RU2014143017A - Препараты для индукции родов - Google Patents
Препараты для индукции родов Download PDFInfo
- Publication number
- RU2014143017A RU2014143017A RU2014143017A RU2014143017A RU2014143017A RU 2014143017 A RU2014143017 A RU 2014143017A RU 2014143017 A RU2014143017 A RU 2014143017A RU 2014143017 A RU2014143017 A RU 2014143017A RU 2014143017 A RU2014143017 A RU 2014143017A
- Authority
- RU
- Russia
- Prior art keywords
- heparan sulfate
- chemically modified
- modified heparin
- activating
- use according
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims 3
- 230000035606 childbirth Effects 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 230000006698 induction Effects 0.000 title 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract 33
- 229920002971 Heparan sulfate Polymers 0.000 claims abstract 29
- 230000003213 activating effect Effects 0.000 claims abstract 19
- 230000000694 effects Effects 0.000 claims abstract 16
- 150000004676 glycans Polymers 0.000 claims abstract 11
- 150000004804 polysaccharides Polymers 0.000 claims abstract 10
- 230000013948 uterine smooth muscle contraction Effects 0.000 claims abstract 9
- 238000011282 treatment Methods 0.000 claims abstract 8
- 230000035800 maturation Effects 0.000 claims abstract 7
- 239000003795 chemical substances by application Substances 0.000 claims abstract 6
- 150000002302 glucosamines Chemical class 0.000 claims abstract 6
- 150000002016 disaccharides Chemical class 0.000 claims abstract 5
- 108010029144 Factor IIa Proteins 0.000 claims abstract 4
- 108010074860 Factor Xa Proteins 0.000 claims abstract 4
- 230000001858 anti-Xa Effects 0.000 claims abstract 4
- 230000002429 anti-coagulating effect Effects 0.000 claims abstract 4
- 150000001720 carbohydrates Chemical group 0.000 claims abstract 4
- 210000003679 cervix uteri Anatomy 0.000 claims abstract 4
- 238000011284 combination treatment Methods 0.000 claims abstract 4
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims abstract 4
- 229960002986 dinoprostone Drugs 0.000 claims abstract 4
- 229920000669 heparin Polymers 0.000 claims abstract 4
- 229960002897 heparin Drugs 0.000 claims abstract 4
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims abstract 4
- 150000003180 prostaglandins Chemical class 0.000 claims abstract 4
- 230000005070 ripening Effects 0.000 claims abstract 4
- 230000008602 contraction Effects 0.000 claims abstract 3
- OJLOPKGSLYJEMD-URPKTTJQSA-N methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(1e)-4-hydroxy-4-methyloct-1-en-1-yl]-5-oxocyclopentyl]heptanoate Chemical compound CCCCC(C)(O)C\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC OJLOPKGSLYJEMD-URPKTTJQSA-N 0.000 claims abstract 2
- 229960005249 misoprostol Drugs 0.000 claims abstract 2
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 claims 4
- 238000011360 adjunctive therapy Methods 0.000 claims 3
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 claims 2
- 101800000989 Oxytocin Proteins 0.000 claims 2
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000000754 myometrium Anatomy 0.000 claims 2
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 claims 2
- 229960001723 oxytocin Drugs 0.000 claims 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 1
- 229960002442 glucosamine Drugs 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 238000005160 1H NMR spectroscopy Methods 0.000 abstract 1
- 206010061692 Benign muscle neoplasm Diseases 0.000 abstract 1
- 201000004458 Myoma Diseases 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261615398P | 2012-03-26 | 2012-03-26 | |
| US61/615,398 | 2012-03-26 | ||
| PCT/SE2013/050332 WO2013147689A1 (en) | 2012-03-26 | 2013-03-25 | Combination treatment comprising sulphated glycosaminoglycans for inducing labor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014143017A true RU2014143017A (ru) | 2016-05-20 |
Family
ID=49260783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014143017A RU2014143017A (ru) | 2012-03-26 | 2013-03-25 | Препараты для индукции родов |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20150045322A1 (enExample) |
| EP (1) | EP2830635A4 (enExample) |
| JP (1) | JP6234989B2 (enExample) |
| CN (1) | CN104203256B (enExample) |
| AU (1) | AU2013240597A1 (enExample) |
| CA (1) | CA2868444A1 (enExample) |
| HK (1) | HK1203369A1 (enExample) |
| IL (1) | IL234689A0 (enExample) |
| MX (1) | MX2014011505A (enExample) |
| MY (1) | MY175743A (enExample) |
| RU (1) | RU2014143017A (enExample) |
| SG (1) | SG11201406119WA (enExample) |
| UA (1) | UA117908C2 (enExample) |
| WO (1) | WO2013147689A1 (enExample) |
| ZA (1) | ZA201406901B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013095215A1 (en) | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
| SMT201800143T1 (it) | 2011-12-19 | 2018-05-02 | Dilafor Ab | Glicosaminoglicani non anticoagulanti comprendenti un'unita ripetitiva di disaccaridi e loro uso medico |
| CA2868403A1 (en) * | 2012-05-08 | 2013-11-14 | Dilafor Ab | Treatment of postpartum haemorrhage with chemically modified heparin or heparan sulphate and a uterotonic agent |
| KR20220142508A (ko) * | 2020-02-17 | 2022-10-21 | 딜라포 아베 | 자간전증 치료용 타폭시파린 |
| CA3255831A1 (en) | 2022-05-03 | 2023-11-09 | Dilafor Ab | NEW MEDICAL USE OF TAFOXIPARIN |
| EP4272749A1 (en) | 2022-05-03 | 2023-11-08 | Dilafor AB | New medical use of tafoxiparin |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2614026B1 (fr) * | 1987-04-16 | 1992-04-17 | Sanofi Sa | Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques |
| US5744457A (en) * | 1995-03-31 | 1998-04-28 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
| US5993810A (en) * | 1996-03-15 | 1999-11-30 | Lebovitz; Shamir Israel | Method of softening or ripening the cervix of a female mammal using collagenase |
| SE521676C2 (sv) * | 2002-01-02 | 2003-11-25 | Dilafor Ab | Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet |
| US8445436B2 (en) * | 2007-12-03 | 2013-05-21 | Florida State University Research Foundation, Inc. | Oxytocin and melatonin compositions and associated methods for inducing labor |
| KR20140097380A (ko) * | 2011-11-28 | 2014-08-06 | 코닝 인코포레이티드 | 평면 투명 시트를 사용한，강력한 광학 터치 스크린 시스템 및 방법 |
| SMT201800143T1 (it) * | 2011-12-19 | 2018-05-02 | Dilafor Ab | Glicosaminoglicani non anticoagulanti comprendenti un'unita ripetitiva di disaccaridi e loro uso medico |
-
2013
- 2013-03-25 US US14/387,936 patent/US20150045322A1/en not_active Abandoned
- 2013-03-25 MY MYPI2014002745A patent/MY175743A/en unknown
- 2013-03-25 WO PCT/SE2013/050332 patent/WO2013147689A1/en not_active Ceased
- 2013-03-25 JP JP2015503158A patent/JP6234989B2/ja active Active
- 2013-03-25 EP EP13770213.0A patent/EP2830635A4/en not_active Withdrawn
- 2013-03-25 MX MX2014011505A patent/MX2014011505A/es unknown
- 2013-03-25 AU AU2013240597A patent/AU2013240597A1/en not_active Abandoned
- 2013-03-25 HK HK15103908.8A patent/HK1203369A1/xx unknown
- 2013-03-25 SG SG11201406119WA patent/SG11201406119WA/en unknown
- 2013-03-25 CN CN201380016550.6A patent/CN104203256B/zh active Active
- 2013-03-25 RU RU2014143017A patent/RU2014143017A/ru not_active Application Discontinuation
- 2013-03-25 UA UAA201411546A patent/UA117908C2/uk unknown
- 2013-03-25 CA CA2868444A patent/CA2868444A1/en not_active Abandoned
-
2014
- 2014-09-16 ZA ZA2014/06901A patent/ZA201406901B/en unknown
- 2014-09-16 IL IL234689A patent/IL234689A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013147689A1 (en) | 2013-10-03 |
| US20150045322A1 (en) | 2015-02-12 |
| SG11201406119WA (en) | 2014-11-27 |
| MY175743A (en) | 2020-07-07 |
| AU2013240597A1 (en) | 2014-10-16 |
| IL234689A0 (en) | 2014-11-30 |
| ZA201406901B (en) | 2017-09-27 |
| HK1203369A1 (en) | 2015-10-30 |
| CA2868444A1 (en) | 2013-10-03 |
| JP6234989B2 (ja) | 2017-11-22 |
| CN104203256B (zh) | 2017-11-24 |
| EP2830635A4 (en) | 2016-03-16 |
| UA117908C2 (uk) | 2018-10-25 |
| JP2015511664A (ja) | 2015-04-20 |
| EP2830635A1 (en) | 2015-02-04 |
| MX2014011505A (es) | 2014-12-05 |
| CN104203256A (zh) | 2014-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20170721 |