JP2016513685A5 - - Google Patents
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- Publication number
- JP2016513685A5 JP2016513685A5 JP2016502351A JP2016502351A JP2016513685A5 JP 2016513685 A5 JP2016513685 A5 JP 2016513685A5 JP 2016502351 A JP2016502351 A JP 2016502351A JP 2016502351 A JP2016502351 A JP 2016502351A JP 2016513685 A5 JP2016513685 A5 JP 2016513685A5
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- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- composition
- hydrogen
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C*(C1=*C(C2=Cc(ccc(*)c3*)c3OC2=O)=C*11CC1)c1c(*)c(*)c(C(C)=I)c(*)c1N* Chemical compound C*(C1=*C(C2=Cc(ccc(*)c3*)c3OC2=O)=C*11CC1)c1c(*)c(*)c(C(C)=I)c(*)c1N* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361788398P | 2013-03-15 | 2013-03-15 | |
| US61/788,398 | 2013-03-15 | ||
| PCT/US2014/027154 WO2014152278A2 (en) | 2013-03-15 | 2014-03-14 | Coumarin derivatives and methods of use in treating hyperproliferative diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513685A JP2016513685A (ja) | 2016-05-16 |
| JP2016513685A5 true JP2016513685A5 (enExample) | 2017-04-20 |
| JP6407955B2 JP6407955B2 (ja) | 2018-10-17 |
Family
ID=51581693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502351A Expired - Fee Related JP6407955B2 (ja) | 2013-03-15 | 2014-03-14 | クマリン誘導体、ならびに過剰増殖疾患を治療する際の使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10369145B2 (enExample) |
| EP (1) | EP2970249A4 (enExample) |
| JP (1) | JP6407955B2 (enExample) |
| KR (1) | KR20150132483A (enExample) |
| CN (1) | CN105246887B (enExample) |
| AU (1) | AU2014240003B2 (enExample) |
| CA (1) | CA2903107C (enExample) |
| HK (1) | HK1218537A1 (enExample) |
| MX (1) | MX379292B (enExample) |
| WO (1) | WO2014152278A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012158913A2 (en) | 2011-05-17 | 2012-11-22 | Discoverybiomed Inc. | Treating protein folding disorders with small molecule cftr correctors |
| US9676779B2 (en) | 2012-11-20 | 2017-06-13 | Discoverybiomed, Inc. | Small molecule CFTR correctors |
| CA2891965A1 (en) | 2012-11-20 | 2014-05-30 | Discoverybiomed, Inc. | Small molecule bicyclic and tricyclic cftr correctors |
| HK1218537A1 (zh) | 2013-03-15 | 2017-02-24 | Discoverybiomed Inc. | 香豆素衍生物以及用於治疗过度增生性疾病的方法 |
| CA2903103C (en) | 2013-03-15 | 2020-06-09 | Discoverybiomed, Inc. | Coumarin derivatives and methods of use in treating cystic fibrosis, chronic obstructive pulmonary disease, and misfolded protein disorders |
| CN105541852B (zh) * | 2016-01-29 | 2017-09-15 | 扬州大学 | 2‑（香豆素‑3‑基）‑6‑甲基吡啶并[5,4‑c]香豆素的合成方法 |
| CN107098895B (zh) * | 2016-02-19 | 2020-01-07 | 湖南大学 | 苯氨基噻唑甲基喹啉酮衍生物及其制备方法与应用 |
| WO2018237174A2 (en) * | 2017-06-21 | 2018-12-27 | The Johns Hopkins University | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MODULATORS FOR THE TREATMENT OF DOMINANT AUTOMATIC RENAL POLYKYSTOSIS |
| CN109464440A (zh) * | 2019-01-17 | 2019-03-15 | 北京大学 | 3-乙酰氨基香豆素在制备治疗或预防肾脏纤维化及慢性肾病的药物中的应用 |
| CN112274517A (zh) * | 2020-10-30 | 2021-01-29 | 江苏大学 | 一种治疗套细胞淋巴瘤的药物组合物 |
| WO2025150943A1 (ko) * | 2024-01-09 | 2025-07-17 | 주식회사 프로티나 | 신규 화합물 및 이의 용도 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5566580A (en) | 1978-11-11 | 1980-05-20 | Kaken Pharmaceut Co Ltd | Coumarin derivative, its preparation and antiallergic agent containing the same as effective component |
| DE10133665A1 (de) | 2001-07-11 | 2003-01-30 | Boehringer Ingelheim Pharma | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung |
| US20030055263A1 (en) | 2001-07-11 | 2003-03-20 | Boehringer Ingelheim Pharma Kg | Carboxylic acid derivatives, medicaments comprising these compounds, their use and processes for their production |
| US6822097B1 (en) * | 2002-02-07 | 2004-11-23 | Amgen, Inc. | Compounds and methods of uses |
| US20060122387A1 (en) | 2002-06-13 | 2006-06-08 | Cti Europe S.R.L. | Derivatives of chromen-2-one as inhibitors of vegf production in mammalian cells |
| CN101076332A (zh) | 2004-10-13 | 2007-11-21 | Ptc医疗公司 | 吡唑或三唑化合物及其用于制备治疗体细胞突变相关疾病的药物的用途 |
| JP2008515992A (ja) | 2004-10-13 | 2008-05-15 | ピーティーシー セラピューティクス，インコーポレーテッド | 体細胞変異に起因する疾患の阻止／治療用医薬を製造するための規定化合物の使用 |
| US7799915B2 (en) | 2004-10-13 | 2010-09-21 | Wyeth Llc | Anilino-pyrimidine analogs |
| US20090012148A1 (en) | 2005-11-01 | 2009-01-08 | Maxfield Frederick R | Reducing cellular cholesterol levels and/or treating or preventing phospholipidosis |
| CN101351208A (zh) | 2005-11-01 | 2009-01-21 | 康乃尔研究基金会有限公司 | 减少细胞胆固醇水平和/或治疗或预防磷脂质病 |
| EP2581451B1 (en) | 2007-12-13 | 2016-03-09 | Indiana University Research and Technology Corporation | Compounds for inhibiting mammalian s-nitrosoglutathione reductase |
| US20120100609A1 (en) * | 2009-03-27 | 2012-04-26 | Crawford Brett E | N-linked glycan biosynthesis modulators |
| ITMI20111068A1 (it) | 2011-06-14 | 2012-12-15 | Azienda Ospedaliera Universitaria I Ntegrata Di Ve | Trimetilangelicina come correttore di cftr in cellule dell'epitelio bronchiale |
| CA2903103C (en) | 2013-03-15 | 2020-06-09 | Discoverybiomed, Inc. | Coumarin derivatives and methods of use in treating cystic fibrosis, chronic obstructive pulmonary disease, and misfolded protein disorders |
| HK1218537A1 (zh) | 2013-03-15 | 2017-02-24 | Discoverybiomed Inc. | 香豆素衍生物以及用於治疗过度增生性疾病的方法 |
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2014
- 2014-03-14 HK HK16106496.8A patent/HK1218537A1/zh unknown
- 2014-03-14 CA CA2903107A patent/CA2903107C/en active Active
- 2014-03-14 JP JP2016502351A patent/JP6407955B2/ja not_active Expired - Fee Related
- 2014-03-14 US US14/775,050 patent/US10369145B2/en active Active
- 2014-03-14 WO PCT/US2014/027154 patent/WO2014152278A2/en not_active Ceased
- 2014-03-14 MX MX2015013175A patent/MX379292B/es unknown
- 2014-03-14 EP EP14768111.8A patent/EP2970249A4/en not_active Withdrawn
- 2014-03-14 CN CN201480015013.4A patent/CN105246887B/zh not_active Expired - Fee Related
- 2014-03-14 AU AU2014240003A patent/AU2014240003B2/en not_active Ceased
- 2014-03-14 KR KR1020157029644A patent/KR20150132483A/ko not_active Ceased