JP2014531409A5 - - Google Patents
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- JP2014531409A5 JP2014531409A5 JP2014526161A JP2014526161A JP2014531409A5 JP 2014531409 A5 JP2014531409 A5 JP 2014531409A5 JP 2014526161 A JP2014526161 A JP 2014526161A JP 2014526161 A JP2014526161 A JP 2014526161A JP 2014531409 A5 JP2014531409 A5 JP 2014531409A5
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- Prior art keywords
- antibody
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- human
- Prior art date
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- 239000000427 antigen Substances 0.000 claims description 26
- 102000036639 antigens Human genes 0.000 claims description 26
- 108091007433 antigens Proteins 0.000 claims description 26
- 239000012634 fragment Substances 0.000 claims description 26
- 108010079206 V-Set Domain-Containing T-Cell Activation Inhibitor 1 Proteins 0.000 claims description 22
- 210000004027 cell Anatomy 0.000 claims description 22
- 206010028980 Neoplasm Diseases 0.000 claims description 20
- 101000955999 Homo sapiens V-set domain-containing T-cell activation inhibitor 1 Proteins 0.000 claims description 16
- 102000055298 human VTCN1 Human genes 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 15
- 201000010099 disease Diseases 0.000 claims description 13
- 201000011510 cancer Diseases 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 208000015181 infectious disease Diseases 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 210000004981 tumor-associated macrophage Anatomy 0.000 claims description 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 210000004881 tumor cell Anatomy 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 3
- 230000001629 suppression Effects 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 206010062016 Immunosuppression Diseases 0.000 claims description 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 2
- 230000001413 cellular effect Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 230000001506 immunosuppresive effect Effects 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 230000005909 tumor killing Effects 0.000 claims description 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims 1
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims 1
- 230000006037 cell lysis Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 description 4
- 230000001747 exhibiting effect Effects 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 239000002246 antineoplastic agent Substances 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 230000002380 cytological effect Effects 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 208000009329 Graft vs Host Disease Diseases 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 206010052779 Transplant rejections Diseases 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 208000024908 graft versus host disease Diseases 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 206010057248 Cell death Diseases 0.000 description 1
- 238000001815 biotherapy Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000005760 tumorsuppression Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161523819P | 2011-08-15 | 2011-08-15 | |
| US61/523,819 | 2011-08-15 | ||
| PCT/US2012/050903 WO2013025779A1 (en) | 2011-08-15 | 2012-08-15 | Anti-b7-h4 antibodies and their uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014531409A JP2014531409A (ja) | 2014-11-27 |
| JP2014531409A5 true JP2014531409A5 (enExample) | 2015-09-17 |
| JP6120848B2 JP6120848B2 (ja) | 2017-04-26 |
Family
ID=47715448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014526161A Expired - Fee Related JP6120848B2 (ja) | 2011-08-15 | 2012-08-15 | 抗ｂ７−ｈ４抗体およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9676854B2 (enExample) |
| EP (1) | EP2756094B1 (enExample) |
| JP (1) | JP6120848B2 (enExample) |
| AU (1) | AU2012296613B2 (enExample) |
| CA (1) | CA2845536A1 (enExample) |
| WO (1) | WO2013025779A1 (enExample) |
Families Citing this family (115)
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