CN104169276A - 作为抗寄生物剂的手性异噁唑啉氮杂环丁烷衍生物的制备方法 - Google Patents

作为抗寄生物剂的手性异噁唑啉氮杂环丁烷衍生物的制备方法 Download PDF

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Publication number
CN104169276A
CN104169276A CN201380014566.3A CN201380014566A CN104169276A CN 104169276 A CN104169276 A CN 104169276A CN 201380014566 A CN201380014566 A CN 201380014566A CN 104169276 A CN104169276 A CN 104169276A
Authority
CN
China
Prior art keywords
phenyl
trifluoromethyl
dichloro
carboxylate
dihydroisoxazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380014566.3A
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English (en)
Chinese (zh)
Inventor
D.比伦
S.D.W.格林伍德
T.L.斯图克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zoetis LLC
Original Assignee
Zoetis LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis LLC filed Critical Zoetis LLC
Publication of CN104169276A publication Critical patent/CN104169276A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201380014566.3A 2012-02-03 2013-01-29 作为抗寄生物剂的手性异噁唑啉氮杂环丁烷衍生物的制备方法 Pending CN104169276A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261594614P 2012-02-03 2012-02-03
US61/594,614 2012-02-03
PCT/US2013/023673 WO2013116236A1 (en) 2012-02-03 2013-01-29 Process for the preparation of chiral isoxazoline azetidine derivatives as antiparasitic agents

Publications (1)

Publication Number Publication Date
CN104169276A true CN104169276A (zh) 2014-11-26

Family

ID=47679107

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380014566.3A Pending CN104169276A (zh) 2012-02-03 2013-01-29 作为抗寄生物剂的手性异噁唑啉氮杂环丁烷衍生物的制备方法

Country Status (13)

Country Link
US (1) US20140371464A1 (enExample)
EP (1) EP2809667A1 (enExample)
JP (1) JP2015505560A (enExample)
CN (1) CN104169276A (enExample)
AR (1) AR092793A1 (enExample)
AU (1) AU2013215374A1 (enExample)
BR (1) BR112014019212A8 (enExample)
CA (1) CA2863629A1 (enExample)
CL (1) CL2014002034A1 (enExample)
MX (1) MX2014009388A (enExample)
RU (1) RU2014131950A (enExample)
UY (1) UY34612A (enExample)
WO (1) WO2013116236A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2872989A1 (en) * 2012-05-09 2013-11-14 Zoetis Llc Azetidine derivatives as antiparasitic agents
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
DK3440062T3 (da) 2016-04-06 2022-01-03 Boehringer Ingelheim Animal Health Usa Inc Fremgangsmåde til fremstillingen af enantiomerisk berigede isoxazolinforbindelser - krystallinsk toluensolvat af (s)-afoxolaner
MX380497B (es) 2016-10-14 2025-03-11 Boehringer Ingelheim Animal Health Usa Inc Compuestos de vinil isoxazolina pesticidas y parasiticidas.
MX2020001724A (es) 2017-08-14 2020-07-29 Boehringer Ingelheim Animal Health Usa Inc Compuestos de pirazol-isoxazolina plaguicidas y parasiticidas.
EP3986878B1 (en) * 2019-06-19 2024-09-25 NMD Pharma A/S Process for the preparation of clc-1 chloride channel inhibitors
KR20230043904A (ko) 2020-07-24 2023-03-31 엘랑코 유에스 인코포레이티드 이속사졸린 화합물 및 이의 중간체의 제조 공정
MX2023014962A (es) 2021-08-11 2024-02-13 Elanco Us Inc Proceso para elaborar derivado de diaril isoxazolina.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101331127A (zh) * 2005-12-16 2008-12-24 杜邦公司 用于防治无脊椎害虫的5-芳基异噁唑啉
CN101400662A (zh) * 2006-03-10 2009-04-01 日产化学工业株式会社 取代异唑啉化合物及有害生物防除剂
CN101652354A (zh) * 2007-04-10 2010-02-17 拜尔农作物科学股份公司 杀虫芳基异噁唑啉衍生物
WO2010070068A2 (en) * 2008-12-19 2010-06-24 Novartis Ag Organic compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
JP2008044880A (ja) * 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
US8303622B2 (en) 2007-03-14 2012-11-06 St. Jude Medical, Inc. Heart valve chordae replacement methods and apparatus
JP5365806B2 (ja) 2007-09-10 2013-12-11 日産化学工業株式会社 置換イソキサゾリン化合物及び有害生物防除剤
WO2009063910A1 (ja) 2007-11-12 2009-05-22 Nissan Chemical Industries, Ltd. 光学活性イソキサゾリン化合物の触媒的不斉合成方法
CN102822168B (zh) 2010-02-25 2016-10-26 先正达参股股份有限公司 制备异恶唑啉衍生物的方法
PH12013500164A1 (en) * 2010-08-05 2015-07-08 Zoetis Services Llc Isoxazoline derivatives as antiparasitic agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101331127A (zh) * 2005-12-16 2008-12-24 杜邦公司 用于防治无脊椎害虫的5-芳基异噁唑啉
CN101400662A (zh) * 2006-03-10 2009-04-01 日产化学工业株式会社 取代异唑啉化合物及有害生物防除剂
CN101652354A (zh) * 2007-04-10 2010-02-17 拜尔农作物科学股份公司 杀虫芳基异噁唑啉衍生物
WO2010070068A2 (en) * 2008-12-19 2010-06-24 Novartis Ag Organic compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
涂海兰等: "新型具杀螨/杀虫作用的2,4-二苯基-1,3-噁唑啉化合物的合成与活性", 《世界农药》 *

Also Published As

Publication number Publication date
US20140371464A1 (en) 2014-12-18
AU2013215374A1 (en) 2014-08-21
BR112014019212A8 (pt) 2017-07-11
UY34612A (es) 2013-09-30
AR092793A1 (es) 2015-05-06
RU2014131950A (ru) 2016-03-27
WO2013116236A1 (en) 2013-08-08
CL2014002034A1 (es) 2014-11-14
JP2015505560A (ja) 2015-02-23
CA2863629A1 (en) 2013-08-08
MX2014009388A (es) 2014-08-27
EP2809667A1 (en) 2014-12-10
BR112014019212A2 (enExample) 2017-06-20

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Application publication date: 20141126