JP2015518491A5 - - Google Patents
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- JP2015518491A5 JP2015518491A5 JP2015510493A JP2015510493A JP2015518491A5 JP 2015518491 A5 JP2015518491 A5 JP 2015518491A5 JP 2015510493 A JP2015510493 A JP 2015510493A JP 2015510493 A JP2015510493 A JP 2015510493A JP 2015518491 A5 JP2015518491 A5 JP 2015518491A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- substituted
- unsubstituted
- alkyl
- diabetes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010012601 diabetes mellitus Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 9
- 208000030533 eye disease Diseases 0.000 claims 9
- 150000001204 N-oxides Chemical class 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000004452 carbocyclyl group Chemical group 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 206010065534 Macular ischaemia Diseases 0.000 claims 1
- 230000002491 angiogenic effect Effects 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 201000007917 background diabetic retinopathy Diseases 0.000 claims 1
- 125000005884 carbocyclylalkyl group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 201000011190 diabetic macular edema Diseases 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 208000038015 macular disease Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 201000007914 proliferative diabetic retinopathy Diseases 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261643058P | 2012-05-04 | 2012-05-04 | |
| US201261643178P | 2012-05-04 | 2012-05-04 | |
| US201261643051P | 2012-05-04 | 2012-05-04 | |
| US61/643,178 | 2012-05-04 | ||
| US61/643,058 | 2012-05-04 | ||
| US61/643,051 | 2012-05-04 | ||
| US201361781907P | 2013-03-14 | 2013-03-14 | |
| US61/781,907 | 2013-03-14 | ||
| PCT/US2013/039562 WO2013166449A2 (en) | 2012-05-04 | 2013-05-03 | Methods for the treatment of diabetic retinopathy and other ophthalmic diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017214372A Division JP2018024702A (ja) | 2012-05-04 | 2017-11-07 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015518491A JP2015518491A (ja) | 2015-07-02 |
| JP2015518491A5 true JP2015518491A5 (https=) | 2016-04-21 |
Family
ID=49515046
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015510493A Pending JP2015518491A (ja) | 2012-05-04 | 2013-05-03 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2017214372A Pending JP2018024702A (ja) | 2012-05-04 | 2017-11-07 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2019187273A Pending JP2020023535A (ja) | 2012-05-04 | 2019-10-11 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2021024721A Pending JP2021075576A (ja) | 2012-05-04 | 2021-02-18 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2023029073A Pending JP2023059991A (ja) | 2012-05-04 | 2023-02-28 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2025017056A Pending JP2025069362A (ja) | 2012-05-04 | 2025-02-04 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017214372A Pending JP2018024702A (ja) | 2012-05-04 | 2017-11-07 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2019187273A Pending JP2020023535A (ja) | 2012-05-04 | 2019-10-11 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2021024721A Pending JP2021075576A (ja) | 2012-05-04 | 2021-02-18 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2023029073A Pending JP2023059991A (ja) | 2012-05-04 | 2023-02-28 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
| JP2025017056A Pending JP2025069362A (ja) | 2012-05-04 | 2025-02-04 | 糖尿病性網膜症及び他の眼の疾患を治療するための方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US9957224B2 (https=) |
| EP (2) | EP3741742A1 (https=) |
| JP (6) | JP2015518491A (https=) |
| KR (1) | KR20150013240A (https=) |
| CN (3) | CN116850163A (https=) |
| AU (1) | AU2013256029A1 (https=) |
| BR (1) | BR112014027571B1 (https=) |
| CA (1) | CA2872433C (https=) |
| EA (1) | EA201492031A1 (https=) |
| ES (1) | ES2792923T3 (https=) |
| HK (2) | HK1203478A1 (https=) |
| IL (1) | IL235446A0 (https=) |
| MX (2) | MX386024B (https=) |
| PH (1) | PH12014502449A1 (https=) |
| SG (1) | SG11201407162SA (https=) |
| TW (1) | TW201406707A (https=) |
| WO (1) | WO2013166449A2 (https=) |
| ZA (1) | ZA201408592B (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010003667A (es) * | 2007-10-05 | 2010-09-28 | Acucela Inc | Compuestos alcoxi para el tratamiento de enfermedades. |
| EP4000610A1 (en) * | 2009-07-02 | 2022-05-25 | Acucela Inc. | Pharmacology of visual cycle modulators |
| AU2012294342B2 (en) | 2011-08-10 | 2017-07-27 | Lankenau Institute For Medical Research | Methods and compositions for the treatment of autoimmune and inflammatory diseases |
| HK1210969A1 (en) | 2012-01-20 | 2016-05-13 | 奥克塞拉有限公司 | Substituted heterocyclic compounds for disease treatment |
| TW201406707A (zh) | 2012-05-04 | 2014-02-16 | Acucela Inc | 用以治療糖尿病性視網膜病變及其他眼部疾病之方法 |
| EP2970099A4 (en) * | 2013-03-12 | 2016-12-21 | Acucela Inc | SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF EYE DISEASES AND DRESSES |
| EP3195838B1 (en) | 2013-03-14 | 2018-08-22 | Optimedica Corporation | Laser capsulovitreotomy |
| WO2015157644A1 (en) | 2014-04-10 | 2015-10-15 | Lankenau Institute For Medical Research | Methods and compositions for the treatment of ocular diseases and disorders |
| US10792374B2 (en) | 2015-10-09 | 2020-10-06 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
| AU2018223810B2 (en) * | 2017-02-27 | 2022-04-21 | Case Western Reserve University | Visual cycle modulators |
| US11712160B2 (en) * | 2017-12-28 | 2023-08-01 | Nikon Corporation | Image processing method, image processing program, image processing device, image display device, and image display method |
| MX2018008165A (es) * | 2018-06-29 | 2019-12-30 | Centro De Retina Medica Y Quirurgica S C | Sistema portátil para la identificación de casos potenciales de edema macular diabético mediante procesamiento de imagen e inteligencia artificial. |
| WO2020014074A1 (en) | 2018-07-07 | 2020-01-16 | Acucela Inc. | Device to prevent retinal hypoxia |
| US11402662B2 (en) | 2018-07-30 | 2022-08-02 | Acucela Inc. | Optical designs of electronic contact lens to decrease myopia progression |
| JP2022512706A (ja) * | 2018-10-16 | 2022-02-07 | エフ．ホフマン－ラ ロシュ アーゲー | 眼科におけるＡｋｔ阻害剤の使用 |
| US11154540B2 (en) * | 2018-10-19 | 2021-10-26 | Medicinova, Inc. | Methods of treating ophthalmic disease/disorder or injury with ibudilast |
| WO2020240867A1 (ja) * | 2019-05-31 | 2020-12-03 | 株式会社ニコン | 画像処理方法、画像処理装置、及び画像処理プログラム |
| CN118718181A (zh) | 2019-06-05 | 2024-10-01 | 里珍纳龙药品有限公司 | 用于精确剂量递送的装置及方法 |
| EP4003250A4 (en) | 2019-07-31 | 2023-08-23 | Acucela Inc. | DEVICE FOR PROJECTING IMAGES ON THE RETINA |
| EP4031933A4 (en) | 2019-09-16 | 2023-10-11 | Acucela Inc. | METHOD FOR ASSEMBLY OF AN ELECTRONIC SOFT CONTACT LENS DESIGNED TO INHIBIT THE PROGRESSION OF MYOPIA |
| WO2021168481A1 (en) | 2020-02-21 | 2021-08-26 | Acucela Inc. | Charging case for electronic contact lens |
| CN111617313B (zh) * | 2020-04-29 | 2022-09-06 | 天津医科大学眼科医院 | 一种眼用线性凝胶在作为临床孔源性视网膜脱离药物方面中的应用 |
| WO2021231684A1 (en) | 2020-05-13 | 2021-11-18 | Acucela Inc. | Electro-switchable spectacles for myopia treatment |
| AU2021287803A1 (en) | 2020-06-08 | 2022-10-27 | Acucela Inc. | Stick on devices using peripheral defocus to treat progressive refractive error |
| CN115698832A (zh) | 2020-06-08 | 2023-02-03 | 奥克塞拉有限公司 | 用于治疗散光的非对称投影透镜 |
| AU2021289593A1 (en) | 2020-06-08 | 2022-10-20 | Acucela Inc. | Projection of defocused images on the peripheral retina to treat refractive error |
| US11281022B2 (en) | 2020-06-10 | 2022-03-22 | Acucela Inc. | Apparatus and methods for the treatment of refractive error using active stimulation |
| US11209672B1 (en) | 2021-04-06 | 2021-12-28 | Acucela Inc. | Supporting pillars for encapsulating a flexible PCB within a soft hydrogel contact lens |
| US11366341B1 (en) | 2021-05-04 | 2022-06-21 | Acucela Inc. | Electronic case for electronic spectacles |
| AU2022278549A1 (en) * | 2021-05-16 | 2023-12-07 | Metanoia Bio Inc. | Methods and compositions for treating ocular neovascular disease |
| WO2022255332A1 (ja) * | 2021-06-03 | 2022-12-08 | 国立大学法人大阪大学 | 未熟児網膜症スクリーニング方法、スクリーニング装置及び学習済モデル |
| USD1120314S1 (en) | 2022-11-30 | 2026-03-24 | Regeneron Pharmaceuticals, Inc. | Dose delivery device |
| WO2024258981A2 (en) * | 2023-06-12 | 2024-12-19 | Synaptogenix, Inc. | Methods for repairing nerve damage using pkc activating therapeutic agents |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9022788D0 (en) | 1990-10-19 | 1990-12-05 | Cortecs Ltd | Pharmaceutical formulations |
| US20030181531A1 (en) * | 2003-02-11 | 2003-09-25 | David Sherris | Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases |
| WO2003039404A2 (en) * | 2001-11-09 | 2003-05-15 | Eyetech Pharmaceuticals | Methods for treating ocular neovascular diseases |
| KR20070011379A (ko) * | 2004-03-17 | 2007-01-24 | 라스 미카엘 라르센 | 시각 사이클 억제에 의한 망막증의 예방 |
| US8969415B2 (en) * | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| BRPI0810063A2 (pt) * | 2007-04-20 | 2014-10-14 | Acucela Inc | Composto, composição farmacêutica, e, métodos para modular fluxo de cromóforo em um ciclo retinóide, para tratar uma doença ou distúrbio oftálmico em um indivíduo, para inibir adaptação ao escuro em uma célula fotorreceptora de bastão da retina, para inibir regeneração de rodopsina em uma célula fotoreceptora de bastão da retina, para reduzir isquemia em um olho de um indivíduo, para inibir neovascularização na retina de um olho de um indivíduo, e para inibir degeneração de uma célula da retina em uma retina |
| NZ601866A (en) * | 2007-06-29 | 2013-12-20 | Acucela Inc | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders |
| MX2010003667A (es) | 2007-10-05 | 2010-09-28 | Acucela Inc | Compuestos alcoxi para el tratamiento de enfermedades. |
| KR101270122B1 (ko) | 2007-11-01 | 2013-05-31 | 어큐셀라 인코포레이티드 | 안과 질환 및 장애를 치료하기 위한 아민 유도체 화합물 |
| MX2011002448A (es) | 2008-09-05 | 2011-05-25 | Acucela Inc | Compuestos enlazados con azufre para el tratamiento de enfermedades y trastornos oftalmicos. |
| JP5773877B2 (ja) | 2008-10-22 | 2015-09-02 | アキュセラ インコーポレイテッド | 眼の疾患及び障害を治療する化合物 |
| EP4000610A1 (en) * | 2009-07-02 | 2022-05-25 | Acucela Inc. | Pharmacology of visual cycle modulators |
| TW201406707A (zh) | 2012-05-04 | 2014-02-16 | Acucela Inc | 用以治療糖尿病性視網膜病變及其他眼部疾病之方法 |
-
2013
- 2013-04-30 TW TW102115446A patent/TW201406707A/zh unknown
- 2013-05-03 CN CN202310810454.4A patent/CN116850163A/zh active Pending
- 2013-05-03 WO PCT/US2013/039562 patent/WO2013166449A2/en not_active Ceased
- 2013-05-03 ES ES13784718T patent/ES2792923T3/es active Active
- 2013-05-03 MX MX2020001835A patent/MX386024B/es unknown
- 2013-05-03 CA CA2872433A patent/CA2872433C/en active Active
- 2013-05-03 MX MX2014013341A patent/MX2014013341A/es active IP Right Grant
- 2013-05-03 KR KR1020147034091A patent/KR20150013240A/ko not_active Withdrawn
- 2013-05-03 BR BR112014027571-8A patent/BR112014027571B1/pt active IP Right Grant
- 2013-05-03 CN CN201710706410.1A patent/CN107865830A/zh active Pending
- 2013-05-03 JP JP2015510493A patent/JP2015518491A/ja active Pending
- 2013-05-03 EP EP20169968.3A patent/EP3741742A1/en active Pending
- 2013-05-03 EP EP13784718.2A patent/EP2844636B1/en active Active
- 2013-05-03 SG SG11201407162SA patent/SG11201407162SA/en unknown
- 2013-05-03 CN CN201380035735.1A patent/CN104411678A/zh active Pending
- 2013-05-03 EA EA201492031A patent/EA201492031A1/ru unknown
- 2013-05-03 AU AU2013256029A patent/AU2013256029A1/en not_active Abandoned
- 2013-05-03 HK HK15103833.8A patent/HK1203478A1/xx unknown
- 2013-05-03 US US13/887,243 patent/US9957224B2/en active Active
-
2014
- 2014-11-02 IL IL235446A patent/IL235446A0/en unknown
- 2014-11-03 PH PH12014502449A patent/PH12014502449A1/en unknown
- 2014-11-21 ZA ZA2014/08592A patent/ZA201408592B/en unknown
-
2015
- 2015-04-21 HK HK18106035.4A patent/HK1246646A1/zh unknown
-
2017
- 2017-11-07 JP JP2017214372A patent/JP2018024702A/ja active Pending
-
2018
- 2018-04-30 US US15/967,080 patent/US10730825B2/en active Active
-
2019
- 2019-10-11 JP JP2019187273A patent/JP2020023535A/ja active Pending
-
2020
- 2020-07-21 US US16/934,715 patent/US11795136B2/en active Active
-
2021
- 2021-02-18 JP JP2021024721A patent/JP2021075576A/ja active Pending
-
2023
- 2023-02-28 JP JP2023029073A patent/JP2023059991A/ja active Pending
- 2023-10-11 US US18/379,142 patent/US20240308951A1/en active Pending
-
2025
- 2025-02-04 JP JP2025017056A patent/JP2025069362A/ja active Pending
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