JP2015514772A5 - - Google Patents
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- Publication number
- JP2015514772A5 JP2015514772A5 JP2015507145A JP2015507145A JP2015514772A5 JP 2015514772 A5 JP2015514772 A5 JP 2015514772A5 JP 2015507145 A JP2015507145 A JP 2015507145A JP 2015507145 A JP2015507145 A JP 2015507145A JP 2015514772 A5 JP2015514772 A5 JP 2015514772A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- group
- alkyl
- amino
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 25
- 241000700605 Viruses Species 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- -1 aminothionyl Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 5
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- 241001115402 Ebolavirus Species 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 2
- 241000713196 Influenza B virus Species 0.000 claims 2
- 241001115401 Marburgvirus Species 0.000 claims 2
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 claims 2
- 241000710772 Yellow fever virus Species 0.000 claims 2
- 125000000266 alpha-aminoacyl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229940051021 yellow-fever virus Drugs 0.000 claims 2
- 241000712892 Arenaviridae Species 0.000 claims 1
- 241001493160 California encephalitis virus Species 0.000 claims 1
- 241000711573 Coronaviridae Species 0.000 claims 1
- 241000709687 Coxsackievirus Species 0.000 claims 1
- 241000725619 Dengue virus Species 0.000 claims 1
- 241000710945 Eastern equine encephalitis virus Species 0.000 claims 1
- 241000709661 Enterovirus Species 0.000 claims 1
- 241000991587 Enterovirus C Species 0.000 claims 1
- 241000711950 Filoviridae Species 0.000 claims 1
- 241000710781 Flaviviridae Species 0.000 claims 1
- 241000190708 Guanarito mammarenavirus Species 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 241000709721 Hepatovirus A Species 0.000 claims 1
- 241000710842 Japanese encephalitis virus Species 0.000 claims 1
- 241000712890 Junin mammarenavirus Species 0.000 claims 1
- 206010023927 Lassa fever Diseases 0.000 claims 1
- 241000712899 Lymphocytic choriomeningitis mammarenavirus Species 0.000 claims 1
- 241000712898 Machupo mammarenavirus Species 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 241000150452 Orthohantavirus Species 0.000 claims 1
- 241000712464 Orthomyxoviridae Species 0.000 claims 1
- 241000711504 Paramyxoviridae Species 0.000 claims 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 1
- 241000150350 Peribunyaviridae Species 0.000 claims 1
- 241000709664 Picornaviridae Species 0.000 claims 1
- 241000713126 Punta Toro virus Species 0.000 claims 1
- 241000725643 Respiratory syncytial virus Species 0.000 claims 1
- 241000713124 Rift Valley fever virus Species 0.000 claims 1
- 241000712908 Tacaribe mammarenavirus Species 0.000 claims 1
- 241000710924 Togaviridae Species 0.000 claims 1
- 241000700647 Variola virus Species 0.000 claims 1
- 241000710959 Venezuelan equine encephalitis virus Species 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 241000710886 West Nile virus Species 0.000 claims 1
- 241000710951 Western equine encephalitis virus Species 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 241001493065 dsRNA viruses Species 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- YXMMTUJDQTVJEN-UHFFFAOYSA-N methyl 2-amino-3-methylpentanoate Chemical compound CCC(C)C(N)C(=O)OC YXMMTUJDQTVJEN-UHFFFAOYSA-N 0.000 claims 1
- QVDXUKJJGUSGLS-UHFFFAOYSA-N methyl 2-amino-4-methylpentanoate Chemical compound COC(=O)C(N)CC(C)C QVDXUKJJGUSGLS-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 230000029812 viral genome replication Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261625994P | 2012-04-18 | 2012-04-18 | |
| US61/625,994 | 2012-04-18 | ||
| PCT/US2013/036945 WO2013158746A1 (en) | 2012-04-18 | 2013-04-17 | Compositions and methods for inhibiting viral polymerase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018007131A Division JP6559266B2 (ja) | 2012-04-18 | 2018-01-19 | ウイルスポリメラーゼを阻害するための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015514772A JP2015514772A (ja) | 2015-05-21 |
| JP2015514772A5 true JP2015514772A5 (OSRAM) | 2016-06-16 |
Family
ID=49384030
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015507145A Pending JP2015514772A (ja) | 2012-04-18 | 2013-04-17 | ウイルスポリメラーゼを阻害するための組成物および方法 |
| JP2018007131A Active JP6559266B2 (ja) | 2012-04-18 | 2018-01-19 | ウイルスポリメラーゼを阻害するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018007131A Active JP6559266B2 (ja) | 2012-04-18 | 2018-01-19 | ウイルスポリメラーゼを阻害するための組成物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9580428B2 (OSRAM) |
| EP (1) | EP2838535B1 (OSRAM) |
| JP (2) | JP2015514772A (OSRAM) |
| KR (3) | KR102156819B1 (OSRAM) |
| CN (1) | CN104379146B (OSRAM) |
| AR (1) | AR090699A1 (OSRAM) |
| AU (1) | AU2013249344B2 (OSRAM) |
| BR (1) | BR112014025909B1 (OSRAM) |
| CA (1) | CA2870722C (OSRAM) |
| IL (1) | IL235123A (OSRAM) |
| MX (1) | MX363270B (OSRAM) |
| RU (1) | RU2654482C2 (OSRAM) |
| TW (1) | TWI664180B (OSRAM) |
| WO (1) | WO2013158746A1 (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX348759B (es) | 2010-10-15 | 2017-06-28 | Biocryst Pharm Inc | Metodos y composiciones para inhibicion de polimerasa. |
| WO2014078778A2 (en) * | 2012-11-16 | 2014-05-22 | Biocryst Pharmaceuticals, Inc. | Antiviral azasugar-containing nucleosides |
| CN103864791B (zh) * | 2014-03-18 | 2016-01-27 | 福建天泉药业股份有限公司 | 一种恩替卡韦衍生物及其制备方法 |
| CN104513249B (zh) * | 2014-12-26 | 2016-08-31 | 苏州明锐医药科技有限公司 | 抗埃博拉病毒药物bcx4430的制备方法 |
| CA2973152A1 (en) * | 2015-01-07 | 2016-07-14 | Euro-Celtique S.A. | Process for manufacture of forodesine |
| TWI874791B (zh) * | 2020-02-18 | 2025-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| WO2021207386A1 (en) * | 2020-04-07 | 2021-10-14 | Biocryst Pharmaceuticals, Inc. | Methods, compositions, and dosing regimens for treatment of sars-cov-2 infections |
| US20230285434A1 (en) * | 2020-04-14 | 2023-09-14 | Oyagen, Inc. | Method for treating arenaviridae infections |
| CN111704619B (zh) * | 2020-07-30 | 2021-10-19 | 四川大学 | 一种Forodesine的制备方法 |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
| CA3098164A1 (en) * | 2020-11-05 | 2022-05-05 | Eurofins Cdmo Alphora Inc. | Process for preparation of advanced intermediate for eribulin synthesys |
| WO2023022216A1 (ja) | 2021-08-20 | 2023-02-23 | 塩野義製薬株式会社 | ウイルス増殖抑制作用を有するヌクレオシド誘導体及びそれらのプロドラッグ |
| CN113666941B (zh) * | 2021-09-01 | 2023-03-10 | 浙江珲达生物科技有限公司 | 一种2,3-O-异亚丙基-D-核糖酸-γ-内酯的重结晶方法 |
| US12552827B2 (en) | 2022-01-21 | 2026-02-17 | Biocryst Pharmaceuticals, Inc. | Synthesis of an antiviral azasugar triphosphate |
| CN116693541A (zh) * | 2023-06-15 | 2023-09-05 | 安徽大学 | 一种4-氯-5h-吡咯并[3,2-d]嘧啶的合成方法 |
| CN118359621B (zh) * | 2024-04-16 | 2025-05-16 | 上海陶术生物科技股份有限公司 | 加利司伟及加利司伟中间体的制备方法和相应的加利司伟中间体 |
| CN118359623B (zh) * | 2024-04-16 | 2025-06-27 | 上海陶术生物科技股份有限公司 | 一种呋咯地辛的合成方法、中间体及应用 |
| CN118359622B (zh) * | 2024-04-16 | 2025-08-26 | 上海陶术生物科技股份有限公司 | 加利司伟中间体的制备方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5985848A (en) * | 1997-10-14 | 1999-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside metabolism |
| CA2696826C (en) * | 1999-04-08 | 2013-01-08 | Industrial Research Limited | Process for preparing inhibitors of nucleoside metabolism |
| MY141594A (en) * | 2000-06-15 | 2010-05-14 | Novirio Pharmaceuticals Ltd | 3'-PRODRUGS OF 2'-DEOXY-ß-L-NUCLEOSIDES |
| AU2001284564A1 (en) * | 2000-08-29 | 2002-03-13 | Albert Einstein College Of Medicine Of Yeshiva University | Nucleoside metabolism inhibitors |
| WO2002069903A2 (en) | 2001-03-06 | 2002-09-12 | Biocryst Pharmaceuticals, Inc. | Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases |
| US7388002B2 (en) | 2001-11-14 | 2008-06-17 | Biocryst Pharmaceuticals, Inc. | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
| US7098334B2 (en) * | 2002-03-25 | 2006-08-29 | Industrial Research Limited | 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases |
| US20040242599A1 (en) | 2003-02-27 | 2004-12-02 | Biocryst Pharmaceuticals, Inc. | Cyclopentene nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
| US20040229839A1 (en) | 2003-05-14 | 2004-11-18 | Biocryst Pharmaceuticals, Inc. | Substituted nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
| US20050187170A1 (en) | 2003-06-16 | 2005-08-25 | Biocryst Pharmaceuticals, Inc. | Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors |
| US20050080053A1 (en) | 2003-08-29 | 2005-04-14 | Biocryst Pharmaceuticals, Inc. | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
| ATE465742T1 (de) * | 2003-09-05 | 2010-05-15 | Anadys Pharmaceuticals Inc | Tlr7-liganden zur behandlung von hepatitis c |
| US20070167353A1 (en) * | 2003-10-24 | 2007-07-19 | John Hilfinger | Prodrug composition |
| WO2006002231A1 (en) * | 2004-06-22 | 2006-01-05 | Biocryst Pharmaceuticals, Inc. | Aza nucleosides, preparation thereof and use as inhibitors of rna viral polymerases |
| US8133870B2 (en) | 2004-10-29 | 2012-03-13 | Biocryst Pharmaceuticals, Inc. | Therapeutic furopyrimidines and thienopyrimidines |
| BRPI0607770A2 (pt) * | 2005-02-28 | 2009-06-13 | Genelabs Tech Inc | compostos de nucleosideo tricìclico para tratamento de infecções virais |
| EP2537520A1 (en) * | 2005-03-29 | 2012-12-26 | Biocryst Pharmaceuticals, Inc. | Hepatics C therapies |
| US7632821B2 (en) * | 2005-08-09 | 2009-12-15 | Merck & Co., Inc. | Ribonucleoside cyclic acetal derivatives for the treatment of RNA-dependent RNA viral infection |
| WO2007069924A1 (en) * | 2005-12-15 | 2007-06-21 | Industrial Research Limited | Deazapurine analogs of 4'-aza-l-nucleosides |
| US7759495B2 (en) * | 2006-08-11 | 2010-07-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EA016830B1 (ru) | 2006-09-11 | 2012-07-30 | Саузерн Рисерч Инститьют | Азольные нуклеозиды и их применение в качестве ингибиторов вариальных рнк- и днк-полимераз |
| SI2114980T1 (sl) | 2007-01-12 | 2012-11-30 | Biocryst Pharm Inc | Protivirusni nukleozidni analogi |
| TW200942243A (en) | 2008-03-05 | 2009-10-16 | Biocryst Pharm Inc | Antiviral therapeutic agents |
| PL2411394T3 (pl) * | 2009-03-24 | 2015-01-30 | Biocryst Pharm Inc | Użyteczne sole farmaceutyczne 7-[(3r, 4r)-3-hydroksy-4-hydroksymetylopirolidyn-1-ylometylo]-3,5-dihydropirolo[3,2-d]pirymidyno-4-nu |
| MX348759B (es) | 2010-10-15 | 2017-06-28 | Biocryst Pharm Inc | Metodos y composiciones para inhibicion de polimerasa. |
-
2013
- 2013-04-16 AR ARP130101229A patent/AR090699A1/es active IP Right Grant
- 2013-04-17 RU RU2014145857A patent/RU2654482C2/ru active
- 2013-04-17 KR KR1020147032192A patent/KR102156819B1/ko active Active
- 2013-04-17 WO PCT/US2013/036945 patent/WO2013158746A1/en not_active Ceased
- 2013-04-17 BR BR112014025909-7A patent/BR112014025909B1/pt active IP Right Grant
- 2013-04-17 MX MX2014012525A patent/MX363270B/es unknown
- 2013-04-17 AU AU2013249344A patent/AU2013249344B2/en active Active
- 2013-04-17 CA CA2870722A patent/CA2870722C/en active Active
- 2013-04-17 CN CN201380031507.7A patent/CN104379146B/zh active Active
- 2013-04-17 US US14/395,355 patent/US9580428B2/en active Active
- 2013-04-17 KR KR1020217002466A patent/KR102409853B1/ko active Active
- 2013-04-17 KR KR1020207016520A patent/KR20200070428A/ko not_active Ceased
- 2013-04-17 EP EP13778292.6A patent/EP2838535B1/en active Active
- 2013-04-17 JP JP2015507145A patent/JP2015514772A/ja active Pending
- 2013-04-17 TW TW102113674A patent/TWI664180B/zh active
-
2014
- 2014-10-19 IL IL235123A patent/IL235123A/en active IP Right Grant
-
2017
- 2017-01-20 US US15/411,297 patent/US20170128454A1/en not_active Abandoned
-
2018
- 2018-01-19 JP JP2018007131A patent/JP6559266B2/ja active Active
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