AU2013274641B2 - Inhibitor of JAK1 and JAK2 - Google Patents
Inhibitor of JAK1 and JAK2 Download PDFInfo
- Publication number
- AU2013274641B2 AU2013274641B2 AU2013274641A AU2013274641A AU2013274641B2 AU 2013274641 B2 AU2013274641 B2 AU 2013274641B2 AU 2013274641 A AU2013274641 A AU 2013274641A AU 2013274641 A AU2013274641 A AU 2013274641A AU 2013274641 B2 AU2013274641 B2 AU 2013274641B2
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- Australia
- Prior art keywords
- cancer
- compound
- cells
- dihydro
- fluoro
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261659679P | 2012-06-14 | 2012-06-14 | |
| US61/659,679 | 2012-06-14 | ||
| PCT/US2013/044211 WO2013188184A1 (en) | 2012-06-14 | 2013-06-05 | Inhibitor of jak1 and jak2 |
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| AU2013274641A1 AU2013274641A1 (en) | 2014-11-20 |
| AU2013274641B2 true AU2013274641B2 (en) | 2015-09-24 |
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| EP (1) | EP2861231B1 (enExample) |
| JP (1) | JP6092376B2 (enExample) |
| KR (1) | KR20150008907A (enExample) |
| CN (1) | CN104349775B (enExample) |
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| IN (1) | IN2014MN02228A (enExample) |
| MX (1) | MX2014015271A (enExample) |
| WO (1) | WO2013188184A1 (enExample) |
| ZA (1) | ZA201407940B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AR105400A1 (es) * | 2015-08-04 | 2017-09-27 | Lilly Co Eli | Inhibidores de jak1 |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| CN110229067A (zh) * | 2019-06-05 | 2019-09-13 | 南京焕然生物科技有限公司 | 一种2-氨基茚制备方法 |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN115141195B (zh) * | 2021-03-03 | 2024-02-06 | 成都先导药物开发股份有限公司 | 一种nuak抑制剂及其用途 |
| TW202325289A (zh) * | 2021-11-09 | 2023-07-01 | 美商雅捷可斯治療公司 | Ｊａｋ２抑制劑之形式及組合物 |
| CN116585312A (zh) * | 2023-04-30 | 2023-08-15 | 兰州大学第二医院 | 含苯氧基丙酸化合物的胰腺癌jak2和stat3双靶向抑制剂及应用 |
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| WO2007140222A2 (en) * | 2006-05-26 | 2007-12-06 | Novartis Ag | Pyrrolopyrimidine compounds and their uses |
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| ES2308731T3 (es) | 2005-02-16 | 2008-12-01 | Astrazeneca Ab | Compuestos quimicos. |
| CN101679429A (zh) * | 2007-04-18 | 2010-03-24 | 阿斯利康(瑞典)有限公司 | 5-氨基吡唑-3-基-3h-咪唑并[4,5-b]吡啶衍生物及其治疗癌的用途 |
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2013
- 2013-06-05 WO PCT/US2013/044211 patent/WO2013188184A1/en not_active Ceased
- 2013-06-05 KR KR20147034683A patent/KR20150008907A/ko not_active Abandoned
- 2013-06-05 IN IN2228MUN2014 patent/IN2014MN02228A/en unknown
- 2013-06-05 JP JP2015517311A patent/JP6092376B2/ja not_active Expired - Fee Related
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- 2013-06-05 EP EP13729215.7A patent/EP2861231B1/en not_active Not-in-force
- 2013-06-05 BR BR112014030651A patent/BR112014030651A2/pt not_active IP Right Cessation
- 2013-06-05 US US14/402,146 patent/US9062050B2/en not_active Expired - Fee Related
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- 2013-06-05 AU AU2013274641A patent/AU2013274641B2/en not_active Ceased
- 2013-06-05 CA CA2871659A patent/CA2871659C/en not_active Expired - Fee Related
- 2013-06-05 ES ES13729215.7T patent/ES2605827T3/es active Active
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2014
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007140222A2 (en) * | 2006-05-26 | 2007-12-06 | Novartis Ag | Pyrrolopyrimidine compounds and their uses |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015519396A (ja) | 2015-07-09 |
| CA2871659A1 (en) | 2013-12-19 |
| BR112014030651A2 (pt) | 2017-06-27 |
| IN2014MN02228A (enExample) | 2015-07-17 |
| US20150133490A1 (en) | 2015-05-14 |
| KR20150008907A (ko) | 2015-01-23 |
| EP2861231A1 (en) | 2015-04-22 |
| JP6092376B2 (ja) | 2017-03-08 |
| AU2013274641A1 (en) | 2014-11-20 |
| EP2861231B1 (en) | 2016-08-31 |
| CA2871659C (en) | 2017-04-04 |
| CN104349775A (zh) | 2015-02-11 |
| CN104349775B (zh) | 2017-06-06 |
| MX2014015271A (es) | 2015-03-05 |
| WO2013188184A1 (en) | 2013-12-19 |
| ZA201407940B (en) | 2016-05-25 |
| US9062050B2 (en) | 2015-06-23 |
| EA201492104A1 (ru) | 2015-06-30 |
| ES2605827T3 (es) | 2017-03-16 |
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