JP2017505782A5 - - Google Patents
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- Publication number
- JP2017505782A5 JP2017505782A5 JP2016550703A JP2016550703A JP2017505782A5 JP 2017505782 A5 JP2017505782 A5 JP 2017505782A5 JP 2016550703 A JP2016550703 A JP 2016550703A JP 2016550703 A JP2016550703 A JP 2016550703A JP 2017505782 A5 JP2017505782 A5 JP 2017505782A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical composition
- pharmaceutical
- agents
- fgfr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 108091008794 FGF receptors Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 2
- 102000052178 fibroblast growth factor receptor activity proteins Human genes 0.000 claims 2
- 229940127084 other anti-cancer agent Drugs 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- -1 salts compounds Chemical class 0.000 claims 2
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 229940113306 Ligase inhibitor Drugs 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 102100022465 Methanethiol oxidase Human genes 0.000 claims 1
- 101710134383 Methanethiol oxidase Proteins 0.000 claims 1
- 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 claims 1
- 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000014767 Myeloproliferative disease Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 108091007960 PI3Ks Proteins 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 claims 1
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000008938 Rhabdoid tumor Diseases 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 claims 1
- 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 108091008605 VEGF receptors Proteins 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 206010065867 alveolar rhabdomyosarcoma Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 239000000436 ligase inhibitor Substances 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 230000002071 myeloproliferative effect Effects 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical group FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461937211P | 2014-02-07 | 2014-02-07 | |
| US61/937,211 | 2014-02-07 | ||
| US201462007562P | 2014-06-04 | 2014-06-04 | |
| US62/007,562 | 2014-06-04 | ||
| US201462069932P | 2014-10-29 | 2014-10-29 | |
| US62/069,932 | 2014-10-29 | ||
| PCT/US2015/014460 WO2015120049A1 (en) | 2014-02-07 | 2015-02-04 | Quinolone derivatives as fibroblast growth factor receptor inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017505782A JP2017505782A (ja) | 2017-02-23 |
| JP2017505782A5 true JP2017505782A5 (enExample) | 2018-02-01 |
| JP6553629B2 JP6553629B2 (ja) | 2019-07-31 |
Family
ID=52589764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016550703A Active JP6553629B2 (ja) | 2014-02-07 | 2015-02-04 | 線維芽細胞増殖因子受容体阻害剤としてのキノロン誘導体 |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US9815834B2 (enExample) |
| EP (1) | EP3102577B1 (enExample) |
| JP (1) | JP6553629B2 (enExample) |
| KR (1) | KR102046448B1 (enExample) |
| CN (1) | CN106459034B (enExample) |
| AU (1) | AU2015214328B2 (enExample) |
| BR (1) | BR112016017137B1 (enExample) |
| CA (1) | CA2937746C (enExample) |
| CY (1) | CY1121444T1 (enExample) |
| DK (1) | DK3102577T3 (enExample) |
| ES (1) | ES2689421T3 (enExample) |
| HU (1) | HUE041594T2 (enExample) |
| IL (1) | IL246933B (enExample) |
| MX (1) | MX369369B (enExample) |
| PL (1) | PL3102577T3 (enExample) |
| PT (1) | PT3102577T (enExample) |
| RU (1) | RU2721723C2 (enExample) |
| SI (1) | SI3102577T1 (enExample) |
| WO (1) | WO2015120049A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106459034B (zh) | 2014-02-07 | 2018-01-12 | 普林斯匹亚生物制药公司 | 作为成纤维细胞生长因子受体抑制剂的喹诺酮衍生物 |
| CN105294681B (zh) | 2014-07-26 | 2017-07-07 | 广东东阳光药业有限公司 | Cdk类小分子抑制剂的化合物及其用途 |
| TWI695831B (zh) | 2014-09-13 | 2020-06-11 | 香港商南北兄弟藥業投資有限公司 | Ｃｒｔｈ２拮抗劑化合物及其用途 |
| JP6940480B2 (ja) * | 2015-08-11 | 2021-09-29 | プリンシピア バイオファーマ インコーポレイテッド | Ｆｇｆｒ阻害剤の合成方法 |
| CN108264510A (zh) * | 2017-01-02 | 2018-07-10 | 上海喆邺生物科技有限公司 | 一种选择性抑制激酶化合物及其用途 |
| WO2018153373A1 (zh) * | 2017-02-27 | 2018-08-30 | 贝达药业股份有限公司 | Fgfr抑制剂及其应用 |
| AU2018229148B2 (en) * | 2017-03-03 | 2022-08-04 | Auckland Uniservices Limited | FGFR kinase inhibitors and pharmaceutical uses |
| WO2019015593A1 (zh) * | 2017-07-19 | 2019-01-24 | 江苏奥赛康药业股份有限公司 | 嘧啶并吡啶酮或者吡啶并吡啶酮类化合物及其应用 |
| WO2019029541A1 (zh) * | 2017-08-08 | 2019-02-14 | 南京药捷安康生物科技有限公司 | 成纤维细胞生长因子受体抑制剂及其用途 |
| CN110016026B (zh) * | 2018-01-08 | 2022-11-25 | 上海凌济生物科技有限公司 | 一类具有抗肿瘤活性的嘧啶并吡啶酮类化合物、制备方法和用途 |
| KR102531596B1 (ko) * | 2018-09-14 | 2023-05-11 | 아비스코 테라퓨틱스 컴퍼니 리미티드 | Fgfr억제제, 그 제조 방법 및 용도 |
| CN113490666A (zh) | 2018-12-19 | 2021-10-08 | 奥瑞生物药品公司 | 作为fgfr酪氨酸激酶的抑制剂的取代的吡唑并[1,5-a]吡啶化合物 |
| EP3898615A1 (en) | 2018-12-19 | 2021-10-27 | Array Biopharma, Inc. | 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer |
| AU2020260018A1 (en) * | 2019-04-19 | 2021-11-04 | Pfizer Inc. | Anti-proliferative agents for treating PAH |
| JP7121218B1 (ja) | 2019-08-08 | 2022-08-17 | ▲ザン▼州片仔▲ファン▼薬業股▲フン▼有限公司 | ピラジン－２（１ｈ）－オン系化合物の製造方法 |
| WO2021108803A1 (en) | 2019-11-26 | 2021-06-03 | Theravance Biopharma R&D Ip, Llc | Fused pyrimidine pyridinone compounds as jak inhibitors |
| KR20240170936A (ko) * | 2022-03-31 | 2024-12-05 | 에이스랜드 테라퓨틱스 (홍콩) 리미티드 | 스피로비시클릭 화합물 |
| CN115368219B (zh) * | 2022-10-25 | 2022-12-27 | 苏州康纯医药科技有限公司 | 一种fgfr抑制剂关键中间体的制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5620981A (en) | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
| US20050009849A1 (en) | 2003-01-03 | 2005-01-13 | Veach Darren R. | Pyridopyrimidine kinase inhibitors |
| JP4616839B2 (ja) | 2003-11-13 | 2011-01-19 | エフ．ホフマン−ラ ロシュ アーゲー | ヒドロキシアルキル置換ピリド−７−ピリミジン−７−オン類 |
| WO2005105097A2 (en) | 2004-04-28 | 2005-11-10 | Gpc Biotech Ag | Pyridopyrimidines for treating inflammatory and other diseases |
| US20090036472A1 (en) | 2005-02-02 | 2009-02-05 | Palle Venkata P | Azabicyclo derivatives as anti-inflammatory agents |
| WO2008150260A1 (en) | 2007-06-06 | 2008-12-11 | Gpc Biotech, Inc. | 8-oxy-2-aminopyrido (2, 3-d) pyrimidin-7-one derivatives as kinase inhibitors and anticancer agents |
| IT1395724B1 (it) | 2009-02-25 | 2012-10-19 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| AU2012255759C1 (en) | 2011-05-17 | 2025-10-23 | Principia Biopharma, Inc. | Kinase inhibitors |
| CN102219860B (zh) * | 2011-05-20 | 2012-09-12 | 烟台荣昌生物工程有限公司 | FGFR-Fc融合蛋白及其用途 |
| BR112014010631A2 (pt) * | 2011-11-04 | 2017-04-25 | Afraxis Holdings Inc | inibidores de pak para o tratamento da síndrome do x frágil |
| BR112015000653A2 (pt) * | 2012-07-11 | 2019-11-05 | Blueprint Medicines Corp | compostos inibidores do receptor de fator de crescimento de fibroblasto, sua composição farmacêutica e seus usos |
| WO2014182829A1 (en) * | 2013-05-09 | 2014-11-13 | Principia Biopharma Inc. | Quinolone derivatives as fibroblast growth factor inhibitors |
| US9851834B2 (en) | 2013-09-10 | 2017-12-26 | Alsentis, Llc | Time domain differential techniques to characterize various stimuli |
| CN106459034B (zh) | 2014-02-07 | 2018-01-12 | 普林斯匹亚生物制药公司 | 作为成纤维细胞生长因子受体抑制剂的喹诺酮衍生物 |
| EP3298011B1 (en) | 2015-05-22 | 2021-11-17 | Principia Biopharma Inc. | Quinolone derivatives as fibroblast growth factor receptor inhibitors |
| JP6940480B2 (ja) | 2015-08-11 | 2021-09-29 | プリンシピア バイオファーマ インコーポレイテッド | Ｆｇｆｒ阻害剤の合成方法 |
-
2015
- 2015-02-04 CN CN201580007653.5A patent/CN106459034B/zh active Active
- 2015-02-04 RU RU2016130932A patent/RU2721723C2/ru active
- 2015-02-04 HU HUE15706577A patent/HUE041594T2/hu unknown
- 2015-02-04 CA CA2937746A patent/CA2937746C/en active Active
- 2015-02-04 ES ES15706577.2T patent/ES2689421T3/es active Active
- 2015-02-04 DK DK15706577.2T patent/DK3102577T3/en active
- 2015-02-04 PL PL15706577T patent/PL3102577T3/pl unknown
- 2015-02-04 JP JP2016550703A patent/JP6553629B2/ja active Active
- 2015-02-04 KR KR1020167021267A patent/KR102046448B1/ko active Active
- 2015-02-04 AU AU2015214328A patent/AU2015214328B2/en active Active
- 2015-02-04 SI SI201530358T patent/SI3102577T1/sl unknown
- 2015-02-04 EP EP15706577.2A patent/EP3102577B1/en active Active
- 2015-02-04 US US15/022,869 patent/US9815834B2/en active Active
- 2015-02-04 MX MX2016010106A patent/MX369369B/es active IP Right Grant
- 2015-02-04 WO PCT/US2015/014460 patent/WO2015120049A1/en not_active Ceased
- 2015-02-04 PT PT15706577T patent/PT3102577T/pt unknown
- 2015-02-04 BR BR112016017137-3A patent/BR112016017137B1/pt active IP Right Grant
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2016
- 2016-03-22 US US15/077,442 patent/US9567334B2/en active Active
- 2016-07-25 IL IL246933A patent/IL246933B/en active IP Right Grant
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2017
- 2017-11-08 US US15/806,525 patent/US10294223B2/en active Active
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2018
- 2018-10-18 CY CY20181101070T patent/CY1121444T1/el unknown
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2019
- 2019-04-12 US US16/383,237 patent/US11078199B2/en active Active
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2021
- 2021-05-03 US US17/306,528 patent/US20210292323A1/en not_active Abandoned
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2023
- 2023-06-30 US US18/217,002 patent/US12162882B2/en active Active