JP2015509528A - ピロキシカムまたはその薬学的に許容される塩とヒアルロン酸またはその薬学的に許容される塩とを含む安定な液状の医薬組成物およびその製造方法 - Google Patents

ピロキシカムまたはその薬学的に許容される塩とヒアルロン酸またはその薬学的に許容される塩とを含む安定な液状の医薬組成物およびその製造方法 Download PDF

Info

Publication number
JP2015509528A
JP2015509528A JP2014560856A JP2014560856A JP2015509528A JP 2015509528 A JP2015509528 A JP 2015509528A JP 2014560856 A JP2014560856 A JP 2014560856A JP 2014560856 A JP2014560856 A JP 2014560856A JP 2015509528 A JP2015509528 A JP 2015509528A
Authority
JP
Japan
Prior art keywords
piroxicam
pharmaceutically acceptable
acceptable salt
cyclodextrin
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014560856A
Other languages
English (en)
Japanese (ja)
Inventor
キム、スンヘ
ソン、ミウォン
ジャン、ソンウ
カン、ミョンジュ
マ、ギョンワン
Original Assignee
ドン−ア エスティ カンパニー リミテッド
ドン−ア エスティ カンパニー リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ドン−ア エスティ カンパニー リミテッド, ドン−ア エスティ カンパニー リミテッド filed Critical ドン−ア エスティ カンパニー リミテッド
Publication of JP2015509528A publication Critical patent/JP2015509528A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2014560856A 2012-03-09 2013-03-07 ピロキシカムまたはその薬学的に許容される塩とヒアルロン酸またはその薬学的に許容される塩とを含む安定な液状の医薬組成物およびその製造方法 Pending JP2015509528A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2012-0024588 2012-03-09
KR1020120024588A KR101383941B1 (ko) 2012-03-09 2012-03-09 피록시캄 또는 약제학적으로 허용되는 그의 염과 히알루론산 또는 약제학적으로 허용되는 그의 염의 안정한 액상 조성물 및 그 제조방법
PCT/KR2013/001856 WO2013133647A1 (fr) 2012-03-09 2013-03-07 Composition pharmaceutique liquide stable contenant du piroxicam ou son sel pharmaceutiquement acceptable et de l'acide hyaluronique ou son sel pharmaceutiquement acceptable et procédé de fabrication de cette composition

Publications (1)

Publication Number Publication Date
JP2015509528A true JP2015509528A (ja) 2015-03-30

Family

ID=49117057

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014560856A Pending JP2015509528A (ja) 2012-03-09 2013-03-07 ピロキシカムまたはその薬学的に許容される塩とヒアルロン酸またはその薬学的に許容される塩とを含む安定な液状の医薬組成物およびその製造方法

Country Status (6)

Country Link
US (1) US9375483B2 (fr)
EP (1) EP2822561A4 (fr)
JP (1) JP2015509528A (fr)
KR (1) KR101383941B1 (fr)
CN (1) CN104349780A (fr)
WO (1) WO2013133647A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101439032B1 (ko) * 2013-06-13 2014-09-05 동아에스티 주식회사 피록시캄과 히알루론산을 포함하는 골관절염 치료를 위한 액상 조성물
US10849923B1 (en) * 2013-10-23 2020-12-01 Donald Wayne Jessup Hyaluronic acid formulation
IT201600075246A1 (it) 2016-07-19 2018-01-19 Jointherapeutics S R L Composizioni comprendenti una matrice polisaccaridica per il rilascio controllato di principi attivi.
KR101947145B1 (ko) 2017-05-22 2019-02-13 동국제약 주식회사 히알루론산과 진통소염제를 함유하는 약제학적 조성물 및 이의 제조방법
IT201800007683A1 (it) * 2018-07-31 2020-01-31 Altergon Sa Composizioni cooperative sinergiche utili per aumento del tessuto molle, rilascio di farmaco e campi correlati
CN114173760A (zh) * 2019-08-01 2022-03-11 河唯真 用于预防或治疗关节及软骨损伤的包含透明质酸和普朗尼克的组合物
CN116288787B (zh) * 2023-02-03 2024-06-14 百事基材料（青岛）股份有限公司 一种含生物活性成分的锦纶大生物纤维的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61500788A (ja) * 1983-12-21 1986-04-24 ヤンセン・フア−マセウテイカ・エヌ・ヴエ− 水に不安定なまたは僅かに溶解性の薬物を含有する医薬調製物およびその製造方法
JPH03236330A (ja) * 1989-12-21 1991-10-22 Nissho Corp 炎症治療剤
JPH0418022A (ja) * 1990-05-10 1992-01-22 Fujikawa Kk ピロキシカムの安定水溶液ならびにその製造法
US5646131A (en) * 1994-02-22 1997-07-08 The Arab Company For Drug Industries And Medical Applicances (Acdima) Method for solubilizing drugs using cyclodextrins and carboxylic acids
JP2007536277A (ja) * 2004-05-07 2007-12-13 エスケイ ファーマシューティカルズ インコーポレイテッド 安定化されたヒアルロナン調製物及びその方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434163A (en) 1981-06-01 1984-02-28 Pfizer Inc. Water-soluble benzothiazine dioxide salts
US4569881A (en) 1983-05-17 1986-02-11 Minnesota Mining And Manufacturing Company Multi-layer amorphous magneto optical recording medium
IT1196033B (it) * 1984-02-22 1988-11-10 Chiesi Farma Spa Composto ad attivita' antiinfiammatoria ottenuto per complessazione con beta-ciclodestrina e relative formulazioni farmaceutiche
US4845183A (en) 1987-11-24 1989-07-04 Hoechst Celanese Corporation Heat resistant polyamide and polybenzoxazole from bis-((amino-hydroxyphenyl)hexafluoroisopropyl)diphenyl ethers
KR920012790A (ko) 1990-12-06 1992-07-27 원본미기재 오일 불침투성 표면을 갖는 엔진 개스킷
US6017900A (en) * 1991-07-03 2000-01-25 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and nsaids
CA2166155C (fr) * 1995-12-27 2008-02-05 Eva Anne Turley Liaison d'agents aux domaines de liaison de l'acide hyaluronique et son utilisation
IT1283252B1 (it) 1996-03-15 1998-04-16 Pulitzer Italiana Soluzioni di piroxicam iniettabili per via parenterale
SK282717B6 (sk) * 2000-03-10 2002-11-06 �Stav Experiment�Lnej Farmakol�Gie Sav Spôsob prípravy ultravysokomolekulových hyalurónanov
WO2005097201A2 (fr) 2004-04-01 2005-10-20 Pierre Fabre Medicament Complexes d’inclusions comprenant du piroxicam, une cyclodextrine et l’arginine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61500788A (ja) * 1983-12-21 1986-04-24 ヤンセン・フア−マセウテイカ・エヌ・ヴエ− 水に不安定なまたは僅かに溶解性の薬物を含有する医薬調製物およびその製造方法
JPH03236330A (ja) * 1989-12-21 1991-10-22 Nissho Corp 炎症治療剤
JPH0418022A (ja) * 1990-05-10 1992-01-22 Fujikawa Kk ピロキシカムの安定水溶液ならびにその製造法
US5646131A (en) * 1994-02-22 1997-07-08 The Arab Company For Drug Industries And Medical Applicances (Acdima) Method for solubilizing drugs using cyclodextrins and carboxylic acids
JP2007536277A (ja) * 2004-05-07 2007-12-13 エスケイ ファーマシューティカルズ インコーポレイテッド 安定化されたヒアルロナン調製物及びその方法

Also Published As

Publication number Publication date
WO2013133647A1 (fr) 2013-09-12
KR101383941B1 (ko) 2014-04-10
KR20130103167A (ko) 2013-09-23
US20150051168A1 (en) 2015-02-19
US9375483B2 (en) 2016-06-28
CN104349780A (zh) 2015-02-11
EP2822561A1 (fr) 2015-01-14
EP2822561A4 (fr) 2015-08-26

Similar Documents

Publication Publication Date Title
JP2015509528A (ja) ピロキシカムまたはその薬学的に許容される塩とヒアルロン酸またはその薬学的に許容される塩とを含む安定な液状の医薬組成物およびその製造方法
EP1845787B1 (fr) Formulations pour l'injection de butanes catecholiques, dont des composes ndga, a des animaux
AU2017210543B2 (en) Ocular formulations for drug-delivery to the posterior segment of the eye
EP2938325B1 (fr) Composition de diclofénac
JP6734971B2 (ja) がん治療薬
BRPI0614827A2 (pt) formulação de inibidor de fator xa e método
AU2008222592B2 (en) Compositions and methods for delivery of anti-cancer agents
AU2002306329B2 (en) Aqueous cilostazol preparation for injection
JP2018531268A (ja) ダントロレンを含む水性組成物
JP6818019B2 (ja) レファムリンの注射可能医薬組成物
KR19980033113A (ko) 국소 마취제 수용액, 국소 마취제의 용해도를 개선시키는 방법, 신경독성이 감소된 국소 마취제 및 국소 마취제의 신경 독성을 감소시키는 방법
JP3648531B2 (ja) ファモチジン注射液
CA2550432A1 (fr) Compositions pharmaceutiques
WO2019136817A1 (fr) Composition de cabazitaxel pour injection et procédé de préparation s'y rapportant
EP3556349B1 (fr) Préparation liquide parentérale comprenant un composé carbamate
JPH11302197A (ja) ヒアルロン酸安定化組成物
US20220008337A1 (en) Pharmaceutical liquid compositions of meloxicam
WO2021124044A1 (fr) Composition pharmaceutique d'inhibiteurs de cyclo-oxygénase - 2
US20240139204A1 (en) Pharmaceutical liquid compositions of meloxicam
JP2005520856A (ja) 貯蔵時に安定なエプレレノン製剤
WO2021090183A1 (fr) Composition liquide de melphalan
KR20190037500A (ko) 히알루론산과 마그네슘을 포함하는 골관절염 치료를 위한 안정한 액상 조성물
JPS59116222A (ja) 水添麦角アルカロイドとヘパリンからなる医薬
JP2008509141A (ja) 非経口製剤の組織刺激を軽減させる方法及び組成物

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140910

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20141031

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20141024

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20150610

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20150611

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150908

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20150911

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151203

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20160517

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20180125