EA201492104A1 - Ингибитор jak1/2 - Google Patents

Ингибитор jak1/2

Info

Publication number
EA201492104A1
EA201492104A1 EA201492104A EA201492104A EA201492104A1 EA 201492104 A1 EA201492104 A1 EA 201492104A1 EA 201492104 A EA201492104 A EA 201492104A EA 201492104 A EA201492104 A EA 201492104A EA 201492104 A1 EA201492104 A1 EA 201492104A1
Authority
EA
Eurasian Patent Office
Prior art keywords
jak1
inhibitor
jak2
cancer
accordingly
Prior art date
Application number
EA201492104A
Other languages
English (en)
Inventor
Тимоти Пол Беркхолдер
Джошуа Райан Клейтон
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201492104A1 publication Critical patent/EA201492104A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В настоящем изобретении предложено аминопиразольное соединение или его фармацевтически приемлемая соль, подавляющее JAK1 и JAK2 и, соответственно, потенциально подходящее для лечения раковых заболеваний.
EA201492104A 2012-06-14 2013-06-05 Ингибитор jak1/2 EA201492104A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261659679P 2012-06-14 2012-06-14
PCT/US2013/044211 WO2013188184A1 (en) 2012-06-14 2013-06-05 Inhibitor of jak1 and jak2

Publications (1)

Publication Number Publication Date
EA201492104A1 true EA201492104A1 (ru) 2015-06-30

Family

ID=48626679

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201492104A EA201492104A1 (ru) 2012-06-14 2013-06-05 Ингибитор jak1/2

Country Status (14)

Country Link
US (1) US9062050B2 (ru)
EP (1) EP2861231B1 (ru)
JP (1) JP6092376B2 (ru)
KR (1) KR20150008907A (ru)
CN (1) CN104349775B (ru)
AU (1) AU2013274641B2 (ru)
BR (1) BR112014030651A2 (ru)
CA (1) CA2871659C (ru)
EA (1) EA201492104A1 (ru)
ES (1) ES2605827T3 (ru)
IN (1) IN2014MN02228A (ru)
MX (1) MX2014015271A (ru)
WO (1) WO2013188184A1 (ru)
ZA (1) ZA201407940B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR105400A1 (es) * 2015-08-04 2017-09-27 Lilly Co Eli Inhibidores de jak1
BR112021018168B1 (pt) 2019-03-21 2023-11-28 Onxeo Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
CN110229067A (zh) * 2019-06-05 2019-09-13 南京焕然生物科技有限公司 一种2-氨基茚制备方法
AU2020378630A1 (en) 2019-11-08 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2022184130A1 (zh) * 2021-03-03 2022-09-09 成都先导药物开发股份有限公司 一种nuak抑制剂及其用途
US20230146125A1 (en) * 2021-11-09 2023-05-11 Ajax Therapeutics, Inc. Forms and compositions of inhibitors of jak2

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1853588T3 (da) 2005-02-16 2008-09-15 Astrazeneca Ab Kemiske forbindelser
TWI398252B (zh) * 2006-05-26 2013-06-11 Novartis Ag 吡咯并嘧啶化合物及其用途
JP2010524911A (ja) * 2007-04-18 2010-07-22 アストラゼネカ アクチボラグ ５−アミノピラゾール−３−イル−３Ｈ−イミダゾ［４，５−ｂ］ピリジン誘導体と癌の治療のためのその使用

Also Published As

Publication number Publication date
AU2013274641A1 (en) 2014-11-20
BR112014030651A2 (pt) 2017-06-27
JP6092376B2 (ja) 2017-03-08
IN2014MN02228A (ru) 2015-07-17
WO2013188184A1 (en) 2013-12-19
CN104349775A (zh) 2015-02-11
EP2861231A1 (en) 2015-04-22
ZA201407940B (en) 2016-05-25
AU2013274641B2 (en) 2015-09-24
US20150133490A1 (en) 2015-05-14
ES2605827T3 (es) 2017-03-16
KR20150008907A (ko) 2015-01-23
CN104349775B (zh) 2017-06-06
JP2015519396A (ja) 2015-07-09
EP2861231B1 (en) 2016-08-31
CA2871659A1 (en) 2013-12-19
US9062050B2 (en) 2015-06-23
MX2014015271A (es) 2015-03-05
CA2871659C (en) 2017-04-04

Similar Documents

Publication Publication Date Title
PH12019501321B1 (en) Use of pyrazolopyrimidine derivatives for the treatment of pi3k-delta related disorders
PH12018500041A1 (en) Substituted aza compoounds as irak-4 inhibitors
PH12018502102A1 (en) Pyrrolotriazine compounds as tam inhibitors
MX2013011329A (es) Combinaciones de compuestos inhibidores de akt y erlotinib y metodos de uso.
NZ729005A (en) Aminopyrimidinyl compounds as jak inhibitors
EA201890307A1 (ru) Индазольные и азаиндазольные соединения как ингибиторы irak-4
PH12015500064B1 (en) Imidazotriazinecarbonitriles useful as kinase inhibitors
UA111382C2 (uk) Інгібітори протеїнкінази
EA201492104A1 (ru) Ингибитор jak1/2
EA201400412A1 (ru) ЗАМЕЩЕННЫЕ БЕНЗИЛИНДАЗОЛЫ ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ Bub1 КИНАЗЫ ДЛЯ ЛЕЧЕНИЯ ГИПЕРПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЙ
EA201591509A1 (ru) Ингибиторы cdc7
PH12015502031B1 (en) Tetrahydropyrrolothiazine compounds
EA201591913A1 (ru) Ингибиторы протеинкиназы
NZ708382A (en) Cycloalkyl bis-thiadiazole inhibitors of glutaminase and their use as therapeutic agents
EA201391208A1 (ru) КОМБИНИРОВАННОЕ ЛЕЧЕНИЕ С ПРИМЕНЕНИЕМ ИНГИБИТОРОВ mTOR/JAK
EA201170834A1 (ru) Соединения, пригодные для ингибирования chk1
PH12019501022A1 (en) Pyrazolopyrimidine compounds and methods of use thereof
EA201690513A1 (ru) Комбинация ингибитора mek и ингибитора erk для применения в лечении гиперпролиферативных заболеваний
EA201300610A1 (ru) Хиназолинкарбоксамидазетидины
EA201590552A1 (ru) Аминохинолины в качестве ингибиторов киназы
EA201692470A1 (ru) Фармацевтические комбинации
EA201390499A1 (ru) Соединения, подходящие для ингибирования снк1
EA201501187A1 (ru) Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний
EA201591175A1 (ru) Трициклические соединения в качестве ингибиторов cftr
EA201990313A1 (ru) Производное триазолопиразинона, пригодное в качестве ингибитора фдэ1 человека