BR112014030651A2 - inibidor de jak1 e jak2 - Google Patents

inibidor de jak1 e jak2

Info

Publication number
BR112014030651A2
BR112014030651A2 BR112014030651A BR112014030651A BR112014030651A2 BR 112014030651 A2 BR112014030651 A2 BR 112014030651A2 BR 112014030651 A BR112014030651 A BR 112014030651A BR 112014030651 A BR112014030651 A BR 112014030651A BR 112014030651 A2 BR112014030651 A2 BR 112014030651A2
Authority
BR
Brazil
Prior art keywords
jak1
jak2 inhibitor
jak2
inhibitor
methylmethyl
Prior art date
Application number
BR112014030651A
Other languages
English (en)
Inventor
Ryan Clayton Joshua
Paul Burkholder Timothy
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR112014030651A2 publication Critical patent/BR112014030651A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

resumo patente de invenção: "inibidor de jak1 e jak2". a presente invenção refere-se a um composto de amino pirazol, que é 3-[(1r)-6-flúor-2,3-di-hidro-1h-inden-1-il]-n-(3-metil-1h-pirazol-5-il)-3h-imidazo[4,5-b]piridin-5-amina ou um sal do mesmo farmaceuticamente aceitável, que inibe jak1 e jak2 e, desta maneira pode ser útil para tratar câncer.
BR112014030651A 2012-06-14 2013-06-05 inibidor de jak1 e jak2 BR112014030651A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261659679P 2012-06-14 2012-06-14
PCT/US2013/044211 WO2013188184A1 (en) 2012-06-14 2013-06-05 Inhibitor of jak1 and jak2

Publications (1)

Publication Number Publication Date
BR112014030651A2 true BR112014030651A2 (pt) 2017-06-27

Family

ID=48626679

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014030651A BR112014030651A2 (pt) 2012-06-14 2013-06-05 inibidor de jak1 e jak2

Country Status (14)

Country Link
US (1) US9062050B2 (pt)
EP (1) EP2861231B1 (pt)
JP (1) JP6092376B2 (pt)
KR (1) KR20150008907A (pt)
CN (1) CN104349775B (pt)
AU (1) AU2013274641B2 (pt)
BR (1) BR112014030651A2 (pt)
CA (1) CA2871659C (pt)
EA (1) EA201492104A1 (pt)
ES (1) ES2605827T3 (pt)
IN (1) IN2014MN02228A (pt)
MX (1) MX2014015271A (pt)
WO (1) WO2013188184A1 (pt)
ZA (1) ZA201407940B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR105400A1 (es) * 2015-08-04 2017-09-27 Lilly Co Eli Inhibidores de jak1
CN114364798A (zh) 2019-03-21 2022-04-15 欧恩科斯欧公司 用于治疗癌症的Dbait分子与激酶抑制剂的组合
CN110229067A (zh) * 2019-06-05 2019-09-13 南京焕然生物科技有限公司 一种2-氨基茚制备方法
AU2020378630A1 (en) 2019-11-08 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2022184130A1 (zh) * 2021-03-03 2022-09-09 成都先导药物开发股份有限公司 一种nuak抑制剂及其用途
WO2023086320A1 (en) * 2021-11-09 2023-05-19 Ajax Therapeutics, Inc. Forms and compositions of inhibitors of jak2

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2308731T3 (es) 2005-02-16 2008-12-01 Astrazeneca Ab Compuestos quimicos.
JO3235B1 (ar) * 2006-05-26 2018-03-08 Astex Therapeutics Ltd مركبات بيررولوبيريميدين و استعمالاتها
US20100204246A1 (en) * 2007-04-18 2010-08-12 Astrazeneca Ab 5-aminopyrazol-3-yl-3h-imidazo (4,5-b) pyridine derivatives and their use for the treatment of cancer

Also Published As

Publication number Publication date
US9062050B2 (en) 2015-06-23
AU2013274641B2 (en) 2015-09-24
JP6092376B2 (ja) 2017-03-08
IN2014MN02228A (pt) 2015-07-17
EP2861231A1 (en) 2015-04-22
KR20150008907A (ko) 2015-01-23
CA2871659A1 (en) 2013-12-19
CN104349775B (zh) 2017-06-06
AU2013274641A1 (en) 2014-11-20
WO2013188184A1 (en) 2013-12-19
ZA201407940B (en) 2016-05-25
EA201492104A1 (ru) 2015-06-30
EP2861231B1 (en) 2016-08-31
MX2014015271A (es) 2015-03-05
JP2015519396A (ja) 2015-07-09
US20150133490A1 (en) 2015-05-14
CA2871659C (en) 2017-04-04
CN104349775A (zh) 2015-02-11
ES2605827T3 (es) 2017-03-16

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law
B08F Application fees: dismissal - article 86 of industrial property law
B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2465 DE 03-04-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.