JP2015505560A - 抗寄生虫薬としてのキラルイソオキサゾリンアゼチジン誘導体の製造法 - Google Patents
抗寄生虫薬としてのキラルイソオキサゾリンアゼチジン誘導体の製造法 Download PDFInfo
- Publication number
- JP2015505560A JP2015505560A JP2014555626A JP2014555626A JP2015505560A JP 2015505560 A JP2015505560 A JP 2015505560A JP 2014555626 A JP2014555626 A JP 2014555626A JP 2014555626 A JP2014555626 A JP 2014555626A JP 2015505560 A JP2015505560 A JP 2015505560A
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- trifluoromethyl
- carboxylate
- dichloro
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(c1ccc(C2(*)CN(*)C2)cc1)=O Chemical compound CC(c1ccc(C2(*)CN(*)C2)cc1)=O 0.000 description 7
- HYRBYWSCPHNZQT-UHFFFAOYSA-N CC(C)(C)OC(N(C1)CC1(c(cc1)ccc1C(C)=O)F)=O Chemical compound CC(C)(C)OC(N(C1)CC1(c(cc1)ccc1C(C)=O)F)=O HYRBYWSCPHNZQT-UHFFFAOYSA-N 0.000 description 1
- VMKIXWAFFVLJCK-UHFFFAOYSA-N CC(C)(C)OC(N(C1)CC1=O)=O Chemical compound CC(C)(C)OC(N(C1)CC1=O)=O VMKIXWAFFVLJCK-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261594614P | 2012-02-03 | 2012-02-03 | |
| US61/594,614 | 2012-02-03 | ||
| PCT/US2013/023673 WO2013116236A1 (en) | 2012-02-03 | 2013-01-29 | Process for the preparation of chiral isoxazoline azetidine derivatives as antiparasitic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2015505560A true JP2015505560A (ja) | 2015-02-23 |
Family
ID=47679107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014555626A Pending JP2015505560A (ja) | 2012-02-03 | 2013-01-29 | 抗寄生虫薬としてのキラルイソオキサゾリンアゼチジン誘導体の製造法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20140371464A1 (enExample) |
| EP (1) | EP2809667A1 (enExample) |
| JP (1) | JP2015505560A (enExample) |
| CN (1) | CN104169276A (enExample) |
| AR (1) | AR092793A1 (enExample) |
| AU (1) | AU2013215374A1 (enExample) |
| BR (1) | BR112014019212A8 (enExample) |
| CA (1) | CA2863629A1 (enExample) |
| CL (1) | CL2014002034A1 (enExample) |
| MX (1) | MX2014009388A (enExample) |
| RU (1) | RU2014131950A (enExample) |
| UY (1) | UY34612A (enExample) |
| WO (1) | WO2013116236A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015516424A (ja) * | 2012-05-09 | 2015-06-11 | ゾエティス・エルエルシー | 駆虫剤としてのアゼチジン誘導体 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| DK3440062T3 (da) | 2016-04-06 | 2022-01-03 | Boehringer Ingelheim Animal Health Usa Inc | Fremgangsmåde til fremstillingen af enantiomerisk berigede isoxazolinforbindelser - krystallinsk toluensolvat af (s)-afoxolaner |
| MX380497B (es) | 2016-10-14 | 2025-03-11 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de vinil isoxazolina pesticidas y parasiticidas. |
| MX2020001724A (es) | 2017-08-14 | 2020-07-29 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de pirazol-isoxazolina plaguicidas y parasiticidas. |
| EP3986878B1 (en) * | 2019-06-19 | 2024-09-25 | NMD Pharma A/S | Process for the preparation of clc-1 chloride channel inhibitors |
| KR20230043904A (ko) | 2020-07-24 | 2023-03-31 | 엘랑코 유에스 인코포레이티드 | 이속사졸린 화합물 및 이의 중간체의 제조 공정 |
| MX2023014962A (es) | 2021-08-11 | 2024-02-13 | Elanco Us Inc | Proceso para elaborar derivado de diaril isoxazolina. |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| CN101331127B (zh) * | 2005-12-16 | 2012-05-23 | 杜邦公司 | 用于防治无脊椎害虫的5-芳基异噁唑啉 |
| WO2007105814A1 (ja) | 2006-03-10 | 2007-09-20 | Nissan Chemical Industries, Ltd. | 置換イソキサゾリン化合物及び有害生物防除剤 |
| JP2008044880A (ja) * | 2006-08-15 | 2008-02-28 | Bayer Cropscience Ag | 殺虫性イソオキサゾリン類 |
| US8303622B2 (en) | 2007-03-14 | 2012-11-06 | St. Jude Medical, Inc. | Heart valve chordae replacement methods and apparatus |
| JP2008260691A (ja) * | 2007-04-10 | 2008-10-30 | Bayer Cropscience Ag | 殺虫性アリールイソオキサゾリン誘導体 |
| JP5365806B2 (ja) | 2007-09-10 | 2013-12-11 | 日産化学工業株式会社 | 置換イソキサゾリン化合物及び有害生物防除剤 |
| WO2009063910A1 (ja) | 2007-11-12 | 2009-05-22 | Nissan Chemical Industries, Ltd. | 光学活性イソキサゾリン化合物の触媒的不斉合成方法 |
| BRPI0923009B1 (pt) * | 2008-12-19 | 2018-07-17 | Elanco Tiergesundheit Ag | compostos de isoxazolina, composição para o controle de parasitas e uso de compostos de isoxazolina para o preparo de composição para o controle de parasitas |
| CN102822168B (zh) | 2010-02-25 | 2016-10-26 | 先正达参股股份有限公司 | 制备异恶唑啉衍生物的方法 |
| PH12013500164A1 (en) * | 2010-08-05 | 2015-07-08 | Zoetis Services Llc | Isoxazoline derivatives as antiparasitic agents |
-
2013
- 2013-01-29 WO PCT/US2013/023673 patent/WO2013116236A1/en not_active Ceased
- 2013-01-29 CN CN201380014566.3A patent/CN104169276A/zh active Pending
- 2013-01-29 JP JP2014555626A patent/JP2015505560A/ja active Pending
- 2013-01-29 AU AU2013215374A patent/AU2013215374A1/en not_active Abandoned
- 2013-01-29 CA CA2863629A patent/CA2863629A1/en not_active Abandoned
- 2013-01-29 US US14/375,056 patent/US20140371464A1/en not_active Abandoned
- 2013-01-29 BR BR112014019212A patent/BR112014019212A8/pt not_active IP Right Cessation
- 2013-01-29 RU RU2014131950A patent/RU2014131950A/ru unknown
- 2013-01-29 MX MX2014009388A patent/MX2014009388A/es unknown
- 2013-01-29 EP EP13703287.6A patent/EP2809667A1/en not_active Withdrawn
- 2013-02-01 AR ARP130100321A patent/AR092793A1/es unknown
- 2013-02-04 UY UY0001034612A patent/UY34612A/es not_active Application Discontinuation
-
2014
- 2014-07-30 CL CL2014002034A patent/CL2014002034A1/es unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015516424A (ja) * | 2012-05-09 | 2015-06-11 | ゾエティス・エルエルシー | 駆虫剤としてのアゼチジン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20140371464A1 (en) | 2014-12-18 |
| AU2013215374A1 (en) | 2014-08-21 |
| BR112014019212A8 (pt) | 2017-07-11 |
| UY34612A (es) | 2013-09-30 |
| AR092793A1 (es) | 2015-05-06 |
| RU2014131950A (ru) | 2016-03-27 |
| WO2013116236A1 (en) | 2013-08-08 |
| CL2014002034A1 (es) | 2014-11-14 |
| CA2863629A1 (en) | 2013-08-08 |
| CN104169276A (zh) | 2014-11-26 |
| MX2014009388A (es) | 2014-08-27 |
| EP2809667A1 (en) | 2014-12-10 |
| BR112014019212A2 (enExample) | 2017-06-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2566083C2 (ru) | Спироциклические производные изоксазолина в качестве противопаразитарных агентов | |
| JP2015505560A (ja) | 抗寄生虫薬としてのキラルイソオキサゾリンアゼチジン誘導体の製造法 | |
| JP5409968B2 (ja) | 駆虫剤としてのイソオキサゾリン誘導体 | |
| CN104603139B (zh) | 作为抗寄生虫剂的螺环衍生物 | |
| JP2013523805A (ja) | 殺虫剤および殺ダニ剤としての置換３，５−ジフェニル−イソオキサゾリン誘導体 | |
| JP5824573B2 (ja) | 抗寄生虫薬としてのイソオキサゾリン誘導体 | |
| JP6049866B2 (ja) | 駆虫剤としてのアゼチジン誘導体 | |
| JP5997779B2 (ja) | 抗寄生虫薬としてのジヒドロフランアゼチジン誘導体 | |
| HK1190393B (en) | Spirocyclic isoxazoline derivatives as antiparasitic agents | |
| HK1190392A (en) | Isoxazoline derivatives as antiparasitic agents | |
| NZ614547B2 (en) | Spirocyclic isoxazoline derivatives as antiparasitic agents |