JP2015501820A5 - - Google Patents
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- Publication number
- JP2015501820A5 JP2015501820A5 JP2014546301A JP2014546301A JP2015501820A5 JP 2015501820 A5 JP2015501820 A5 JP 2015501820A5 JP 2014546301 A JP2014546301 A JP 2014546301A JP 2014546301 A JP2014546301 A JP 2014546301A JP 2015501820 A5 JP2015501820 A5 JP 2015501820A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- deuterated
- hydrogen
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 24
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 6
- YZCKVEUIGOORGS-OUBTZVSYSA-N deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 5
- 229910052805 deuterium Inorganic materials 0.000 claims 5
- -1 imidazolidinedione compound Chemical class 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010000496 Acne Diseases 0.000 claims 2
- 230000002378 acidificating Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000012442 inert solvent Substances 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 102100007495 AR Human genes 0.000 claims 1
- 102000007399 Nuclear hormone receptors Human genes 0.000 claims 1
- NNFCIKHAZHQZJG-UHFFFAOYSA-N Potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- MNWBNISUBARLIT-UHFFFAOYSA-N Sodium cyanide Chemical compound [Na+].N#[C-] MNWBNISUBARLIT-UHFFFAOYSA-N 0.000 claims 1
- LEIMLDGFXIOXMT-UHFFFAOYSA-N Trimethylsilyl cyanide Chemical compound C[Si](C)(C)C#N LEIMLDGFXIOXMT-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 201000004384 alopecia Diseases 0.000 claims 1
- 239000003936 androgen receptor antagonist Substances 0.000 claims 1
- 108010080146 androgen receptors Proteins 0.000 claims 1
- 239000000010 aprotic solvent Substances 0.000 claims 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- 230000003660 hair regeneration Effects 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110418859.0 | 2011-12-14 | ||
| CN2011104188590A CN103159680A (zh) | 2011-12-14 | 2011-12-14 | 咪唑二酮类化合物及其用途 |
| PCT/CN2012/086573 WO2013087004A1 (zh) | 2011-12-14 | 2012-12-13 | 咪唑二酮类化合物及其用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015501820A JP2015501820A (ja) | 2015-01-19 |
| JP2015501820A5 true JP2015501820A5 (de) | 2015-04-23 |
| JP5933746B2 JP5933746B2 (ja) | 2016-06-15 |
Family
ID=48583248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014546301A Active JP5933746B2 (ja) | 2011-12-14 | 2012-12-13 | イミダゾリジンジオン系化合物およびその用途 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9346764B2 (de) |
| EP (1) | EP2792674B1 (de) |
| JP (1) | JP5933746B2 (de) |
| CN (2) | CN103159680A (de) |
| AU (1) | AU2012350482B2 (de) |
| CA (1) | CA2859224C (de) |
| ES (1) | ES2587903T3 (de) |
| HK (1) | HK1198166A1 (de) |
| PL (1) | PL2792674T3 (de) |
| WO (1) | WO2013087004A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2908326C (en) * | 2013-05-29 | 2017-09-12 | Hinova Pharmaceuticals Inc. | Imidazolidinedione compounds and their uses |
| JP6346944B2 (ja) * | 2013-09-19 | 2018-06-20 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | 組み合わせ薬物療法 |
| CN106543085A (zh) * | 2013-10-14 | 2017-03-29 | 杭州普晒医药科技有限公司 | 恩杂鲁胺的固态形式及其制备方法和用途 |
| CN104803919A (zh) * | 2014-01-26 | 2015-07-29 | 上海医药工业研究院 | 用于制备恩杂鲁胺中间体的方法 |
| WO2016051423A2 (en) * | 2014-10-01 | 2016-04-07 | Laurus Labs Private Limited | An improved process for the preparation of enzalutamide |
| CN106432090B (zh) * | 2015-10-30 | 2019-08-20 | 成都海创药业有限公司 | 一种氘代咪唑酮化合物的晶型及其制备方法和用途 |
| CN107303278B (zh) * | 2016-04-25 | 2020-11-13 | 成都海创药业有限公司 | 一种hc-1119固体分散体及其制备方法 |
| CN107954936B (zh) * | 2016-10-17 | 2021-03-19 | 海创药业股份有限公司 | 一种制备氘代咪唑二酮类化合物的方法 |
| RU2733950C1 (ru) | 2017-02-13 | 2020-10-08 | Канпу Биофармасьютикалс, Лтд. | Комбинация для лечения рака предстательной железы, фармацевтическая композиция и способ лечения |
| WO2019025250A1 (en) | 2017-08-04 | 2019-02-07 | Basf Se | SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI |
| KR20210016515A (ko) * | 2018-03-29 | 2021-02-16 | 하이노바 파마슈티컬스 인코포레이티드 | 중수소화 이미다졸리딘디온 화합물 및 이의 용도 |
| JP2021521190A (ja) * | 2018-04-13 | 2021-08-26 | ヒノバ ファーマシューティカルズ インコーポレイテッド | 重水素化アミド及び重水素化スルホンアミドを合成する新規な方法 |
| EP3795153A4 (de) * | 2018-05-14 | 2022-03-09 | Hinova Pharmaceuticals Inc. | Hc-1119-formulierung, herstellungsverfahren und verwendung davon |
| WO2020095183A1 (en) | 2018-11-05 | 2020-05-14 | Pfizer Inc. | Combination for treating cancer |
| CN112442009B (zh) * | 2019-08-30 | 2023-10-03 | 润佳（苏州）医药科技有限公司 | 氘代化合物及其在治疗癌症方面的应用 |
| WO2021185291A1 (zh) * | 2020-03-17 | 2021-09-23 | 南京明德新药研发有限公司 | 蛋白降解调节剂与其使用方法 |
| US20240000783A1 (en) | 2020-08-13 | 2024-01-04 | Pfizer Inc. | Combination therapy |
| CN114181155A (zh) * | 2021-12-21 | 2022-03-15 | 上海朝晖药业有限公司 | 碘-恩杂鲁胺及其制备方法及其应用 |
| CN115181043B (zh) * | 2022-07-27 | 2024-05-07 | 爱斯特（成都）生物制药股份有限公司 | 一种连续流制备4-异硫氰基-2-(三氟甲基)苯甲腈的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ591119A (en) * | 2005-05-13 | 2012-08-31 | Univ California | Use of diarylhydantoin compounds for treating specific cancers |
| PT3412290T (pt) | 2006-03-27 | 2021-04-19 | Univ California | Modulador do recetor de androgénios para o tratamento de cancro da próstata e doenças associadas ao recetor de androgénios |
| JP5350217B2 (ja) * | 2006-03-29 | 2013-11-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ジアリールチオヒダントイン化合物 |
| CN101817787B (zh) * | 2009-02-26 | 2013-07-24 | 童友之 | 抗前列腺癌的雄性激素受体拮抗剂 |
| EP2475647B1 (de) | 2009-09-10 | 2015-11-04 | Suzhou Kintor Pharmaceuticals, Inc. | Androgenrezeptorantagonisten und verwendungen davon |
| WO2013067151A1 (en) * | 2011-11-02 | 2013-05-10 | Medivation Prostate Therapeutics, Inc. | Treatment methods using diarylthiohydantoin derivatives |
-
2011
- 2011-12-14 CN CN2011104188590A patent/CN103159680A/zh active Pending
-
2012
- 2012-12-13 AU AU2012350482A patent/AU2012350482B2/en active Active
- 2012-12-13 US US14/364,147 patent/US9346764B2/en active Active
- 2012-12-13 JP JP2014546301A patent/JP5933746B2/ja active Active
- 2012-12-13 WO PCT/CN2012/086573 patent/WO2013087004A1/zh active Application Filing
- 2012-12-13 ES ES12858174.1T patent/ES2587903T3/es active Active
- 2012-12-13 CA CA2859224A patent/CA2859224C/en active Active
- 2012-12-13 PL PL12858174.1T patent/PL2792674T3/pl unknown
- 2012-12-13 EP EP12858174.1A patent/EP2792674B1/de active Active
- 2012-12-13 CN CN201280052853.9A patent/CN104024228B/zh active Active
-
2014
- 2014-11-19 HK HK14111671A patent/HK1198166A1/xx unknown
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