CA2871659C - Inhibitor of jak1 and jak2 - Google Patents

Inhibitor of jak1 and jak2 Download PDF

Info

Publication number
CA2871659C
CA2871659C CA2871659A CA2871659A CA2871659C CA 2871659 C CA2871659 C CA 2871659C CA 2871659 A CA2871659 A CA 2871659A CA 2871659 A CA2871659 A CA 2871659A CA 2871659 C CA2871659 C CA 2871659C
Authority
CA
Canada
Prior art keywords
cancer
compound
cells
salt
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2871659A
Other languages
English (en)
French (fr)
Other versions
CA2871659A1 (en
Inventor
Timothy Paul Burkholder
Joshua Ryan Clayton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CA2871659A1 publication Critical patent/CA2871659A1/en
Application granted granted Critical
Publication of CA2871659C publication Critical patent/CA2871659C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2871659A 2012-06-14 2013-06-05 Inhibitor of jak1 and jak2 Expired - Fee Related CA2871659C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261659679P 2012-06-14 2012-06-14
US61/659,679 2012-06-14
PCT/US2013/044211 WO2013188184A1 (en) 2012-06-14 2013-06-05 Inhibitor of jak1 and jak2

Publications (2)

Publication Number Publication Date
CA2871659A1 CA2871659A1 (en) 2013-12-19
CA2871659C true CA2871659C (en) 2017-04-04

Family

ID=48626679

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2871659A Expired - Fee Related CA2871659C (en) 2012-06-14 2013-06-05 Inhibitor of jak1 and jak2

Country Status (14)

Country Link
US (1) US9062050B2 (enExample)
EP (1) EP2861231B1 (enExample)
JP (1) JP6092376B2 (enExample)
KR (1) KR20150008907A (enExample)
CN (1) CN104349775B (enExample)
AU (1) AU2013274641B2 (enExample)
BR (1) BR112014030651A2 (enExample)
CA (1) CA2871659C (enExample)
EA (1) EA201492104A1 (enExample)
ES (1) ES2605827T3 (enExample)
IN (1) IN2014MN02228A (enExample)
MX (1) MX2014015271A (enExample)
WO (1) WO2013188184A1 (enExample)
ZA (1) ZA201407940B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR105400A1 (es) * 2015-08-04 2017-09-27 Lilly Co Eli Inhibidores de jak1
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
CN110229067A (zh) * 2019-06-05 2019-09-13 南京焕然生物科技有限公司 一种2-氨基茚制备方法
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN115141195B (zh) * 2021-03-03 2024-02-06 成都先导药物开发股份有限公司 一种nuak抑制剂及其用途
WO2023086320A1 (en) * 2021-11-09 2023-05-19 Ajax Therapeutics, Inc. Forms and compositions of inhibitors of jak2
CN116585312A (zh) * 2023-04-30 2023-08-15 兰州大学第二医院 含苯氧基丙酸化合物的胰腺癌jak2和stat3双靶向抑制剂及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006087530A1 (en) 2005-02-16 2006-08-24 Astrazeneca Ab Chemical compounds
TWI398252B (zh) * 2006-05-26 2013-06-11 Novartis Ag 吡咯并嘧啶化合物及其用途
US20100204246A1 (en) * 2007-04-18 2010-08-12 Astrazeneca Ab 5-aminopyrazol-3-yl-3h-imidazo (4,5-b) pyridine derivatives and their use for the treatment of cancer

Also Published As

Publication number Publication date
AU2013274641A1 (en) 2014-11-20
US9062050B2 (en) 2015-06-23
KR20150008907A (ko) 2015-01-23
MX2014015271A (es) 2015-03-05
BR112014030651A2 (pt) 2017-06-27
CA2871659A1 (en) 2013-12-19
EA201492104A1 (ru) 2015-06-30
CN104349775A (zh) 2015-02-11
AU2013274641B2 (en) 2015-09-24
EP2861231A1 (en) 2015-04-22
WO2013188184A1 (en) 2013-12-19
ES2605827T3 (es) 2017-03-16
EP2861231B1 (en) 2016-08-31
JP2015519396A (ja) 2015-07-09
ZA201407940B (en) 2016-05-25
JP6092376B2 (ja) 2017-03-08
US20150133490A1 (en) 2015-05-14
CN104349775B (zh) 2017-06-06
IN2014MN02228A (enExample) 2015-07-17

Similar Documents

Publication Publication Date Title
CA2871659C (en) Inhibitor of jak1 and jak2
AU2020217339B2 (en) Salts of Pl3K inhibitor and processes for their preparation
ES2424642T3 (es) Compuestos y composiciones como inhibidores de la proteína quinasa
AU2016323399B2 (en) 8-(6-(3-(amino)propoxy)-3-pyridyl)-1 -isopropyl-imidazo(4,5-c)quinolin-2-one derivatives as selective modulators of ataxia telangiectasia mutated (ATM) kinase for the treatment of cancer
US9447101B2 (en) Pyrrolo[2,1-f][1,2,4]triazine compound, and preparation method and application thereof
US7897600B2 (en) Amino pyrazole compound
CA2966559A1 (en) Thieno[2,3-c]pyrrol-4-one derivatives as erk inhibitors
CA2793024A1 (en) Imidazopyridine compounds, compositions and methods of use
CN108864079A (zh) 一种三嗪化合物及其药学上可接受的盐
CN114945574B (zh) Btk抑制剂
CN108697713B (zh) 用于制备三环pi3k抑制剂化合物的方法及用其治疗癌症的方法
WO2020077944A1 (zh) 嘌呤系列衍生物及其制备方法和用途
CN119019454A (zh) 一种杂芳基衍生物的制备及用途
WO2024033458A1 (en) Bicyclic tetrahydroazepine derivatives
HK1203499B (en) Pyrrolo[2,1-f][1,2,4]triazine compound, and preparation method and application thereof
HK1177743A (en) Pyrido[3,2-d]pyrimidine pi3k delta inhibitor compounds and methods of use

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20141024

MKLA Lapsed

Effective date: 20190605