JP2015506944A5 - - Google Patents

Info

Publication number

JP2015506944A5

JP2015506944A5 JP2014553444A JP2014553444A JP2015506944A5 JP 2015506944 A5 JP2015506944 A5 JP 2015506944A5 JP 2014553444 A JP2014553444 A JP 2014553444A JP 2014553444 A JP2014553444 A JP 2014553444A JP 2015506944 A5 JP2015506944 A5 JP 2015506944A5

Authority

JP

Japan

Prior art keywords

bile acid

fgf19

individual

seq

level

Prior art date

2013-01-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 59
• 239000003613 bile acid Substances 0.000 claims 59
• 238000000034 method Methods 0.000 claims 51
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 44
• 102100031734 Fibroblast growth factor 19 Human genes 0.000 claims 42
• 101000846394 Homo sapiens Fibroblast growth factor 19 Proteins 0.000 claims 42
• 239000000090 biomarker Substances 0.000 claims 41
• 230000004060 metabolic process Effects 0.000 claims 41
• 239000003814 drug Substances 0.000 claims 33
• 150000001413 amino acids Chemical group 0.000 claims 22
• 201000010099 disease Diseases 0.000 claims 22
• 208000035475 disorder Diseases 0.000 claims 22
• 238000011282 treatment Methods 0.000 claims 18
• 239000003795 chemical substances by application Substances 0.000 claims 11
• 239000005557 antagonist Substances 0.000 claims 10
• 102000004190 Enzymes Human genes 0.000 claims 6
• 108090000790 Enzymes Proteins 0.000 claims 6
• 229940088598 enzyme Drugs 0.000 claims 6
• 210000004185 liver Anatomy 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 claims 4
• 102000055025 Adenosine deaminases Human genes 0.000 claims 4
• 102100036475 Alanine aminotransferase 1 Human genes 0.000 claims 4
• 108010082126 Alanine transaminase Proteins 0.000 claims 4
• 108010003415 Aspartate Aminotransferases Proteins 0.000 claims 4
• 102000004625 Aspartate Aminotransferases Human genes 0.000 claims 4
• 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 4
• 102000013529 alpha-Fetoproteins Human genes 0.000 claims 4
• 108010026331 alpha-Fetoproteins Proteins 0.000 claims 4
• 238000003556 assay Methods 0.000 claims 4
• 230000002062 proliferating effect Effects 0.000 claims 4
• 210000002966 serum Anatomy 0.000 claims 4
• 231100000419 toxicity Toxicity 0.000 claims 4
• 230000001988 toxicity Effects 0.000 claims 4
• 231100000331 toxic Toxicity 0.000 claims 3
• 230000002588 toxic effect Effects 0.000 claims 3
• 102100028162 ATP-binding cassette sub-family C member 3 Human genes 0.000 claims 2
• 102100028282 Bile salt export pump Human genes 0.000 claims 2
• 102000003914 Cholinesterases Human genes 0.000 claims 2
• 108090000322 Cholinesterases Proteins 0.000 claims 2
• 102100027844 Fibroblast growth factor receptor 4 Human genes 0.000 claims 2
• 101710107035 Gamma-glutamyltranspeptidase Proteins 0.000 claims 2
• 101710173228 Glutathione hydrolase proenzyme Proteins 0.000 claims 2
• 101000986633 Homo sapiens ATP-binding cassette sub-family C member 3 Proteins 0.000 claims 2
• 101000917134 Homo sapiens Fibroblast growth factor receptor 4 Proteins 0.000 claims 2
• SMEROWZSTRWXGI-UHFFFAOYSA-N Lithocholsaeure Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 SMEROWZSTRWXGI-UHFFFAOYSA-N 0.000 claims 2
• -1 MRP2 Proteins 0.000 claims 2
• 108010093662 Member 11 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 101001122350 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Proteins 0.000 claims 2
• 238000008050 Total Bilirubin Reagent Methods 0.000 claims 2
• 102000012086 alpha-L-Fucosidase Human genes 0.000 claims 2
• 108010061314 alpha-L-Fucosidase Proteins 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 229940048961 cholinesterase Drugs 0.000 claims 2
• 229960003964 deoxycholic acid Drugs 0.000 claims 2
• KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims 2
• KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 102000006640 gamma-Glutamyltransferase Human genes 0.000 claims 2
• 230000002209 hydrophobic effect Effects 0.000 claims 2
• SMEROWZSTRWXGI-HVATVPOCSA-N lithocholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 SMEROWZSTRWXGI-HVATVPOCSA-N 0.000 claims 2
• 102000040430 polynucleotide Human genes 0.000 claims 2
• 108091033319 polynucleotide Proteins 0.000 claims 2
• 239000002157 polynucleotide Substances 0.000 claims 2
• 229920001184 polypeptide Polymers 0.000 claims 2
• 102000004196 processed proteins & peptides Human genes 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 150000003384 small molecules Chemical class 0.000 claims 2
• 238000002560 therapeutic procedure Methods 0.000 claims 2
• 206010012735 Diarrhoea Diseases 0.000 claims 1
• 230000003247 decreasing effect Effects 0.000 claims 1
• 230000018044 dehydration Effects 0.000 claims 1
• 238000006297 dehydration reaction Methods 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 208000026775 severe diarrhea Diseases 0.000 claims 1
• 238000011287 therapeutic dose Methods 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 238000011285 therapeutic regimen Methods 0.000 claims 1
• 230000004580 weight loss Effects 0.000 claims 1