JP2014531897A5 - - Google Patents
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- JP2014531897A5 JP2014531897A5 JP2014528847A JP2014528847A JP2014531897A5 JP 2014531897 A5 JP2014531897 A5 JP 2014531897A5 JP 2014528847 A JP2014528847 A JP 2014528847A JP 2014528847 A JP2014528847 A JP 2014528847A JP 2014531897 A5 JP2014531897 A5 JP 2014531897A5
- Authority
- JP
- Japan
- Prior art keywords
- variant
- seq
- amino acid
- endostatin
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110280441 | 2011-09-09 | ||
| CN201110280441.8 | 2011-09-09 | ||
| PCT/CN2012/081210 WO2013034116A1 (zh) | 2011-09-09 | 2012-09-10 | 对atp结合位点进行突变的血管内皮抑制素突变体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014531897A JP2014531897A (ja) | 2014-12-04 |
| JP2014531897A5 true JP2014531897A5 (https=) | 2015-11-05 |
| JP6336389B2 JP6336389B2 (ja) | 2018-06-06 |
Family
ID=47831548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014528847A Active JP6336389B2 (ja) | 2011-09-09 | 2012-09-10 | Ａｔｐ結合部位に変異を有するエンドスタチン変異体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10647968B2 (https=) |
| EP (1) | EP2754718B1 (https=) |
| JP (1) | JP6336389B2 (https=) |
| CN (2) | CN108291248B (https=) |
| AU (1) | AU2012306826B2 (https=) |
| CA (1) | CA2848118C (https=) |
| IL (1) | IL231419A0 (https=) |
| RU (1) | RU2014113924A (https=) |
| WO (1) | WO2013034116A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104926933B (zh) * | 2014-03-19 | 2018-09-07 | 北京仁和天通生物科技有限公司 | Endostatin突变体、Endostatin突变体与聚乙二醇的交联物以及它们的应用 |
| CN107148277B (zh) * | 2014-11-03 | 2022-03-22 | 清华大学 | 一种抑制脂肪细胞分化和胰岛素耐受的药物 |
| EP3269731B1 (en) * | 2015-02-13 | 2023-10-04 | Tsinghua University | Molecular design of recombinant protein drug |
| CN110498851B (zh) * | 2015-11-10 | 2022-10-11 | 孙嘉琳 | 一种抗肿瘤蛋白内皮抑素的衍生物及应用 |
| WO2018086603A1 (zh) * | 2016-11-10 | 2018-05-17 | 北京普罗吉生物科技发展有限公司 | 聚乙二醇化血管内皮抑制素类似物及其应用 |
| EP3662922B1 (en) * | 2017-07-30 | 2025-03-05 | Tsinghua University | A combination of endostatin and a dna double strand break inducing chemotherapeutic agent for treating p53(-) melanoma and p53(-) non-small cell lung cancer |
| CN114645025B (zh) * | 2022-04-13 | 2023-12-22 | 南开大学 | 一种人源atp合成酶的纯化方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2313251A1 (en) * | 1997-12-08 | 1999-06-17 | Beth Israel Deaconess Medical Center | Mutants of endostatin, "em 1" having anti-angiogenic activity and methods of use thereof |
| AU4982200A (en) * | 1999-05-06 | 2000-11-21 | Burnham Institute, The | Antiangiogenic endostatin peptides, endostatin variants and methods of use |
| CN1237072C (zh) * | 2000-05-22 | 2006-01-18 | 烟台荣昌生物工程有限公司 | 生产内皮抑制素的方法 |
| JP4511108B2 (ja) * | 2002-05-31 | 2010-07-28 | オンコリクス インコーポレイテッド | ヒトプロラクチン拮抗剤−血管新生阻害剤融合蛋白質 |
| CN100475270C (zh) | 2006-01-20 | 2009-04-08 | 清华大学 | 一种治疗肿瘤的药物及其应用 |
| CN101143894A (zh) * | 2007-06-22 | 2008-03-19 | 中国药科大学 | 高效抑制血管生成多肽及其物理化学修饰方法和应用 |
| EP2270055A4 (en) * | 2008-04-04 | 2011-06-29 | Procell Therapeutics Inc | CELLPERMEABLE RECOMBINANT ENDOSTATINE PROTEIN, POLYNUCLEOTIDE FOR ITS CODING AND ANTICIPATED PREPARATION WITH THE PROTEIN AS AN ACTIVE SUBSTANCE |
| CN101256139A (zh) * | 2008-04-18 | 2008-09-03 | 山东先声麦得津生物制药有限公司 | 一种血管内皮抑制素生物活性的检测方法 |
| CN101890155B (zh) * | 2010-05-25 | 2012-07-25 | 江苏先声药物研究有限公司 | 一种药物组合物及其应用 |
-
2012
- 2012-09-10 CN CN201280078261.4A patent/CN108291248B/zh active Active
- 2012-09-10 CA CA2848118A patent/CA2848118C/en active Active
- 2012-09-10 RU RU2014113924/10A patent/RU2014113924A/ru not_active Application Discontinuation
- 2012-09-10 WO PCT/CN2012/081210 patent/WO2013034116A1/zh not_active Ceased
- 2012-09-10 AU AU2012306826A patent/AU2012306826B2/en active Active
- 2012-09-10 US US14/343,694 patent/US10647968B2/en active Active
- 2012-09-10 JP JP2014528847A patent/JP6336389B2/ja active Active
- 2012-09-10 EP EP12830317.9A patent/EP2754718B1/en active Active
- 2012-09-10 CN CN202410186085.0A patent/CN117987505A/zh active Pending
-
2014
- 2014-03-09 IL IL231419A patent/IL231419A0/en active IP Right Grant
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