JP2015501291A5 - - Google Patents
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- JP2015501291A5 JP2015501291A5 JP2014532118A JP2014532118A JP2015501291A5 JP 2015501291 A5 JP2015501291 A5 JP 2015501291A5 JP 2014532118 A JP2014532118 A JP 2014532118A JP 2014532118 A JP2014532118 A JP 2014532118A JP 2015501291 A5 JP2015501291 A5 JP 2015501291A5
- Authority
- JP
- Japan
- Prior art keywords
- region
- antibody
- fusion protein
- protein according
- regions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161539416P | 2011-09-26 | 2011-09-26 | |
| US61/539,416 | 2011-09-26 | ||
| PCT/US2012/057393 WO2013049254A1 (en) | 2011-09-26 | 2012-09-26 | Hybrid constant regions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015501291A JP2015501291A (ja) | 2015-01-15 |
| JP2015501291A5 true JP2015501291A5 (enExample) | 2015-11-19 |
| JP6205363B2 JP6205363B2 (ja) | 2017-09-27 |
Family
ID=47996377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014532118A Active JP6205363B2 (ja) | 2011-09-26 | 2012-09-26 | ハイブリッド定常領域 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8952134B2 (enExample) |
| EP (1) | EP2760891B1 (enExample) |
| JP (1) | JP6205363B2 (enExample) |
| CN (1) | CN103974977A (enExample) |
| CA (1) | CA2849765C (enExample) |
| WO (1) | WO2013049254A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9382319B2 (en) | 2011-09-26 | 2016-07-05 | Jn Biosciences Llc | Hybrid constant regions |
| WO2013049254A1 (en) | 2011-09-26 | 2013-04-04 | Jn Biosciences Llc | Hybrid constant regions |
| KR102023401B1 (ko) | 2012-05-10 | 2019-11-04 | 바이오아트라, 엘엘씨 | 다중-특이적 모노클로날 항체 |
| IN2015DN01361A (enExample) * | 2012-08-02 | 2015-07-03 | Jn Biosciences Llc | |
| US20150038682A1 (en) * | 2013-08-02 | 2015-02-05 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via homomultimerizing peptide |
| DK3041862T3 (da) * | 2013-09-05 | 2020-07-27 | Igm Biosciences Inc | Modificerede bispecifikke, penta- og hexavalente ig-m-antistoffer med konstant kæde |
| EP3114137A1 (en) * | 2014-03-05 | 2017-01-11 | UCB Biopharma SPRL | Multimeric fc proteins |
| RU2016139006A (ru) | 2014-03-05 | 2018-04-05 | Юсб Биофарма Спрл | Мультимерные fc-белки |
| US10280208B2 (en) | 2014-04-30 | 2019-05-07 | Albert Einstein College Of Medicine | TMIGD2 and its derivatives as blockers or binders of cancer-expressed HHLA2 for immunotherapies |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| JP7179464B2 (ja) * | 2015-01-20 | 2022-11-29 | アイジーエム バイオサイエンシズ インコーポレイテッド | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 |
| AU2016238246B2 (en) * | 2015-03-25 | 2021-05-13 | Igm Biosciences, Inc. | Multi-valent hepatitis B virus antigen binding molecules and uses thereof |
| HK1249532A1 (zh) * | 2015-04-07 | 2018-11-02 | F. Hoffmann-La Roche Ag | 具有激动剂活性的抗原结合复合体及使用方法 |
| JP6811723B2 (ja) * | 2015-04-17 | 2021-01-13 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多価ヒト免疫不全ウイルス抗原結合分子およびその使用方法 |
| GB201515745D0 (en) * | 2015-09-04 | 2015-10-21 | Ucb Biopharma Sprl | Proteins |
| CN108602857A (zh) * | 2016-01-27 | 2018-09-28 | 瑞士杰特贝林生物制品重组设备股份公司 | 重组IgG Fc多聚体 |
| AU2017300647A1 (en) * | 2016-07-20 | 2019-02-07 | Igm Biosciences, Inc. | Multimeric GITR binding molecules and uses thereof |
| KR102696143B1 (ko) * | 2017-04-07 | 2024-08-21 | 아이쥐엠 바이오사이언스 인코포레이티드 | 보체-의존성 세포용해 효과기 기능의 조정을 위한 변형된 인간 IgM 불변 영역 |
| AU2018266711B2 (en) * | 2017-05-08 | 2025-02-06 | Adimab, Llc | Anti-CD3-binding domains and antibodies comprising them, and methods for their generation and use |
| KR20200123782A (ko) * | 2018-02-26 | 2020-10-30 | 아이쥐엠 바이오사이언스 인코포레이티드 | 암치료를 위해 화학치료제와 병용된 다중결합 항-dr5 결합분자의 용도 |
| CN112513081A (zh) | 2018-06-14 | 2021-03-16 | 生物蛋白有限公司 | 多重特异性抗体构建体 |
| DK3806903T5 (da) * | 2018-06-14 | 2024-08-19 | 2Seventy Bio Inc | Cd79a kimæriske antigenreceptorer |
| JP2022505663A (ja) * | 2018-10-23 | 2022-01-14 | アイジーエム バイオサイエンシズ インコーポレイテッド | ＩｇＭ－Ｆｃベース及びＩｇＡ－Ｆｃベースの多価結合分子 |
| US12492231B2 (en) | 2018-11-14 | 2025-12-09 | Jn Biosciences Llc | Multimeric hybrid Fc proteins for replacement of IVIG |
| WO2020247929A1 (en) | 2019-06-07 | 2020-12-10 | Adimab, Llc | High affinity anti-cd3 antibodies, and methods for their generation and use |
| JP7649258B2 (ja) * | 2019-06-14 | 2025-03-19 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 癌を治療するための組成物および方法 |
| KR20220147121A (ko) * | 2020-02-27 | 2022-11-02 | 화후이 헬스 리미티드 | 가용성 ace2 및 융합 단백질, 및 이의 응용 |
| WO2022080912A1 (ko) * | 2020-10-16 | 2022-04-21 | 주식회사 아이엠바이오로직스 | IgM 영역을 이용한 융합단백질 플랫폼 |
| EP4342908A4 (en) * | 2021-06-17 | 2024-10-23 | Fapon Biotech Inc. | CHIMERIC IMMUNGLOBULIN |
| AU2022310862A1 (en) | 2021-07-14 | 2024-02-01 | Regeneron Pharmaceuticals, Inc. | Engineered t cell receptors fused to binding domains from antibodies |
| IL316032A (en) | 2022-04-08 | 2024-11-01 | Regeneron Pharma | Multicomponent receptor and signaling complexes |
| WO2023200311A1 (ko) * | 2022-04-15 | 2023-10-19 | 주식회사 아이엠바이오로직스 | 반감기가 향상된 융합단백질 플랫폼 |
| WO2024196707A2 (en) * | 2023-03-17 | 2024-09-26 | The Board Of Trustees Of The University Of Illinois | Chimeric antibody molecules based on tetrameric teleost immunoglobulin m |
| CN118339300A (zh) * | 2024-01-02 | 2024-07-12 | 江苏集萃药康生物科技股份有限公司 | 产生人源化抗体的动物模型及其构建方法 |
| KR20250173023A (ko) * | 2024-05-30 | 2025-12-10 | 주식회사 아이엠바이오로직스 | J 사슬에 연결되는 링커 및 이를 포함하는 j 사슬 복합체 |
| CN119638846B (zh) * | 2025-01-09 | 2025-11-04 | 康复大学青岛中心医院 | uMtCK抗体或其抗原结合片段 |
| CN121405821B (zh) * | 2025-12-30 | 2026-04-10 | 山东大学 | 一种融合蛋白及在制备治疗或预防乙肝病毒产品中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8719963D0 (en) * | 1987-08-24 | 1987-09-30 | Cattaneo A | Recombinant dna products |
| DE10001372A1 (de) * | 2000-01-14 | 2001-08-02 | Deutsches Krebsforsch | Anti-CD3-Einzelketten-Antikörper mit humanem Cmu3- und Cmu4- Domänen |
| ATE442386T1 (de) * | 2000-04-28 | 2009-09-15 | Planet Biotechnology Inc | Immunoadhesin zur impfung gegen rhinovirus |
| CN101684158A (zh) * | 2001-01-17 | 2010-03-31 | 特鲁比昂药品公司 | 结合域-免疫球蛋白融合蛋白 |
| US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| HUP0303428A2 (hu) * | 2001-03-07 | 2004-01-28 | Merck Patent Gmbh. | Expressziós eljárás hibrid izotípusú antitestcsoportot tartalmazó fehérjékhez |
| US7754308B2 (en) * | 2003-11-13 | 2010-07-13 | So.F.Ter S.P.A. | Artificial turf systems having a vulcanised thermoplastic elastomer or styrene-ethylene-butadiene-styrene polymer as infill material |
| WO2008148884A1 (en) | 2007-06-08 | 2008-12-11 | Universite De La Mediterranee | Compositions and methods for treating pancreatic tumors |
| WO2013049254A1 (en) | 2011-09-26 | 2013-04-04 | Jn Biosciences Llc | Hybrid constant regions |
-
2012
- 2012-09-26 WO PCT/US2012/057393 patent/WO2013049254A1/en not_active Ceased
- 2012-09-26 JP JP2014532118A patent/JP6205363B2/ja active Active
- 2012-09-26 CA CA2849765A patent/CA2849765C/en active Active
- 2012-09-26 CN CN201280047037.9A patent/CN103974977A/zh active Pending
- 2012-09-26 EP EP12836751.3A patent/EP2760891B1/en active Active
- 2012-09-26 US US13/627,929 patent/US8952134B2/en active Active
-
2014
- 2014-11-17 US US14/543,845 patent/US20150073130A1/en not_active Abandoned
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