JP2015510882A5 - - Google Patents
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- JP2015510882A5 JP2015510882A5 JP2014560955A JP2014560955A JP2015510882A5 JP 2015510882 A5 JP2015510882 A5 JP 2015510882A5 JP 2014560955 A JP2014560955 A JP 2014560955A JP 2014560955 A JP2014560955 A JP 2014560955A JP 2015510882 A5 JP2015510882 A5 JP 2015510882A5
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- JP
- Japan
- Prior art keywords
- concentration
- antibody
- seq
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000004965 antibodies Human genes 0.000 claims 12
- 108090001123 antibodies Proteins 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
- 229940068968 Polysorbate 80 Drugs 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 4
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 4
- 229920000053 polysorbate 80 Polymers 0.000 claims 4
- 239000007979 citrate buffer Substances 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 206010002556 Ankylosing spondylitis Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010037162 Psoriatic arthropathy Diseases 0.000 claims 2
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 2
- 201000009251 multiple myeloma Diseases 0.000 claims 2
- 239000003186 pharmaceutical solution Substances 0.000 claims 2
- 201000004681 psoriasis Diseases 0.000 claims 2
- 201000001263 psoriatic arthritis Diseases 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Claims (10)
- 約８０ｍｇ／ｍＬ〜約１５０ｍｇ／ｍＬの範囲の濃度の抗ＩＬ−１７抗体、約２０ｍＭの濃度のクエン酸緩衝液、約２００ｍＭの濃度の塩化ナトリウム、約０．０２％（ｗ／ｖ）〜約０．０３％（ｗ／ｖ）の範囲の濃度のポリソルベート−８０、および約５．７のｐＨを含む医薬製剤であって、前記抗ＩＬ−１７抗体は軽鎖（ＬＣ）および重鎖（ＨＣ）を有する抗体を含み、前記ＬＣは配列番号４のアミノ酸配列であり、前記ＨＣは配列番号５のアミノ酸配列である、医薬製剤。
- 前記抗ＩＬ−１７抗体が２つの軽鎖（ＬＣ）および２つの重鎖（ＨＣ）を含む抗体を含み、各々のＬＣが配列番号４のアミノ酸配列であり、各々のＨＣが配列番号５のアミノ酸配列である、請求項１に記載の製剤。
- 前記抗ＩＬ−１７抗体の濃度が約８０ｍｇ／ｍＬである、請求項１〜２のいずれか一項に記載の製剤。
- 前記ポリソルベート−８０の濃度が約０．０３％（ｗ／ｖ）である、請求項１〜３のいずれか一項に記載の製剤。
- 前記製剤が抗ＩＬ−１７抗体医薬溶液製剤である、請求項１〜４のいずれか一項に記載の製剤。
- 約８０ｍｇ／ｍＬの濃度の抗ＩＬ−１７抗体、約２０ｍＭの濃度のクエン酸緩衝液、約２００ｍＭの濃度の塩化ナトリウム、約０．０３％の濃度のポリソルベート−８０、および約５．７のｐＨを含む医薬製剤であって、前記抗ＩＬ−１７抗体は２つの軽鎖（ＬＣ）および２つの重鎖（ＨＣ）を含む抗体を含み、各々のＬＣは配列番号４のアミノ酸配列であり、各々のＨＣは配列番号５のアミノ酸配列である、医薬製剤。
- 約８０ｍｇ／ｍＬの濃度の抗ＩＬ−１７抗体、約２０ｍＭの濃度のクエン酸緩衝液、約２００ｍＭの濃度の塩化ナトリウム、約０．０３％の濃度のポリソルベート−８０、および約５．７のｐＨを含む医薬溶液製剤であって、前記抗ＩＬ−１７抗体は２つの軽鎖（ＬＣ）および２つの重鎖（ＨＣ）を含む抗体を含み、各々のＬＣは配列番号４のアミノ酸配列であり、各々のＨＣは配列番号５のアミノ酸配列である、医薬溶液製剤。
- 有効量の請求項１〜７のいずれか一項に記載の医薬製剤を含む、関節リウマチ、乾癬、強直性脊椎炎、乾癬性関節炎または多発性骨髄腫を治療するための医薬。
- 治療に使用するための請求項１〜７のいずれか一項に記載の医薬製剤。
- 関節リウマチ、乾癬、強直性脊椎炎、乾癬性関節炎または多発性骨髄腫の治療に使用するための請求項１〜７のいずれか一項に記載の医薬製剤。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261607671P | 2012-03-07 | 2012-03-07 | |
| US61/607,671 | 2012-03-07 | ||
| PCT/US2013/028516 WO2013134052A1 (en) | 2012-03-07 | 2013-03-01 | Il-17 antibody formulation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015510882A JP2015510882A (ja) | 2015-04-13 |
| JP2015510882A5 true JP2015510882A5 (ja) | 2016-03-24 |
| JP6117252B2 JP6117252B2 (ja) | 2017-04-19 |
Family
ID=47892018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014560955A Active JP6117252B2 (ja) | 2012-03-07 | 2013-03-01 | Ｉｌ−１７抗体製剤 |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US9376491B2 (ja) |
| EP (2) | EP2822590B1 (ja) |
| JP (1) | JP6117252B2 (ja) |
| KR (1) | KR101653082B1 (ja) |
| CN (1) | CN104159612B (ja) |
| AU (1) | AU2013230490B2 (ja) |
| BR (1) | BR112014021308B1 (ja) |
| CA (1) | CA2866128C (ja) |
| CL (1) | CL2014002204A1 (ja) |
| CY (1) | CY1118393T1 (ja) |
| DK (1) | DK2822590T3 (ja) |
| EA (1) | EA030742B1 (ja) |
| EC (1) | ECSP14017562A (ja) |
| ES (1) | ES2610707T3 (ja) |
| HK (1) | HK1199844A1 (ja) |
| HR (1) | HRP20161604T1 (ja) |
| HU (1) | HUE031290T2 (ja) |
| IL (1) | IL234053B (ja) |
| LT (1) | LT2822590T (ja) |
| MA (1) | MA37317B1 (ja) |
| ME (1) | ME02565B (ja) |
| MX (1) | MX362191B (ja) |
| MY (1) | MY167233A (ja) |
| NZ (1) | NZ627648A (ja) |
| PE (1) | PE20142275A1 (ja) |
| PH (1) | PH12014501985A1 (ja) |
| PL (1) | PL2822590T3 (ja) |
| PT (1) | PT2822590T (ja) |
| RS (1) | RS55417B1 (ja) |
| SG (1) | SG11201404491XA (ja) |
| SI (1) | SI2822590T1 (ja) |
| TN (1) | TN2014000341A1 (ja) |
| UA (1) | UA114620C2 (ja) |
| WO (1) | WO2013134052A1 (ja) |
| ZA (1) | ZA201405654B (ja) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR103173A1 (es) | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
| WO2018211517A1 (en) | 2017-05-16 | 2018-11-22 | Bhami's Research Laboratory, Pvt. Ltd. | High concentration protein formulations with reduced viscosity |
| WO2019027828A1 (en) | 2017-08-04 | 2019-02-07 | Eli Lilly And Company | DOSAGE SCHEME OF ANTI-IL-17 ANTIBODIES |
| JP7212675B2 (ja) * | 2017-08-23 | 2023-01-25 | イーライ リリー アンド カンパニー | 性器乾癬の治療 |
| MX2017016884A (es) * | 2017-12-19 | 2019-06-20 | Probiomed S A De C V | Formulacion farmaceutica estable de una proteina anti-tnfa. |
| EP3888678A4 (en) * | 2018-11-29 | 2022-02-16 | Harbour Biomed Therapeutics Limited | PREPARATION OF AN ANTI-PD-L1 ANTIBODY |
| BR112021015034A2 (pt) * | 2019-02-18 | 2021-10-05 | Eli Lilly And Company | Formulação de anticorpo terapêutico |
| EP4268803A1 (en) * | 2020-12-22 | 2023-11-01 | Bio-Thera Solutions, Ltd. | Stable antibody preparation, preparation method for same, and applications thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2481753B1 (en) * | 2005-12-13 | 2018-04-18 | Eli Lilly and Company | Anti-IL-17 Antibodies |
| CN101557799B (zh) | 2006-12-05 | 2012-08-22 | 克鲁塞尔荷兰公司 | 液体抗狂犬病抗体制剂 |
| HUE035618T2 (en) * | 2010-01-15 | 2018-05-28 | Kirin Amgen Inc | Antibody presentation and therapeutic regimens |
-
2013
- 2013-03-01 JP JP2014560955A patent/JP6117252B2/ja active Active
- 2013-03-01 PE PE2014001367A patent/PE20142275A1/es active IP Right Grant
- 2013-03-01 EA EA201491471A patent/EA030742B1/ru not_active IP Right Cessation
- 2013-03-01 EP EP13710214.1A patent/EP2822590B1/en active Active
- 2013-03-01 NZ NZ627648A patent/NZ627648A/en unknown
- 2013-03-01 ES ES13710214.1T patent/ES2610707T3/es active Active
- 2013-03-01 HU HUE13710214A patent/HUE031290T2/hu unknown
- 2013-03-01 UA UAA201409450A patent/UA114620C2/uk unknown
- 2013-03-01 KR KR1020147024733A patent/KR101653082B1/ko active Protection Beyond IP Right Term
- 2013-03-01 PL PL13710214T patent/PL2822590T3/pl unknown
- 2013-03-01 SI SI201330364A patent/SI2822590T1/sl unknown
- 2013-03-01 MY MYPI2014702489A patent/MY167233A/en unknown
- 2013-03-01 CA CA2866128A patent/CA2866128C/en active Active
- 2013-03-01 ME MEP-2016-259A patent/ME02565B/me unknown
- 2013-03-01 CN CN201380012452.5A patent/CN104159612B/zh active Active
- 2013-03-01 LT LTEP13710214.1T patent/LT2822590T/lt unknown
- 2013-03-01 EP EP16195503.4A patent/EP3156073A1/en not_active Withdrawn
- 2013-03-01 DK DK13710214.1T patent/DK2822590T3/en active
- 2013-03-01 WO PCT/US2013/028516 patent/WO2013134052A1/en active Application Filing
- 2013-03-01 US US14/379,755 patent/US9376491B2/en active Active
- 2013-03-01 BR BR112014021308-9A patent/BR112014021308B1/pt active IP Right Grant
- 2013-03-01 SG SG11201404491XA patent/SG11201404491XA/en unknown
- 2013-03-01 RS RS20160994A patent/RS55417B1/sr unknown
- 2013-03-01 AU AU2013230490A patent/AU2013230490B2/en active Active
- 2013-03-01 PT PT137102141T patent/PT2822590T/pt unknown
- 2013-03-01 MX MX2014010710A patent/MX362191B/es active IP Right Grant
-
2014
- 2014-07-30 ZA ZA2014/05654A patent/ZA201405654B/en unknown
- 2014-08-06 TN TNP2014000341A patent/TN2014000341A1/fr unknown
- 2014-08-11 IL IL234053A patent/IL234053B/en active IP Right Grant
- 2014-08-19 CL CL2014002204A patent/CL2014002204A1/es unknown
- 2014-09-02 MA MA37317A patent/MA37317B1/fr unknown
- 2014-09-05 PH PH12014501985A patent/PH12014501985A1/en unknown
- 2014-09-05 EC ECIEPI201417562A patent/ECSP14017562A/es unknown
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2015
- 2015-01-15 HK HK15100440.9A patent/HK1199844A1/zh unknown
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2016
- 2016-06-10 US US15/178,583 patent/US9845353B2/en active Active
- 2016-11-30 HR HRP20161604TT patent/HRP20161604T1/hr unknown
- 2016-12-23 CY CY20161101339T patent/CY1118393T1/el unknown
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2017
- 2017-11-10 US US15/808,939 patent/US10472416B2/en active Active
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