JP2015511820A5 - - Google Patents

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Publication number

JP2015511820A5

JP2015511820A5 JP2014560327A JP2014560327A JP2015511820A5 JP 2015511820 A5 JP2015511820 A5 JP 2015511820A5 JP 2014560327 A JP2014560327 A JP 2014560327A JP 2014560327 A JP2014560327 A JP 2014560327A JP 2015511820 A5 JP2015511820 A5 JP 2015511820A5

Authority

JP

Japan

Prior art keywords

composition

solvent

layer

components

applying

Prior art date

2013-03-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000002904 solvent Substances 0.000 claims 26
• 239000003153 chemical reaction reagent Substances 0.000 claims 9
• WQXNXVUDBPYKBA-UHFFFAOYSA-N Ectoine Natural products CC1=NCCC(C(O)=O)N1 WQXNXVUDBPYKBA-UHFFFAOYSA-N 0.000 claims 8
• 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 claims 7
• 238000002405 diagnostic procedure Methods 0.000 claims 7
• AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 claims 6
• 108090000790 Enzymes Proteins 0.000 claims 5
• 102000004190 Enzymes Human genes 0.000 claims 5
• 239000012491 analyte Substances 0.000 claims 5
• 210000001124 body fluid Anatomy 0.000 claims 5
• 230000003287 optical effect Effects 0.000 claims 5
• KIIBBJKLKFTNQO-WHFBIAKZSA-N 5-hydroxyectoine Chemical compound CC1=N[C@H](C(O)=O)[C@@H](O)CN1 KIIBBJKLKFTNQO-WHFBIAKZSA-N 0.000 claims 4
• 101710088194 Dehydrogenase Proteins 0.000 claims 4
• 239000010839 body fluid Substances 0.000 claims 4
• WQXNXVUDBPYKBA-YFKPBYRVSA-N ectoine Chemical group CC1=[NH+][C@H](C([O-])=O)CCN1 WQXNXVUDBPYKBA-YFKPBYRVSA-N 0.000 claims 4
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 4
• PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 3
• 230000001419 dependent effect Effects 0.000 claims 3
• VWWQXMAJTJZDQX-UYBVJOGSSA-N flavin adenine dinucleotide Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1CO[P@](O)(=O)O[P@@](O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C2=NC(=O)NC(=O)C2=NC2=C1C=C(C)C(C)=C2 VWWQXMAJTJZDQX-UYBVJOGSSA-N 0.000 claims 3
• 235000019162 flavin adenine dinucleotide Nutrition 0.000 claims 3
• 239000011714 flavin adenine dinucleotide Substances 0.000 claims 3
• 229940093632 flavin-adenine dinucleotide Drugs 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• MMXZSJMASHPLLR-UHFFFAOYSA-N pyrroloquinoline quinone Chemical compound C12=C(C(O)=O)C=C(C(O)=O)N=C2C(=O)C(=O)C2=C1NC(C(=O)O)=C2 MMXZSJMASHPLLR-UHFFFAOYSA-N 0.000 claims 3
• DUXQJVAWRJYWOK-LURJTMIESA-N (7s)-2-methyl-4,5,6,7-tetrahydro-1h-1,3-diazepine-7-carboxylic acid Chemical compound CC1=NCCC[C@@H](C(O)=O)N1 DUXQJVAWRJYWOK-LURJTMIESA-N 0.000 claims 2
• ZYDGCYWJDWIJCS-UHFFFAOYSA-N 1-methoxyphenazine Chemical compound C1=CC=C2N=C3C(OC)=CC=CC3=NC2=C1 ZYDGCYWJDWIJCS-UHFFFAOYSA-N 0.000 claims 2
• VEPOHXYIFQMVHW-XOZOLZJESA-N 2,3-dihydroxybutanedioic acid (2S,3S)-3,4-dimethyl-2-phenylmorpholine Chemical compound OC(C(O)C(O)=O)C(O)=O.C[C@H]1[C@@H](OCCN1C)c1ccccc1 VEPOHXYIFQMVHW-XOZOLZJESA-N 0.000 claims 2
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
• BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims 2
• 150000001408 amides Chemical class 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 108010054770 glucose dehydrogenase (pyrroloquinoline-quinone) Proteins 0.000 claims 2
• -1 hydroxyectoin ester Chemical class 0.000 claims 2
• 230000001939 inductive effect Effects 0.000 claims 2
• KOOMFXGDLMRWSN-UHFFFAOYSA-N n-phenylnitrous amide Chemical compound O=NNC1=CC=CC=C1 KOOMFXGDLMRWSN-UHFFFAOYSA-N 0.000 claims 2
• CTZNAAOWALUAJG-UHFFFAOYSA-N 4-(5-ethylphenazin-5-ium-1-yl)oxybutanoic acid;trifluoromethanesulfonate Chemical compound [O-]S(=O)(=O)C(F)(F)F.C1=CC=C2[N+](CC)=C(C=CC=C3)C3=NC2=C1OCCCC(O)=O CTZNAAOWALUAJG-UHFFFAOYSA-N 0.000 claims 1
• RXGJTUSBYWCRBK-UHFFFAOYSA-M 5-methylphenazinium methyl sulfate Chemical compound COS([O-])(=O)=O.C1=CC=C2[N+](C)=C(C=CC=C3)C3=NC2=C1 RXGJTUSBYWCRBK-UHFFFAOYSA-M 0.000 claims 1
• 102100031126 6-phosphogluconolactonase Human genes 0.000 claims 1
• 108010029731 6-phosphogluconolactonase Proteins 0.000 claims 1
• YYVYAPXYZVYDHN-UHFFFAOYSA-N 9,10-phenanthroquinone Chemical group C1=CC=C2C(=O)C(=O)C3=CC=CC=C3C2=C1 YYVYAPXYZVYDHN-UHFFFAOYSA-N 0.000 claims 1
• 102000028526 Dihydrolipoamide Dehydrogenase Human genes 0.000 claims 1
• 108010028127 Dihydrolipoamide Dehydrogenase Proteins 0.000 claims 1
• 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 claims 1
• 102000006746 NADH Dehydrogenase Human genes 0.000 claims 1
• 108010086428 NADH Dehydrogenase Proteins 0.000 claims 1
• DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 claims 1
• DGPLSUKWXXSBCU-UHFFFAOYSA-N [[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [4-(3-carbamoylpyridin-1-ium-1-yl)-2,3-dihydroxycyclopentyl]methyl phosphate Chemical group NC(=O)C1=CC=C[N+](C2C(C(O)C(COP([O-])(=O)OP(O)(=O)OCC3C(C(O)C(O3)N3C4=NC=NC(N)=C4N=C3)O)C2)O)=C1 DGPLSUKWXXSBCU-UHFFFAOYSA-N 0.000 claims 1
• KNTVBBGVOSDILJ-UHFFFAOYSA-N [n-(hydroxymethyl)-4-nitrosoanilino]methanol;hydrochloride Chemical group Cl.OCN(CO)C1=CC=C(N=O)C=C1 KNTVBBGVOSDILJ-UHFFFAOYSA-N 0.000 claims 1
• FEYCFVFRMKWAOH-UHFFFAOYSA-N benzo[h]quinoline-2,3-dione Chemical compound C1=CC=C2C3=NC(=O)C(=O)C=C3C=CC2=C1 FEYCFVFRMKWAOH-UHFFFAOYSA-N 0.000 claims 1
• 238000001514 detection method Methods 0.000 claims 1
• 238000001035 drying Methods 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 230000002255 enzymatic effect Effects 0.000 claims 1
• 150000002148 esters Chemical class 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000005259 measurement Methods 0.000 claims 1
• 229950006238 nadide Drugs 0.000 claims 1
• 229940101270 nicotinamide adenine dinucleotide (nad) Drugs 0.000 claims 1
• 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims 1
• 230000003647 oxidation Effects 0.000 claims 1
• 238000007254 oxidation reaction Methods 0.000 claims 1
• 125000001791 phenazinyl group Chemical group C1(=CC=CC2=NC3=CC=CC=C3N=C12)* 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• 239000007787 solid Substances 0.000 claims 1