JP2014533098A - グルカゴン結合核酸 - Google Patents

グルカゴン結合核酸 Download PDF

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Publication number
JP2014533098A
JP2014533098A JP2014536148A JP2014536148A JP2014533098A JP 2014533098 A JP2014533098 A JP 2014533098A JP 2014536148 A JP2014536148 A JP 2014536148A JP 2014536148 A JP2014536148 A JP 2014536148A JP 2014533098 A JP2014533098 A JP 2014533098A
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Japan
Prior art keywords
present
nucleic acid
acid molecule
seq
nucleotide sequence
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Pending
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JP2014536148A
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English (en)
Japanese (ja)
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JP2014533098A5 (enExample
Inventor
プルシュケ，ヴェルナー
ゼル，ジモーネ
ファーター，アクセル
ブッフナー，クラウス
マーシュ，クリスティアン
クルースマン，スヴェン
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ノクソン・ファルマ・アクチエンゲゼルシャフト
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Priority claimed from PCT/EP2012/000089 external-priority patent/WO2012095303A1/en
Application filed by ノクソン・ファルマ・アクチエンゲゼルシャフト filed Critical ノクソン・ファルマ・アクチエンゲゼルシャフト
Publication of JP2014533098A publication Critical patent/JP2014533098A/ja
Publication of JP2014533098A5 publication Critical patent/JP2014533098A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014536148A 2011-10-21 2012-10-22 グルカゴン結合核酸 Pending JP2014533098A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP11008473 2011-10-21
EP11008473.8 2011-10-21
EP11008467 2011-10-21
EP11008467.0 2011-10-21
PCT/EP2012/000089 WO2012095303A1 (en) 2011-01-10 2012-01-10 Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same
EPPCT/EP2012/000089 2012-01-10
EP12000107 2012-01-10
EP12000107.8 2012-01-10
PCT/EP2012/004421 WO2013056852A1 (en) 2011-10-21 2012-10-22 Glucagon binding nucleic acids

Publications (2)

Publication Number Publication Date
JP2014533098A true JP2014533098A (ja) 2014-12-11
JP2014533098A5 JP2014533098A5 (enExample) 2015-12-10

Family

ID=48140366

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014536148A Pending JP2014533098A (ja) 2011-10-21 2012-10-22 グルカゴン結合核酸

Country Status (12)

Country Link
US (1) US20150232852A1 (enExample)
EP (1) EP2768960A1 (enExample)
JP (1) JP2014533098A (enExample)
KR (1) KR20140083039A (enExample)
CN (1) CN103958682A (enExample)
AU (1) AU2012325233A1 (enExample)
BR (1) BR112014009104A2 (enExample)
CA (1) CA2852802A1 (enExample)
IL (1) IL231980A0 (enExample)
MX (1) MX2014004658A (enExample)
SG (1) SG11201401362TA (enExample)
WO (1) WO2013056852A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021063038A (ja) * 2019-10-16 2021-04-22 国立研究開発法人産業技術総合研究所 グルカゴン認識ペプチド並びにグルカゴン検出法
WO2025205956A1 (ja) * 2024-03-26 2025-10-02 国立研究開発法人産業技術総合研究所 グルカゴン認識ペプチド並びにグルカゴン検出法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2802660T (pt) 2012-01-10 2020-04-21 Aptarion Biotech Ag Novos ácidos nucleicos que se ligam a c5a
CN103343126B (zh) * 2013-07-19 2015-12-02 暨南大学 莱克多巴胺适配体与检测莱克多巴胺的适配体电化学生物传感器
WO2015113776A1 (en) * 2014-02-03 2015-08-06 Noxxon Pharma Ag Methods for the preparation of a polyalkoxylated nucleic acid molecule
ES2607639B1 (es) * 2015-09-30 2018-02-28 Urquima, S.A Sal de ácido maleico de un intermedio de silodosina
WO2017062693A1 (en) * 2015-10-07 2017-04-13 Remd Biotherapeutics, Inc. Methods for treating rare genetic disorders using glucagon receptor antagonistic antibodies
BR112019009373A8 (pt) 2016-11-30 2023-04-11 Noxxon Pharma Ag Método para polialcoxilação de ácidos nucleicos que permite recuperação e reutilização do excesso de reagente de polialcoxilação

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007014292A (ja) * 2005-07-08 2007-01-25 Tokyo Univ Of Agriculture & Technology アプタマーの同定方法

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US6011020A (en) 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US6395029B1 (en) 1999-01-19 2002-05-28 The Children's Hospital Of Philadelphia Sustained delivery of polyionic bioactive agents
US6677136B2 (en) * 2000-05-03 2004-01-13 Amgen Inc. Glucagon antagonists
US6652886B2 (en) 2001-02-16 2003-11-25 Expression Genetics Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
EP1306382A1 (de) 2001-10-26 2003-05-02 Noxxon Pharma AG Modifizierte L-Nukleinsäure
EP1438321B1 (de) 2001-10-26 2010-05-26 Noxxon Pharma AG Modifizierte l-nukleinsäure
WO2003070823A2 (en) 2002-02-20 2003-08-28 The General Hospital Corporation Conjugates comprising a biodegradable polymer and uses therefor
AU2004230927B9 (en) 2003-04-13 2011-12-01 Enzon Pharmaceuticals, Inc. Polymeric oligonucleotide prodrugs
GB0314472D0 (en) 2003-06-20 2003-07-23 Warwick Effect Polymers Ltd Polymer
KR101189555B1 (ko) 2004-02-09 2012-10-16 주프라몰 파렌테랄 콜로이츠 게엠베하 폴리사카라이드 및 폴리뉴클레오티드로부터 접합체를제조하는 방법
CA2786794C (en) 2004-03-23 2017-09-12 Complex Biosystems Gmbh Aromatic polymeric cascade prodrug linker reagent
EP1807092B1 (en) 2004-11-05 2016-09-07 The Children's Hospital of Philadelphia Biodegradable linkers for molecular therapies
MX2007013760A (es) * 2005-05-04 2008-01-28 Noxxon Pharma Ag Uso novedoso de spiegelmers.
WO2008034122A2 (en) 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Hindered ester-based biodegradable linkers for oligonucleotide delivery
WO2008052774A2 (en) 2006-10-31 2008-05-08 Noxxon Pharma Ag Methods for detection of a single- or double-stranded nucleic acid molecule
WO2012095303A1 (en) * 2011-01-10 2012-07-19 Noxxon Pharma Ag Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007014292A (ja) * 2005-07-08 2007-01-25 Tokyo Univ Of Agriculture & Technology アプタマーの同定方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
EATON BRUCE E: "POST SELEX COMBINATORIAL OPTIMIZATION OF APTAMERS", BIOORGANIC & MEDICINAL CHEMISTRY, vol. V5 N6, JPN5014003218, 1 January 1997 (1997-01-01), GB, pages 1087 - 1096, ISSN: 0003362417 *
JOHN FERGUSON: "NUCLEIC APTAMER AGAINST FIBRILLATION OF GLUCAGON", [ONLINE], JPN5014011358, 16 September 2011 (2011-09-16), ISSN: 0003362414 *
VATER A. ET AL., CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, vol. 6(2)(2003), JPN6016027823, pages 253 - 261, ISSN: 0003362416 *
YOSHIDA W. ET AL., BIOSENSORS AND BIOELECTRONICS, vol. 24(2009), JPN6016027820, pages 1116 - 1120, ISSN: 0003362415 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021063038A (ja) * 2019-10-16 2021-04-22 国立研究開発法人産業技術総合研究所 グルカゴン認識ペプチド並びにグルカゴン検出法
JP7418788B2 (ja) 2019-10-16 2024-01-22 国立研究開発法人産業技術総合研究所 グルカゴン認識ペプチド並びにグルカゴン検出法
WO2025205956A1 (ja) * 2024-03-26 2025-10-02 国立研究開発法人産業技術総合研究所 グルカゴン認識ペプチド並びにグルカゴン検出法

Also Published As

Publication number Publication date
KR20140083039A (ko) 2014-07-03
AU2012325233A1 (en) 2014-04-24
EP2768960A1 (en) 2014-08-27
MX2014004658A (es) 2015-08-13
US20150232852A1 (en) 2015-08-20
SG11201401362TA (en) 2014-05-29
BR112014009104A2 (pt) 2017-04-18
IL231980A0 (en) 2014-05-28
AU2012325233A2 (en) 2014-04-24
CN103958682A (zh) 2014-07-30
CA2852802A1 (en) 2013-04-25
WO2013056852A1 (en) 2013-04-25

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