JP2015508103A5 - - Google Patents
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- Publication number
- JP2015508103A5 JP2015508103A5 JP2014558843A JP2014558843A JP2015508103A5 JP 2015508103 A5 JP2015508103 A5 JP 2015508103A5 JP 2014558843 A JP2014558843 A JP 2014558843A JP 2014558843 A JP2014558843 A JP 2014558843A JP 2015508103 A5 JP2015508103 A5 JP 2015508103A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- pharmaceutical composition
- effective amount
- kinase inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 16
- 229920003245 polyoctenamer Polymers 0.000 claims 16
- 229960002756 Azacitidine Drugs 0.000 claims 9
- UHDGCWIWMRVCDJ-XVFCMESISA-N Cytidine Chemical class O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-XVFCMESISA-N 0.000 claims 9
- 208000002154 Non-Small-Cell Lung Carcinoma Diseases 0.000 claims 9
- 108009000071 Non-small cell lung cancer Proteins 0.000 claims 9
- NMUSYJAQQFHJEW-KVTDHHQDSA-N U-18,496 Chemical group O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- AAKJLRGGTJKAMG-UHFFFAOYSA-N Erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 6
- 229960001433 Erlotinib Drugs 0.000 claims 6
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- -1 clathrate Substances 0.000 claims 3
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrugs Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001875 compounds Chemical group 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 230000005713 exacerbation Effects 0.000 claims 1
- 230000004083 survival Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261603012P | 2012-02-24 | 2012-02-24 | |
| US61/603,012 | 2012-02-24 | ||
| US201261716424P | 2012-10-19 | 2012-10-19 | |
| US61/716,424 | 2012-10-19 | ||
| US201261725805P | 2012-11-13 | 2012-11-13 | |
| US61/725,805 | 2012-11-13 | ||
| PCT/US2013/027235 WO2013126636A1 (en) | 2012-02-24 | 2013-02-22 | Methods for treating non- small cell lung cancer using tor kinase inhibitor combination therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015508103A JP2015508103A (ja) | 2015-03-16 |
| JP2015508103A5 true JP2015508103A5 (pt-PT) | 2016-03-10 |
| JP6114317B2 JP6114317B2 (ja) | 2017-04-12 |
Family
ID=47790539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014558843A Active JP6114317B2 (ja) | 2012-02-24 | 2013-02-22 | Ｔｏｒキナーゼ阻害剤の組合せ療法を用いて、非小細胞肺がんを処置する方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9375443B2 (pt-PT) |
| EP (1) | EP2817029B1 (pt-PT) |
| JP (1) | JP6114317B2 (pt-PT) |
| KR (1) | KR102064626B1 (pt-PT) |
| CN (1) | CN104271159B (pt-PT) |
| AU (1) | AU2013202305B2 (pt-PT) |
| BR (1) | BR112014020786A2 (pt-PT) |
| CA (1) | CA2864905A1 (pt-PT) |
| EA (1) | EA028462B1 (pt-PT) |
| ES (1) | ES2742398T3 (pt-PT) |
| HK (1) | HK1199825A1 (pt-PT) |
| IL (2) | IL234169B (pt-PT) |
| MX (1) | MX358303B (pt-PT) |
| MY (1) | MY174308A (pt-PT) |
| NI (1) | NI201400095A (pt-PT) |
| NZ (1) | NZ628410A (pt-PT) |
| PH (2) | PH12014501880B1 (pt-PT) |
| SG (1) | SG11201405064RA (pt-PT) |
| TW (1) | TWI615143B (pt-PT) |
| WO (1) | WO2013126636A1 (pt-PT) |
| ZA (1) | ZA201406052B (pt-PT) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7017638B2 (ja) | 2018-02-07 | 2022-02-08 | ラブレス バイオメディカル リサーチ インスティテュート | 吸入可能な乾燥粉末シチジン類似体組成物及び癌への治療として使用する方法 |
| JP7273886B2 (ja) | 2015-11-20 | 2023-05-15 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的プロテアーゼ１阻害剤としてのプリノン |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
| CN105188704B (zh) | 2013-01-16 | 2017-09-19 | 西格诺药品有限公司 | 被取代的吡咯并嘧啶化合物、其组合物和使用其的治疗方法 |
| AU2014223501A1 (en) * | 2013-02-28 | 2015-09-17 | Signal Pharmaceuticals, Llc | Treatment of cancer with TOR kinase inhibitors |
| TWI654979B (zh) | 2013-04-17 | 2019-04-01 | 美商標誌製藥公司 | 使用ｔｏｒ激酶抑制劑組合療法以治療癌症之方法 |
| US9782427B2 (en) * | 2013-04-17 | 2017-10-10 | Signal Pharmaceuticals, Llc | Methods for treating cancer using TOR kinase inhibitor combination therapy |
| WO2014172423A1 (en) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one |
| TWI656875B (zh) | 2013-04-17 | 2019-04-21 | 美商標誌製藥公司 | 藉二氫吡并吡治療癌症 |
| TW201521725A (zh) | 2013-04-17 | 2015-06-16 | Signal Pharm Llc | 使用ｔｏｒ激酶抑制劑組合療法以治療癌症之方法 |
| KR102221005B1 (ko) | 2013-04-17 | 2021-02-26 | 시그날 파마소티칼 엘엘씨 | 전립선암 치료를 위한 디하이드로피라지노-피라진 화합물 및 안드로겐 수용체 길항제를 포함하는 조합 요법 |
| KR102271344B1 (ko) | 2013-04-17 | 2021-07-01 | 시그날 파마소티칼 엘엘씨 | 디하이드로피라지노-피라진을 사용한 암의 치료 |
| CN107474051B (zh) | 2013-05-29 | 2020-10-30 | 西格诺药品有限公司 | 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途 |
| NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
| WO2015160880A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
| WO2015160882A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | SOLID FORMS COMPRISING 7-(6-(2-HYDROXYPROPAN-2YL) PYRIDIN-3-YL)-1-(TRANS)-4-METHOXYCYCLOHEXYL)-3, 4-DIHYDROPYRAZINO[2,3-b] PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
| WO2015160868A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | Methods for treating cancer using tor kinase inhibitor combination therapy |
| NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
| JP2017520603A (ja) | 2014-07-14 | 2017-07-27 | シグナル ファーマシューティカルズ，エルエルシー | 置換ピロロピリミジン化合物を使用するがんの治療方法及びその組成物 |
| WO2018144791A1 (en) * | 2017-02-03 | 2018-08-09 | Millennium Pharmaceuticals, Inc. | Combination of vps34 inhibitors and mtor inhibitors |
| SG11201912403SA (en) | 2017-06-22 | 2020-01-30 | Celgene Corp | Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection |
| US11535621B2 (en) * | 2019-07-31 | 2022-12-27 | Ribon Therapeutics, Inc. | Heterobicyclic amides as inhibitors of CD38 |
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-
2013
- 2013-02-22 AU AU2013202305A patent/AU2013202305B2/en not_active Ceased
- 2013-02-22 SG SG11201405064RA patent/SG11201405064RA/en unknown
- 2013-02-22 TW TW102106348A patent/TWI615143B/zh active
- 2013-02-22 EP EP13707520.6A patent/EP2817029B1/en active Active
- 2013-02-22 EA EA201491584A patent/EA028462B1/ru not_active IP Right Cessation
- 2013-02-22 CA CA2864905A patent/CA2864905A1/en not_active Abandoned
- 2013-02-22 ES ES13707520T patent/ES2742398T3/es active Active
- 2013-02-22 MY MYPI2014702320A patent/MY174308A/en unknown
- 2013-02-22 BR BR112014020786-0A patent/BR112014020786A2/pt not_active IP Right Cessation
- 2013-02-22 NZ NZ628410A patent/NZ628410A/en not_active IP Right Cessation
- 2013-02-22 KR KR1020147026551A patent/KR102064626B1/ko active IP Right Grant
- 2013-02-22 JP JP2014558843A patent/JP6114317B2/ja active Active
- 2013-02-22 MX MX2014010198A patent/MX358303B/es active IP Right Grant
- 2013-02-22 CN CN201380021414.6A patent/CN104271159B/zh active Active
- 2013-02-22 US US13/773,686 patent/US9375443B2/en active Active
- 2013-02-22 WO PCT/US2013/027235 patent/WO2013126636A1/en active Application Filing
-
2014
- 2014-08-18 IL IL234169A patent/IL234169B/en active IP Right Grant
- 2014-08-18 ZA ZA2014/06052A patent/ZA201406052B/en unknown
- 2014-08-20 PH PH12014501880A patent/PH12014501880B1/en unknown
- 2014-08-22 NI NI201400095A patent/NI201400095A/es unknown
-
2015
- 2015-01-12 HK HK15100301.7A patent/HK1199825A1/xx unknown
-
2017
- 2017-08-17 PH PH12017501500A patent/PH12017501500A1/en unknown
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2020
- 2020-05-13 IL IL274647A patent/IL274647A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7273886B2 (ja) | 2015-11-20 | 2023-05-15 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的プロテアーゼ１阻害剤としてのプリノン |
| JP7017638B2 (ja) | 2018-02-07 | 2022-02-08 | ラブレス バイオメディカル リサーチ インスティテュート | 吸入可能な乾燥粉末シチジン類似体組成物及び癌への治療として使用する方法 |