JP2015178529A5 - - Google Patents
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- JP2015178529A5 JP2015178529A5 JP2015129772A JP2015129772A JP2015178529A5 JP 2015178529 A5 JP2015178529 A5 JP 2015178529A5 JP 2015129772 A JP2015129772 A JP 2015129772A JP 2015129772 A JP2015129772 A JP 2015129772A JP 2015178529 A5 JP2015178529 A5 JP 2015178529A5
- Authority
- JP
- Japan
- Prior art keywords
- hsv
- seq
- vaccine formulation
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229960005486 vaccine Drugs 0.000 claims 65
- 238000009472 formulation Methods 0.000 claims 54
- 239000000203 mixture Substances 0.000 claims 54
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims 51
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 48
- 229920001184 polypeptide Polymers 0.000 claims 35
- 102000004196 processed proteins & peptides Human genes 0.000 claims 35
- 108090000765 processed proteins & peptides Proteins 0.000 claims 35
- 125000003275 alpha amino acid group Chemical group 0.000 claims 31
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims 17
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 14
- 150000001413 amino acids Chemical class 0.000 claims 13
- 208000024891 symptom Diseases 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 11
- 230000002163 immunogen Effects 0.000 claims 11
- 125000000539 amino acid group Chemical group 0.000 claims 10
- 208000015181 infectious disease Diseases 0.000 claims 10
- 230000037430 deletion Effects 0.000 claims 9
- 238000012217 deletion Methods 0.000 claims 9
- 230000003902 lesion Effects 0.000 claims 8
- 239000003937 drug carrier Substances 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 230000007485 viral shedding Effects 0.000 claims 4
- 230000005867 T cell response Effects 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 206010019233 Headaches Diseases 0.000 claims 2
- 208000001688 Herpes Genitalis Diseases 0.000 claims 2
- 101150027427 ICP4 gene Proteins 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 208000037048 Prodromal Symptoms Diseases 0.000 claims 2
- 208000003251 Pruritus Diseases 0.000 claims 2
- 206010037660 Pyrexia Diseases 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 201000004946 genital herpes Diseases 0.000 claims 2
- 231100000869 headache Toxicity 0.000 claims 2
- 230000007794 irritation Effects 0.000 claims 2
- 230000007803 itching Effects 0.000 claims 2
- 206010025482 malaise Diseases 0.000 claims 2
- 230000036407 pain Effects 0.000 claims 2
- PIGTXFOGKFOFTO-FVFWYJKVSA-N (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-carboxy-4-formyl-8-hydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound O([C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)C[C@@H](O)[C@]1(CCC(C[C@H]14)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O PIGTXFOGKFOFTO-FVFWYJKVSA-N 0.000 claims 1
- 208000032420 Latent Infection Diseases 0.000 claims 1
- 210000000447 Th1 cell Anatomy 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 230000005875 antibody response Effects 0.000 claims 1
- 230000005540 biological transmission Effects 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 230000036755 cellular response Effects 0.000 claims 1
- 208000037771 disease arising from reactivation of latent virus Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000014599 transmission of virus Effects 0.000 claims 1
- 230000007419 viral reactivation Effects 0.000 claims 1
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18078409P | 2009-05-22 | 2009-05-22 | |
| US61/180,784 | 2009-05-22 | ||
| US23562809P | 2009-08-20 | 2009-08-20 | |
| US61/235,628 | 2009-08-20 | ||
| US24058709P | 2009-09-08 | 2009-09-08 | |
| US24062609P | 2009-09-08 | 2009-09-08 | |
| US61/240,626 | 2009-09-08 | ||
| US61/240,587 | 2009-09-08 | ||
| US30591810P | 2010-02-18 | 2010-02-18 | |
| US61/305,918 | 2010-02-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012512087A Division JP5771605B2 (ja) | 2009-05-22 | 2010-05-24 | 単純ヘルペスウイルス２型に対するワクチン：免疫応答を誘発する組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015178529A JP2015178529A (ja) | 2015-10-08 |
| JP2015178529A5 true JP2015178529A5 (cg-RX-API-DMAC7.html) | 2016-06-09 |
| JP6096839B2 JP6096839B2 (ja) | 2017-03-15 |
Family
ID=43126545
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012512087A Expired - Fee Related JP5771605B2 (ja) | 2009-05-22 | 2010-05-24 | 単純ヘルペスウイルス２型に対するワクチン：免疫応答を誘発する組成物および方法 |
| JP2015129772A Expired - Fee Related JP6096839B2 (ja) | 2009-05-22 | 2015-06-29 | 単純ヘルペスウイルス２型に対するワクチン：免疫応答を誘発する組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012512087A Expired - Fee Related JP5771605B2 (ja) | 2009-05-22 | 2010-05-24 | 単純ヘルペスウイルス２型に対するワクチン：免疫応答を誘発する組成物および方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US8617564B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2432504B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5771605B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101746872B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN106924728B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010249330B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI1012811A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2797937C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2732815T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL216508A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2011012347A (cg-RX-API-DMAC7.html) |
| MY (1) | MY159500A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ597182A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2585961C9 (cg-RX-API-DMAC7.html) |
| SG (1) | SG176207A1 (cg-RX-API-DMAC7.html) |
| WO (2) | WO2010135749A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201109444B (cg-RX-API-DMAC7.html) |
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| EP2432504B1 (en) * | 2009-05-22 | 2019-05-01 | Genocea Biosciences, Inc. | Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response |
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| US9782474B2 (en) | 2010-11-24 | 2017-10-10 | Genocea Biosciences, Inc. | Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response |
| WO2012139099A2 (en) * | 2011-04-08 | 2012-10-11 | Duke University | Herpes simplex virus vaccine |
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| AU2012340712B2 (en) * | 2011-11-23 | 2017-09-14 | Genocea Biosciences, Inc. | Nucleic acid vaccines against Herpes Simplex Virus type 2: compositions and methods for eliciting an immune response |
| US9895435B2 (en) * | 2012-05-16 | 2018-02-20 | Immune Design Corp. | Vaccines for HSV-2 |
| WO2014052971A1 (en) * | 2012-09-30 | 2014-04-03 | The Regents Of The University Of Michigan | Immunogenic compositions comprising nanoemulsions |
| CN103074337B (zh) * | 2012-12-04 | 2014-07-09 | 昆明寰基生物芯片产业有限公司 | 一段单纯疱疹病毒dna序列及应用 |
| CA2900008C (en) | 2013-02-07 | 2025-10-07 | Children's Medical Center Corporation | PROTEIN ANTIGENS THAT CONFER PROTECTION AGAINST COLONIZATION AND/OR PNEUMOCOCCAL DISEASE |
| WO2014164699A1 (en) * | 2013-03-11 | 2014-10-09 | The Regents Of The University Of California | Herpes virus vaccines and treatments |
| US10918712B2 (en) | 2014-03-03 | 2021-02-16 | Albert Einstein College Of Medicine | Passive transfer of immunity using recombinant herpes simplex virus 2 (HSV-2) vaccine vectors |
| CN110938604B (zh) * | 2014-03-03 | 2024-04-05 | 阿尔伯特爱因斯坦医学院 | 重组单纯疱疹病毒2(hsv-2)疫苗载体 |
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| PT3377637T (pt) * | 2016-04-08 | 2020-06-17 | Krystal Biotech Inc | Composições para uso em métodos para o tratamento de ferimentos, transtornos e doenças da pele |
| EP3519427A4 (en) * | 2016-09-28 | 2020-03-11 | Genocea Biosciences Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF HERPES |
| KR101962683B1 (ko) * | 2016-09-28 | 2019-03-27 | 주식회사 에스엘백시젠 | Hsv-2 감염 예방 및 치료용 dna 백신 |
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| CA3073161A1 (en) * | 2017-08-17 | 2019-02-21 | The Trustees Of The University Of Pennsylvania | Modified mrna vaccines encoding herpes simplex virus glycoproteins and uses thereof |
| US11213582B2 (en) * | 2018-08-08 | 2022-01-04 | The Regents Of The University Of California | Protection against recurrent genital herpes by therapeutic immunization with herpes simplex virus type 2 ribonucleotide reductase protein subunits |
| CA3111459A1 (en) | 2018-09-12 | 2020-03-19 | Affinivax, Inc. | Multivalent pneumococcal vaccines |
| KR20210141554A (ko) | 2019-03-21 | 2021-11-23 | 코디악 바이오사이언시즈, 인크. | 세포외 소포 접합체 및 이의 용도 |
| AU2020240135A1 (en) | 2019-03-21 | 2021-10-14 | Lonza Sales Ag | Extracellular vesicles for vaccine delivery |
| CN109943592B (zh) * | 2019-04-29 | 2020-11-17 | 华中农业大学 | 含猪伪狂犬病病毒gD蛋白基因的重组杆状病毒转移载体、重组杆状病毒及制备方法和应用 |
| CN110804088A (zh) * | 2019-11-18 | 2020-02-18 | 维塔恩(广州)医药有限公司 | 巨细胞病毒相关抗原短肽及其应用 |
| CN110845583A (zh) * | 2019-11-18 | 2020-02-28 | 维塔恩(广州)医药有限公司 | 水痘带状疱疹病毒相关抗原短肽及其应用 |
| CN110746497A (zh) * | 2019-11-18 | 2020-02-04 | 维塔恩(广州)医药有限公司 | 肺炎衣原体相关抗原短肽及其应用 |
| CN110724181A (zh) * | 2019-11-18 | 2020-01-24 | 维塔恩(广州)医药有限公司 | 单纯疱疹病毒相关抗原短肽及其应用 |
| KR20230166118A (ko) | 2021-04-02 | 2023-12-06 | 크리스탈 바이오테크, 인크. | 암 요법을 위한 바이러스 벡터 |
| KR20240099160A (ko) | 2021-09-09 | 2024-06-28 | 아피니백스, 인크. | 다가 폐렴구균 백신 |
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| US8057804B2 (en) | 2006-12-28 | 2011-11-15 | The Trustees Of The University Of Pennsylvania | Herpes simplex virus combined subunit vaccines and methods of use thereof |
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- 2010-05-24 EP EP10778532.1A patent/EP2432504B1/en not_active Not-in-force
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