JP2015511228A5 - - Google Patents
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- Publication number
- JP2015511228A5 JP2015511228A5 JP2014555250A JP2014555250A JP2015511228A5 JP 2015511228 A5 JP2015511228 A5 JP 2015511228A5 JP 2014555250 A JP2014555250 A JP 2014555250A JP 2014555250 A JP2014555250 A JP 2014555250A JP 2015511228 A5 JP2015511228 A5 JP 2015511228A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- compound according
- methyl
- pharmaceutical composition
- fluorine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000001257 hydrogen Substances 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 239000011737 fluorine Substances 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1202027.7 | 2012-02-06 | ||
| GBGB1202027.7A GB201202027D0 (en) | 2012-02-06 | 2012-02-06 | Pharmaceutical compounds |
| PCT/EP2013/052182 WO2013117522A1 (en) | 2012-02-06 | 2013-02-04 | Aurora and flt3 kinases modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015511228A JP2015511228A (ja) | 2015-04-16 |
| JP2015511228A5 true JP2015511228A5 (enExample) | 2016-03-17 |
| JP6034880B2 JP6034880B2 (ja) | 2016-11-30 |
Family
ID=45896692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014555250A Active JP6034880B2 (ja) | 2012-02-06 | 2013-02-04 | オーロラおよびｆｌｔ３キナーゼモジュレーター |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9133180B2 (enExample) |
| EP (1) | EP2812328B1 (enExample) |
| JP (1) | JP6034880B2 (enExample) |
| KR (1) | KR102052780B1 (enExample) |
| CN (1) | CN104169277B (enExample) |
| AU (1) | AU2013218167B2 (enExample) |
| BR (1) | BR112014019254B1 (enExample) |
| CA (1) | CA2863759C (enExample) |
| DK (1) | DK2812328T3 (enExample) |
| ES (1) | ES2560260T3 (enExample) |
| GB (1) | GB201202027D0 (enExample) |
| IL (1) | IL233988A (enExample) |
| MX (1) | MX338481B (enExample) |
| PL (1) | PL2812328T3 (enExample) |
| PT (1) | PT2812328E (enExample) |
| RU (1) | RU2643809C2 (enExample) |
| SG (1) | SG11201404277WA (enExample) |
| WO (1) | WO2013117522A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2522968B2 (ja) | 1987-10-23 | 1996-08-07 | 尾池工業株式会社 | 印刷回路転写箔およびその製造法 |
| EP3666770A4 (en) * | 2017-08-07 | 2021-04-07 | Joint Stock Company "Biocad" | NEW HETEROCYCLIC COMPOUNDS AS CDK8 / 19 INHIBITORS |
| GB201816369D0 (en) | 2018-10-08 | 2018-11-28 | Sareum Ltd | Pharmaceutical compounds |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE794096A (fr) | 1972-08-07 | 1973-05-16 | Lepetit Spa | Oxazoles 2,4,5-trisubstitues et leur preparation |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| JPH06310767A (ja) | 1993-04-26 | 1994-11-04 | Nec Corp | 寒剤容器の断熱支持構造 |
| US6218529B1 (en) | 1995-07-31 | 2001-04-17 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer |
| CA2744096C (en) | 1996-07-31 | 2013-07-30 | Laboratory Corporation Of America Holdings | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
| DE19653355A1 (de) | 1996-12-20 | 1998-06-25 | Dresden Arzneimittel | Neue, antikonvulsiv wirkende Aminoimidazole und Verfahren zu ihrer Herstellung |
| GB0003154D0 (en) | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
| EE200200715A (et) | 2000-06-28 | 2004-08-16 | Astrazeneca Ab | Asendatud kinasoliini derivaadid ja nende kasutamine inhibiitoritena |
| HU230376B1 (hu) | 2000-10-30 | 2016-03-29 | Janssen Pharmaceutica N.V | Tripeptidil peptidáz inhibitorok |
| JP4570955B2 (ja) | 2002-07-09 | 2010-10-27 | バーテクス ファーマスーティカルズ インコーポレイテッド | プロテインキナーゼ阻害活性を持つイミダゾール類 |
| AU2003902208A0 (en) * | 2003-05-08 | 2003-05-22 | Fujisawa Pharmaceutical Co., Ltd. | Inhibitor of cox |
| DK1684750T3 (da) | 2003-10-23 | 2010-08-09 | Ab Science | 2-aminoaryloxazol-forbindelser som tyrosinkinase-inhibitorer |
| DE602005003951T4 (de) * | 2004-05-14 | 2012-10-11 | Millennium Pharmaceuticals, Inc. | Verbindungen und verfahren zur inhibierung der mitotischen progression durch hemmung von aurorakinase |
| GB0504753D0 (en) | 2005-03-08 | 2005-04-13 | Astrazeneca Ab | Chemical compounds |
| US7947707B2 (en) | 2005-10-07 | 2011-05-24 | Kissei Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same |
| DK200600313A (da) | 2006-03-03 | 2006-03-13 | Novo Nordisk As | Treating type 2 diabetes or metabolic syndrome with an interleukin 1beta inhibitor or an interleukin 1beta synthesis or release inhibitor |
| ES2352320T3 (es) | 2006-05-12 | 2011-02-17 | Ab Science | Nuevo procedimiento para la síntesis de compuestos de 2-aminoxazol. |
| US20090093452A1 (en) | 2006-08-24 | 2009-04-09 | Pfizer Inc. | Pyrrole, Thiophene, Furan, Imidazole, Oxazole, and Thiazole Derivatives |
| JO2701B1 (en) * | 2006-12-21 | 2013-03-03 | جلاكسو جروب ليميتد | Vehicles |
| GB0709031D0 (en) * | 2007-05-10 | 2007-06-20 | Sareum Ltd | Pharmaceutical compounds |
| AU2009274454A1 (en) | 2008-04-21 | 2010-01-28 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
| GB0820819D0 (en) * | 2008-11-13 | 2008-12-24 | Sareum Ltd | Pharmaceutical compounds |
| EP2320293A1 (en) * | 2009-11-05 | 2011-05-11 | Koninklijke Philips Electronics N.V. | Sleep element for improving the sleep of a person |
| ES2539170T3 (es) * | 2010-01-12 | 2015-06-26 | Ab Science | Inhibidores de quinasas de oxazol |
| US9062038B2 (en) | 2010-08-11 | 2015-06-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| PL2634185T3 (pl) | 2012-03-02 | 2016-06-30 | Sareum Ltd | Inhibitory kinazy TYK2 |
-
2012
- 2012-02-06 GB GBGB1202027.7A patent/GB201202027D0/en not_active Ceased
-
2013
- 2013-02-04 KR KR1020147024086A patent/KR102052780B1/ko active Active
- 2013-02-04 RU RU2014131784A patent/RU2643809C2/ru active
- 2013-02-04 CN CN201380013544.5A patent/CN104169277B/zh active Active
- 2013-02-04 SG SG11201404277WA patent/SG11201404277WA/en unknown
- 2013-02-04 DK DK13702642.3T patent/DK2812328T3/en active
- 2013-02-04 ES ES13702642.3T patent/ES2560260T3/es active Active
- 2013-02-04 MX MX2014009323A patent/MX338481B/es active IP Right Grant
- 2013-02-04 AU AU2013218167A patent/AU2013218167B2/en not_active Ceased
- 2013-02-04 WO PCT/EP2013/052182 patent/WO2013117522A1/en not_active Ceased
- 2013-02-04 PL PL13702642T patent/PL2812328T3/pl unknown
- 2013-02-04 JP JP2014555250A patent/JP6034880B2/ja active Active
- 2013-02-04 PT PT137026423T patent/PT2812328E/pt unknown
- 2013-02-04 BR BR112014019254-5A patent/BR112014019254B1/pt not_active IP Right Cessation
- 2013-02-04 CA CA2863759A patent/CA2863759C/en active Active
- 2013-02-04 EP EP13702642.3A patent/EP2812328B1/en active Active
- 2013-02-04 US US14/376,729 patent/US9133180B2/en active Active
-
2014
- 2014-08-05 IL IL233988A patent/IL233988A/en active IP Right Grant
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