JP2014531910A - 再構成後の精製第ｖｉｉｉ因子の安定性を改善するための方法 - Google Patents
再構成後の精製第ｖｉｉｉ因子の安定性を改善するための方法 Download PDFInfo
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
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- Chemical & Material Sciences (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019527541A (ja) * | 2016-06-24 | 2019-10-03 | モガム・インスティテュート・フォー・バイオメディカル・リサーチＭｏｇａｍ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂｉｏｍｅｄｉｃａｌ Ｒｅｓｅａｒｃｈ | 組換え型一本鎖ｆｖｉｉｉおよびその化学コンジュゲート |
| JP2021530437A (ja) * | 2018-05-18 | 2021-11-11 | 鄭州晟斯生物科技有限公司Zhengzhou Gensciences Inc | 改良されたｆｖｉｉｉ融合タンパク質及びその応用 |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103917554B (zh) | 2011-10-18 | 2017-03-08 | 杰特有限公司 | 用于改善重构后纯化的因子viii的稳定性的方法 |
| ES2926798T3 (es) * | 2013-03-15 | 2022-10-28 | Bioverativ Therapeutics Inc | Formulaciones de polipéptido de factor VIII |
| EA201691111A1 (ru) | 2014-01-10 | 2017-01-30 | Байоджен Ма Инк. | Химерные белки фактора viii и их применение |
| CN106456720A (zh) * | 2014-04-01 | 2017-02-22 | 爱德技术生物科学有限公司 | 在无钙作为赋形剂下因子viii的稳定性 |
| US9907835B2 (en) * | 2014-04-01 | 2018-03-06 | Advanced Bioscience Farmacêutica LTDA | Stable Factor VIII formulations with low sugar-glycine |
| DK3193911T5 (da) * | 2014-07-25 | 2024-10-14 | Csl Behring Gmbh | Forbedrede faktor VII-præparater til brug ved behandling af hæmofili A |
| JP6516829B2 (ja) * | 2014-08-04 | 2019-05-22 | シーエスエル、リミテッド | 第ｖｉｉｉ因子製剤 |
| JP6877469B2 (ja) | 2016-06-24 | 2021-05-26 | モガム・インスティテュート・フォー・バイオメディカル・リサーチＭｏｇａｍ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂｉｏｍｅｄｉｃａｌ Ｒｅｓｅａｒｃｈ | Ｆｖｉｉｉおよびｖｗｆ因子を含むキメラタンパク質、ならびにそれらの使用 |
| KR20190090827A (ko) | 2016-12-02 | 2019-08-02 | 바이오버라티브 테라퓨틱스 인크. | 키메라 응고 인자를 사용해 혈우병성 관절증을 치료하는 방법 |
| KR20200057051A (ko) | 2017-09-27 | 2020-05-25 | 시질론 테라퓨틱스, 인크. | 활성 세포를 포함하는 방법, 조성물 및 이식 가능한 요소 |
| WO2019074886A1 (en) | 2017-10-09 | 2019-04-18 | Terumo Bct Biotechnologies, Llc | LYOPHILIZATION CONTAINER AND METHOD OF USE |
| WO2019195056A1 (en) | 2018-04-04 | 2019-10-10 | Sigilon Therapeutics, Inc. | Methods, compositions, and implantable elements comprising stem cells |
| CN112203646A (zh) | 2018-04-04 | 2021-01-08 | 西吉隆医疗股份有限公司 | 可植入颗粒和相关方法 |
| KR102914074B1 (ko) | 2018-05-18 | 2026-01-16 | 바이오버라티브 테라퓨틱스 인크. | A형 혈우병의 치료 방법 |
| UY38389A (es) | 2018-09-27 | 2020-04-30 | Sigilon Therapeutics Inc | Dispositivos implantables para terapia celular y métodos relacionados |
| US11609042B2 (en) | 2019-03-14 | 2023-03-21 | Terumo Bct Biotechnologies, Llc | Multi-part lyophilization container and method of use |
| EP3736286A1 (en) | 2019-05-09 | 2020-11-11 | Biotest AG | Single chain factor viii molecule |
| EP4061942A4 (en) | 2019-11-22 | 2023-12-20 | Sigilon Therapeutics, Inc. | MONOCLONAL CELL LINES EXPRESSING AN EXOGENEOUS SUBSTANCE AND THEIR USES |
| CN120659872A (zh) | 2022-10-11 | 2025-09-16 | 西吉隆医疗股份有限公司 | 用于治疗疾病的经工程化的细胞和可植入元件 |
| WO2024081309A1 (en) | 2022-10-11 | 2024-04-18 | Sigilon Therapeutics, Inc. | Engineered cells and implantable elements for treatment of disease |
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| US20040147436A1 (en) * | 2003-01-28 | 2004-07-29 | Hun-Taek Kim | Factor VIII polypeptide |
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| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| MX9203440A (es) | 1985-04-12 | 1992-07-01 | Genetics Inst | Proteinas procoagulantes novedosas. |
| KR910006424B1 (ko) | 1985-08-21 | 1991-08-24 | 인코텍스 비.브이 | 편성브리프(brief) 제조방법 |
| US5422260A (en) * | 1986-05-29 | 1995-06-06 | Genetics Institute, Inc. -Legal Affairs | Human factor VIII:c muteins |
| IL84168A0 (en) | 1986-10-15 | 1988-03-31 | Rorer Int Overseas | Human factor viii-c analogs,process for the preparation thereof and pharmaceutical compositions containing the same |
| JP2872255B2 (ja) | 1987-01-30 | 1999-03-17 | バイオジエン，インコーポレイティド | ファクター▲ｖｉｉｉ▼の高収量生産法 |
| EP0294910B1 (en) | 1987-06-12 | 1996-09-11 | Immuno Ag | Novel proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them |
| IE69026B1 (en) | 1987-06-12 | 1996-08-07 | Immuno Ag | Novel proteins with factor VIII activity process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them |
| DE3720246A1 (de) | 1987-06-19 | 1988-12-29 | Behringwerke Ag | Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet |
| FR2619314B1 (fr) | 1987-08-11 | 1990-06-15 | Transgene Sa | Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant |
| US5605884A (en) | 1987-10-29 | 1997-02-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Factor VIII formulations in high ionic strength media |
| US5661008A (en) | 1991-03-15 | 1997-08-26 | Kabi Pharmacia Ab | Recombinant human factor VIII derivatives |
| DE4111393A1 (de) | 1991-04-09 | 1992-10-15 | Behringwerke Ag | Stabilisierte faktor viii-praeparationen |
| AT403764B (de) | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
| PT1754718E (pt) | 1996-04-24 | 2011-07-13 | Univ Michigan | Factor viii resistente à inactivação |
| WO2000024759A1 (en) | 1998-10-23 | 2000-05-04 | The Trustees Of The University Of Pennsylvania | Systemic delivery of gene products via skin |
| EP1194161B1 (en) | 1999-07-13 | 2005-11-23 | Biovitrum Ab | Stable factor viii compositions |
| DK1266006T3 (da) | 2000-03-22 | 2006-01-16 | Octagene Gmbh | Fremstilling af rekombinante muteiner af blodkoagulationsfaktor VIII i humane cellelinier |
| AU2002312660A1 (en) * | 2001-05-31 | 2002-12-16 | D. Collen Research Foundation Vzw Onderwijsen Navorsing Campus Gasthuisberg K.U. Leuven | Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools |
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-
2012
- 2012-10-18 CN CN201280051574.0A patent/CN103917554B/zh active Active
- 2012-10-18 CA CA2850579A patent/CA2850579A1/en not_active Abandoned
- 2012-10-18 KR KR1020147013298A patent/KR20140084208A/ko not_active Ceased
- 2012-10-18 US US14/351,513 patent/US9394353B2/en active Active
- 2012-10-18 JP JP2014536237A patent/JP2014531910A/ja not_active Withdrawn
- 2012-10-18 WO PCT/EP2012/070701 patent/WO2013057219A1/en not_active Ceased
- 2012-10-18 AU AU2012318292A patent/AU2012318292B2/en active Active
- 2012-10-18 HK HK14112047.2A patent/HK1198541A1/xx unknown
- 2012-10-18 EP EP12772987.9A patent/EP2768853A1/en not_active Ceased
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2016
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2017
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2018
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2019
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2020
- 2020-12-02 US US17/109,366 patent/US11510968B2/en active Active
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| JPS63503357A (ja) * | 1986-05-29 | 1988-12-08 | ジェネティックス・インスチチュート・インコーポレーテッド | 新規な凝固活性タンパク質 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019527541A (ja) * | 2016-06-24 | 2019-10-03 | モガム・インスティテュート・フォー・バイオメディカル・リサーチＭｏｇａｍ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂｉｏｍｅｄｉｃａｌ Ｒｅｓｅａｒｃｈ | 組換え型一本鎖ｆｖｉｉｉおよびその化学コンジュゲート |
| JP2021118696A (ja) * | 2016-06-24 | 2021-08-12 | モガム・インスティテュート・フォー・バイオメディカル・リサーチMogam Institute For Biomedical Research | 組換え型一本鎖ｆｖｉｉｉおよびその化学コンジュゲート |
| JP7235511B2 (ja) | 2016-06-24 | 2023-03-08 | モガム・インスティテュート・フォー・バイオメディカル・リサーチ | 組換え型一本鎖ｆｖｉｉｉおよびその化学コンジュゲート |
| JP2021530437A (ja) * | 2018-05-18 | 2021-11-11 | 鄭州晟斯生物科技有限公司Zhengzhou Gensciences Inc | 改良されたｆｖｉｉｉ融合タンパク質及びその応用 |
| JP2023093634A (ja) * | 2018-05-18 | 2023-07-04 | 鄭州晟斯生物科技有限公司 | 改良されたｆｖｉｉｉ融合タンパク質及びその応用 |
| JP7492780B2 (ja) | 2018-05-18 | 2024-05-30 | 鄭州晟斯生物科技有限公司 | 改良されたｆｖｉｉｉ融合タンパク質及びその応用 |
| US12440572B2 (en) | 2018-05-18 | 2025-10-14 | Zhengzhou Gensciences Inc. | FVIII fusion protein and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| HK1198541A1 (en) | 2015-05-15 |
| US11510968B2 (en) | 2022-11-29 |
| US20190038722A1 (en) | 2019-02-07 |
| JP2017114889A (ja) | 2017-06-29 |
| AU2012318292B2 (en) | 2015-08-20 |
| WO2013057219A1 (en) | 2013-04-25 |
| US20140249086A1 (en) | 2014-09-04 |
| US10537616B2 (en) | 2020-01-21 |
| EP2768853A1 (en) | 2014-08-27 |
| US20200268854A1 (en) | 2020-08-27 |
| KR20140084208A (ko) | 2014-07-04 |
| US10881717B2 (en) | 2021-01-05 |
| AU2012318292A1 (en) | 2013-05-02 |
| CA2850579A1 (en) | 2013-04-25 |
| US20210308229A1 (en) | 2021-10-07 |
| CN103917554B (zh) | 2017-03-08 |
| US9956269B2 (en) | 2018-05-01 |
| CN103917554A (zh) | 2014-07-09 |
| US9394353B2 (en) | 2016-07-19 |
| US20160367641A1 (en) | 2016-12-22 |
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