JP2015502199A5 - - Google Patents

Info

Publication number

JP2015502199A5

JP2015502199A5 JP2014541327A JP2014541327A JP2015502199A5 JP 2015502199 A5 JP2015502199 A5 JP 2015502199A5 JP 2014541327 A JP2014541327 A JP 2014541327A JP 2014541327 A JP2014541327 A JP 2014541327A JP 2015502199 A5 JP2015502199 A5 JP 2015502199A5

Authority

JP

Japan

Prior art keywords

composition

silk fibroin

fibroin particles

compositions

original volume

Prior art date

2012-11-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000000203 mixture Substances 0.000 claims 48
• 108010022355 Fibroins Proteins 0.000 claims 28
• 239000002245 particle Substances 0.000 claims 26
• 210000001519 tissue Anatomy 0.000 claims 7
• 239000013543 active substance Substances 0.000 claims 6
• 239000007972 injectable composition Substances 0.000 claims 6
• 239000013060 biological fluid Substances 0.000 claims 4
• 239000012141 concentrate Substances 0.000 claims 4
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 3
• 108010035532 Collagen Proteins 0.000 claims 3
• 102000008186 Collagen Human genes 0.000 claims 3
• 229920001436 collagen Polymers 0.000 claims 3
• 229920002674 hyaluronan Polymers 0.000 claims 3
• 229960003160 hyaluronic acid Drugs 0.000 claims 3
• 230000003190 augmentative effect Effects 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 230000004956 cell adhesive effect Effects 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 239000002537 cosmetic Substances 0.000 claims 2
• 230000002500 effect on skin Effects 0.000 claims 2
• 238000000227 grinding Methods 0.000 claims 2
• 239000000463 material Substances 0.000 claims 2
• 239000011148 porous material Substances 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 239000007787 solid Substances 0.000 claims 2
• 101800002011 Amphipathic peptide Proteins 0.000 claims 1
• 229920001661 Chitosan Polymers 0.000 claims 1
• 102000016942 Elastin Human genes 0.000 claims 1
• 108010014258 Elastin Proteins 0.000 claims 1
• 108010067306 Fibronectins Proteins 0.000 claims 1
• 102000016359 Fibronectins Human genes 0.000 claims 1
• 102000007547 Laminin Human genes 0.000 claims 1
• 108010085895 Laminin Proteins 0.000 claims 1
• 102000016611 Proteoglycans Human genes 0.000 claims 1
• 108010067787 Proteoglycans Proteins 0.000 claims 1
• 108010031318 Vitronectin Proteins 0.000 claims 1
• 102100035140 Vitronectin Human genes 0.000 claims 1
• 229940035674 anesthetics Drugs 0.000 claims 1
• 230000003712 anti-aging effect Effects 0.000 claims 1
• 239000003963 antioxidant agent Substances 0.000 claims 1
• 238000000889 atomisation Methods 0.000 claims 1
• 239000007844 bleaching agent Substances 0.000 claims 1
• 210000001185 bone marrow Anatomy 0.000 claims 1
• 230000010261 cell growth Effects 0.000 claims 1
• 239000003086 colorant Substances 0.000 claims 1
• 239000002872 contrast media Substances 0.000 claims 1
• 239000007854 depigmenting agent Substances 0.000 claims 1
• CGMRCMMOCQYHAD-UHFFFAOYSA-J dicalcium hydroxide phosphate Chemical compound [OH-].[Ca++].[Ca++].[O-]P([O-])([O-])=O CGMRCMMOCQYHAD-UHFFFAOYSA-J 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 229920002549 elastin Polymers 0.000 claims 1
• 239000000945 filler Substances 0.000 claims 1
• 238000011049 filling Methods 0.000 claims 1
• 239000003193 general anesthetic agent Substances 0.000 claims 1
• 150000004676 glycans Chemical class 0.000 claims 1
• 239000003102 growth factor Substances 0.000 claims 1
• 239000000017 hydrogel Substances 0.000 claims 1
• 102000006495 integrins Human genes 0.000 claims 1
• 108010044426 integrins Proteins 0.000 claims 1
• 238000002386 leaching Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000004005 microsphere Substances 0.000 claims 1
• 229940035363 muscle relaxants Drugs 0.000 claims 1
• 239000003158 myorelaxant agent Substances 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 239000000816 peptidomimetic Substances 0.000 claims 1
• 229920001432 poly(L-lactide) Polymers 0.000 claims 1
• 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 1
• 239000004926 polymethyl methacrylate Substances 0.000 claims 1
• 229920001282 polysaccharide Polymers 0.000 claims 1
• 239000005017 polysaccharide Substances 0.000 claims 1
• 239000003361 porogen Substances 0.000 claims 1
• 239000000843 powder Substances 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 238000010298 pulverizing process Methods 0.000 claims 1
• 210000000130 stem cell Anatomy 0.000 claims 1
• 239000000516 sunscreening agent Substances 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1