JP2014531031A - 小分析物の定量的検出のためのポイントオブケア免疫アッセイ - Google Patents

小分析物の定量的検出のためのポイントオブケア免疫アッセイ Download PDF

Info

Publication number
JP2014531031A
JP2014531031A JP2014537362A JP2014537362A JP2014531031A JP 2014531031 A JP2014531031 A JP 2014531031A JP 2014537362 A JP2014537362 A JP 2014537362A JP 2014537362 A JP2014537362 A JP 2014537362A JP 2014531031 A JP2014531031 A JP 2014531031A
Authority
JP
Japan
Prior art keywords
analyte
capture
competitive assay
assay method
zone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014537362A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014531031A5 (https=
Inventor
フィリップ ギブズ,
フィリップ ギブズ,
Original Assignee
デシマドックス, エルエルシー
デシマドックス, エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by デシマドックス, エルエルシー, デシマドックス, エルエルシー filed Critical デシマドックス, エルエルシー
Publication of JP2014531031A publication Critical patent/JP2014531031A/ja
Publication of JP2014531031A5 publication Critical patent/JP2014531031A5/ja
Pending legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306Solid-phase reaction mechanisms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1048SELEX
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54386Analytical elements
    • G01N33/54387Immunochromatographic test strips
    • G01N33/54388Immunochromatographic test strips based on lateral flow
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2470/00Immunochemical assays or immunoassays characterised by the reaction format or reaction type
    • G01N2470/04Sandwich assay format
    • G01N2470/06Second binding partner specifically binding complex of analyte with first binding partner

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2014537362A 2011-10-21 2012-10-22 小分析物の定量的検出のためのポイントオブケア免疫アッセイ Pending JP2014531031A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161550141P 2011-10-21 2011-10-21
US61/550,141 2011-10-21
US201261637143P 2012-04-23 2012-04-23
US61/637,143 2012-04-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017075025A Division JP2017138325A (ja) 2011-10-21 2017-04-05 小分析物の定量的検出のためのポイントオブケア免疫アッセイ

Publications (2)

Publication Number Publication Date
JP2014531031A true JP2014531031A (ja) 2014-11-20
JP2014531031A5 JP2014531031A5 (https=) 2015-12-10

Family

ID=47116496

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014537362A Pending JP2014531031A (ja) 2011-10-21 2012-10-22 小分析物の定量的検出のためのポイントオブケア免疫アッセイ
JP2017075025A Pending JP2017138325A (ja) 2011-10-21 2017-04-05 小分析物の定量的検出のためのポイントオブケア免疫アッセイ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017075025A Pending JP2017138325A (ja) 2011-10-21 2017-04-05 小分析物の定量的検出のためのポイントオブケア免疫アッセイ

Country Status (6)

Country Link
US (2) US20130102003A1 (https=)
EP (1) EP2769219B1 (https=)
JP (2) JP2014531031A (https=)
AU (2) AU2012325697B2 (https=)
CA (1) CA2853103C (https=)
WO (1) WO2013059805A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017170824A1 (ja) * 2016-03-31 2017-10-05 積水メディカル株式会社 簡易免疫測定を利用した癌胎児性フィブロネクチンの検出方法
WO2018043687A3 (ja) * 2016-08-31 2018-04-26 積水化学工業株式会社 診断薬用蛍光粒子及びそれを用いた免疫測定試薬
JP6339298B1 (ja) * 2017-04-20 2018-06-06 株式会社キュア・アップ 禁煙患者のためのプログラム、装置、システム及び方法
JP2022177204A (ja) * 2018-05-09 2022-11-30 株式会社Cureapp 禁煙患者のためのプログラム、装置、システム及び方法

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10101324B2 (en) 2012-12-03 2018-10-16 The Regents Of The University Of California Non-competitive immunoassays to detect small molecules using nanopeptamers
CA3042642A1 (en) 2013-08-12 2015-02-19 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
CN105705938B (zh) 2013-08-19 2020-11-06 休斯敦大学系统 磷光报告物
US20150064672A1 (en) * 2013-09-05 2015-03-05 Matthew Bars Systems and methods for treatment of substance addiction
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10648974B2 (en) 2014-05-28 2020-05-12 Carehealth America Corporation Ethyl glucuronide lateral flow test strips, immunoassays, devices and methods for detecting or measuring thereof
CA2955229C (en) 2014-07-17 2020-03-10 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
GB2528657B (en) * 2014-07-24 2019-03-13 Intelligent Fingerprinting Ltd Sample analysing device
AU2015336065A1 (en) 2014-10-20 2017-05-04 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
EP3256856A4 (en) * 2014-12-17 2018-06-06 Singulex, Inc. Multiplexed single molecule analyzer
BR112017021305A2 (pt) * 2015-04-06 2018-06-26 Bludiagnostics Inc dispositivo de teste de fluxo lateral, e, método e kit para detecção quantitativa de um analito em uma amostra de saliva
WO2016198987A1 (en) * 2015-06-10 2016-12-15 Abs Advanced Biomedical Systems S.R.L. Device and method for immunochromatographic assay
EA037478B1 (ru) 2015-08-04 2021-04-01 Дьюк Юниверсити Генетически кодируемые внутренне неупорядоченные полимеры-"невидимки" для доставки и способы их применения
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
WO2017210476A1 (en) 2016-06-01 2017-12-07 Duke University Nonfouling biosensors
JP2020500150A (ja) 2016-09-23 2020-01-09 デューク ユニバーシティ 下限臨界溶液温度挙動を有する非反復かつ非構造的ポリペプチド
WO2018132732A1 (en) 2017-01-12 2018-07-19 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
KR102582297B1 (ko) 2017-05-19 2023-09-25 필립모리스 프로덕츠 에스.에이. 대상체의 흡연 상태를 구별하기 위한 진단 테스트
WO2019006374A1 (en) 2017-06-30 2019-01-03 Duke University ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
WO2019018697A1 (en) 2017-07-19 2019-01-24 Evanostics, Llc CARTRIDGES FOR ORAL FLUID ANALYSIS AND METHODS OF USE
EP3665187A4 (en) * 2017-08-08 2021-04-21 OraSure Technologies, Inc. TEST PROCEDURES FOR IMPROVED ANALYTE DETECTION
US11262367B2 (en) 2017-12-15 2022-03-01 Evanostics Llc Optical reader for analyte testing
WO2019147954A1 (en) 2018-01-26 2019-08-01 Duke University Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same
EP3788343B1 (en) 2018-04-30 2024-03-27 Duke University Stimuli-responsive peg-like polymer-based drug delivery platform
US11649275B2 (en) 2018-08-02 2023-05-16 Duke University Dual agonist fusion proteins
IT201800008274A1 (it) * 2018-08-31 2020-03-02 Alifax Srl Metodo immunometrico per analisi cliniche biologiche
US12594347B2 (en) 2018-09-07 2026-04-07 Duke University Nanoparticulate drug delivery systems
US12066383B2 (en) 2018-12-18 2024-08-20 Aspida Dx Inc. Optical analyte detection
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
CN114631025A (zh) * 2019-08-29 2022-06-14 米雷亚·C·阿罗诺维茨 侧向流动免疫化学中的定量分析物检测
CN110672834A (zh) * 2019-09-26 2020-01-10 北京丹大生物技术有限公司 一种快速检测样品中铅含量的试剂盒
CN112029771B (zh) * 2019-11-13 2021-12-14 安徽省昂普拓迈生物科技有限责任公司 一种特异性结合哌替啶的核酸适配体及其应用
WO2024173482A2 (en) * 2023-02-14 2024-08-22 North Carolina State University Compositions and methods related to aptamer-based sensors

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1062420A (ja) * 1996-06-05 1998-03-06 Boehringer Mannheim Gmbh 表面上の分析物を検出する方法
JP2006506634A (ja) * 2002-11-18 2006-02-23 ヴァルション テクニリネン ツッキムスケスクス 小さな分析物のための非競合的な免疫アッセイ法
JP2007522462A (ja) * 2004-02-13 2007-08-09 ベー・エル・アー・ハー・エム・エス・アクティエンゲゼルシャフト 医療診断目的のためのエンドセリン形成の測定方法、ならびに、このような方法を実施するための抗体およびキット
JP2008125484A (ja) * 2006-11-24 2008-06-05 Nec Soft Ltd ウサギ由来のIgG抗体に結合性を有する核酸分子
JP2008524582A (ja) * 2004-12-15 2008-07-10 キンバリー クラーク ワールドワイド インコーポレイテッド 試料効率の高い横流型免疫学的検定装置
JP2009526234A (ja) * 2006-02-09 2009-07-16 ユニバーシティー オブ サウス フロリダ Bcl−2レベルの上昇による癌の検出
JP2009189310A (ja) * 2008-02-15 2009-08-27 Olympus Corp 高親和性核酸フラグメント群の塩基配列決定方法および核酸アプタマーのスクリーニング方法
JP2009529885A (ja) * 2006-03-17 2009-08-27 バイオマリン ファーマシューティカル インコーポレイテッド リソソーム酵素に対する抗体の検出のためのアッセイ
JP2009531694A (ja) * 2006-03-24 2009-09-03 ユニヴァーシティー オブ イースト アングリア 物質の蛍光に基づく検出
JP2009195187A (ja) * 2008-02-22 2009-09-03 Olympus Corp 核酸アプタマーのスクリーニング方法
JP2010512516A (ja) * 2006-12-07 2010-04-22 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 分析物の効率的かつ正確な検出のための材料および方法
WO2010131748A1 (ja) * 2009-05-15 2010-11-18 地方独立行政法人神奈川県立病院機構 ペプチドを認識するアプタマー
WO2011010673A1 (ja) * 2009-07-21 2011-01-27 積水メディカル株式会社 インスリン測定方法
JP2011155913A (ja) * 2010-02-01 2011-08-18 Nec Soft Ltd TNF−αに結合するアプタマー分子

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0232357B1 (en) 1985-08-05 1991-01-30 Rijksuniversiteit Leiden Labelled macromolecules; a process for their preparation and their use for immunological or immunocytochemical assays
US5846713A (en) 1990-06-11 1998-12-08 Nexstar Pharmaceuticals, Inc. High affinity HKGF nucleic acid ligands and inhibitors
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5503978A (en) 1990-06-11 1996-04-02 University Research Corporation Method for identification of high affinity DNA ligands of HIV-1 reverse transcriptase
US5780228A (en) 1990-06-11 1998-07-14 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands to lectins
US6030776A (en) 1990-06-11 2000-02-29 Nexstar Pharmaceuticals, Inc. Parallel SELEX
US5795721A (en) 1990-06-11 1998-08-18 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of ICP4
US5731424A (en) 1990-06-11 1998-03-24 Nexstar Pharmaceuticals, Inc. High affinity TGFβ nucleic acid ligands and inhibitors
US5869641A (en) 1990-06-11 1999-02-09 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of CD4
US6001988A (en) 1990-06-11 1999-12-14 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands to lectins
US6011020A (en) 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
US5861254A (en) 1997-01-31 1999-01-19 Nexstar Pharmaceuticals, Inc. Flow cell SELEX
US5476766A (en) 1990-06-11 1995-12-19 Nexstar Pharmaceuticals, Inc. Ligands of thrombin
US5864026A (en) 1990-06-11 1999-01-26 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue selex
US6028186A (en) 1991-06-10 2000-02-22 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of cytokines
US5451504A (en) * 1991-07-29 1995-09-19 Serex, Inc. Method and device for detecting the presence of analyte in a sample
US5631146A (en) 1995-01-19 1997-05-20 The General Hospital Corporation DNA aptamers and catalysts that bind adenosine or adenosine-5'-phosphates and methods for isolation thereof
US6013443A (en) 1995-05-03 2000-01-11 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue SELEX
US6020130A (en) 1995-06-07 2000-02-01 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands that bind to and inhibit DNA polymerases
US5792613A (en) 1996-06-12 1998-08-11 The Curators Of The University Of Missouri Method for obtaining RNA aptamers based on shape selection
US6051698A (en) 1997-06-06 2000-04-18 Janjic; Nebojsa Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US7638093B2 (en) * 2004-01-28 2009-12-29 Dnt Scientific Research, Llc Interrupted flow rapid confirmatory immunological testing device and method
EP1733233B1 (en) * 2004-03-30 2012-12-12 GE Healthcare Bio-Sciences Corp. Lateral flow format, materials and methods
EP1787121B1 (en) * 2004-07-29 2010-08-25 Relia Diagnostic Systems, LLC Lateral flow system and assay

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1062420A (ja) * 1996-06-05 1998-03-06 Boehringer Mannheim Gmbh 表面上の分析物を検出する方法
JP2006506634A (ja) * 2002-11-18 2006-02-23 ヴァルション テクニリネン ツッキムスケスクス 小さな分析物のための非競合的な免疫アッセイ法
US20060246506A1 (en) * 2002-11-18 2006-11-02 Valtion Teknillinen Tutkimuskeskus Non-competitive immunoassay for small analytes
JP2007522462A (ja) * 2004-02-13 2007-08-09 ベー・エル・アー・ハー・エム・エス・アクティエンゲゼルシャフト 医療診断目的のためのエンドセリン形成の測定方法、ならびに、このような方法を実施するための抗体およびキット
JP2008524582A (ja) * 2004-12-15 2008-07-10 キンバリー クラーク ワールドワイド インコーポレイテッド 試料効率の高い横流型免疫学的検定装置
JP2009526234A (ja) * 2006-02-09 2009-07-16 ユニバーシティー オブ サウス フロリダ Bcl−2レベルの上昇による癌の検出
JP2009529885A (ja) * 2006-03-17 2009-08-27 バイオマリン ファーマシューティカル インコーポレイテッド リソソーム酵素に対する抗体の検出のためのアッセイ
JP2009531694A (ja) * 2006-03-24 2009-09-03 ユニヴァーシティー オブ イースト アングリア 物質の蛍光に基づく検出
JP2008125484A (ja) * 2006-11-24 2008-06-05 Nec Soft Ltd ウサギ由来のIgG抗体に結合性を有する核酸分子
JP2010512516A (ja) * 2006-12-07 2010-04-22 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 分析物の効率的かつ正確な検出のための材料および方法
JP2009189310A (ja) * 2008-02-15 2009-08-27 Olympus Corp 高親和性核酸フラグメント群の塩基配列決定方法および核酸アプタマーのスクリーニング方法
JP2009195187A (ja) * 2008-02-22 2009-09-03 Olympus Corp 核酸アプタマーのスクリーニング方法
WO2010131748A1 (ja) * 2009-05-15 2010-11-18 地方独立行政法人神奈川県立病院機構 ペプチドを認識するアプタマー
WO2011010673A1 (ja) * 2009-07-21 2011-01-27 積水メディカル株式会社 インスリン測定方法
JP2011155913A (ja) * 2010-02-01 2011-08-18 Nec Soft Ltd TNF−αに結合するアプタマー分子

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JAYASENA, S. D.: "Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics", CLINICAL CHEMISTRY, vol. 45, no. 9, JPN6016038173, September 1999 (1999-09-01), pages 1628 - 1650, ISSN: 0003835885 *
LI, Y. ET AL.: "Detection of Protein Biomarkers Using RNA Aptamer Microarrays and Enzymatically Amplified Surface Pl", ANALYTICAL CHEMISTRY, vol. 79, no. 3, JPN6017037927, 1 February 2007 (2007-02-01), US, pages 1082 - 1088, ISSN: 0003835884 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017170824A1 (ja) * 2016-03-31 2017-10-05 積水メディカル株式会社 簡易免疫測定を利用した癌胎児性フィブロネクチンの検出方法
JP6254333B1 (ja) * 2016-03-31 2017-12-27 積水メディカル株式会社 簡易免疫測定を利用した癌胎児性フィブロネクチンの検出方法
WO2018043687A3 (ja) * 2016-08-31 2018-04-26 積水化学工業株式会社 診断薬用蛍光粒子及びそれを用いた免疫測定試薬
JP6339298B1 (ja) * 2017-04-20 2018-06-06 株式会社キュア・アップ 禁煙患者のためのプログラム、装置、システム及び方法
WO2018193592A1 (ja) * 2017-04-20 2018-10-25 株式会社キュア・アップ 禁煙患者のためのプログラム、装置、システム及び方法
US10923220B2 (en) 2017-04-20 2021-02-16 Cureapp, Inc. Program, device, system and method for patient who is attempting to quit smoking
JP2022177204A (ja) * 2018-05-09 2022-11-30 株式会社Cureapp 禁煙患者のためのプログラム、装置、システム及び方法

Also Published As

Publication number Publication date
AU2012325697A1 (en) 2014-05-22
US20130102003A1 (en) 2013-04-25
EP2769219B1 (en) 2017-08-30
EP2769219A1 (en) 2014-08-27
CA2853103A1 (en) 2013-04-25
HK1201577A1 (en) 2015-09-04
WO2013059805A1 (en) 2013-04-25
CA2853103C (en) 2020-01-07
US20190204309A1 (en) 2019-07-04
AU2012325697B2 (en) 2015-11-26
JP2017138325A (ja) 2017-08-10
AU2016200720A1 (en) 2016-02-25

Similar Documents

Publication Publication Date Title
EP2769219B1 (en) Point-of care immunoassay for quantitative small analyte detection
CN110462403B (zh) 用于区分受试者的吸烟状况的诊断测试
EP3519824B1 (en) Improved methods of assessing uch-l1 in patient samples
JP7344801B2 (ja) グリア原線維性酸性タンパク質(gfap)及び/又はユビキチンカルボキシ末端ヒドロラーゼl1(uch-l1)を使用する、整形外科損傷を負っており、軽度外傷性脳損傷(tbi)などの頭部への損傷を負ったか又は負った可能性がある対象についての診断及び査定の一助となるための方法
US10866251B2 (en) Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers
JP2010518847A5 (https=)
CN110546513A (zh) 使用早期生物标记物帮助超急性诊断和确定人类受试者中的创伤性脑损伤的方法
TW202217316A (zh) 用於偵測tau蛋白病或類澱粉蛋白生成疾病的基於血液之檢定
US20220276234A1 (en) Point-of-care immunoassay for quantitative small analyte detection
HK1201577B (en) Point-of care immunoassay for quantitative small analyte detection
Townsend et al. Salivary analysis of drugs—potential and difficulties
JP2025501182A (ja) Tbi(外傷性脳損傷)に対して陰性である、頭部コンピュータ断層撮影(ct)スキャンを受けたことがある又は頭部ctスキャンを受けたことがない対象において亜急性外傷性脳損傷(tbi)を決定するためのバイオマーカーの使用
KR20240139074A (ko) 샘플에서 유비퀴틴 카르복시-말단 히드롤라제 l1 및/또는 신경교 섬유성 산성 단백질의 존재를 검출하거나 또는 그의 양을 측정하기 위한 측면 유동 방법, 검정 및 기기
JP2025503439A (ja) 血液試料におけるuch-l1、gfap及び他のバイオマーカーを決定するためのシステム及び方法
JP2024534849A (ja) 脳の損傷を診断する方法及びシステム
RU2775675C2 (ru) Диагностический тест для распознавания статуса курения субъекта
US20240110928A1 (en) Biomarkers and methods for differentiating between mild and supermild traumatic brain injury
JP2024544071A (ja) 頭部コンピュータ断層撮影スキャンの結果が外傷性脳損傷(tbi)に関して陰性の対象においてtbiを判定するための1種以上のバイオマーカーの使用
Sharma Development of colorimetric lateral flow assay for quantitative detection of anti-doping markers in sports
HK40123156A (en) Improved methods of assessing uch-l1 status in patient samples
Class et al. Patent application title: IMMUNOASSAYS FOR MEPERIDINE AND METABOLITES Inventors: Ivan Mcconnell (Crumlin, GB) Ivan Mcconnell (Crumlin, GB) Elouard Benchikh (Crumlin, GB) Elouard Benchikh (Crumlin, GB) Philip Lowry (Crumlin, GB) Philip Lowry (Crumlin, GB) Peter Fitzgerald (Crumlin, GB) Peter Fitzgerald (Crumlin, GB)
HK40021807B (zh) 用心肌肌钙蛋白i和早期生物标记物帮助诊断和评价人受试者中轻度创伤性脑损伤的方法
HK40015192A (en) Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1
HK40012576A (en) Improved methods of assessing gfap status in patient samples
HK40020584A (en) Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151021

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20151021

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20160826

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20161005

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161226

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170303

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170405

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20170405

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171004

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20171221

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180302

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180403

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20180403

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20180711