JP2012092108A5 - - Google Patents

Info

Publication number

JP2012092108A5

JP2012092108A5 JP2011252115A JP2011252115A JP2012092108A5 JP 2012092108 A5 JP2012092108 A5 JP 2012092108A5 JP 2011252115 A JP2011252115 A JP 2011252115A JP 2011252115 A JP2011252115 A JP 2011252115A JP 2012092108 A5 JP2012092108 A5 JP 2012092108A5

Authority

JP

Japan

Prior art keywords

increased

composition

peptide

group

bioactive component

Prior art date

2011-11-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 12
• 239000000203 mixture Substances 0.000 claims 6
• 229960003604 testosterone Drugs 0.000 claims 6
• 238000000034 method Methods 0.000 claims 5
• 108090000765 processed proteins & peptides Proteins 0.000 claims 5
• 230000000975 bioactive effect Effects 0.000 claims 4
• 239000006286 aqueous extract Substances 0.000 claims 3
• 230000015572 biosynthetic process Effects 0.000 claims 3
• 238000004007 reversed phase HPLC Methods 0.000 claims 3
• 230000019100 sperm motility Effects 0.000 claims 3
• 238000003786 synthesis reaction Methods 0.000 claims 3
• 240000005739 Eurycoma longifolia Species 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 239000012501 chromatography medium Substances 0.000 claims 2
• DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims 1
• HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
• 108010015899 Glycopeptides Proteins 0.000 claims 1
• 102000002068 Glycopeptides Human genes 0.000 claims 1
• 238000011993 High Performance Size Exclusion Chromatography Methods 0.000 claims 1
• 208000007466 Male Infertility Diseases 0.000 claims 1
• 206010057672 Male sexual dysfunction Diseases 0.000 claims 1
• 238000013375 chromatographic separation Methods 0.000 claims 1
• 238000004587 chromatography analysis Methods 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 238000005194 fractionation Methods 0.000 claims 1
• 238000004128 high performance liquid chromatography Methods 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 238000001542 size-exclusion chromatography Methods 0.000 claims 1
• 210000001550 testis Anatomy 0.000 claims 1