JP2015511664A5 - - Google Patents
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- Publication number
- JP2015511664A5 JP2015511664A5 JP2015503158A JP2015503158A JP2015511664A5 JP 2015511664 A5 JP2015511664 A5 JP 2015511664A5 JP 2015503158 A JP2015503158 A JP 2015503158A JP 2015503158 A JP2015503158 A JP 2015503158A JP 2015511664 A5 JP2015511664 A5 JP 2015511664A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- heparan sulfate
- chemically modified
- modified heparin
- heparin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 20
- 229920002971 Heparan sulfate Polymers 0.000 claims 19
- 230000013948 uterine smooth muscle contraction Effects 0.000 claims 10
- 238000011282 treatment Methods 0.000 claims 9
- 150000004676 glycans Polymers 0.000 claims 8
- 230000035800 maturation Effects 0.000 claims 8
- 230000001737 promoting effect Effects 0.000 claims 7
- 150000004804 polysaccharides Polymers 0.000 claims 5
- 229960002986 dinoprostone Drugs 0.000 claims 4
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 4
- 150000002016 disaccharides Chemical class 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 4
- 150000003180 prostaglandins Chemical class 0.000 claims 4
- 210000003679 cervix uteri Anatomy 0.000 claims 3
- 150000002301 glucosamine derivatives Chemical class 0.000 claims 3
- 229960002897 heparin Drugs 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- 238000005160 1H NMR spectroscopy Methods 0.000 claims 2
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 claims 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 2
- AEMOLEFTQBMNLQ-HNFCZKTMSA-N L-idopyranuronic acid Chemical class OC1O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-HNFCZKTMSA-N 0.000 claims 2
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 claims 2
- 101800000989 Oxytocin Proteins 0.000 claims 2
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 238000011374 additional therapy Methods 0.000 claims 2
- 230000002429 anti-coagulating effect Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000011284 combination treatment Methods 0.000 claims 2
- 230000001186 cumulative effect Effects 0.000 claims 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N glucosamine group Chemical group OC1[C@H](N)[C@@H](O)[C@H](O)[C@H](O1)CO MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 2
- 229940097043 glucuronic acid Drugs 0.000 claims 2
- 229920000669 heparin Polymers 0.000 claims 2
- OJLOPKGSLYJEMD-URPKTTJQSA-N methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(1e)-4-hydroxy-4-methyloct-1-en-1-yl]-5-oxocyclopentyl]heptanoate Chemical compound CCCCC(C)(O)C\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC OJLOPKGSLYJEMD-URPKTTJQSA-N 0.000 claims 2
- 229960005249 misoprostol Drugs 0.000 claims 2
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 claims 2
- 229960001723 oxytocin Drugs 0.000 claims 2
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 claims 2
- 238000001228 spectrum Methods 0.000 claims 2
- 210000004291 uterus Anatomy 0.000 claims 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 1
- 238000007385 chemical modification Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229960002442 glucosamine Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261615398P | 2012-03-26 | 2012-03-26 | |
| US61/615,398 | 2012-03-26 | ||
| PCT/SE2013/050332 WO2013147689A1 (en) | 2012-03-26 | 2013-03-25 | Combination treatment comprising sulphated glycosaminoglycans for inducing labor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015511664A JP2015511664A (ja) | 2015-04-20 |
| JP2015511664A5 true JP2015511664A5 (enExample) | 2016-05-26 |
| JP6234989B2 JP6234989B2 (ja) | 2017-11-22 |
Family
ID=49260783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503158A Active JP6234989B2 (ja) | 2012-03-26 | 2013-03-25 | 分娩を誘発するための療法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20150045322A1 (enExample) |
| EP (1) | EP2830635A4 (enExample) |
| JP (1) | JP6234989B2 (enExample) |
| CN (1) | CN104203256B (enExample) |
| AU (1) | AU2013240597A1 (enExample) |
| CA (1) | CA2868444A1 (enExample) |
| HK (1) | HK1203369A1 (enExample) |
| IL (1) | IL234689A0 (enExample) |
| MX (1) | MX2014011505A (enExample) |
| MY (1) | MY175743A (enExample) |
| RU (1) | RU2014143017A (enExample) |
| SG (1) | SG11201406119WA (enExample) |
| UA (1) | UA117908C2 (enExample) |
| WO (1) | WO2013147689A1 (enExample) |
| ZA (1) | ZA201406901B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2856492C (en) | 2011-12-19 | 2017-01-10 | Dilafor Ab | Non anti-coagulative glycosaminoglycans comprising repeating disaccharide unit and their medical use |
| WO2013095215A1 (en) | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
| WO2013169194A1 (en) * | 2012-05-08 | 2013-11-14 | Dilafor Ab | Treatment of postpartum haemorrhage with chemically modified heparin or heparan sulphate and a uterotonic agent |
| AU2021223494B2 (en) | 2020-02-17 | 2026-01-08 | Dilafor Ab | Tafoxiparin for the treatment of preeclampsia |
| WO2023213788A1 (en) | 2022-05-03 | 2023-11-09 | Dilafor Ab | New medical use of tafoxiparin |
| EP4272749A1 (en) | 2022-05-03 | 2023-11-08 | Dilafor AB | New medical use of tafoxiparin |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2614026B1 (fr) * | 1987-04-16 | 1992-04-17 | Sanofi Sa | Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques |
| US5744457A (en) * | 1995-03-31 | 1998-04-28 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
| US5993810A (en) * | 1996-03-15 | 1999-11-30 | Lebovitz; Shamir Israel | Method of softening or ripening the cervix of a female mammal using collagenase |
| SE521676C2 (sv) * | 2002-01-02 | 2003-11-25 | Dilafor Ab | Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet |
| WO2009073184A1 (en) * | 2007-12-03 | 2009-06-11 | Florida State University Research Foundation, Inc. | Compositions for inducing labor and associated methods |
| CN104160366A (zh) * | 2011-11-28 | 2014-11-19 | 康宁股份有限公司 | 使用平面透明薄板的稳固的光学触摸屏系统和方法 |
| CA2856492C (en) * | 2011-12-19 | 2017-01-10 | Dilafor Ab | Non anti-coagulative glycosaminoglycans comprising repeating disaccharide unit and their medical use |
-
2013
- 2013-03-25 RU RU2014143017A patent/RU2014143017A/ru not_active Application Discontinuation
- 2013-03-25 MX MX2014011505A patent/MX2014011505A/es unknown
- 2013-03-25 CN CN201380016550.6A patent/CN104203256B/zh active Active
- 2013-03-25 JP JP2015503158A patent/JP6234989B2/ja active Active
- 2013-03-25 EP EP13770213.0A patent/EP2830635A4/en not_active Withdrawn
- 2013-03-25 MY MYPI2014002745A patent/MY175743A/en unknown
- 2013-03-25 WO PCT/SE2013/050332 patent/WO2013147689A1/en not_active Ceased
- 2013-03-25 SG SG11201406119WA patent/SG11201406119WA/en unknown
- 2013-03-25 US US14/387,936 patent/US20150045322A1/en not_active Abandoned
- 2013-03-25 HK HK15103908.8A patent/HK1203369A1/xx unknown
- 2013-03-25 UA UAA201411546A patent/UA117908C2/uk unknown
- 2013-03-25 AU AU2013240597A patent/AU2013240597A1/en not_active Abandoned
- 2013-03-25 CA CA2868444A patent/CA2868444A1/en not_active Abandoned
-
2014
- 2014-09-16 ZA ZA2014/06901A patent/ZA201406901B/en unknown
- 2014-09-16 IL IL234689A patent/IL234689A0/en unknown
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