CN103998087B - 用于吸入分布独立性给药的雾化装置 - Google Patents

用于吸入分布独立性给药的雾化装置 Download PDF

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Publication number
CN103998087B
CN103998087B CN201280062267.2A CN201280062267A CN103998087B CN 103998087 B CN103998087 B CN 103998087B CN 201280062267 A CN201280062267 A CN 201280062267A CN 103998087 B CN103998087 B CN 103998087B
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CN
China
Prior art keywords
powder
container
openings
flow
inhalation
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280062267.2A
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English (en)
Chinese (zh)
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CN103998087A (zh
Inventor
L·陈
T·K·昂
J·韦尔斯
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Novartis AG
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Novartis AG
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Publication of CN103998087A publication Critical patent/CN103998087A/zh
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Publication of CN103998087B publication Critical patent/CN103998087B/zh
Expired - Fee Related legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0093—Inhalators mechanically breath-triggered without arming or cocking, e.g. acting directly on the delivery valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
CN201280062267.2A 2011-12-16 2012-12-14 用于吸入分布独立性给药的雾化装置 Expired - Fee Related CN103998087B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161576768P 2011-12-16 2011-12-16
US201161576735P 2011-12-16 2011-12-16
US61/576,735 2011-12-16
US61/576,768 2011-12-16
PCT/US2012/069938 WO2013090841A2 (en) 2011-12-16 2012-12-14 Aerosolization apparatus for inhalation profile-independent drug delivery

Publications (2)

Publication Number Publication Date
CN103998087A CN103998087A (zh) 2014-08-20
CN103998087B true CN103998087B (zh) 2017-04-05

Family

ID=47501481

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280062267.2A Expired - Fee Related CN103998087B (zh) 2011-12-16 2012-12-14 用于吸入分布独立性给药的雾化装置

Country Status (13)

Country Link
US (1) US9744318B2 (enExample)
EP (1) EP2790761B1 (enExample)
JP (1) JP2015500712A (enExample)
KR (1) KR20140103939A (enExample)
CN (1) CN103998087B (enExample)
AU (1) AU2012351947B2 (enExample)
BR (1) BR112014014399A2 (enExample)
CA (1) CA2858247A1 (enExample)
ES (1) ES2924032T3 (enExample)
IL (1) IL232762A0 (enExample)
MX (1) MX2014007277A (enExample)
RU (1) RU2615076C2 (enExample)
WO (1) WO2013090841A2 (enExample)

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US8822663B2 (en) 2010-08-06 2014-09-02 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2622064B1 (en) 2010-10-01 2019-05-29 Modernatx, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
US8710200B2 (en) 2011-03-31 2014-04-29 Moderna Therapeutics, Inc. Engineered nucleic acids encoding a modified erythropoietin and their expression
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP3492109B1 (en) 2011-10-03 2020-03-04 ModernaTX, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
HRP20220717T1 (hr) 2011-12-16 2022-07-22 Modernatx, Inc. Modificirani pripravci mrna
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
WO2013151665A2 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins associated with human disease
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US9597380B2 (en) 2012-11-26 2017-03-21 Modernatx, Inc. Terminally modified RNA
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
AR095222A1 (es) * 2013-04-03 2015-09-30 Sanofi Sa Elemento de medición para un dispositivo de inhalación y montaje para un dispositivo de inhalación que comprende un elemento de medición
EP3024523B1 (en) 2013-07-22 2018-08-29 Inhalation Sciences Sweden AB Apparatus and method for generating an aerosol
SG11201602503TA (en) 2013-10-03 2016-04-28 Moderna Therapeutics Inc Polynucleotides encoding low density lipoprotein receptor
JP2017047130A (ja) * 2015-09-04 2017-03-09 原田車両設計株式会社 薬剤吸入装置
KR20180050320A (ko) * 2015-09-09 2018-05-14 노파르티스 아게 분무-건조된 제제의 폐로의 표적화된 전달
CN205916436U (zh) * 2016-07-13 2017-02-01 深圳市合川医疗科技有限公司 一种泡罩穿刺元件
EP3612259B1 (en) * 2017-04-17 2022-11-09 Respira Therapeutics, Inc. Unit dose dry powder inhaler
IL273553B2 (en) * 2017-10-02 2024-09-01 Novartis Ag A method for preparing a pharmacy product
CN108635643B (zh) * 2018-06-04 2025-01-10 润生药业有限公司 一种干粉吸入装置
US11864587B2 (en) * 2018-06-15 2024-01-09 Valley Product Concepts, LLC Capsules for use in personal vaporizers
WO2020135920A1 (en) * 2018-12-28 2020-07-02 Université Libre de Bruxelles Kit for inhaled chemotherapy, and treatment of lung cancer with said kit
EP3947385A1 (en) * 2019-04-04 2022-02-09 Novartis AG Siremadlin succinate
CN110286064B (zh) * 2019-08-05 2021-07-27 贵州大学 一种矿物颗粒润湿性测量装置及其测量方法
CN115089825A (zh) * 2022-07-06 2022-09-23 苏州易合医药有限公司 肺部给药装置

Citations (4)

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US6089228A (en) * 1994-09-21 2000-07-18 Inhale Therapeutic Systems Apparatus and methods for dispersing dry powder medicaments
US20050161041A1 (en) * 2000-05-16 2005-07-28 Carlos Schuler Systems devices and methods for opening receptacles having a powder to be fluidized
US20100108058A1 (en) * 2006-10-25 2010-05-06 Mark Glusker Powder dispersion apparatus, method of making and using the apparatus, and components that can be used on the apparatus and other devices
US7810494B2 (en) * 2003-09-15 2010-10-12 Vectura Limited Dry powder inhaler

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US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
CH684746A5 (de) 1993-02-25 1994-12-15 Alusuisse Lonza Services Ag Laminat.
KR100419037B1 (ko) 1994-03-07 2004-06-12 넥타르 테라퓨틱스 폐를통한인슐린의전달방법및그조성물
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US5693609A (en) 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
JP3708553B2 (ja) 1995-04-14 2005-10-19 ネクター セラピューティクス 向上した分散性を有する粉末型薬理組成物
US6258341B1 (en) 1995-04-14 2001-07-10 Inhale Therapeutic Systems, Inc. Stable glassy state powder formulations
US6503480B1 (en) 1997-05-23 2003-01-07 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
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US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
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US6606992B1 (en) 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
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US6089228A (en) * 1994-09-21 2000-07-18 Inhale Therapeutic Systems Apparatus and methods for dispersing dry powder medicaments
US20050161041A1 (en) * 2000-05-16 2005-07-28 Carlos Schuler Systems devices and methods for opening receptacles having a powder to be fluidized
US7810494B2 (en) * 2003-09-15 2010-10-12 Vectura Limited Dry powder inhaler
US20100108058A1 (en) * 2006-10-25 2010-05-06 Mark Glusker Powder dispersion apparatus, method of making and using the apparatus, and components that can be used on the apparatus and other devices

Also Published As

Publication number Publication date
AU2012351947A1 (en) 2014-06-26
US9744318B2 (en) 2017-08-29
ES2924032T3 (es) 2022-10-04
WO2013090841A2 (en) 2013-06-20
EP2790761B1 (en) 2022-05-11
CA2858247A1 (en) 2013-06-20
EP2790761A2 (en) 2014-10-22
JP2015500712A (ja) 2015-01-08
RU2014128828A (ru) 2016-02-10
BR112014014399A2 (pt) 2017-06-13
MX2014007277A (es) 2014-07-28
CN103998087A (zh) 2014-08-20
US20140318539A1 (en) 2014-10-30
KR20140103939A (ko) 2014-08-27
WO2013090841A3 (en) 2013-08-08
RU2615076C2 (ru) 2017-04-03
AU2012351947B2 (en) 2017-08-17
IL232762A0 (en) 2014-07-31

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Granted publication date: 20170405

Termination date: 20171214

CF01 Termination of patent right due to non-payment of annual fee