JP2015504057A5 - - Google Patents
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- Publication number
- JP2015504057A5 JP2015504057A5 JP2014550478A JP2014550478A JP2015504057A5 JP 2015504057 A5 JP2015504057 A5 JP 2015504057A5 JP 2014550478 A JP2014550478 A JP 2014550478A JP 2014550478 A JP2014550478 A JP 2014550478A JP 2015504057 A5 JP2015504057 A5 JP 2015504057A5
- Authority
- JP
- Japan
- Prior art keywords
- chromen
- pyrazin
- pyridin
- methylimidazo
- dimethylimidazo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161582064P | 2011-12-30 | 2011-12-30 | |
| US61/582,064 | 2011-12-30 | ||
| PCT/US2012/071899 WO2013101974A1 (en) | 2011-12-30 | 2012-12-28 | Compounds for treating spinal muscular atrophy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015504057A JP2015504057A (ja) | 2015-02-05 |
| JP2015504057A5 true JP2015504057A5 (https=) | 2016-02-12 |
| JP6193881B2 JP6193881B2 (ja) | 2017-09-06 |
Family
ID=48698624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014550478A Active JP6193881B2 (ja) | 2011-12-30 | 2012-12-28 | 脊髄性筋萎縮症を治療するための化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | USRE47689E1 (https=) |
| EP (1) | EP2797592B1 (https=) |
| JP (1) | JP6193881B2 (https=) |
| KR (1) | KR102057351B1 (https=) |
| CN (1) | CN104244944B (https=) |
| BR (1) | BR112014016287B1 (https=) |
| CA (1) | CA2861609C (https=) |
| EA (1) | EA029984B1 (https=) |
| MX (1) | MX352861B (https=) |
| WO (1) | WO2013101974A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX357834B (es) | 2012-01-26 | 2018-07-26 | Ptc Therapeutics Inc | Compuestos de tipo isocumarina sustituidos para tratar la atrofia muscular espinal. |
| EP2812004B1 (en) | 2012-02-10 | 2018-06-27 | PTC Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| CA2865957C (en) | 2012-03-01 | 2020-02-11 | F. Hoffmann-La Roche Ag | Compounds for treating spinal muscular atrophy |
| CA2868026C (en) | 2012-03-23 | 2021-02-16 | Ptc Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| CA2894992A1 (en) * | 2012-12-24 | 2014-07-03 | Ramot At Tel-Aviv University Ltd. | Agents for treating genetic diseases resulting from nonsense mutations, and methods for identifying the same |
| CN103360269B (zh) * | 2013-07-16 | 2015-07-08 | 临海市联盛化学有限公司 | 一种3-氯-2-氨基苯酚的制备方法 |
| EP3035935B1 (en) | 2013-08-19 | 2020-03-11 | F. Hoffmann-La Roche AG | Compounds for use in the prophylaxis and treatment of cancer |
| US10195202B2 (en) | 2013-12-19 | 2019-02-05 | Ptc Therapeutics, Inc. | Methods for modulating the amount of RNA transcripts |
| WO2015095449A1 (en) * | 2013-12-19 | 2015-06-25 | Ptc Therapeutics, Inc. | Methods for modulating the amount rna transcripts |
| RU2688665C2 (ru) | 2014-04-22 | 2019-05-22 | Университет Базель | Новый способ получения производных триазина, пиримидина и пиридина |
| ES2761423T3 (es) | 2014-05-15 | 2020-05-19 | Hoffmann La Roche | Compuestos para tratar la atrofia muscular espinal |
| US10882868B2 (en) | 2014-05-15 | 2021-01-05 | Hoffmann-La Roche Inc. | Compounds for treating spinal muscular atrophy |
| RU2725979C2 (ru) * | 2014-06-25 | 2020-07-08 | Ф. Хоффманн-Ля Рош Аг | ИМИДАЗО[1,2-а]ПИРАЗИН-1-ИЛ-БЕНЗАМИДЫ ДЛЯ ЛЕЧЕНИЯ СПИНАЛЬНОЙ МЫШЕЧНОЙ АТРОФИИ |
| CN104744376A (zh) * | 2015-03-14 | 2015-07-01 | 长沙深橙生物科技有限公司 | 一种2-异丙基嘧啶衍生物的制备方法 |
| CN104803921A (zh) * | 2015-03-14 | 2015-07-29 | 长沙深橙生物科技有限公司 | 一种苯取代嘧啶衍生物的制备方法 |
| US10668171B2 (en) | 2015-05-30 | 2020-06-02 | Ptc Therapeutics, Inc. | Methods for modulating RNA splicing |
| EA036399B1 (ru) | 2015-11-12 | 2020-11-06 | Ф. Хоффманн-Ля Рош Аг | Композиции для лечения спинальной мышечной атрофии |
| WO2017081111A1 (en) * | 2015-11-12 | 2017-05-18 | F. Hoffmann-La Roche Ag | Compounds for treating amyotrophic lateral sclerosis |
| WO2017087364A1 (en) * | 2015-11-16 | 2017-05-26 | Ptc Therapeutics, Inc. | Hydrogen isotope-enriched analogues of 1,2,4-oxandiazole benzoic acid compounds, compositions and uses thereof |
| EA201800367A1 (ru) | 2015-12-10 | 2019-02-28 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы лечения болезни хантингтона |
| WO2017097728A1 (en) | 2015-12-10 | 2017-06-15 | F. Hoffmann-La Roche Ag | Bridged piperidine derivatives |
| MX2018010109A (es) * | 2016-02-23 | 2018-12-17 | Univ Indiana Res & Tech Corp | Terapias de combinacion para tratamiento de atrofia muscular espinal. |
| EP3527570A4 (en) | 2016-10-14 | 2020-04-15 | Jiangsu Hengrui Medicine Co., Ltd. | FIVE-LINKED HETERARYARYLE CYCLE BRIDGE DERIVATIVE, METHOD FOR PREPARING SAME, AND MEDICAL USE THEREOF |
| JP2019535789A (ja) | 2016-11-28 | 2019-12-12 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｒｎａスプライシングを調節する方法 |
| EP3634953B1 (en) | 2017-06-05 | 2024-01-03 | PTC Therapeutics, Inc. | Compounds for treating huntington's disease |
| JP2020523365A (ja) | 2017-06-14 | 2020-08-06 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｒｎａスプライシングを改変する方法 |
| CN111182898B (zh) | 2017-06-28 | 2024-04-16 | Ptc医疗公司 | 用于治疗亨廷顿氏病的方法 |
| MX2019015580A (es) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics Inc | Metodos para tratar la enfermedad de huntington. |
| JP7312749B2 (ja) | 2017-08-04 | 2023-07-21 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングをモジュレートする方法および組成物 |
| SG11202002610TA (en) * | 2017-09-22 | 2020-04-29 | Hoffmann La Roche | Process for the prepration of 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one derivatives |
| KR20200143376A (ko) | 2018-03-13 | 2020-12-23 | 샤이어 휴먼 지네틱 테라피즈 인크. | 혈장 칼리크레인 억제제로서의 치환된 이미다조피리딘 및 이의 용도 |
| EA202092001A1 (ru) | 2018-03-27 | 2021-01-29 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Соединения для лечения болезни гентингтона |
| WO2020005877A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| CN112469707B (zh) | 2018-06-27 | 2024-06-21 | 利伯纳生物科学株式会社 | 脊髓性肌萎缩症的预防剂或治疗剂 |
| EP3814360B8 (en) | 2018-06-27 | 2024-11-06 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| HRP20240935T1 (hr) | 2018-06-27 | 2024-11-22 | Ptc Therapeutics, Inc. | Heterociklični i heteroaril spojevi za liječenje huntingtonove bolesti |
| EP3908308A4 (en) * | 2019-01-08 | 2023-03-22 | Texas Tech University System | SMALL MOLECULE ANALOGUES OF PROTEIN E4ORF1 FOR THE TREATMENT AND PREVENTION OF METABOLIC DISORDERS |
| JP7551629B2 (ja) | 2019-02-05 | 2024-09-17 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| WO2020163405A1 (en) | 2019-02-05 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| JP7603595B2 (ja) | 2019-02-06 | 2024-12-20 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| JP7603594B2 (ja) | 2019-02-06 | 2024-12-20 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| AU2020230955B2 (en) | 2019-03-01 | 2025-06-05 | Illumina Cambridge Limited | Exocyclic amine-substituted coumarin compounds and their uses as fluorescent labels |
| CN109943092A (zh) * | 2019-04-09 | 2019-06-28 | 浙江工业大学 | 具有高荧光量子产率的咪唑类香豆素类染料及其合成方法 |
| JP7649257B2 (ja) | 2019-05-13 | 2025-03-19 | ピーティーシー セラピューティクス， インコーポレイテッド | ハンチントン病を処置するための化合物 |
| US11129829B2 (en) | 2019-06-17 | 2021-09-28 | Skyhawk Therapeutics, Inc. | Methods for modulating splicing |
| CN114667289B (zh) | 2019-09-18 | 2025-08-26 | 武田药品工业有限公司 | 杂芳基血浆激肽释放酶抑制剂 |
| EP4031547B1 (en) | 2019-09-18 | 2024-07-17 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof |
| CN110862395B (zh) * | 2019-11-13 | 2020-09-29 | 株洲千金药业股份有限公司 | 一种制备他达拉非重要杂质的原料化合物的制备方法 |
| CN114315807B (zh) * | 2022-01-05 | 2023-09-15 | 江南大学 | 一种吡啶鎓盐光引发剂及其制备方法和应用 |
| AU2024286618A1 (en) * | 2023-06-09 | 2025-10-30 | F. Hoffmann-La Roche Ag | Inducible gene expression system |
| US12180195B1 (en) | 2023-11-01 | 2024-12-31 | King Faisal University | 6-(6-bromo-2-oxo-2H-chromen-3-yl)-4-(2,4-dichlorophenyl)-2-alkoxynicotinonitrile as an antimicrobial compound |
| WO2025111409A1 (en) * | 2023-11-21 | 2025-05-30 | Biogen Ma Inc. | Heterocyclic compounds of formula (i) for use in the treatment of spinal muscular atrophy via modulation of smn2 splicing |
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|---|---|---|---|---|
| DE1020636B (de) * | 1954-11-12 | 1957-12-12 | Geigy Ag J R | Verfahren zur Herstellung von 3-Phenyl-7-acylamino-cumarinen |
| CH419146A (de) * | 1961-04-27 | 1966-08-31 | Geigy Ag J R | Verfahren zur Herstellung von 3-Phenyl-7-pyrazolyl-cumarinen |
| US3311636A (en) * | 1963-03-14 | 1967-03-28 | Upjohn Co | Organic chemical compounds and process |
| DE1245306B (de) | 1963-05-11 | 1967-07-27 | Bayer Ag | Aufhellungsmittel |
| DE1594845C3 (de) | 1966-03-19 | 1982-05-19 | Bayer Ag, 5090 Leverkusen | Substituierte v-Triazol-(2)-yl-cumarinverbindungen und deren Verwendung als Aufhellungsmittel |
| CH505089A (de) * | 1968-08-23 | 1971-03-31 | Bayer Ag | Verfahren zur Herstellung von 3-substituierten-7-Aminocumarinen |
| JPS5023687B2 (https=) * | 1972-03-07 | 1975-08-09 | ||
| CH620322B (de) * | 1976-03-26 | Ciba Geigy Ag | Verwendung von 3-phenyl-7-(v-triazol-2-yl)-cumarinen zum optischen aufhellen von organischen materialien. | |
| FR2361680A1 (fr) * | 1976-08-11 | 1978-03-10 | Du Pont | Plaques d'impression planographiques et leur preparation |
| DE2807761A1 (de) * | 1978-02-23 | 1979-08-30 | Basf Ag | Cumarinderivate |
| DE2815956A1 (de) * | 1978-04-13 | 1979-10-18 | Bayer Ag | Verfahren zur herstellung von in 2-stellung substituierten triazolen-1,2,3 |
| DE2950291A1 (de) * | 1979-12-14 | 1981-06-19 | Basf Ag, 6700 Ludwigshafen | Neue cumarinverbindungen und verfahren zur herstellung von cumarinverbindungen |
| JPS56140990A (en) * | 1980-04-07 | 1981-11-04 | Showa Kagaku Kogyo Kk | 3-phenylcoumarin derivative bearing dicarbonylimide group |
| DE3101141A1 (de) * | 1981-01-16 | 1982-09-02 | Bayer Ag, 5090 Leverkusen | Triazolylcumarinverbindungen, sowie deren herstellung und verwendung als optiche aufheller, scintillatoren und laserfarbstoffe |
| JPS62267285A (ja) | 1986-05-16 | 1987-11-19 | Kyorin Pharmaceut Co Ltd | 新規ピラゾロピリジン誘導体 |
| ATE106566T1 (de) | 1989-11-21 | 1994-06-15 | Bayer Ag | Optischer biosensor. |
| DE59010069D1 (de) * | 1989-11-21 | 1996-02-29 | Bayer Ag | Cumarinderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und Thiazolyl-essigsäurederivate als Zwischenprodukte |
| EP0448241A3 (en) * | 1990-02-28 | 1992-03-04 | Konica Corporation | Light-sensitive silver halide photographic material |
| CA2123740C (en) * | 1993-05-19 | 2002-12-17 | Hee-Gwon Chae | Electric vacuum cleaner |
| JPH073179A (ja) * | 1993-06-15 | 1995-01-06 | Nippon Kayaku Co Ltd | インクジェットプリント用インク組成物及びこれを用いる染色法 |
| KR20040068240A (ko) * | 2001-12-14 | 2004-07-30 | 노보 노르디스크 에이/에스 | 호르몬 민감성 리파아제의 활성을 감소시키기 위한 화합물및 그들의 사용 |
| GB0205281D0 (en) * | 2002-03-06 | 2002-04-17 | Novartis Ag | Organic compounds |
| CN1180016C (zh) * | 2002-04-04 | 2004-12-15 | 中国石化上海石油化工股份有限公司 | 用于制造增白聚丙烯纤维的增白聚丙烯母粒 |
| CN100528846C (zh) * | 2002-09-11 | 2009-08-19 | 株式会社吴羽 | 胺化合物及其用途 |
| CA2595477A1 (en) * | 2005-01-21 | 2006-07-27 | Janssen Pharmaceutica N.V. | Novel heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors |
| AR059339A1 (es) | 2006-02-09 | 2008-03-26 | Chugai Pharmaceutical Co Ltd | Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene |
| WO2008013997A2 (en) * | 2006-07-27 | 2008-01-31 | The Trustees Of Columbia University In The City Of New York | Fluorescent substrates for monoamine transporters as optical false neurotransmitters |
| AU2007336291A1 (en) * | 2006-12-20 | 2008-06-26 | Neurosearch A/S | Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP2242754A1 (en) * | 2008-02-05 | 2010-10-27 | NeuroSearch A/S | Novel 9-aza-bicyclo[3.3.1]non-3-yloxy chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| DE102008018132A1 (de) * | 2008-04-09 | 2009-10-15 | Henkel Ag & Co. Kgaa | Kationische Direktzieher und Mittel zum Färben von keratinhaltigen Fasern |
| WO2009151546A2 (en) | 2008-05-27 | 2009-12-17 | Ptc Therapeutics, Inc. | Methods for treating spinal muscular atrophy |
| US8932818B2 (en) | 2008-08-13 | 2015-01-13 | Ptc Therapeutics, Inc. | Screening assays for compounds that modulate programmed ribosomal frameshifting |
| JP5819196B2 (ja) | 2008-10-29 | 2015-11-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 液晶ディスプレイ |
| MX357834B (es) | 2012-01-26 | 2018-07-26 | Ptc Therapeutics Inc | Compuestos de tipo isocumarina sustituidos para tratar la atrofia muscular espinal. |
| EP2812004B1 (en) | 2012-02-10 | 2018-06-27 | PTC Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| CA2865957C (en) | 2012-03-01 | 2020-02-11 | F. Hoffmann-La Roche Ag | Compounds for treating spinal muscular atrophy |
| CA2868026C (en) | 2012-03-23 | 2021-02-16 | Ptc Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
-
2012
- 2012-12-28 MX MX2014007877A patent/MX352861B/es active IP Right Grant
- 2012-12-28 WO PCT/US2012/071899 patent/WO2013101974A1/en not_active Ceased
- 2012-12-28 JP JP2014550478A patent/JP6193881B2/ja active Active
- 2012-12-28 EP EP12862080.4A patent/EP2797592B1/en active Active
- 2012-12-28 BR BR112014016287-5A patent/BR112014016287B1/pt active IP Right Grant
- 2012-12-28 KR KR1020147021262A patent/KR102057351B1/ko active Active
- 2012-12-28 EA EA201491296A patent/EA029984B1/ru not_active IP Right Cessation
- 2012-12-28 US US15/695,299 patent/USRE47689E1/en active Active
- 2012-12-28 US US14/369,294 patent/US9617268B2/en not_active Ceased
- 2012-12-28 CA CA2861609A patent/CA2861609C/en active Active
- 2012-12-28 CN CN201280071056.5A patent/CN104244944B/zh active Active