JP2015180703A5 - - Google Patents

Info

Publication number

JP2015180703A5

JP2015180703A5 JP2015141004A JP2015141004A JP2015180703A5 JP 2015180703 A5 JP2015180703 A5 JP 2015180703A5 JP 2015141004 A JP2015141004 A JP 2015141004A JP 2015141004 A JP2015141004 A JP 2015141004A JP 2015180703 A5 JP2015180703 A5 JP 2015180703A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

cyano

chloro

insulin resistance

composition according

Prior art date

2015-07-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 7
• 206010022489 Insulin Resistance Diseases 0.000 claims 6
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 6
• 150000003839 salts Chemical class 0.000 claims 5
• 229910052739 hydrogen Inorganic materials 0.000 claims 4
• 239000001257 hydrogen Substances 0.000 claims 4
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
• 150000001875 compounds Chemical class 0.000 claims 3
• 201000001320 Atherosclerosis Diseases 0.000 claims 2
• 206010070901 Diabetic dyslipidaemia Diseases 0.000 claims 2
• 208000032928 Dyslipidaemia Diseases 0.000 claims 2
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
• 208000031226 Hyperlipidaemia Diseases 0.000 claims 2
• 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
• -1 cyano, methoxy Chemical group 0.000 claims 2
• 206010012601 diabetes mellitus Diseases 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 125000001153 fluoro group Chemical group F* 0.000 claims 2
• 239000008103 glucose Substances 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• XMVJITFPVVRMHC-UHFFFAOYSA-N roxarsone Chemical group OC1=CC=C([As](O)(O)=O)C=C1[N+]([O-])=O XMVJITFPVVRMHC-UHFFFAOYSA-N 0.000 claims 2
• 230000002792 vascular Effects 0.000 claims 2
• NIONDZDPPYHYKY-SNAWJCMRSA-N (2E)-hexenoic acid Chemical compound CCC\C=C\C(O)=O NIONDZDPPYHYKY-SNAWJCMRSA-N 0.000 claims 1
• 229910052783 alkali metal Inorganic materials 0.000 claims 1
• 150000001340 alkali metals Chemical class 0.000 claims 1
• 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
• 229910052782 aluminium Inorganic materials 0.000 claims 1
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
• 150000001412 amines Chemical class 0.000 claims 1
• 150000003863 ammonium salts Chemical class 0.000 claims 1
• 239000002585 base Substances 0.000 claims 1
• 125000001246 bromo group Chemical group Br* 0.000 claims 1
• 150000001768 cations Chemical class 0.000 claims 1
• 125000001309 chloro group Chemical group Cl* 0.000 claims 1
• 125000004093 cyano group Chemical group *C#N 0.000 claims 1
• 125000005843 halogen group Chemical group 0.000 claims 1
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
• 210000003734 kidney Anatomy 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1