2861231B1 (en) 2016-08-31
CA2871659C (en) 2017-04-04
CN104349775A (zh) 2015-02-11
AU2013274641B2 (en) 2015-09-24
MX2014015271A (es) 2015-03-05
WO2013188184A1 (en) 2013-12-19
ZA201407940B (en) 2016-05-25
US9062050B2 (en) 2015-06-23
EA201492104A1 (ru) 2015-06-30
ES2605827T3 (es) 2017-03-16

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Granted publication date: 20170606

Termination date: 20180605