JP2014533681A5 - - Google Patents
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- Publication number
- JP2014533681A5 JP2014533681A5 JP2014541807A JP2014541807A JP2014533681A5 JP 2014533681 A5 JP2014533681 A5 JP 2014533681A5 JP 2014541807 A JP2014541807 A JP 2014541807A JP 2014541807 A JP2014541807 A JP 2014541807A JP 2014533681 A5 JP2014533681 A5 JP 2014533681A5
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- JP
- Japan
- Prior art keywords
- peptide
- seq
- set forth
- sequence set
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 206010018338 Glioma Diseases 0.000 claims 9
- 208000032612 Glial tumor Diseases 0.000 claims 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 claims 2
- 206010003571 Astrocytoma Diseases 0.000 claims 2
- 108010069514 Cyclic Peptides Proteins 0.000 claims 2
- 102000001189 Cyclic Peptides Human genes 0.000 claims 2
- 206010014967 Ependymoma Diseases 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 201000010133 Oligodendroglioma Diseases 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 210000002540 macrophage Anatomy 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 2
- 239000008158 vegetable oil Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010057249 Phagocytosis Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000004058 mixed glioma Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
- 230000008782 phagocytosis Effects 0.000 claims 1
- 230000000770 proinflammatory effect Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000000722 protumoral effect Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161561080P | 2011-11-17 | 2011-11-17 | |
| US61/561,080 | 2011-11-17 | ||
| US201261583745P | 2012-01-06 | 2012-01-06 | |
| US61/583,745 | 2012-01-06 | ||
| PCT/IB2012/056533 WO2013072901A2 (en) | 2011-11-17 | 2012-11-18 | Compositions and methods for treating glioma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014533681A JP2014533681A (ja) | 2014-12-15 |
| JP2014533681A5 true JP2014533681A5 (enExample) | 2016-01-14 |
| JP6426001B2 JP6426001B2 (ja) | 2018-11-21 |
Family
ID=47358252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014541807A Expired - Fee Related JP6426001B2 (ja) | 2011-11-17 | 2012-11-18 | 神経膠腫を治療するための組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9453050B2 (enExample) |
| EP (1) | EP2780363B1 (enExample) |
| JP (1) | JP6426001B2 (enExample) |
| KR (1) | KR20140103122A (enExample) |
| CA (1) | CA2856329A1 (enExample) |
| IL (1) | IL232648B (enExample) |
| WO (1) | WO2013072901A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201220573D0 (en) | 2012-11-15 | 2013-01-02 | Univ Central Lancashire | Methods of diagnosing proliferative disorders |
| DE102014207498A1 (de) * | 2014-04-17 | 2015-10-22 | Universitätsklinikum Hamburg-Eppendorf | Viraler Vektor für den zielgerichteten Gentransfer in Gehirn und Rückenmark |
| CN107002037A (zh) * | 2014-09-26 | 2017-08-01 | 新加坡国立大学 | 用于调节th‑gm细胞功能的方法和组合物 |
| US11078264B2 (en) * | 2018-10-17 | 2021-08-03 | University Of Connecticut | Inhibiting granulocyte macrophage-colony stimulating factor (GM-CSF) prevents preterm birth |
| EP3886888A4 (en) * | 2018-11-28 | 2022-09-28 | Glia Sp. z o.o. | COMPOSITIONS AND METHODS OF TREATMENT OF GLIOMA |
| CN112007142B (zh) * | 2019-05-31 | 2025-04-22 | 生物蚕茧研究所股份有限公司 | 向抗炎m2表型小胶质细胞的极性转化促进剂 |
| PL441229A1 (pl) * | 2022-05-19 | 2023-11-20 | Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polska Akademia Nauk | Zaprojektowane, syntetyczne peptydy, zawierające je kompozycje i sposoby ich zastosowania w leczeniu glejaków złośliwych |
| WO2024155124A1 (ko) * | 2023-01-20 | 2024-07-25 | (주)넥셀 | 치주염 및 임플란트 주변염 예방 또는 치료용 재조합 단백질 및 이를 포함하는 치주염 및 임플란트 주변염 예방 또는 치료용 조성물 |
| CN116650650A (zh) * | 2023-06-12 | 2023-08-29 | 郑州大学 | 一种抑制食管鳞癌中肿瘤相关巨噬细胞浸润的方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6410516B1 (en) | 1986-01-09 | 2002-06-25 | President & Fellows Of Harvard College | Nuclear factors associated with transcriptional regulation |
| AU630496B2 (en) * | 1989-07-14 | 1992-10-29 | Schering Corporation | Antagonists of gm-csf derived from the carboxyl terminus |
| EP0486572B1 (en) * | 1989-08-11 | 1998-01-07 | Amrad Corporation Limited | Improvements in granulocyte-macrophage colony-stimulating factor receptor and derivatives thereof |
| AUPN780096A0 (en) * | 1996-01-30 | 1996-02-22 | Medvet Science Pty. Ltd. | Cytokine antagonists and agonists |
| US5837231A (en) * | 1996-06-27 | 1998-11-17 | Regents Of The University Of Minnesota | GM-CSF administration for the treatment and prevention of recurrence of brain tumors |
| US6372720B1 (en) | 1998-02-05 | 2002-04-16 | Kenneth J. Longmuir | Liposome fusion and delivery vehicle |
| CA2288680A1 (en) | 1998-11-12 | 2000-05-12 | Jcr Pharmaceuticals Co., Ltd. | Modulation of cell proliferative disorders by cyclic rgd |
| US6551990B2 (en) * | 1998-12-07 | 2003-04-22 | University Of Washington | Methods of inhibiting ectopic calcification |
| EP1140194A2 (en) | 1998-12-23 | 2001-10-10 | G.D. SEARLE & CO. | Use of cyclooxygenase-2 inhibitor, a matrix metallaproteinase inhibitor, an antineoplastic agent and optionally radiation as a combined treatment of neoplasia |
| US6521593B1 (en) | 1999-02-01 | 2003-02-18 | Childrens Hospital Los Angeles | Methods for inhibiting brain tumor growth |
| ES2362715T3 (es) * | 2000-03-30 | 2011-07-12 | Dendreon Corporation | Composiciones y métodos para inmunoterapia a base de células dendríticas. |
| US7767802B2 (en) | 2001-01-09 | 2010-08-03 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| US7611711B2 (en) * | 2001-01-17 | 2009-11-03 | Vegenics Limited | VEGFR-3 inhibitor materials and methods |
| US7063860B2 (en) | 2001-08-13 | 2006-06-20 | University Of Pittsburgh | Application of lipid vehicles and use for drug delivery |
| AU2003276828A1 (en) * | 2002-05-10 | 2004-03-11 | Children's Medical Center Corporation | Minicell display and products therefrom |
| EP1848453B1 (en) * | 2005-02-18 | 2010-10-27 | Proximagen Ltd. | Treatment for neurodegeneration |
| EP2385061A3 (en) * | 2005-05-10 | 2012-02-22 | Neoloch Aps | Neuritogenic peptides |
| JP2009508650A (ja) * | 2005-09-21 | 2009-03-05 | ダスク テクノロジーズ， エルエルシー | 臓器および組織機能のための方法および組成 |
| ES2521679T3 (es) | 2006-01-18 | 2014-11-13 | Merck Patent Gmbh | Terapia específica usando ligandos de integrinas para el tratamiento del cáncer |
| RU2495050C2 (ru) * | 2006-03-27 | 2013-10-10 | Медимьюн Лимитед | Связующий элемент для рецептора gm-csf |
| WO2008112659A2 (en) | 2007-03-09 | 2008-09-18 | Pathologica Llc | Regulation of osteopontin |
| WO2009052286A1 (en) | 2007-10-16 | 2009-04-23 | Ventana Medical Systems, Inc. | Grading, staging, and prognosing cancer using osteopontin-c |
| NZ621196A (en) * | 2008-01-22 | 2015-08-28 | Araim Pharmaceuticals Inc | Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage |
| US20110230423A1 (en) | 2008-11-20 | 2011-09-22 | Martin Andreas Picard | Therapy and medicament using integrin ligands for treating cancer |
| NZ597339A (en) | 2009-05-25 | 2013-10-25 | Merck Patent Gmbh | Continuous administration of cilengitide in cancer treatments |
| CA2798074A1 (en) * | 2010-04-27 | 2011-11-03 | The Johns Hopkins University | Immunogenic compositions and methods for treating neoplasia |
-
2012
- 2012-11-18 WO PCT/IB2012/056533 patent/WO2013072901A2/en not_active Ceased
- 2012-11-18 JP JP2014541807A patent/JP6426001B2/ja not_active Expired - Fee Related
- 2012-11-18 CA CA2856329A patent/CA2856329A1/en not_active Abandoned
- 2012-11-18 EP EP12801640.9A patent/EP2780363B1/en not_active Not-in-force
- 2012-11-18 KR KR1020147016562A patent/KR20140103122A/ko not_active Ceased
-
2014
- 2014-05-15 IL IL232648A patent/IL232648B/en unknown
- 2014-05-16 US US14/280,095 patent/US9453050B2/en not_active Expired - Fee Related
-
2016
- 2016-08-09 US US15/232,165 patent/US20170035851A1/en not_active Abandoned