CN103974977A - 杂交恒定区 - Google Patents

杂交恒定区 Download PDF

Info

Publication number
CN103974977A
CN103974977A CN201280047037.9A CN201280047037A CN103974977A CN 103974977 A CN103974977 A CN 103974977A CN 201280047037 A CN201280047037 A CN 201280047037A CN 103974977 A CN103974977 A CN 103974977A
Authority
CN
China
Prior art keywords
antibody
region
regions
fusion protein
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280047037.9A
Other languages
English (en)
Chinese (zh)
Inventor
J.·云·曹
鹤下直哉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jn Bio-Science LLC
Original Assignee
Jn Bio-Science LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jn Bio-Science LLC filed Critical Jn Bio-Science LLC
Publication of CN103974977A publication Critical patent/CN103974977A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201280047037.9A 2011-09-26 2012-09-26 杂交恒定区 Pending CN103974977A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161539416P 2011-09-26 2011-09-26
US61/539,416 2011-09-26
PCT/US2012/057393 WO2013049254A1 (en) 2011-09-26 2012-09-26 Hybrid constant regions

Publications (1)

Publication Number Publication Date
CN103974977A true CN103974977A (zh) 2014-08-06

Family

ID=47996377

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280047037.9A Pending CN103974977A (zh) 2011-09-26 2012-09-26 杂交恒定区

Country Status (6)

Country Link
US (2) US8952134B2 (enExample)
EP (1) EP2760891B1 (enExample)
JP (1) JP6205363B2 (enExample)
CN (1) CN103974977A (enExample)
CA (1) CA2849765C (enExample)
WO (1) WO2013049254A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108602857A (zh) * 2016-01-27 2018-09-28 瑞士杰特贝林生物制品重组设备股份公司 重组IgG Fc多聚体
CN109561681A (zh) * 2016-07-20 2019-04-02 Igm生物科学股份有限公司 多聚gitr结合分子及其用途
CN112368021A (zh) * 2018-06-14 2021-02-12 蓝鸟生物公司 Cd79a嵌合抗原受体
CN114206936A (zh) * 2019-06-14 2022-03-18 2赛文缇生物公司 用于治疗癌症的组合物和方法
CN119638846A (zh) * 2025-01-09 2025-03-18 康复大学青岛中心医院 uMtCK抗体或其抗原结合片段

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9382319B2 (en) 2011-09-26 2016-07-05 Jn Biosciences Llc Hybrid constant regions
EP2760891B1 (en) 2011-09-26 2018-11-07 JN Biosciences LLC Hybrid constant regions
US9969813B2 (en) 2012-05-10 2018-05-15 Bioatla, Llc Multi-specific monoclonal antibodies
JP2015524821A (ja) 2012-08-02 2015-08-27 ジェイエヌ バイオサイエンシーズ エルエルシー システイン変異及びμ尾部を介して多量体化した抗体又は融合タンパク質
US20150038682A1 (en) * 2013-08-02 2015-02-05 Jn Biosciences Llc Antibodies or fusion proteins multimerized via homomultimerizing peptide
CN105722855B (zh) * 2013-09-05 2021-04-23 Igm生物科学股份有限公司 恒定链经修饰的双特异性五价和六价Ig-M抗体
TW201619188A (zh) * 2014-03-05 2016-06-01 優稀美生物醫藥公司 多聚體Ｆｃ蛋白質
AU2015226101B2 (en) * 2014-03-05 2019-08-22 Ucb Biopharma Sprl Multimeric Fc proteins
WO2015167948A1 (en) * 2014-04-30 2015-11-05 Albert Einstein College Of Medicine Of Yeshiva University Tmigd2 and its derivatives as blockers or binders of cancer-expressed hhla2 for immunotherapies
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
CA2972990A1 (en) * 2015-01-20 2016-07-28 Beatrice Tien-Yi WANG Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof
WO2016154593A1 (en) * 2015-03-25 2016-09-29 Igm Biosciences, Inc. Multi-valent hepatitis b virus antigen binding molecules and uses thereof
JP6955445B2 (ja) 2015-04-07 2021-10-27 ジェネンテック， インコーポレイテッド アゴニスト性の活性を有する抗原結合複合体及びその使用方法
CN107847591B (zh) 2015-04-17 2023-07-28 Igm生物科学股份有限公司 多价人免疫缺陷病毒抗原结合分子及其应用
GB201515745D0 (en) * 2015-09-04 2015-10-21 Ucb Biopharma Sprl Proteins
KR102696143B1 (ko) * 2017-04-07 2024-08-21 아이쥐엠 바이오사이언스 인코포레이티드 보체-의존성 세포용해 효과기 기능의 조정을 위한 변형된 인간 IgM 불변 영역
AU2018266711B2 (en) * 2017-05-08 2025-02-06 Adimab, Llc Anti-CD3-binding domains and antibodies comprising them, and methods for their generation and use
CN111757941A (zh) * 2018-02-26 2020-10-09 Igm生物科学股份有限公司 多聚体抗dr5结合分子与化学治疗剂联合用于治疗癌症的用途
US12473360B2 (en) 2018-06-14 2025-11-18 Bioatla, Inc. Multi-specific antibody constructs
EP3870223A4 (en) * 2018-10-23 2022-08-24 IGM Biosciences, Inc. MULTIVALENT IGM AND IGA-FC BASED BINDING MOLECULES
WO2020102251A1 (en) * 2018-11-14 2020-05-22 Jn Biosciences Llc Multimeric hybrid fc proteins for replacement of ivig
KR20220147121A (ko) * 2020-02-27 2022-11-02 화후이 헬스 리미티드 가용성 ace2 및 융합 단백질, 및 이의 응용
KR102450007B1 (ko) * 2020-10-16 2022-10-04 주식회사 아이엠바이오로직스 IgM 영역을 이용한 융합단백질 플랫폼
US20240270831A1 (en) * 2021-06-17 2024-08-15 Fapon Biotech Inc. Chimeric immunoglobulin
AU2022310862A1 (en) 2021-07-14 2024-02-01 Regeneron Pharmaceuticals, Inc. Engineered t cell receptors fused to binding domains from antibodies
JP2025511872A (ja) 2022-04-08 2025-04-16 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 多部位受容体及びシグナル伝達複合体
WO2024196707A2 (en) * 2023-03-17 2024-09-26 The Board Of Trustees Of The University Of Illinois Chimeric antibody molecules based on tetrameric teleost immunoglobulin m
CN118339300A (zh) * 2024-01-02 2024-07-12 江苏集萃药康生物科技股份有限公司 产生人源化抗体的动物模型及其构建方法
KR20250173023A (ko) * 2024-05-30 2025-12-10 주식회사 아이엠바이오로직스 J 사슬에 연결되는 링커 및 이를 포함하는 j 사슬 복합체

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7148321B2 (en) * 2001-03-07 2006-12-12 Emd Lexigen Research Center Corp. Expression technology for proteins containing a hybrid isotype antibody moiety
US7754308B2 (en) * 2003-11-13 2010-07-13 So.F.Ter S.P.A. Artificial turf systems having a vulcanised thermoplastic elastomer or styrene-ethylene-butadiene-styrene polymer as infill material

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8719963D0 (en) * 1987-08-24 1987-09-30 Cattaneo A Recombinant dna products
DE10001372A1 (de) * 2000-01-14 2001-08-02 Deutsches Krebsforsch Anti-CD3-Einzelketten-Antikörper mit humanem Cmu3- und Cmu4- Domänen
DK1290027T3 (da) 2000-04-28 2010-01-18 Planet Biotechnology Inc Immunoadhæsin til forebyggelse af rhinovirusinfektion
US7754208B2 (en) * 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
CN101684158A (zh) * 2001-01-17 2010-03-31 特鲁比昂药品公司 结合域-免疫球蛋白融合蛋白
WO2008148884A1 (en) * 2007-06-08 2008-12-11 Universite De La Mediterranee Compositions and methods for treating pancreatic tumors
EP2760891B1 (en) 2011-09-26 2018-11-07 JN Biosciences LLC Hybrid constant regions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7148321B2 (en) * 2001-03-07 2006-12-12 Emd Lexigen Research Center Corp. Expression technology for proteins containing a hybrid isotype antibody moiety
US7754308B2 (en) * 2003-11-13 2010-07-13 So.F.Ter S.P.A. Artificial turf systems having a vulcanised thermoplastic elastomer or styrene-ethylene-butadiene-styrene polymer as infill material

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MICHAELA SCHAFFNER,ET AL: "CHIMERIC INTERLEUKIN 2 RECEPTOR α CHAIN ANTIBODY DERIVATIVES WITH FUSED μ AND γ CHAINS PERMIT IMPROVED RECRUITMENT OF EFFECTOR FUNCTIONS", 《MOLECULAR IMMUNOLOGY》 *
MICHAELA SCHAFFNER,ET AL: "CHIMERIC INTERLEUKIN 2 RECEPTOR α CHAIN ANTIBODY DERIVATIVES WITH FUSED μ AND γ CHAINS PERMIT IMPROVED RECRUITMENT OF EFFECTOR FUNCTIONS", 《MOLECULAR IMMUNOLOGY》, vol. 32, no. 1, 31 December 1995 (1995-12-31), pages 9 - 20 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108602857A (zh) * 2016-01-27 2018-09-28 瑞士杰特贝林生物制品重组设备股份公司 重组IgG Fc多聚体
CN109561681A (zh) * 2016-07-20 2019-04-02 Igm生物科学股份有限公司 多聚gitr结合分子及其用途
CN112368021A (zh) * 2018-06-14 2021-02-12 蓝鸟生物公司 Cd79a嵌合抗原受体
US12060419B2 (en) 2018-06-14 2024-08-13 Regeneron Pharmaceuticals, Inc. CD79A chimeric antigen receptors
CN112368021B (zh) * 2018-06-14 2025-02-21 2赛文缇生物公司 Cd79a嵌合抗原受体
CN114206936A (zh) * 2019-06-14 2022-03-18 2赛文缇生物公司 用于治疗癌症的组合物和方法
CN119638846A (zh) * 2025-01-09 2025-03-18 康复大学青岛中心医院 uMtCK抗体或其抗原结合片段
CN119638846B (zh) * 2025-01-09 2025-11-04 康复大学青岛中心医院 uMtCK抗体或其抗原结合片段

Also Published As

Publication number Publication date
CA2849765A1 (en) 2013-04-04
US8952134B2 (en) 2015-02-10
US20130089547A1 (en) 2013-04-11
JP6205363B2 (ja) 2017-09-27
WO2013049254A1 (en) 2013-04-04
EP2760891A4 (en) 2015-06-24
US20150073130A1 (en) 2015-03-12
JP2015501291A (ja) 2015-01-15
EP2760891B1 (en) 2018-11-07
EP2760891A1 (en) 2014-08-06
CA2849765C (en) 2021-10-19

Similar Documents

Publication Publication Date Title
US8952134B2 (en) Hybrid constant regions
US9540442B2 (en) Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece
US10053517B2 (en) Hybrid constant regions
JP7321303B2 (ja) Ｃｄ３結合抗体
JP7575100B2 (ja) 免疫細胞活性化のための二重特異性抗体
JP2022122927A (ja) Ｃｄ３結合抗体
US20150038682A1 (en) Antibodies or fusion proteins multimerized via homomultimerizing peptide
KR102746908B1 (ko) 신규한 이중특이적 cd3/cd20 폴리펩티드 복합체
CN116323671A (zh) 具有增加的选择性的多靶向性双特异性抗原结合分子
CN115093481A (zh) 新型双特异性cd3/cd20多肽复合物
US20250101104A1 (en) Bispecific molecule with tunable affinity to a targeted antigen
JP2025540657A (ja) 抗ｃｄ３抗体
CN117157314A (zh) Pd-l1抗体、融合蛋白及其用途
US20260022174A1 (en) Trispecific Antibodies for Activation of Immune Cells
HK40092434A (zh) Btla抗体

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20140806

RJ01 Rejection of invention patent application after publication