JP2014531897A5 - - Google Patents
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- Publication number
- JP2014531897A5 JP2014531897A5 JP2014528847A JP2014528847A JP2014531897A5 JP 2014531897 A5 JP2014531897 A5 JP 2014531897A5 JP 2014528847 A JP2014528847 A JP 2014528847A JP 2014528847 A JP2014528847 A JP 2014528847A JP 2014531897 A5 JP2014531897 A5 JP 2014531897A5
- Authority
- JP
- Japan
- Prior art keywords
- variant
- seq
- amino acid
- endostatin
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100031162 Collagen alpha-1(XVIII) chain Human genes 0.000 claims description 13
- 108010079505 Endostatins Proteins 0.000 claims description 13
- 230000000694 effects Effects 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 7
- 108091006112 ATPases Proteins 0.000 claims description 5
- 102000057290 Adenosine Triphosphatases Human genes 0.000 claims description 5
- 238000003556 assay Methods 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 230000004071 biological effect Effects 0.000 claims description 2
- FDZZZRQASAIRJF-UHFFFAOYSA-M malachite green Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1C(C=1C=CC=CC=1)=C1C=CC(=[N+](C)C)C=C1 FDZZZRQASAIRJF-UHFFFAOYSA-M 0.000 claims description 2
- 229940107698 malachite green Drugs 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- 125000000539 amino acid group Chemical group 0.000 claims 8
- 230000035772 mutation Effects 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 230000033115 angiogenesis Effects 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000002829 reductive effect Effects 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000001772 anti-angiogenic effect Effects 0.000 claims 1
- -1 aromatic amino acid Chemical class 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000008034 disappearance Effects 0.000 claims 1
- 230000010595 endothelial cell migration Effects 0.000 claims 1
- 238000010353 genetic engineering Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000036961 partial effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000001875 tumorinhibitory effect Effects 0.000 claims 1
- 230000029918 bioluminescence Effects 0.000 description 1
- 238000005415 bioluminescence Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110280441.8 | 2011-09-09 | ||
| CN201110280441 | 2011-09-09 | ||
| PCT/CN2012/081210 WO2013034116A1 (zh) | 2011-09-09 | 2012-09-10 | 对atp结合位点进行突变的血管内皮抑制素突变体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014531897A JP2014531897A (ja) | 2014-12-04 |
| JP2014531897A5 true JP2014531897A5 (enExample) | 2015-11-05 |
| JP6336389B2 JP6336389B2 (ja) | 2018-06-06 |
Family
ID=47831548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014528847A Active JP6336389B2 (ja) | 2011-09-09 | 2012-09-10 | Ａｔｐ結合部位に変異を有するエンドスタチン変異体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10647968B2 (enExample) |
| EP (1) | EP2754718B1 (enExample) |
| JP (1) | JP6336389B2 (enExample) |
| CN (2) | CN117987505A (enExample) |
| AU (1) | AU2012306826B2 (enExample) |
| CA (1) | CA2848118C (enExample) |
| IL (1) | IL231419A0 (enExample) |
| RU (1) | RU2014113924A (enExample) |
| WO (1) | WO2013034116A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104926933B (zh) * | 2014-03-19 | 2018-09-07 | 北京仁和天通生物科技有限公司 | Endostatin突变体、Endostatin突变体与聚乙二醇的交联物以及它们的应用 |
| EP3246043A4 (en) * | 2014-11-03 | 2018-09-05 | Tsinghua University | Drug for inhibiting adipose cell differentiation and insulin resistance |
| AU2016218635B2 (en) * | 2015-02-13 | 2020-07-23 | Beijing Protgen Ltd. | Molecular design of recombinant protein drug |
| CN106674352B (zh) * | 2015-11-10 | 2020-05-15 | 孙嘉琳 | 抗肿瘤蛋白内皮抑素的衍生物及应用 |
| CA3043380A1 (en) * | 2016-11-10 | 2018-05-17 | Beijing Protgen Ltd. | Pegylated endostatin analogue and application thereof |
| WO2019024814A1 (zh) * | 2017-07-30 | 2019-02-07 | 清华大学 | 抑制dna依赖蛋白激酶催化亚基的药物 |
| CN114645025B (zh) * | 2022-04-13 | 2023-12-22 | 南开大学 | 一种人源atp合成酶的纯化方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010015868A (ko) * | 1997-12-08 | 2001-02-26 | 베쓰 이스라엘 디코니스 메디칼 센터 | 피치아 효모 발현계를 사용하여 항혈관형성 단백질인엔도스타틴, 안지오스타틴 또는 레스틴을 생성시키는 방법 |
| AU4982200A (en) * | 1999-05-06 | 2000-11-21 | Burnham Institute, The | Antiangiogenic endostatin peptides, endostatin variants and methods of use |
| CN1237072C (zh) * | 2000-05-22 | 2006-01-18 | 烟台荣昌生物工程有限公司 | 生产内皮抑制素的方法 |
| JP4511108B2 (ja) * | 2002-05-31 | 2010-07-28 | オンコリクス インコーポレイテッド | ヒトプロラクチン拮抗剤−血管新生阻害剤融合蛋白質 |
| CN100475270C (zh) * | 2006-01-20 | 2009-04-08 | 清华大学 | 一种治疗肿瘤的药物及其应用 |
| CN101143894A (zh) * | 2007-06-22 | 2008-03-19 | 中国药科大学 | 高效抑制血管生成多肽及其物理化学修饰方法和应用 |
| EP2270055A4 (en) * | 2008-04-04 | 2011-06-29 | Procell Therapeutics Inc | CELLPERMEABLE RECOMBINANT ENDOSTATINE PROTEIN, POLYNUCLEOTIDE FOR ITS CODING AND ANTICIPATED PREPARATION WITH THE PROTEIN AS AN ACTIVE SUBSTANCE |
| CN101256139A (zh) * | 2008-04-18 | 2008-09-03 | 山东先声麦得津生物制药有限公司 | 一种血管内皮抑制素生物活性的检测方法 |
| CN101890155B (zh) * | 2010-05-25 | 2012-07-25 | 江苏先声药物研究有限公司 | 一种药物组合物及其应用 |
-
2012
- 2012-09-10 CA CA2848118A patent/CA2848118C/en active Active
- 2012-09-10 RU RU2014113924/10A patent/RU2014113924A/ru not_active Application Discontinuation
- 2012-09-10 JP JP2014528847A patent/JP6336389B2/ja active Active
- 2012-09-10 AU AU2012306826A patent/AU2012306826B2/en active Active
- 2012-09-10 US US14/343,694 patent/US10647968B2/en active Active
- 2012-09-10 CN CN202410186085.0A patent/CN117987505A/zh active Pending
- 2012-09-10 WO PCT/CN2012/081210 patent/WO2013034116A1/zh not_active Ceased
- 2012-09-10 EP EP12830317.9A patent/EP2754718B1/en active Active
- 2012-09-10 CN CN201280078261.4A patent/CN108291248B/zh active Active
-
2014
- 2014-03-09 IL IL231419A patent/IL231419A0/en active IP Right Grant
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