JP2014532416A5 - - Google Patents
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- JP2014532416A5 JP2014532416A5 JP2014539105A JP2014539105A JP2014532416A5 JP 2014532416 A5 JP2014532416 A5 JP 2014532416A5 JP 2014539105 A JP2014539105 A JP 2014539105A JP 2014539105 A JP2014539105 A JP 2014539105A JP 2014532416 A5 JP2014532416 A5 JP 2014532416A5
- Authority
- JP
- Japan
- Prior art keywords
- murine
- human
- endogenous
- gene
- animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161552900P | 2011-10-28 | 2011-10-28 | |
| US61/552,900 | 2011-10-28 | ||
| US201161556579P | 2011-11-07 | 2011-11-07 | |
| US61/556,579 | 2011-11-07 | ||
| PCT/US2012/062379 WO2013063556A1 (en) | 2011-10-28 | 2012-10-29 | Humanized il-6 and il-6 receptor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016224713A Division JP2017035115A (ja) | 2011-10-28 | 2016-11-18 | ヒト化ｉｌ−６および／またはｉｌ−６受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532416A JP2014532416A (ja) | 2014-12-08 |
| JP2014532416A5 true JP2014532416A5 (cg-RX-API-DMAC7.html) | 2015-12-03 |
| JP6120451B2 JP6120451B2 (ja) | 2017-04-26 |
Family
ID=47295138
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539105A Active JP6120451B2 (ja) | 2011-10-28 | 2012-10-29 | ヒト化ｉｌ−６および／またはｉｌ−６受容体 |
| JP2016224713A Pending JP2017035115A (ja) | 2011-10-28 | 2016-11-18 | ヒト化ｉｌ−６および／またはｉｌ−６受容体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016224713A Pending JP2017035115A (ja) | 2011-10-28 | 2016-11-18 | ヒト化ｉｌ−６および／またはｉｌ−６受容体 |
Country Status (27)
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3417701T3 (da) | 2009-10-06 | 2022-03-14 | Regeneron Pharma | Genmodificerede mus og indpodning |
| MX338971B (es) | 2011-02-15 | 2016-05-06 | Inst Res Biomedicine Irb | Ratones de m-csf humanizada. |
| WO2013063556A1 (en) | 2011-10-28 | 2013-05-02 | Regeneron Pharmaceuticals, Inc. | Humanized il-6 and il-6 receptor |
| US20130261016A1 (en) * | 2012-03-28 | 2013-10-03 | Meso Scale Technologies, Llc | Diagnostic methods for inflammatory disorders |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| CN120718856A (zh) | 2012-09-07 | 2025-09-30 | 再生元制药公司 | 经遗传修饰的非人动物及其使用方法 |
| EP2896291B1 (en) * | 2012-09-13 | 2019-03-20 | Chugai Seiyaku Kabushiki Kaisha | Gene knock-in non-human animal |
| ES2748662T3 (es) * | 2012-11-05 | 2020-03-17 | Institute For Res In Biomedicine Irb | Roedores inmunodeficientes modificados genéticamente y métodos de uso de los mismos |
| SMT201900429T1 (it) | 2013-02-20 | 2019-09-09 | Regeneron Pharma | Topi esprimenti co-recettori umanizzati linfociti t |
| EP2958937B1 (en) | 2013-02-22 | 2018-08-15 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized major histocompatibility complex |
| GB2513884B (en) | 2013-05-08 | 2015-06-17 | Univ Bristol | Method and apparatus for producing an acoustic field |
| DK4269430T3 (da) * | 2013-09-23 | 2025-08-18 | Regeneron Pharma | Ikke-menneskelige dyr, der har et humaniseret signalregulerende proteingen |
| SI3138397T1 (sl) * | 2013-10-15 | 2019-04-30 | Regeneron Pharmaceuticals, Inc. | Humanizirane živali IL-15 |
| KR102173297B1 (ko) * | 2013-11-19 | 2020-11-03 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 증식-유도 리간드 유전자를 가지고 있는 비-인간 동물 |
| MY183188A (en) * | 2013-11-19 | 2021-02-18 | Regeneron Pharma | Non-human animals having a humanized b-cell activating factor gene |
| US9612658B2 (en) | 2014-01-07 | 2017-04-04 | Ultrahaptics Ip Ltd | Method and apparatus for providing tactile sensations |
| WO2016039801A1 (en) | 2014-01-31 | 2016-03-17 | Boehringer Ingelheim International Gmbh | Novel anti-baff antibodies |
| ES2794942T3 (es) | 2014-04-08 | 2020-11-19 | Regeneron Pharma | Animales no humanos que tienen receptores Fc-gamma humanizados |
| JP6598798B2 (ja) | 2014-05-05 | 2019-10-30 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｃ５およびｃ３動物 |
| NO2785538T3 (cg-RX-API-DMAC7.html) | 2014-05-07 | 2018-08-04 | ||
| EP4306648A3 (en) | 2014-05-19 | 2024-04-17 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice expressing human epo |
| US9497945B2 (en) * | 2014-05-30 | 2016-11-22 | Regeneron Pharmaceuticals, Inc. | Humanized dipeptidyl peptidase IV (DPP4) animals |
| WO2015196051A1 (en) * | 2014-06-19 | 2015-12-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized programmed cell death 1 gene |
| GB2530036A (en) | 2014-09-09 | 2016-03-16 | Ultrahaptics Ltd | Method and apparatus for modulating haptic feedback |
| RS63410B1 (sr) | 2014-11-24 | 2022-08-31 | Regeneron Pharma | Ne-humane životinje koje eksprimiraju humanizovani cd3 kompleks |
| BR112017010490A2 (pt) * | 2014-12-05 | 2018-04-03 | Regeneron Pharma | roedor, polipeptídeo cd47, célula ou tecido de roedor isolado, célula-tronco emprionária de roedor, embrião de roedor, e, métodos de produzir um roedor, de fornecimento de um roedor, de enxerto de células humanas em um roedor, de avaliação de eficácia terapêutica de uma droga direcionada a células humanas e de avaliar as propriedades farmacocinéticas, de avaliar a toxicidade específica e inespecífica de uma droga direcionada ao cd47 humano. |
| LT3230320T (lt) | 2014-12-09 | 2021-01-11 | Regeneron Pharmaceuticals, Inc. | Gyvūnai, išskyrus žmogų, turintys humanizuotą diferenciacijos klasterio 274 geną |
| CN107534810B (zh) | 2015-02-20 | 2019-12-20 | 超级触觉资讯处理有限公司 | 用于提供改进的触觉反馈的方法 |
| AU2016221500B2 (en) | 2015-02-20 | 2021-06-10 | Ultrahaptics Ip Limited | Perceptions in a haptic system |
| DK3280257T3 (da) | 2015-04-06 | 2023-09-04 | Regeneron Pharma | Humaniseret T-celle-formidlet immunrespons i ikke-humane dyr |
| PT3282835T (pt) | 2015-04-13 | 2023-07-25 | Univ Yale | Ratinhos knockin de sirpa-il15 humanizadas e métodos de utilização dos mesmos |
| US10818162B2 (en) | 2015-07-16 | 2020-10-27 | Ultrahaptics Ip Ltd | Calibration techniques in haptic systems |
| LT3376857T (lt) | 2015-11-20 | 2021-06-25 | Regeneron Pharmaceuticals, Inc. | Gyvūnai, ne žmonės, turintys humanizuotą limfocitų aktyvavimo geną |
| KR102851747B1 (ko) | 2015-12-08 | 2025-08-28 | 리제너론 파마슈티칼스 인코포레이티드 | 효소 내재화 조성물 및 방법 |
| US11189140B2 (en) | 2016-01-05 | 2021-11-30 | Ultrahaptics Ip Ltd | Calibration and detection techniques in haptic systems |
| CA3012693C (en) | 2016-02-04 | 2022-08-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered angptl8 gene |
| CN109068621B (zh) | 2016-02-29 | 2021-07-20 | 再生元制药公司 | 具有人源化的tmprss基因的啮齿类动物 |
| EP3462853B1 (en) | 2016-06-03 | 2023-03-01 | Regeneron Pharmaceuticals, Inc. | Rodents expressing exogenous terminal deoxynucleotidyltransferase |
| US10531212B2 (en) | 2016-06-17 | 2020-01-07 | Ultrahaptics Ip Ltd. | Acoustic transducers in haptic systems |
| US10268275B2 (en) | 2016-08-03 | 2019-04-23 | Ultrahaptics Ip Ltd | Three-dimensional perceptions in haptic systems |
| US10755538B2 (en) | 2016-08-09 | 2020-08-25 | Ultrahaptics ilP LTD | Metamaterials and acoustic lenses in haptic systems |
| CN107815467B (zh) * | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| US10943578B2 (en) | 2016-12-13 | 2021-03-09 | Ultrahaptics Ip Ltd | Driving techniques for phased-array systems |
| US10497358B2 (en) | 2016-12-23 | 2019-12-03 | Ultrahaptics Ip Ltd | Transducer driver |
| CN108467873B (zh) | 2017-03-17 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | 一种cd132基因缺失的免疫缺陷动物模型的制备方法及应用 |
| CN108588126B (zh) | 2017-03-31 | 2020-04-10 | 北京百奥赛图基因生物技术有限公司 | Cd47基因人源化改造动物模型的制备方法及应用 |
| WO2018177441A1 (en) * | 2017-03-31 | 2018-10-04 | Beijing Biocytogen Co., Ltd | GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα |
| WO2019067875A1 (en) | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS AND METHODS OF USE |
| US11531395B2 (en) | 2017-11-26 | 2022-12-20 | Ultrahaptics Ip Ltd | Haptic effects from focused acoustic fields |
| AU2018375796B2 (en) | 2017-11-30 | 2024-11-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized TRKB locus |
| EP3729418B1 (en) | 2017-12-22 | 2024-11-20 | Ultrahaptics Ip Ltd | Minimizing unwanted responses in haptic systems |
| WO2019122912A1 (en) | 2017-12-22 | 2019-06-27 | Ultrahaptics Limited | Tracking in haptic systems |
| AU2019242586B2 (en) | 2018-03-26 | 2025-09-11 | Regeneron Pharmaceuticals, Inc. | Humanized rodents for testing therapeutic agents |
| IL321087A (en) | 2018-05-02 | 2025-07-01 | Ultrahaptics Ip Ltd | Blocking plate structure for improved acoustic transmission efficiency |
| PL3823443T3 (pl) * | 2018-07-16 | 2024-09-23 | Regeneron Pharmaceuticals, Inc. | Modele gryzoni z chorobą ditra i ich zastosowania |
| US11098951B2 (en) | 2018-09-09 | 2021-08-24 | Ultrahaptics Ip Ltd | Ultrasonic-assisted liquid manipulation |
| US11378997B2 (en) | 2018-10-12 | 2022-07-05 | Ultrahaptics Ip Ltd | Variable phase and frequency pulse-width modulation technique |
| WO2020125639A1 (en) * | 2018-12-17 | 2020-06-25 | Biocytogen Jiangsu Co., Ltd. | Genetically modified non-human animal with human or chimeric genes |
| US11550395B2 (en) | 2019-01-04 | 2023-01-10 | Ultrahaptics Ip Ltd | Mid-air haptic textures |
| US12373033B2 (en) | 2019-01-04 | 2025-07-29 | Ultrahaptics Ip Ltd | Mid-air haptic textures |
| CN114107385A (zh) * | 2019-01-17 | 2022-03-01 | 百奥赛图(北京)医药科技股份有限公司 | 人源化转基因动物 |
| IL286905B2 (en) | 2019-04-04 | 2024-06-01 | Regeneron Pharma | Non-human animals containing the human coagulation factor 12 locus |
| US11842517B2 (en) | 2019-04-12 | 2023-12-12 | Ultrahaptics Ip Ltd | Using iterative 3D-model fitting for domain adaptation of a hand-pose-estimation neural network |
| US20220340926A1 (en) * | 2019-05-27 | 2022-10-27 | Transgenic Inc. | Exon-humanized mouse |
| WO2020247452A1 (en) | 2019-06-04 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
| SG11202111256XA (en) | 2019-06-07 | 2021-11-29 | Regeneron Pharma | Non-human animals comprising a humanized albumin locus |
| US11374586B2 (en) | 2019-10-13 | 2022-06-28 | Ultraleap Limited | Reducing harmonic distortion by dithering |
| KR20220080737A (ko) | 2019-10-13 | 2022-06-14 | 울트라립 리미티드 | 가상 마이크로폰들에 의한 동적 캡핑 |
| US11169610B2 (en) | 2019-11-08 | 2021-11-09 | Ultraleap Limited | Tracking techniques in haptic systems |
| CN111304246B (zh) * | 2019-12-17 | 2021-05-04 | 百奥赛图江苏基因生物技术有限公司 | 一种人源化细胞因子动物模型、制备方法及应用 |
| US11715453B2 (en) | 2019-12-25 | 2023-08-01 | Ultraleap Limited | Acoustic transducer structures |
| US12250931B2 (en) * | 2020-01-28 | 2025-03-18 | Regeneron Pharmaceuticals, Inc. | Genetically modified mouse with a humanized PNPLA3 gene and methods of use |
| EP4138550A1 (en) | 2020-04-21 | 2023-03-01 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cxcl13 gene |
| US11816267B2 (en) | 2020-06-23 | 2023-11-14 | Ultraleap Limited | Features of airborne ultrasonic fields |
| US11886639B2 (en) | 2020-09-17 | 2024-01-30 | Ultraleap Limited | Ultrahapticons |
| AU2022249328A1 (en) | 2021-03-31 | 2023-09-21 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice comprising humanized cellular immune system components with improved diversity of tcrβ repertoire |
| US20240224964A9 (en) | 2022-09-29 | 2024-07-11 | Regeneron Pharmaceuticals, Inc. | Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
| WO2025250495A1 (en) | 2024-05-28 | 2025-12-04 | Regeneron Pharmaceuticals, Inc. | Acceleration of human hepatocyte engraftment in humanized liver animals by supplementing paracrine ligands or agonists that activate human liver regeneration signals |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0786007A1 (en) * | 1994-10-14 | 1997-07-30 | Basf Aktiengesellschaft | Transgenic nonhuman animal having functionally disrupted interleukin-1-beta converting enzyme gene |
| CN100350973C (zh) | 1994-10-21 | 2007-11-28 | 岸本忠三 | 用于治疗il－6产生所致疾病的药物组合物 |
| US20030082721A1 (en) * | 2001-01-17 | 2003-05-01 | Tai-Jay Chang | Transgenic animals expressing androgen receptor complex-associated protein |
| CN1560081A (zh) * | 2004-02-17 | 2005-01-05 | 大连帝恩生物工程有限公司 | 用能产生人IgGl重链－κ轻链小鼠作为制备人源化单克隆抗体和应用 |
| PL1802193T3 (pl) | 2004-10-19 | 2014-09-30 | Regeneron Pharma | Sposób wytwarzania myszy homozygotycznej pod względem modyfikacji genetycznej |
| US7759541B2 (en) * | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
| GB2434578A (en) | 2006-01-26 | 2007-08-01 | Univ Basel | Transgenic animals |
| CN101454345B (zh) | 2006-06-02 | 2012-08-08 | 瑞泽恩制药公司 | 人il-6受体的高亲和力抗体 |
| WO2008027986A2 (en) * | 2006-09-01 | 2008-03-06 | Therapeutic Human Polyclonals, Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| FR2942218A1 (fr) | 2009-02-13 | 2010-08-20 | Eurocave Sa | Appareil de service au verre d'un liquide, notamment de vin |
| DK3417701T3 (da) * | 2009-10-06 | 2022-03-14 | Regeneron Pharma | Genmodificerede mus og indpodning |
| EP3336102A3 (en) * | 2009-12-21 | 2018-08-01 | Regeneron Pharmaceuticals, Inc. | Humanized fc gamma r mice |
| MX338971B (es) | 2011-02-15 | 2016-05-06 | Inst Res Biomedicine Irb | Ratones de m-csf humanizada. |
| JP6352634B2 (ja) | 2011-09-30 | 2018-07-04 | 中外製薬株式会社 | 標的抗原に対する免疫応答を誘導する抗原結合分子 |
| LT3590332T (lt) | 2011-10-28 | 2022-08-10 | Regeneron Pharmaceuticals, Inc. | Genetiškai modifikuotos pelės, ekspresuojančios chimerines pagrindinio audinių dermės komplekso (mhc) ii molekules |
| WO2013063556A1 (en) | 2011-10-28 | 2013-05-02 | Regeneron Pharmaceuticals, Inc. | Humanized il-6 and il-6 receptor |
| LT3262932T (lt) | 2011-10-28 | 2019-08-26 | Regeneron Pharmaceuticals, Inc. | Pelės su genetiškai modifikuotu pagrindiniu histosuderinamumo kompleksu |
-
2012
- 2012-10-29 WO PCT/US2012/062379 patent/WO2013063556A1/en not_active Ceased
- 2012-10-29 DK DK12795905.4T patent/DK2663575T3/en active
- 2012-10-29 SG SG10202100485XA patent/SG10202100485XA/en unknown
- 2012-10-29 MY MYPI2017703646A patent/MY186903A/en unknown
- 2012-10-29 CN CN201280065013.6A patent/CN104039821A/zh active Pending
- 2012-10-29 RS RS20140677A patent/RS53683B1/sr unknown
- 2012-10-29 IN IN3920CHN2014 patent/IN2014CN03920A/en unknown
- 2012-10-29 JP JP2014539105A patent/JP6120451B2/ja active Active
- 2012-10-29 RU RU2014121324A patent/RU2634417C2/ru active
- 2012-10-29 US US13/662,880 patent/US8878001B2/en active Active
- 2012-10-29 ES ES14177863.9T patent/ES2624605T3/es active Active
- 2012-10-29 ES ES12795905.4T patent/ES2525368T3/es active Active
- 2012-10-29 RU RU2017129763A patent/RU2751240C2/ru active
- 2012-10-29 CA CA2853731A patent/CA2853731C/en active Active
- 2012-10-29 BR BR112014008529A patent/BR112014008529A2/pt not_active Application Discontinuation
- 2012-10-29 DK DK14177863.9T patent/DK2818478T3/en active
- 2012-10-29 SI SI201230941A patent/SI2818478T1/sl unknown
- 2012-10-29 LT LTEP14177863.9T patent/LT2818478T/lt unknown
- 2012-10-29 RS RS20170430A patent/RS55949B1/sr unknown
- 2012-10-29 SM SM20170222T patent/SMT201700222T1/it unknown
- 2012-10-29 EP EP14177863.9A patent/EP2818478B1/en active Active
- 2012-10-29 MY MYPI2014000768A patent/MY172726A/en unknown
- 2012-10-29 PT PT127959054T patent/PT2663575E/pt unknown
- 2012-10-29 HR HRP20141192AT patent/HRP20141192T1/hr unknown
- 2012-10-29 SI SI201230111T patent/SI2663575T1/sl unknown
- 2012-10-29 EP EP12795905.4A patent/EP2663575B1/en active Active
- 2012-10-29 SG SG11201400945UA patent/SG11201400945UA/en unknown
- 2012-10-29 CN CN201810620759.8A patent/CN108866101A/zh active Pending
- 2012-10-29 HU HUE14177863A patent/HUE033400T2/en unknown
- 2012-10-29 KR KR1020207005686A patent/KR102234632B1/ko active Active
- 2012-10-29 PT PT141778639T patent/PT2818478T/pt unknown
- 2012-10-29 KR KR1020147014316A patent/KR102084927B1/ko active Active
- 2012-10-29 MX MX2014004900A patent/MX358390B/es active IP Right Grant
- 2012-10-29 PL PL12795905T patent/PL2663575T3/pl unknown
- 2012-10-29 SG SG10201600965YA patent/SG10201600965YA/en unknown
- 2012-10-29 PL PL14177863T patent/PL2818478T3/pl unknown
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2014
- 2014-04-03 IL IL231896A patent/IL231896B/en active IP Right Grant
- 2014-04-10 ZA ZA2014/02635A patent/ZA201402635B/en unknown
- 2014-09-19 US US14/490,877 patent/US9078418B2/en active Active
- 2014-09-19 US US14/490,875 patent/US9125386B2/en active Active
- 2014-12-11 CY CY20141101035T patent/CY1116614T1/el unknown
- 2014-12-15 SM SM201400187T patent/SMT201400187B/xx unknown
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2015
- 2015-06-10 US US14/735,710 patent/US9392777B2/en active Active
- 2015-07-30 AU AU2015207889A patent/AU2015207889B2/en active Active
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2016
- 2016-01-18 IL IL243665A patent/IL243665B/en active IP Right Grant
- 2016-01-18 IL IL243666A patent/IL243666B/en active IP Right Grant
- 2016-06-09 US US15/177,582 patent/US9622460B2/en active Active
- 2016-11-14 US US15/350,739 patent/US10004211B2/en active Active
- 2016-11-18 JP JP2016224713A patent/JP2017035115A/ja active Pending
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2017
- 2017-04-28 HR HRP20170656TT patent/HRP20170656T1/hr unknown
- 2017-04-28 CY CY20171100474T patent/CY1118952T1/el unknown
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2018
- 2018-06-06 US US16/001,074 patent/US10433528B2/en active Active
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2019
- 2019-01-28 IL IL264508A patent/IL264508B/en active IP Right Grant
- 2019-07-03 US US16/502,197 patent/US11102962B2/en active Active
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2021
- 2021-07-26 US US17/385,039 patent/US12239111B2/en active Active
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2025
- 2025-01-29 US US19/039,847 patent/US20250287931A1/en active Pending
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