JP2014533098A - グルカゴン結合核酸 - Google Patents

グルカゴン結合核酸 Download PDF

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Publication number
JP2014533098A
JP2014533098A JP2014536148A JP2014536148A JP2014533098A JP 2014533098 A JP2014533098 A JP 2014533098A JP 2014536148 A JP2014536148 A JP 2014536148A JP 2014536148 A JP2014536148 A JP 2014536148A JP 2014533098 A JP2014533098 A JP 2014533098A
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JP
Japan
Prior art keywords
present
nucleic acid
acid molecule
seq
nucleotide sequence
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Pending
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JP2014536148A
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English (en)
Japanese (ja)
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JP2014533098A5 (enExample
Inventor
プルシュケ，ヴェルナー
ゼル，ジモーネ
ファーター，アクセル
ブッフナー，クラウス
マーシュ，クリスティアン
クルースマン，スヴェン
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ノクソン・ファルマ・アクチエンゲゼルシャフト
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Priority claimed from PCT/EP2012/000089 external-priority patent/WO2012095303A1/en
Application filed by ノクソン・ファルマ・アクチエンゲゼルシャフト filed Critical ノクソン・ファルマ・アクチエンゲゼルシャフト
Publication of JP2014533098A publication Critical patent/JP2014533098A/ja
Publication of JP2014533098A5 publication Critical patent/JP2014533098A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014536148A 2011-10-21 2012-10-22 グルカゴン結合核酸 Pending JP2014533098A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP11008467.0 2011-10-21
EP11008473.8 2011-10-21
EP11008467 2011-10-21
EP11008473 2011-10-21
EPPCT/EP2012/000089 2012-01-10
EP12000107 2012-01-10
PCT/EP2012/000089 WO2012095303A1 (en) 2011-01-10 2012-01-10 Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same
EP12000107.8 2012-01-10
PCT/EP2012/004421 WO2013056852A1 (en) 2011-10-21 2012-10-22 Glucagon binding nucleic acids

Publications (2)

Publication Number Publication Date
JP2014533098A true JP2014533098A (ja) 2014-12-11
JP2014533098A5 JP2014533098A5 (enExample) 2015-12-10

Family

ID=48140366

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014536148A Pending JP2014533098A (ja) 2011-10-21 2012-10-22 グルカゴン結合核酸

Country Status (12)

Country Link
US (1) US20150232852A1 (enExample)
EP (1) EP2768960A1 (enExample)
JP (1) JP2014533098A (enExample)
KR (1) KR20140083039A (enExample)
CN (1) CN103958682A (enExample)
AU (1) AU2012325233A1 (enExample)
BR (1) BR112014009104A2 (enExample)
CA (1) CA2852802A1 (enExample)
IL (1) IL231980A0 (enExample)
MX (1) MX2014004658A (enExample)
SG (1) SG11201401362TA (enExample)
WO (1) WO2013056852A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021063038A (ja) * 2019-10-16 2021-04-22 国立研究開発法人産業技術総合研究所 グルカゴン認識ペプチド並びにグルカゴン検出法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014016877B1 (pt) 2012-01-10 2022-03-15 Aptarion Biotech Ag Molécula de l-ácido nucleico capaz de se ligar a c5a humana, seus usos, bem como composição farmacêutica, complexo, método para a seleção de um antagonista de uma atividade mediada por c5a e kit para a detecção de c5a
CN103343126B (zh) * 2013-07-19 2015-12-02 暨南大学 莱克多巴胺适配体与检测莱克多巴胺的适配体电化学生物传感器
US10513536B2 (en) 2014-02-03 2019-12-24 Noxxon Pharma Ag Methods for the preparation of a polyalkoxylated nucleic acid molecule
ES2607639B1 (es) * 2015-09-30 2018-02-28 Urquima, S.A Sal de ácido maleico de un intermedio de silodosina
US20190062441A1 (en) * 2015-10-07 2019-02-28 Remd Biotherapeutics, Inc. Methods For Treating Rare Genetic Disorders Using Glucagon Receptor Antagonistic Antibodies
DE17829597T1 (de) 2016-11-30 2019-12-05 Noxxon Pharma Ag Verfahren zur polyalkoxylierung von nukleinsäuren zur rückgewinnung und wiederverwendung einer überschüssigen polyalkoxylierungsreagenz

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007014292A (ja) * 2005-07-08 2007-01-25 Tokyo Univ Of Agriculture & Technology アプタマーの同定方法

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US6011020A (en) 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US6395029B1 (en) 1999-01-19 2002-05-28 The Children's Hospital Of Philadelphia Sustained delivery of polyionic bioactive agents
US6677136B2 (en) * 2000-05-03 2004-01-13 Amgen Inc. Glucagon antagonists
US6652886B2 (en) 2001-02-16 2003-11-25 Expression Genetics Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
ES2346640T4 (es) 2001-10-26 2011-04-26 Noxxon Pharma Ag Ácido l-nucleico modificado.
EP1306382A1 (de) 2001-10-26 2003-05-02 Noxxon Pharma AG Modifizierte L-Nukleinsäure
EP2138575B8 (en) 2002-02-20 2013-07-24 Mersana Therapeutics, Inc. Conjugates comprising a biodegradable polymer and uses therefor
KR20060015505A (ko) 2003-04-13 2006-02-17 엔존 파마슈티컬즈, 인코포레이티드 올리고뉴클레오타이드 전구약물
GB0314472D0 (en) 2003-06-20 2003-07-23 Warwick Effect Polymers Ltd Polymer
US20090281296A1 (en) 2004-02-09 2009-11-12 Supramol Parenteral Colloid Gmbh Process for the production of conjugates from polysaccharides and polynucelotides
ES2741524T3 (es) 2004-03-23 2020-02-11 Ascendis Pharma Gmbh Profármaco polimérico con un enlazador autoinmolador
WO2006052790A2 (en) 2004-11-05 2006-05-18 The Children's Hospital Of Philadelphia Biodegradable linkers for molecular therapies
CA2607185A1 (en) * 2005-05-04 2006-11-09 Noxxon Pharma Ag Intracellular active agents
CN101534643A (zh) 2006-09-15 2009-09-16 安佐制药股份有限公司 用于递送寡核苷酸的基于位阻酯的生物可降解连接体
EP2407558A1 (en) 2006-10-31 2012-01-18 Noxxon Pharma AG Methods for the detection of a single- or double-stranded nucleic acid molecule
KR20140026357A (ko) * 2011-01-10 2014-03-05 녹손 파르마 아게 목표 분자에 결합력을 갖는 핵산 및 이를 제조하는 방법

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007014292A (ja) * 2005-07-08 2007-01-25 Tokyo Univ Of Agriculture & Technology アプタマーの同定方法

Non-Patent Citations (4)

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Title
EATON BRUCE E: "POST SELEX COMBINATORIAL OPTIMIZATION OF APTAMERS", BIOORGANIC & MEDICINAL CHEMISTRY, vol. V5 N6, JPN5014003218, 1 January 1997 (1997-01-01), GB, pages 1087 - 1096, ISSN: 0003362417 *
JOHN FERGUSON: "NUCLEIC APTAMER AGAINST FIBRILLATION OF GLUCAGON", [ONLINE], JPN5014011358, 16 September 2011 (2011-09-16), ISSN: 0003362414 *
VATER A. ET AL., CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, vol. 6(2)(2003), JPN6016027823, pages 253 - 261, ISSN: 0003362416 *
YOSHIDA W. ET AL., BIOSENSORS AND BIOELECTRONICS, vol. 24(2009), JPN6016027820, pages 1116 - 1120, ISSN: 0003362415 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021063038A (ja) * 2019-10-16 2021-04-22 国立研究開発法人産業技術総合研究所 グルカゴン認識ペプチド並びにグルカゴン検出法
JP7418788B2 (ja) 2019-10-16 2024-01-22 国立研究開発法人産業技術総合研究所 グルカゴン認識ペプチド並びにグルカゴン検出法

Also Published As

Publication number Publication date
MX2014004658A (es) 2015-08-13
CN103958682A (zh) 2014-07-30
IL231980A0 (en) 2014-05-28
AU2012325233A1 (en) 2014-04-24
SG11201401362TA (en) 2014-05-29
US20150232852A1 (en) 2015-08-20
KR20140083039A (ko) 2014-07-03
BR112014009104A2 (pt) 2017-04-18
WO2013056852A1 (en) 2013-04-25
EP2768960A1 (en) 2014-08-27
CA2852802A1 (en) 2013-04-25
AU2012325233A2 (en) 2014-04-24

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