RU2014143017A - Препараты для индукции родов - Google Patents
Препараты для индукции родов Download PDFInfo
- Publication number
- RU2014143017A RU2014143017A RU2014143017A RU2014143017A RU2014143017A RU 2014143017 A RU2014143017 A RU 2014143017A RU 2014143017 A RU2014143017 A RU 2014143017A RU 2014143017 A RU2014143017 A RU 2014143017A RU 2014143017 A RU2014143017 A RU 2014143017A
- Authority
- RU
- Russia
- Prior art keywords
- heparan sulfate
- chemically modified
- modified heparin
- activating
- use according
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims 3
- 230000035606 childbirth Effects 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 230000006698 induction Effects 0.000 title 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract 33
- 229920002971 Heparan sulfate Polymers 0.000 claims abstract 29
- 230000003213 activating effect Effects 0.000 claims abstract 19
- 230000000694 effects Effects 0.000 claims abstract 16
- 150000004676 glycans Polymers 0.000 claims abstract 11
- 150000004804 polysaccharides Polymers 0.000 claims abstract 10
- 230000013948 uterine smooth muscle contraction Effects 0.000 claims abstract 9
- 238000011282 treatment Methods 0.000 claims abstract 8
- 230000035800 maturation Effects 0.000 claims abstract 7
- 239000003795 chemical substances by application Substances 0.000 claims abstract 6
- 150000002302 glucosamines Chemical class 0.000 claims abstract 6
- 150000002016 disaccharides Chemical class 0.000 claims abstract 5
- 108010029144 Factor IIa Proteins 0.000 claims abstract 4
- 108010074860 Factor Xa Proteins 0.000 claims abstract 4
- 230000001858 anti-Xa Effects 0.000 claims abstract 4
- 230000002429 anti-coagulating effect Effects 0.000 claims abstract 4
- 150000001720 carbohydrates Chemical group 0.000 claims abstract 4
- 210000003679 cervix uteri Anatomy 0.000 claims abstract 4
- 238000011284 combination treatment Methods 0.000 claims abstract 4
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims abstract 4
- 229960002986 dinoprostone Drugs 0.000 claims abstract 4
- 229920000669 heparin Polymers 0.000 claims abstract 4
- 229960002897 heparin Drugs 0.000 claims abstract 4
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims abstract 4
- 150000003180 prostaglandins Chemical class 0.000 claims abstract 4
- 230000005070 ripening Effects 0.000 claims abstract 4
- 230000008602 contraction Effects 0.000 claims abstract 3
- OJLOPKGSLYJEMD-URPKTTJQSA-N methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(1e)-4-hydroxy-4-methyloct-1-en-1-yl]-5-oxocyclopentyl]heptanoate Chemical compound CCCCC(C)(O)C\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC OJLOPKGSLYJEMD-URPKTTJQSA-N 0.000 claims abstract 2
- 229960005249 misoprostol Drugs 0.000 claims abstract 2
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 claims 4
- 238000011360 adjunctive therapy Methods 0.000 claims 3
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 claims 2
- 101800000989 Oxytocin Proteins 0.000 claims 2
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000000754 myometrium Anatomy 0.000 claims 2
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 claims 2
- 229960001723 oxytocin Drugs 0.000 claims 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 1
- 229960002442 glucosamine Drugs 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 238000005160 1H NMR spectroscopy Methods 0.000 abstract 1
- 206010061692 Benign muscle neoplasm Diseases 0.000 abstract 1
- 201000004458 Myoma Diseases 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261615398P | 2012-03-26 | 2012-03-26 | |
| US61/615,398 | 2012-03-26 | ||
| PCT/SE2013/050332 WO2013147689A1 (en) | 2012-03-26 | 2013-03-25 | Combination treatment comprising sulphated glycosaminoglycans for inducing labor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014143017A true RU2014143017A (ru) | 2016-05-20 |
Family
ID=49260783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014143017A RU2014143017A (ru) | 2012-03-26 | 2013-03-25 | Препараты для индукции родов |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20150045322A1 (enExample) |
| EP (1) | EP2830635A4 (enExample) |
| JP (1) | JP6234989B2 (enExample) |
| CN (1) | CN104203256B (enExample) |
| AU (1) | AU2013240597A1 (enExample) |
| CA (1) | CA2868444A1 (enExample) |
| HK (1) | HK1203369A1 (enExample) |
| IL (1) | IL234689A0 (enExample) |
| MX (1) | MX2014011505A (enExample) |
| MY (1) | MY175743A (enExample) |
| RU (1) | RU2014143017A (enExample) |
| SG (1) | SG11201406119WA (enExample) |
| UA (1) | UA117908C2 (enExample) |
| WO (1) | WO2013147689A1 (enExample) |
| ZA (1) | ZA201406901B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2794665T3 (da) | 2011-12-19 | 2018-01-29 | Dilafor Ab | Ikke-antikoagulative glycosaminoglycaner omfattende disaccharid-gentagelsesenhed og medicinsk anvendelse deraf |
| WO2013095215A1 (en) | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
| US20150099703A1 (en) * | 2012-05-08 | 2015-04-09 | Dilafor Ab | Treatment of postpartum haemorrhage with chemically modified heparin or heparan sulphate and a uterotonic agent |
| US12502403B2 (en) | 2020-02-17 | 2025-12-23 | Dilafor Ab | Tafoxiparin for the treatment of preeclampsia |
| CA3255831A1 (en) | 2022-05-03 | 2023-11-09 | Dilafor Ab | NEW MEDICAL USE OF TAFOXIPARIN |
| EP4272749A1 (en) | 2022-05-03 | 2023-11-08 | Dilafor AB | New medical use of tafoxiparin |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2614026B1 (fr) * | 1987-04-16 | 1992-04-17 | Sanofi Sa | Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques |
| US5744457A (en) * | 1995-03-31 | 1998-04-28 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
| US5993810A (en) * | 1996-03-15 | 1999-11-30 | Lebovitz; Shamir Israel | Method of softening or ripening the cervix of a female mammal using collagenase |
| SE521676C2 (sv) * | 2002-01-02 | 2003-11-25 | Dilafor Ab | Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet |
| US8445436B2 (en) * | 2007-12-03 | 2013-05-21 | Florida State University Research Foundation, Inc. | Oxytocin and melatonin compositions and associated methods for inducing labor |
| WO2013081896A1 (en) * | 2011-11-28 | 2013-06-06 | Corning Incorporated | Robust optical touch-screen systems and methods using a planar transparent sheet |
| DK2794665T3 (da) * | 2011-12-19 | 2018-01-29 | Dilafor Ab | Ikke-antikoagulative glycosaminoglycaner omfattende disaccharid-gentagelsesenhed og medicinsk anvendelse deraf |
-
2013
- 2013-03-25 CN CN201380016550.6A patent/CN104203256B/zh active Active
- 2013-03-25 CA CA2868444A patent/CA2868444A1/en not_active Abandoned
- 2013-03-25 HK HK15103908.8A patent/HK1203369A1/xx unknown
- 2013-03-25 RU RU2014143017A patent/RU2014143017A/ru not_active Application Discontinuation
- 2013-03-25 AU AU2013240597A patent/AU2013240597A1/en not_active Abandoned
- 2013-03-25 US US14/387,936 patent/US20150045322A1/en not_active Abandoned
- 2013-03-25 EP EP13770213.0A patent/EP2830635A4/en not_active Withdrawn
- 2013-03-25 MY MYPI2014002745A patent/MY175743A/en unknown
- 2013-03-25 MX MX2014011505A patent/MX2014011505A/es unknown
- 2013-03-25 SG SG11201406119WA patent/SG11201406119WA/en unknown
- 2013-03-25 WO PCT/SE2013/050332 patent/WO2013147689A1/en not_active Ceased
- 2013-03-25 UA UAA201411546A patent/UA117908C2/uk unknown
- 2013-03-25 JP JP2015503158A patent/JP6234989B2/ja active Active
-
2014
- 2014-09-16 IL IL234689A patent/IL234689A0/en unknown
- 2014-09-16 ZA ZA2014/06901A patent/ZA201406901B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015511664A (ja) | 2015-04-20 |
| WO2013147689A1 (en) | 2013-10-03 |
| JP6234989B2 (ja) | 2017-11-22 |
| UA117908C2 (uk) | 2018-10-25 |
| MY175743A (en) | 2020-07-07 |
| CN104203256A (zh) | 2014-12-10 |
| IL234689A0 (en) | 2014-11-30 |
| MX2014011505A (es) | 2014-12-05 |
| CA2868444A1 (en) | 2013-10-03 |
| US20150045322A1 (en) | 2015-02-12 |
| HK1203369A1 (en) | 2015-10-30 |
| CN104203256B (zh) | 2017-11-24 |
| SG11201406119WA (en) | 2014-11-27 |
| AU2013240597A1 (en) | 2014-10-16 |
| EP2830635A4 (en) | 2016-03-16 |
| EP2830635A1 (en) | 2015-02-04 |
| ZA201406901B (en) | 2017-09-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2014143008A (ru) | Способ лечения остановки родов | |
| RU2014129816A (ru) | Неантикоагулянтные гликозаминогликаны, содержащие повторяющиеся дисахаридные звенья, и их медицинское применение | |
| JP2015514705A5 (enExample) | ||
| JP2015511664A5 (enExample) | ||
| SI2794666T1 (en) | Use of chemically modified heparin derivatives in sickle cell disease | |
| JP2015500388A5 (enExample) | ||
| JP2011522879A5 (enExample) | ||
| JP6234989B2 (ja) | 分娩を誘発するための療法 | |
| JP2011037849A (ja) | 消化性潰瘍及び十二指腸潰瘍の治療及び予防に使用されるヒアルロン酸混合物 | |
| RU2014149230A (ru) | Лечение послеродового кровотечения (прк) | |
| HRP20230820T1 (hr) | Heparan-sulfat, s visokom stopom 3-o-sulfatiranja u glukozaminskim ostacima | |
| JP2015516415A5 (enExample) | ||
| EP3082869B1 (en) | Combination of glycosaminoglycans and cyclodextrins | |
| PT1461049E (pt) | Utilização de glicosaminoglicanos sulfatados para estabelecer um parto efectivo em mulheres | |
| JP2016534078A5 (enExample) | ||
| TH156845A (th) | วิธีการสำหรับการบำบัดภาวะการคลอดชะงัก | |
| Steiner et al. | A prospective randomized trial of low molecular weight heparin-DHE and conventional heparin-DHE (with acenocoumarol) in patients undergoing gynaecological surgery | |
| TW202135834A (zh) | 抗發炎或抗血管生成之醫藥組成物 | |
| Peso-Echarri et al. | Polysaccharides as bioactive components of functional food | |
| MX2024014636A (es) | Composiciones para el cuidado de la piel y metodos de uso | |
| TH152504A (th) | การบำบัดรักษาของภาวะตกเลือดหลังคลอดด้วยเฮปาริน หรือ เฮปารินซัลเฟตที่ถูกดัดแปลงทางเคมี และยากระตุ้นการหดตัวของมดลูก |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20170721 |