JP2015500712A5 - - Google Patents
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- Publication number
- JP2015500712A5 JP2015500712A5 JP2014547529A JP2014547529A JP2015500712A5 JP 2015500712 A5 JP2015500712 A5 JP 2015500712A5 JP 2014547529 A JP2014547529 A JP 2014547529A JP 2014547529 A JP2014547529 A JP 2014547529A JP 2015500712 A5 JP2015500712 A5 JP 2015500712A5
- Authority
- JP
- Japan
- Prior art keywords
- powder
- openings
- receptacle
- pharmaceutical formulation
- outflow openings
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000843 powder Substances 0.000 claims description 64
- 239000008194 pharmaceutical composition Substances 0.000 claims description 23
- 239000000443 aerosol Substances 0.000 claims description 10
- 230000003434 inspiratory effect Effects 0.000 claims description 5
- 239000013543 active substance Substances 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 230000002209 hydrophobic effect Effects 0.000 claims description 2
- 229910021645 metal ion Inorganic materials 0.000 claims description 2
- 239000011859 microparticle Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 210000000214 mouth Anatomy 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 150000003904 phospholipids Chemical class 0.000 claims description 2
- 230000002685 pulmonary effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 2
- BLUGYPPOFIHFJS-UUFHNPECSA-N (2s)-n-[(2s)-1-[[(3r,4s,5s)-3-methoxy-1-[(2s)-2-[(1r,2r)-1-methoxy-2-methyl-3-oxo-3-[[(1s)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 BLUGYPPOFIHFJS-UUFHNPECSA-N 0.000 description 1
- 208000007934 ACTH-independent macronodular adrenal hyperplasia Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161576735P | 2011-12-16 | 2011-12-16 | |
| US201161576768P | 2011-12-16 | 2011-12-16 | |
| US61/576,735 | 2011-12-16 | ||
| US61/576,768 | 2011-12-16 | ||
| PCT/US2012/069938 WO2013090841A2 (en) | 2011-12-16 | 2012-12-14 | Aerosolization apparatus for inhalation profile-independent drug delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015500712A JP2015500712A (ja) | 2015-01-08 |
| JP2015500712A5 true JP2015500712A5 (enExample) | 2015-11-12 |
Family
ID=47501481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547529A Ceased JP2015500712A (ja) | 2011-12-16 | 2012-12-14 | 吸入プロファイルに依存しない薬剤送達のためのエアロゾル投与装置 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9744318B2 (enExample) |
| EP (1) | EP2790761B1 (enExample) |
| JP (1) | JP2015500712A (enExample) |
| KR (1) | KR20140103939A (enExample) |
| CN (1) | CN103998087B (enExample) |
| AU (1) | AU2012351947B2 (enExample) |
| BR (1) | BR112014014399A2 (enExample) |
| CA (1) | CA2858247A1 (enExample) |
| ES (1) | ES2924032T3 (enExample) |
| IL (1) | IL232762A0 (enExample) |
| MX (1) | MX2014007277A (enExample) |
| RU (1) | RU2615076C2 (enExample) |
| WO (1) | WO2013090841A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2857499A1 (en) | 2010-10-01 | 2015-04-08 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| PT3682905T (pt) | 2011-10-03 | 2022-04-07 | Modernatx Inc | Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações |
| ES2923757T3 (es) | 2011-12-16 | 2022-09-30 | Modernatx Inc | Composiciones de ARNm modificado |
| WO2013151664A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| PT2922554T (pt) | 2012-11-26 | 2022-06-28 | Modernatx Inc | Arn modificado nas porções terminais |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| AR095222A1 (es) * | 2013-04-03 | 2015-09-30 | Sanofi Sa | Elemento de medición para un dispositivo de inhalación y montaje para un dispositivo de inhalación que comprende un elemento de medición |
| EP3024523B1 (en) | 2013-07-22 | 2018-08-29 | Inhalation Sciences Sweden AB | Apparatus and method for generating an aerosol |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| JP2017047130A (ja) * | 2015-09-04 | 2017-03-09 | 原田車両設計株式会社 | 薬剤吸入装置 |
| WO2017042696A1 (en) * | 2015-09-09 | 2017-03-16 | Novartis Ag | Targeted delivery of spray-dried formulations to the lungs |
| CN205916436U (zh) * | 2016-07-13 | 2017-02-01 | 深圳市合川医疗科技有限公司 | 一种泡罩穿刺元件 |
| WO2018195086A1 (en) * | 2017-04-17 | 2018-10-25 | Respira Therapeutics, Inc. | Powder dispersion devices and methods |
| EP3691616A1 (en) * | 2017-10-02 | 2020-08-12 | Novartis AG | Method for preparing a pharmaceutical product |
| CN108635643B (zh) * | 2018-06-04 | 2025-01-10 | 润生药业有限公司 | 一种干粉吸入装置 |
| WO2019241651A1 (en) * | 2018-06-15 | 2019-12-19 | Valley Product Concepts, LLC | Capsules for use in personal vaporizers |
| WO2020135920A1 (en) * | 2018-12-28 | 2020-07-02 | Université Libre de Bruxelles | Kit for inhaled chemotherapy, and treatment of lung cancer with said kit |
| CA3124939A1 (en) * | 2019-04-04 | 2020-10-08 | Novartis Ag | Siremadlin succinate |
| CN110286064B (zh) * | 2019-08-05 | 2021-07-27 | 贵州大学 | 一种矿物颗粒润湿性测量装置及其测量方法 |
| CN115089825A (zh) * | 2022-07-06 | 2022-09-23 | 苏州易合医药有限公司 | 肺部给药装置 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
| CH684746A5 (de) | 1993-02-25 | 1994-12-15 | Alusuisse Lonza Services Ag | Laminat. |
| US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| DE69535897D1 (de) | 1994-03-07 | 2009-01-22 | Nektar Therapeutics | Verfahren und Zusammensetzung für die pulmonale Darreichung von Insulin |
| ATE387925T1 (de) | 1994-09-21 | 2008-03-15 | Nektar Therapeutics | Vorrichtung und verfahren zum dispergieren von trockenen pulvermedikamenten |
| US5693609A (en) | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| AU706195B2 (en) | 1995-04-14 | 1999-06-10 | Inhale Therapeutic Systems | Powdered pharmaceutical formulations having improved dispersibility |
| US6258341B1 (en) | 1995-04-14 | 2001-07-10 | Inhale Therapeutic Systems, Inc. | Stable glassy state powder formulations |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US6503480B1 (en) | 1997-05-23 | 2003-01-07 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6270869B1 (en) | 1998-12-02 | 2001-08-07 | Alusuisse Technology & Management Ltd. | Cold formable laminate films |
| US6606992B1 (en) | 1999-06-30 | 2003-08-19 | Nektar Therapeutics | Systems and methods for aerosolizing pharmaceutical formulations |
| DE60025019T2 (de) | 1999-10-29 | 2006-08-24 | Nektar Therapeutics, San Carlos | Trockenpulverzusammensetzungen mit verbesserter dispersivität |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| PT1280520E (pt) | 2000-05-10 | 2014-12-16 | Novartis Ag | Pós à base de fosfolípidos para administração de fármacos |
| US6668827B2 (en) * | 2000-05-16 | 2003-12-30 | Nektar Therapeutics | Systems devices and methods for opening receptacles having a powder to be fluidized |
| SE0101825D0 (sv) * | 2001-05-22 | 2001-05-22 | Astrazeneca Ab | An Inhalation device |
| GB0315509D0 (en) * | 2003-07-02 | 2003-08-06 | Meridica Ltd | Dispensing device |
| GB2405798A (en) * | 2003-09-15 | 2005-03-16 | Vectura Ltd | Dry powder inhaler with primary and secondary piercing elements and a medicament pack for use with an inhalation device. |
| GB0427856D0 (en) * | 2004-12-20 | 2005-01-19 | Glaxo Group Ltd | Maniflod for use in medicament dispenser |
| EP2668970B1 (en) * | 2006-10-25 | 2016-07-06 | Novartis AG | Powder dispersion apparatus |
| EP2082764A1 (en) | 2008-01-24 | 2009-07-29 | Boehringer Ingelheim International GmbH | Inhaler |
| US8834930B2 (en) * | 2008-05-15 | 2014-09-16 | Novartis Ag | Pulmonary delivery of a fluoroquinolone |
| MY155524A (en) * | 2008-06-13 | 2015-10-30 | Mannkind Corp | A dry powder inhaler and system for drug delivery |
| WO2010039200A2 (en) | 2008-09-30 | 2010-04-08 | Oriel Therapeutics, Inc. | Dry powder inhalers with endless strips and cooperating piercers and related methods |
-
2012
- 2012-12-14 CN CN201280062267.2A patent/CN103998087B/zh not_active Expired - Fee Related
- 2012-12-14 RU RU2014128828A patent/RU2615076C2/ru not_active IP Right Cessation
- 2012-12-14 WO PCT/US2012/069938 patent/WO2013090841A2/en not_active Ceased
- 2012-12-14 MX MX2014007277A patent/MX2014007277A/es unknown
- 2012-12-14 US US14/364,478 patent/US9744318B2/en not_active Expired - Fee Related
- 2012-12-14 KR KR1020147015785A patent/KR20140103939A/ko not_active Withdrawn
- 2012-12-14 JP JP2014547529A patent/JP2015500712A/ja not_active Ceased
- 2012-12-14 ES ES12809952T patent/ES2924032T3/es active Active
- 2012-12-14 CA CA2858247A patent/CA2858247A1/en not_active Abandoned
- 2012-12-14 AU AU2012351947A patent/AU2012351947B2/en not_active Expired - Fee Related
- 2012-12-14 EP EP12809952.0A patent/EP2790761B1/en not_active Not-in-force
- 2012-12-14 BR BR112014014399A patent/BR112014014399A2/pt not_active IP Right Cessation
-
2014
- 2014-05-22 IL IL232762A patent/IL232762A0/en unknown
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