IN2014MN02228A - - Google Patents

Info

Publication number
IN2014MN02228A
IN2014MN02228A IN2228MUN2014A IN2014MN02228A IN 2014MN02228 A IN2014MN02228 A IN 2014MN02228A IN 2228MUN2014 A IN2228MUN2014 A IN 2228MUN2014A IN 2014MN02228 A IN2014MN02228 A IN 2014MN02228A
Authority
IN
India
Prior art keywords
jak2
inden
imidazo
pyrazol
pyridin
Prior art date
Application number
Inventor
Timothy Paul Burkholder
Joshua Ryan Clayton
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IN2014MN02228A publication Critical patent/IN2014MN02228A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention provides an amino pyrazole compound which is 3 [(lR) 6 fluoro 2 3 dihydro 1H inden l yl] N (3 methyl IH pyrazol 5 yl) 3H imidazo[4 5 b]pyridin 5 amine or a pharmaceutically acceptable salt thereof that inhibits JAK1 and JAK2 and therefore may be useful in treating cancer.
IN2228MUN2014 2012-06-14 2013-06-05 IN2014MN02228A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261659679P 2012-06-14 2012-06-14
PCT/US2013/044211 WO2013188184A1 (en) 2012-06-14 2013-06-05 Inhibitor of jak1 and jak2

Publications (1)

Publication Number Publication Date
IN2014MN02228A true IN2014MN02228A (en) 2015-07-17

Family

ID=48626679

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2228MUN2014 IN2014MN02228A (en) 2012-06-14 2013-06-05

Country Status (14)

Country Link
US (1) US9062050B2 (en)
EP (1) EP2861231B1 (en)
JP (1) JP6092376B2 (en)
KR (1) KR20150008907A (en)
CN (1) CN104349775B (en)
AU (1) AU2013274641B2 (en)
BR (1) BR112014030651A2 (en)
CA (1) CA2871659C (en)
EA (1) EA201492104A1 (en)
ES (1) ES2605827T3 (en)
IN (1) IN2014MN02228A (en)
MX (1) MX2014015271A (en)
WO (1) WO2013188184A1 (en)
ZA (1) ZA201407940B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR105400A1 (en) * 2015-08-04 2017-09-27 Lilly Co Eli JAK1 INHIBITORS
BR112021018168B1 (en) 2019-03-21 2023-11-28 Onxeo PHARMACEUTICAL COMPOSITION, COMBINATION AND KIT COMPRISING A DBAIT MOLECULE AND A KINASE INHIBITOR FOR THE TREATMENT OF CANCER
CN110229067A (en) * 2019-06-05 2019-09-13 南京焕然生物科技有限公司 A kind of 2- amino indenes preparation method
AU2020378630A1 (en) 2019-11-08 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2022184130A1 (en) * 2021-03-03 2022-09-09 成都先导药物开发股份有限公司 Nuak inhibitor and use thereof
US20230146125A1 (en) * 2021-11-09 2023-05-11 Ajax Therapeutics, Inc. Forms and compositions of inhibitors of jak2

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1853588T3 (en) 2005-02-16 2008-09-15 Astrazeneca Ab Chemical compounds
TWI398252B (en) * 2006-05-26 2013-06-11 Novartis Ag Pyrrolopyrimidine compounds and their uses
JP2010524911A (en) * 2007-04-18 2010-07-22 アストラゼネカ アクチボラグ 5-Aminopyrazol-3-yl-3H-imidazo [4,5-b] pyridine derivatives and their use for the treatment of cancer

Also Published As

Publication number Publication date
AU2013274641A1 (en) 2014-11-20
BR112014030651A2 (en) 2017-06-27
JP6092376B2 (en) 2017-03-08
WO2013188184A1 (en) 2013-12-19
CN104349775A (en) 2015-02-11
EP2861231A1 (en) 2015-04-22
ZA201407940B (en) 2016-05-25
AU2013274641B2 (en) 2015-09-24
US20150133490A1 (en) 2015-05-14
ES2605827T3 (en) 2017-03-16
KR20150008907A (en) 2015-01-23
CN104349775B (en) 2017-06-06
JP2015519396A (en) 2015-07-09
EP2861231B1 (en) 2016-08-31
CA2871659A1 (en) 2013-12-19
US9062050B2 (en) 2015-06-23
MX2014015271A (en) 2015-03-05
EA201492104A1 (en) 2015-06-30
CA2871659C (en) 2017-04-04

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