JP2015500712A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015500712A5 JP2015500712A5 JP2014547529A JP2014547529A JP2015500712A5 JP 2015500712 A5 JP2015500712 A5 JP 2015500712A5 JP 2014547529 A JP2014547529 A JP 2014547529A JP 2014547529 A JP2014547529 A JP 2014547529A JP 2015500712 A5 JP2015500712 A5 JP 2015500712A5
- Authority
- JP
- Japan
- Prior art keywords
- powder
- openings
- receptacle
- pharmaceutical formulation
- outflow openings
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000843 powder Substances 0.000 claims description 64
- 239000008194 pharmaceutical composition Substances 0.000 claims description 23
- 239000000443 aerosol Substances 0.000 claims description 10
- 230000003434 inspiratory effect Effects 0.000 claims description 5
- 239000013543 active substance Substances 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 230000002209 hydrophobic effect Effects 0.000 claims description 2
- 229910021645 metal ion Inorganic materials 0.000 claims description 2
- 239000011859 microparticle Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 210000000214 mouth Anatomy 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 150000003904 phospholipids Chemical class 0.000 claims description 2
- 230000002685 pulmonary effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 2
- BLUGYPPOFIHFJS-UUFHNPECSA-N (2s)-n-[(2s)-1-[[(3r,4s,5s)-3-methoxy-1-[(2s)-2-[(1r,2r)-1-methoxy-2-methyl-3-oxo-3-[[(1s)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 BLUGYPPOFIHFJS-UUFHNPECSA-N 0.000 description 1
- 208000007934 ACTH-independent macronodular adrenal hyperplasia Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161576735P | 2011-12-16 | 2011-12-16 | |
| US201161576768P | 2011-12-16 | 2011-12-16 | |
| US61/576,735 | 2011-12-16 | ||
| US61/576,768 | 2011-12-16 | ||
| PCT/US2012/069938 WO2013090841A2 (en) | 2011-12-16 | 2012-12-14 | Aerosolization apparatus for inhalation profile-independent drug delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015500712A JP2015500712A (ja) | 2015-01-08 |
| JP2015500712A5 true JP2015500712A5 (enExample) | 2015-11-12 |
Family
ID=47501481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547529A Ceased JP2015500712A (ja) | 2011-12-16 | 2012-12-14 | 吸入プロファイルに依存しない薬剤送達のためのエアロゾル投与装置 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9744318B2 (enExample) |
| EP (1) | EP2790761B1 (enExample) |
| JP (1) | JP2015500712A (enExample) |
| KR (1) | KR20140103939A (enExample) |
| CN (1) | CN103998087B (enExample) |
| AU (1) | AU2012351947B2 (enExample) |
| BR (1) | BR112014014399A2 (enExample) |
| CA (1) | CA2858247A1 (enExample) |
| ES (1) | ES2924032T3 (enExample) |
| IL (1) | IL232762A0 (enExample) |
| MX (1) | MX2014007277A (enExample) |
| RU (1) | RU2615076C2 (enExample) |
| WO (1) | WO2013090841A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3431485B2 (en) | 2010-10-01 | 2024-09-04 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| CA2892529C (en) | 2012-11-26 | 2023-04-25 | Moderna Therapeutics, Inc. | Terminally modified rna |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| AR095222A1 (es) * | 2013-04-03 | 2015-09-30 | Sanofi Sa | Elemento de medición para un dispositivo de inhalación y montaje para un dispositivo de inhalación que comprende un elemento de medición |
| EP3024523B1 (en) | 2013-07-22 | 2018-08-29 | Inhalation Sciences Sweden AB | Apparatus and method for generating an aerosol |
| EA201690675A1 (ru) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности |
| JP2017047130A (ja) * | 2015-09-04 | 2017-03-09 | 原田車両設計株式会社 | 薬剤吸入装置 |
| RU2731212C2 (ru) * | 2015-09-09 | 2020-08-31 | Новартис Аг | Направленная доставка высушенных распылением композиций в легкие |
| CN205916436U (zh) * | 2016-07-13 | 2017-02-01 | 深圳市合川医疗科技有限公司 | 一种泡罩穿刺元件 |
| PT3612259T (pt) * | 2017-04-17 | 2023-01-26 | Respira Therapeutics Inc | Inalador de pó seco de dosagem unitária |
| EP3691616A1 (en) * | 2017-10-02 | 2020-08-12 | Novartis AG | Method for preparing a pharmaceutical product |
| CN108635643B (zh) * | 2018-06-04 | 2025-01-10 | 润生药业有限公司 | 一种干粉吸入装置 |
| CA3103893A1 (en) * | 2018-06-15 | 2019-12-19 | Valley Product Concepts, LLC | Capsules for use in personal vaporizers |
| WO2020135920A1 (en) * | 2018-12-28 | 2020-07-02 | Université Libre de Bruxelles | Kit for inhaled chemotherapy, and treatment of lung cancer with said kit |
| CN113631558A (zh) * | 2019-04-04 | 2021-11-09 | 诺华股份有限公司 | Siremadlin琥珀酸酯 |
| CN110286064B (zh) * | 2019-08-05 | 2021-07-27 | 贵州大学 | 一种矿物颗粒润湿性测量装置及其测量方法 |
| CN115089825A (zh) * | 2022-07-06 | 2022-09-23 | 苏州易合医药有限公司 | 肺部给药装置 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
| CH684746A5 (de) | 1993-02-25 | 1994-12-15 | Alusuisse Lonza Services Ag | Laminat. |
| ATE264096T1 (de) | 1994-03-07 | 2004-04-15 | Nektar Therapeutics | Verfahren und mittel zur verabreichung von insulin über die lunge |
| US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| CZ289029B6 (cs) * | 1994-09-21 | 2001-10-17 | Inhale Therapeutic Systems | Způsob aerosolizace práąku, zejména práąkového léku a zařízení k provádění tohoto způsobu |
| US5693609A (en) | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| ES2237767T3 (es) | 1995-04-14 | 2005-08-01 | Nektar Therapeutics | Composiciones farmaceuticas en polvo que tienen una dispersabilidad mejorada. |
| US6258341B1 (en) | 1995-04-14 | 2001-07-10 | Inhale Therapeutic Systems, Inc. | Stable glassy state powder formulations |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US6503480B1 (en) | 1997-05-23 | 2003-01-07 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6270869B1 (en) | 1998-12-02 | 2001-08-07 | Alusuisse Technology & Management Ltd. | Cold formable laminate films |
| US6606992B1 (en) | 1999-06-30 | 2003-08-19 | Nektar Therapeutics | Systems and methods for aerosolizing pharmaceutical formulations |
| CN1188111C (zh) | 1999-10-29 | 2005-02-09 | 耐科塔医药公司 | 分散性得到改进的干粉组合物 |
| CA2382133C (en) | 2000-05-10 | 2010-11-23 | Alliance Pharmaceutical Corporation | Phospholipid-based powders for drug delivery |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| US6668827B2 (en) * | 2000-05-16 | 2003-12-30 | Nektar Therapeutics | Systems devices and methods for opening receptacles having a powder to be fluidized |
| SE0101825D0 (sv) * | 2001-05-22 | 2001-05-22 | Astrazeneca Ab | An Inhalation device |
| GB0315509D0 (en) * | 2003-07-02 | 2003-08-06 | Meridica Ltd | Dispensing device |
| GB2405798A (en) * | 2003-09-15 | 2005-03-16 | Vectura Ltd | Dry powder inhaler with primary and secondary piercing elements and a medicament pack for use with an inhalation device. |
| GB0427856D0 (en) * | 2004-12-20 | 2005-01-19 | Glaxo Group Ltd | Maniflod for use in medicament dispenser |
| EP2668970B1 (en) * | 2006-10-25 | 2016-07-06 | Novartis AG | Powder dispersion apparatus |
| EP2082764A1 (en) | 2008-01-24 | 2009-07-29 | Boehringer Ingelheim International GmbH | Inhaler |
| KR101621986B1 (ko) * | 2008-05-15 | 2016-05-17 | 노파르티스 아게 | 플루오로퀴놀론의 폐 전달 |
| CN103252007B (zh) * | 2008-06-13 | 2016-06-22 | 曼金德公司 | 干粉吸入器和用于药物输送的系统 |
| WO2010039200A2 (en) | 2008-09-30 | 2010-04-08 | Oriel Therapeutics, Inc. | Dry powder inhalers with endless strips and cooperating piercers and related methods |
-
2012
- 2012-12-14 EP EP12809952.0A patent/EP2790761B1/en active Active
- 2012-12-14 MX MX2014007277A patent/MX2014007277A/es unknown
- 2012-12-14 AU AU2012351947A patent/AU2012351947B2/en not_active Expired - Fee Related
- 2012-12-14 US US14/364,478 patent/US9744318B2/en not_active Expired - Fee Related
- 2012-12-14 CN CN201280062267.2A patent/CN103998087B/zh not_active Expired - Fee Related
- 2012-12-14 RU RU2014128828A patent/RU2615076C2/ru not_active IP Right Cessation
- 2012-12-14 KR KR1020147015785A patent/KR20140103939A/ko not_active Withdrawn
- 2012-12-14 JP JP2014547529A patent/JP2015500712A/ja not_active Ceased
- 2012-12-14 BR BR112014014399A patent/BR112014014399A2/pt not_active IP Right Cessation
- 2012-12-14 WO PCT/US2012/069938 patent/WO2013090841A2/en not_active Ceased
- 2012-12-14 CA CA2858247A patent/CA2858247A1/en not_active Abandoned
- 2012-12-14 ES ES12809952T patent/ES2924032T3/es active Active
-
2014
- 2014-05-22 IL IL232762A patent/IL232762A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015500712A5 (enExample) | ||
| RU2484852C2 (ru) | Устройство и способ дезагрегации порошкообразного средства 854 | |
| RU2014128828A (ru) | Устройство аэрозолизации для независимой от профиля вдоха доставки лекарственного средства | |
| TWI653065B (zh) | 尼古丁粉末吸入器、及將尼古丁吸入至一用戶之肺中的方法 | |
| CN101384288B (zh) | 干粉吸入器设备 | |
| JP2011513450A5 (enExample) | ||
| JP2004508903A (ja) | 連続式乾燥粉末吸入器 | |
| US20170106154A1 (en) | Dry powder inhaler | |
| JP2009537199A (ja) | 簡易吸入器 | |
| DK3099364T3 (en) | Powder chamber for high-dose drug administration | |
| JP7096384B2 (ja) | １回用量乾燥粉末吸入器 | |
| JP6247439B2 (ja) | 薬物製品、乾燥粉末吸入器、および、ポリフラックスコライダ配置体 | |
| JP2011513451A5 (enExample) | ||
| JP2022140723A (ja) | 粉末を吸入するための吸入デバイス及び方法 | |
| JP2008502417A (ja) | ポッドを用いる吸入器 | |
| JP5939981B2 (ja) | 薬剤吸入器及び薬剤供給方法 | |
| EP2617451B1 (en) | Drug delivery assembly, and single dose inhaler for dry powder drug delivery having such assembly | |
| US20070101991A1 (en) | Optimizing release of dry medicament powder | |
| WO2013181459A1 (en) | Inhalation device, systems, and methods for administering powdered medicaments to mechanically ventilated subjects |