IL232648B - An isolated peptide to inhibit gm–csf activity - Google Patents

An isolated peptide to inhibit gm–csf activity

Info

Publication number
IL232648B
IL232648B IL232648A IL23264814A IL232648B IL 232648 B IL232648 B IL 232648B IL 232648 A IL232648 A IL 232648A IL 23264814 A IL23264814 A IL 23264814A IL 232648 B IL232648 B IL 232648B
Authority
IL
Israel
Prior art keywords
inhibiting
isolated peptide
csf activity
csf
activity
Prior art date
Application number
IL232648A
Other languages
English (en)
Hebrew (he)
Other versions
IL232648A0 (en
Inventor
Bozena Kaminska-Kaczmarek
Malgorzata Sielska
Aleksandra Ellert-Miklaszewska
Pawel Wisniewski
Original Assignee
Nencki Inst Of Experimental Biology
Glia Sp Z O O
Kaminska Kaczmarek Bozena
Malgorzata Sielska
Ellert Miklaszewska Aleksandra
Pawel Wisniewski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nencki Inst Of Experimental Biology, Glia Sp Z O O, Kaminska Kaczmarek Bozena, Malgorzata Sielska, Ellert Miklaszewska Aleksandra, Pawel Wisniewski filed Critical Nencki Inst Of Experimental Biology
Publication of IL232648A0 publication Critical patent/IL232648A0/en
Publication of IL232648B publication Critical patent/IL232648B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
IL232648A 2011-11-17 2014-05-15 An isolated peptide to inhibit gm–csf activity IL232648B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161561080P 2011-11-17 2011-11-17
US201261583745P 2012-01-06 2012-01-06
PCT/IB2012/056533 WO2013072901A2 (en) 2011-11-17 2012-11-18 Compositions and methods for treating glioma

Publications (2)

Publication Number Publication Date
IL232648A0 IL232648A0 (en) 2014-06-30
IL232648B true IL232648B (en) 2021-12-01

Family

ID=47358252

Family Applications (1)

Application Number Title Priority Date Filing Date
IL232648A IL232648B (en) 2011-11-17 2014-05-15 An isolated peptide to inhibit gm–csf activity

Country Status (7)

Country Link
US (2) US9453050B2 (enExample)
EP (1) EP2780363B1 (enExample)
JP (1) JP6426001B2 (enExample)
KR (1) KR20140103122A (enExample)
CA (1) CA2856329A1 (enExample)
IL (1) IL232648B (enExample)
WO (1) WO2013072901A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201220573D0 (en) 2012-11-15 2013-01-02 Univ Central Lancashire Methods of diagnosing proliferative disorders
DE102014207498A1 (de) * 2014-04-17 2015-10-22 Universitätsklinikum Hamburg-Eppendorf Viraler Vektor für den zielgerichteten Gentransfer in Gehirn und Rückenmark
EP3739039B1 (en) * 2014-09-26 2024-08-28 National University of Singapore Methods and compositions for modulating th-gm cell function
US11078264B2 (en) * 2018-10-17 2021-08-03 University Of Connecticut Inhibiting granulocyte macrophage-colony stimulating factor (GM-CSF) prevents preterm birth
US20230054634A1 (en) * 2018-11-28 2023-02-23 Glia Sp. Z O.O. Compositions and methods for treating glioma
CN112007142B (zh) * 2019-05-31 2025-04-22 生物蚕茧研究所股份有限公司 向抗炎m2表型小胶质细胞的极性转化促进剂
PL441229A1 (pl) * 2022-05-19 2023-11-20 Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polska Akademia Nauk Zaprojektowane, syntetyczne peptydy, zawierające je kompozycje i sposoby ich zastosowania w leczeniu glejaków złośliwych
KR102899196B1 (ko) * 2023-01-20 2025-12-12 (주) 넥셀 치주염 및 임플란트 주변염 예방 또는 치료용 재조합 단백질 및 이를 포함하는 치주염 및 임플란트 주변염 예방 또는 치료용 조성물
CN116650650A (zh) * 2023-06-12 2023-08-29 郑州大学 一种抑制食管鳞癌中肿瘤相关巨噬细胞浸润的方法

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US6150090A (en) 1986-01-09 2000-11-21 Massachusetts Institute Of Technology Nuclear factors associated with transcriptional regulation
PH27534A (en) * 1989-07-14 1993-08-18 Schering Corp Antoganists of gm-csf derived from the carboxyl terminus
JP3267966B2 (ja) * 1989-08-11 2002-03-25 アムラド・コーポレイション・リミテッド 顆粒球―マクロファージコロニー刺激因子受容体およびその誘導体における改良
AUPN780096A0 (en) * 1996-01-30 1996-02-22 Medvet Science Pty. Ltd. Cytokine antagonists and agonists
US5837231A (en) * 1996-06-27 1998-11-17 Regents Of The University Of Minnesota GM-CSF administration for the treatment and prevention of recurrence of brain tumors
US6372720B1 (en) 1998-02-05 2002-04-16 Kenneth J. Longmuir Liposome fusion and delivery vehicle
CA2288680A1 (en) 1998-11-12 2000-05-12 Jcr Pharmaceuticals Co., Ltd. Modulation of cell proliferative disorders by cyclic rgd
US6551990B2 (en) * 1998-12-07 2003-04-22 University Of Washington Methods of inhibiting ectopic calcification
JP2002533404A (ja) 1998-12-23 2002-10-08 ジー・ディー・サール・アンド・カンパニー 新生物形成の治療における組合わせ療法としてインテグリン拮抗剤及び放射線治療を使用する方法
US6521593B1 (en) 1999-02-01 2003-02-18 Childrens Hospital Los Angeles Methods for inhibiting brain tumor growth
DK1272633T3 (da) * 2000-03-30 2011-05-23 Dendreon Corp Præparater og fremgangsmåder til dendritisk celle-baseret immunterapi
US7767802B2 (en) 2001-01-09 2010-08-03 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of anti-apoptotic genes
US7611711B2 (en) * 2001-01-17 2009-11-03 Vegenics Limited VEGFR-3 inhibitor materials and methods
US7063860B2 (en) 2001-08-13 2006-06-20 University Of Pittsburgh Application of lipid vehicles and use for drug delivery
AU2003276828A1 (en) * 2002-05-10 2004-03-11 Children's Medical Center Corporation Minicell display and products therefrom
DE602006017806D1 (de) * 2005-02-18 2010-12-09 Proximagen Ltd Behandlung von neurodegeneration
EP2377884A1 (en) * 2005-05-10 2011-10-19 Neoloch Aps Neuritogenic peptides
AU2006292203A1 (en) * 2005-09-21 2007-03-29 Dask Technologies, Llc Methods and compositions for organ and tissue functionality
EP2335733B1 (en) 2006-01-18 2014-08-06 Merck Patent GmbH Specific therapy using integrin ligands for treating cancer
CA2647449C (en) * 2006-03-27 2017-05-16 Medimmune Limited Binding member for gm-csf receptor
ES2627676T3 (es) 2007-03-09 2017-07-31 Pathologica Llc MGBG para la regulación de osteopontina y el tratamiento de la esclerosis múltiple
ES2538362T3 (es) 2007-10-16 2015-06-19 Ventana Medical Systems, Inc. Clasificación, estadificación y pronóstico del cáncer mediante el uso de osteopontina-C
JP5542064B2 (ja) * 2008-01-22 2014-07-09 アライム ファーマシューティカルズ，インコーポレーテッド 組織の損傷に関連した疾患及び障害を予防及び治療する、組織保護ペプチド及びペプチド類似体
KR20110086757A (ko) 2008-11-20 2011-07-29 메르크 파텐트 게엠베하 암을 치료하기 위해 인테그린 리간드를 사용하는 신규한 치료요법 및 약제
EP2445534A2 (en) 2009-05-25 2012-05-02 Merck Patent GmbH Continuous administration of cilengitide in cancer treatments
JP6042802B2 (ja) * 2010-04-27 2016-12-14 ザ・ジョンズ・ホプキンス・ユニバーシティ 新生物（腫瘍）を治療するための免疫原性組成物及び方法。

Also Published As

Publication number Publication date
IL232648A0 (en) 2014-06-30
KR20140103122A (ko) 2014-08-25
JP6426001B2 (ja) 2018-11-21
US20140256628A1 (en) 2014-09-11
US20170035851A1 (en) 2017-02-09
WO2013072901A2 (en) 2013-05-23
EP2780363B1 (en) 2019-07-03
US9453050B2 (en) 2016-09-27
CA2856329A1 (en) 2013-05-23
EP2780363A2 (en) 2014-09-24
JP2014533681A (ja) 2014-12-15
WO2013072901A3 (en) 2013-07-25

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