KR20140103122A - 신경교종을 치료하기 위한 조성물 및 방법 - Google Patents

신경교종을 치료하기 위한 조성물 및 방법 Download PDF

Info

Publication number
KR20140103122A
KR20140103122A KR1020147016562A KR20147016562A KR20140103122A KR 20140103122 A KR20140103122 A KR 20140103122A KR 1020147016562 A KR1020147016562 A KR 1020147016562A KR 20147016562 A KR20147016562 A KR 20147016562A KR 20140103122 A KR20140103122 A KR 20140103122A
Authority
KR
South Korea
Prior art keywords
peptide
glioma
csf
seq
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020147016562A
Other languages
English (en)
Korean (ko)
Inventor
보제나 카민스카-카츠마렉
말고르자타 시엘스카
파벨 비스니에프스키
알렉산드라 엘레르트-미클라셰프스카
Original Assignee
넨키 인스티튜트 오브 익스페리멘탈 바이올로지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 넨키 인스티튜트 오브 익스페리멘탈 바이올로지 filed Critical 넨키 인스티튜트 오브 익스페리멘탈 바이올로지
Publication of KR20140103122A publication Critical patent/KR20140103122A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
KR1020147016562A 2011-11-17 2012-11-18 신경교종을 치료하기 위한 조성물 및 방법 Ceased KR20140103122A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161561080P 2011-11-17 2011-11-17
US61/561,080 2011-11-17
US201261583745P 2012-01-06 2012-01-06
US61/583,745 2012-01-06
PCT/IB2012/056533 WO2013072901A2 (en) 2011-11-17 2012-11-18 Compositions and methods for treating glioma

Publications (1)

Publication Number Publication Date
KR20140103122A true KR20140103122A (ko) 2014-08-25

Family

ID=47358252

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147016562A Ceased KR20140103122A (ko) 2011-11-17 2012-11-18 신경교종을 치료하기 위한 조성물 및 방법

Country Status (7)

Country Link
US (2) US9453050B2 (enExample)
EP (1) EP2780363B1 (enExample)
JP (1) JP6426001B2 (enExample)
KR (1) KR20140103122A (enExample)
CA (1) CA2856329A1 (enExample)
IL (1) IL232648B (enExample)
WO (1) WO2013072901A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220025115A (ko) * 2014-09-26 2022-03-03 내셔널 유니버시티 오브 싱가포르 Th-gm 세포 기능 조절 방법 및 조성물
WO2024155124A1 (ko) * 2023-01-20 2024-07-25 (주)넥셀 치주염 및 임플란트 주변염 예방 또는 치료용 재조합 단백질 및 이를 포함하는 치주염 및 임플란트 주변염 예방 또는 치료용 조성물

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201220573D0 (en) 2012-11-15 2013-01-02 Univ Central Lancashire Methods of diagnosing proliferative disorders
DE102014207498A1 (de) * 2014-04-17 2015-10-22 Universitätsklinikum Hamburg-Eppendorf Viraler Vektor für den zielgerichteten Gentransfer in Gehirn und Rückenmark
US11078264B2 (en) 2018-10-17 2021-08-03 University Of Connecticut Inhibiting granulocyte macrophage-colony stimulating factor (GM-CSF) prevents preterm birth
EP3886888A4 (en) * 2018-11-28 2022-09-28 Glia Sp. z o.o. COMPOSITIONS AND METHODS OF TREATMENT OF GLIOMA
CN112007142B (zh) * 2019-05-31 2025-04-22 生物蚕茧研究所股份有限公司 向抗炎m2表型小胶质细胞的极性转化促进剂
KR102758046B1 (ko) * 2021-11-05 2025-01-23 (주) 넥셀 궤양성 대장염 예방 또는 치료용 재조합 단백질 및 이를 포함하는 궤양성 대장염 예방 또는 치료용 조성물
PL441229A1 (pl) * 2022-05-19 2023-11-20 Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polska Akademia Nauk Zaprojektowane, syntetyczne peptydy, zawierające je kompozycje i sposoby ich zastosowania w leczeniu glejaków złośliwych
CN116650650A (zh) * 2023-06-12 2023-08-29 郑州大学 一种抑制食管鳞癌中肿瘤相关巨噬细胞浸润的方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150090A (en) 1986-01-09 2000-11-21 Massachusetts Institute Of Technology Nuclear factors associated with transcriptional regulation
NZ234479A (en) * 1989-07-14 1992-03-26 Schering Corp Antagonists of gm-csf derived from the carboxyl terminus, antibodies, hybridomas and pharmaceutical compositions containing anti-idiotypic antibodies
DK0486572T3 (da) * 1989-08-11 1998-05-04 Amrad Corp Ltd Forbedringer i granulocyt-makrofag-kolonistimulerende faktorreceptor og derivater deraf
AUPN780096A0 (en) * 1996-01-30 1996-02-22 Medvet Science Pty. Ltd. Cytokine antagonists and agonists
US5837231A (en) * 1996-06-27 1998-11-17 Regents Of The University Of Minnesota GM-CSF administration for the treatment and prevention of recurrence of brain tumors
US6372720B1 (en) 1998-02-05 2002-04-16 Kenneth J. Longmuir Liposome fusion and delivery vehicle
AU756916B2 (en) 1998-11-12 2003-01-23 Jcr Pharmaceuticals Co., Ltd. Modulation of cell proliferative disorders by cyclic RGD
US6551990B2 (en) * 1998-12-07 2003-04-22 University Of Washington Methods of inhibiting ectopic calcification
WO2000038715A2 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. Use of an integrin antagonist and radiation in the treatment of neoplasia
US6521593B1 (en) 1999-02-01 2003-02-18 Childrens Hospital Los Angeles Methods for inhibiting brain tumor growth
US7060279B2 (en) * 2000-03-30 2006-06-13 Dendreon Corporation Compositions and methods for dendritic cell-based immunotherapy
US7767802B2 (en) 2001-01-09 2010-08-03 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of anti-apoptotic genes
US7611711B2 (en) * 2001-01-17 2009-11-03 Vegenics Limited VEGFR-3 inhibitor materials and methods
WO2003015698A2 (en) 2001-08-13 2003-02-27 University Of Pittsburgh Application of lipid vehicles and use for drug delivery
WO2004018498A2 (en) * 2002-05-10 2004-03-04 Children's Medical Center Corporation Minicell display and products therefrom
EP1848453B1 (en) * 2005-02-18 2010-10-27 Proximagen Ltd. Treatment for neurodegeneration
EP2377884A1 (en) * 2005-05-10 2011-10-19 Neoloch Aps Neuritogenic peptides
JP2009508650A (ja) * 2005-09-21 2009-03-05 ダスク テクノロジーズ, エルエルシー 臓器および組織機能のための方法および組成
KR20080089489A (ko) 2006-01-18 2008-10-06 메르크 파텐트 게엠베하 인테그린 리간드를 사용하는 암치료용 특이적 요법
KR101481844B1 (ko) * 2006-03-27 2015-01-13 메디뮨 리미티드 Gm-csf 수용체에 대한 결합 성분
DK2121586T3 (en) 2007-03-09 2017-06-19 Pathologica Llc MGBG FOR THE REGULATION OF OSTEOPONTIN AND THE TREATMENT OF MULTIPLE SCLEROSIS
DK2201138T3 (en) 2007-10-16 2015-05-18 Ventana Med Syst Inc GRADING, STAGE DETERMINATION AND FORECAST OF CANCER USING osteopontin-C
WO2009094172A2 (en) * 2008-01-22 2009-07-30 Araim Pharmaceuticals, Inc. Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage
AU2009317549A1 (en) 2008-11-20 2011-07-07 Merck Patent Gmbh New therapy and medicament using integrin ligands for treating cancer
AU2010252280A1 (en) 2009-05-25 2012-01-19 Merck Patent Gmbh Continuous administration of cilengitide in cancer treatments
CA2798074A1 (en) * 2010-04-27 2011-11-03 The Johns Hopkins University Immunogenic compositions and methods for treating neoplasia

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220025115A (ko) * 2014-09-26 2022-03-03 내셔널 유니버시티 오브 싱가포르 Th-gm 세포 기능 조절 방법 및 조성물
WO2024155124A1 (ko) * 2023-01-20 2024-07-25 (주)넥셀 치주염 및 임플란트 주변염 예방 또는 치료용 재조합 단백질 및 이를 포함하는 치주염 및 임플란트 주변염 예방 또는 치료용 조성물

Also Published As

Publication number Publication date
WO2013072901A3 (en) 2013-07-25
EP2780363A2 (en) 2014-09-24
US20140256628A1 (en) 2014-09-11
IL232648A0 (en) 2014-06-30
IL232648B (en) 2021-12-01
JP2014533681A (ja) 2014-12-15
EP2780363B1 (en) 2019-07-03
WO2013072901A2 (en) 2013-05-23
JP6426001B2 (ja) 2018-11-21
US20170035851A1 (en) 2017-02-09
US9453050B2 (en) 2016-09-27
CA2856329A1 (en) 2013-05-23

Similar Documents

Publication Publication Date Title
JP6426001B2 (ja) 神経膠腫を治療するための組成物および方法
EP2513146B1 (en) Antibodies against ror1 capable of inducing cell death of cll
EP3428186A1 (en) Treatment of fibrosis of the liver with antibodies which prevent il-11:il-11ralpha interaction
US20130273057A1 (en) Methods and compositions for the treatment and diagnosis of vascular inflammatory disorders or endothelial cell disorders
US20210277102A1 (en) Compositions and methods for treating a tumor suppressor deficient cancer
KR20200100866A (ko) 항-전이성 요법에서 axl 신호전달의 저해
US20090048432A1 (en) Anti-il-20 antibody and its use in treating il-20 associated inflammatory diseases
JP2011256179A (ja) 血管形成及び腫瘍増殖阻害用ポリペプチド化合物及びその応用
WO2011066284A1 (en) Methods and compositions for the treatment of immune disorders
KR20150122786A (ko) 암 전이의 진단, 예후 및 치료를 위한 방법
JP6053255B2 (ja) 新規癌抗原eEF2
KR20130107203A (ko) 섬유증의 검출 및 치료
Li et al. Pathogenic Tconvs promote inflammatory macrophage polarization through GM‐CSF and exacerbate abdominal aortic aneurysm formation
JP6078633B2 (ja) 治療用のチオレドキシン相互作用タンパク質(txnip)のインヒビター
CN106029101A (zh) 生物材料和其治疗用途
JP2024511569A (ja) 免疫増強剤
CN106177953A (zh) Tlr3抑制剂在制备防治肿瘤转移产品中的应用
US20240307531A1 (en) Compositions and methods of treating sarcoma lung metastasis
US20250388639A1 (en) Therapeutic applications based on the inhibition of G Protein-Coupled Receptor 182 (GPR182)
EP3468564A1 (en) Methods for diagnosing and treating metastatic cancer
US20250297310A1 (en) Hematopoietic loss of y chromosome leads to cardiac fibrosis and dysfunction and is associated with death due to heart failure
EP2575883B1 (en) Treatment of inflammatory disorders
US11155820B2 (en) Target of VGSC β3 protein for prevention, treatment and diagnostic detection of cancers
KR101522729B1 (ko) 파골세포 융합의 새로운 바이오 마커인 piro
US9150929B2 (en) Anaplastic thyroid cancers harbor novel oncogenic mutations of the ALK gene

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20140617

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
N231 Notification of change of applicant
PN2301 Change of applicant

Patent event date: 20150327

Comment text: Notification of Change of Applicant

Patent event code: PN23011R01D

A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20171108

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20190827

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20200611

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20190827

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I