AU2012325697B2 - Point-of care immunoassay for quantitative small analyte detection - Google Patents

Point-of care immunoassay for quantitative small analyte detection Download PDF

Info

Publication number
AU2012325697B2
AU2012325697B2 AU2012325697A AU2012325697A AU2012325697B2 AU 2012325697 B2 AU2012325697 B2 AU 2012325697B2 AU 2012325697 A AU2012325697 A AU 2012325697A AU 2012325697 A AU2012325697 A AU 2012325697A AU 2012325697 B2 AU2012325697 B2 AU 2012325697B2
Authority
AU
Australia
Prior art keywords
analyte
capture
binding
sample
assay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2012325697A
Other languages
English (en)
Other versions
AU2012325697A1 (en
Inventor
Phillip Gibbs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Decimadx LLC
Original Assignee
Decimadx LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Decimadx LLC filed Critical Decimadx LLC
Publication of AU2012325697A1 publication Critical patent/AU2012325697A1/en
Application granted granted Critical
Publication of AU2012325697B2 publication Critical patent/AU2012325697B2/en
Priority to AU2016200720A priority Critical patent/AU2016200720A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306Solid-phase reaction mechanisms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1048SELEX
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54386Analytical elements
    • G01N33/54387Immunochromatographic test strips
    • G01N33/54388Immunochromatographic test strips based on lateral flow
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2470/00Immunochemical assays or immunoassays characterised by the reaction format or reaction type
    • G01N2470/04Sandwich assay format
    • G01N2470/06Second binding partner specifically binding complex of analyte with first binding partner

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2012325697A 2011-10-21 2012-10-22 Point-of care immunoassay for quantitative small analyte detection Active AU2012325697B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2016200720A AU2016200720A1 (en) 2011-10-21 2016-02-04 Point-of care immunoassay for quantitative small analyte detection

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161550141P 2011-10-21 2011-10-21
US61/550,141 2011-10-21
US201261637143P 2012-04-23 2012-04-23
US61/637,143 2012-04-23
PCT/US2012/061354 WO2013059805A1 (en) 2011-10-21 2012-10-22 Point-of care immunoassay for quantitative small analyte detection

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016200720A Division AU2016200720A1 (en) 2011-10-21 2016-02-04 Point-of care immunoassay for quantitative small analyte detection

Publications (2)

Publication Number Publication Date
AU2012325697A1 AU2012325697A1 (en) 2014-05-22
AU2012325697B2 true AU2012325697B2 (en) 2015-11-26

Family

ID=47116496

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2012325697A Active AU2012325697B2 (en) 2011-10-21 2012-10-22 Point-of care immunoassay for quantitative small analyte detection
AU2016200720A Abandoned AU2016200720A1 (en) 2011-10-21 2016-02-04 Point-of care immunoassay for quantitative small analyte detection

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2016200720A Abandoned AU2016200720A1 (en) 2011-10-21 2016-02-04 Point-of care immunoassay for quantitative small analyte detection

Country Status (6)

Country Link
US (2) US20130102003A1 (https=)
EP (1) EP2769219B1 (https=)
JP (2) JP2014531031A (https=)
AU (2) AU2012325697B2 (https=)
CA (1) CA2853103C (https=)
WO (1) WO2013059805A1 (https=)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10101324B2 (en) 2012-12-03 2018-10-16 The Regents Of The University Of California Non-competitive immunoassays to detect small molecules using nanopeptamers
CA3042642A1 (en) 2013-08-12 2015-02-19 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
CN105705938B (zh) 2013-08-19 2020-11-06 休斯敦大学系统 磷光报告物
US20150064672A1 (en) * 2013-09-05 2015-03-05 Matthew Bars Systems and methods for treatment of substance addiction
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10648974B2 (en) 2014-05-28 2020-05-12 Carehealth America Corporation Ethyl glucuronide lateral flow test strips, immunoassays, devices and methods for detecting or measuring thereof
CA2955229C (en) 2014-07-17 2020-03-10 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
GB2528657B (en) * 2014-07-24 2019-03-13 Intelligent Fingerprinting Ltd Sample analysing device
AU2015336065A1 (en) 2014-10-20 2017-05-04 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
EP3256856A4 (en) * 2014-12-17 2018-06-06 Singulex, Inc. Multiplexed single molecule analyzer
BR112017021305A2 (pt) * 2015-04-06 2018-06-26 Bludiagnostics Inc dispositivo de teste de fluxo lateral, e, método e kit para detecção quantitativa de um analito em uma amostra de saliva
WO2016198987A1 (en) * 2015-06-10 2016-12-15 Abs Advanced Biomedical Systems S.R.L. Device and method for immunochromatographic assay
EA037478B1 (ru) 2015-08-04 2021-04-01 Дьюк Юниверсити Генетически кодируемые внутренне неупорядоченные полимеры-"невидимки" для доставки и способы их применения
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
WO2017170824A1 (ja) * 2016-03-31 2017-10-05 積水メディカル株式会社 簡易免疫測定を利用した癌胎児性フィブロネクチンの検出方法
WO2017210476A1 (en) 2016-06-01 2017-12-07 Duke University Nonfouling biosensors
EP3508851A4 (en) * 2016-08-31 2020-07-29 Sekisui Chemical Co., Ltd. FLUORESCENT PARTICLES FOR A DIAGNOSIS AGENT AND IMMUNOLOGICAL ASSAY REAGENT USER
JP2020500150A (ja) 2016-09-23 2020-01-09 デューク ユニバーシティ 下限臨界溶液温度挙動を有する非反復かつ非構造的ポリペプチド
WO2018132732A1 (en) 2017-01-12 2018-07-19 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
WO2018193592A1 (ja) * 2017-04-20 2018-10-25 株式会社キュア・アップ 禁煙患者のためのプログラム、装置、システム及び方法
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
KR102582297B1 (ko) 2017-05-19 2023-09-25 필립모리스 프로덕츠 에스.에이. 대상체의 흡연 상태를 구별하기 위한 진단 테스트
WO2019006374A1 (en) 2017-06-30 2019-01-03 Duke University ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
WO2019018697A1 (en) 2017-07-19 2019-01-24 Evanostics, Llc CARTRIDGES FOR ORAL FLUID ANALYSIS AND METHODS OF USE
EP3665187A4 (en) * 2017-08-08 2021-04-21 OraSure Technologies, Inc. TEST PROCEDURES FOR IMPROVED ANALYTE DETECTION
US11262367B2 (en) 2017-12-15 2022-03-01 Evanostics Llc Optical reader for analyte testing
WO2019147954A1 (en) 2018-01-26 2019-08-01 Duke University Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same
EP3788343B1 (en) 2018-04-30 2024-03-27 Duke University Stimuli-responsive peg-like polymer-based drug delivery platform
JP7151987B2 (ja) * 2018-05-09 2022-10-12 株式会社Cureapp 禁煙患者のためのプログラム、装置、システム及び方法
US11649275B2 (en) 2018-08-02 2023-05-16 Duke University Dual agonist fusion proteins
IT201800008274A1 (it) * 2018-08-31 2020-03-02 Alifax Srl Metodo immunometrico per analisi cliniche biologiche
US12594347B2 (en) 2018-09-07 2026-04-07 Duke University Nanoparticulate drug delivery systems
US12066383B2 (en) 2018-12-18 2024-08-20 Aspida Dx Inc. Optical analyte detection
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
CN114631025A (zh) * 2019-08-29 2022-06-14 米雷亚·C·阿罗诺维茨 侧向流动免疫化学中的定量分析物检测
CN110672834A (zh) * 2019-09-26 2020-01-10 北京丹大生物技术有限公司 一种快速检测样品中铅含量的试剂盒
CN112029771B (zh) * 2019-11-13 2021-12-14 安徽省昂普拓迈生物科技有限责任公司 一种特异性结合哌替啶的核酸适配体及其应用
WO2024173482A2 (en) * 2023-02-14 2024-08-22 North Carolina State University Compositions and methods related to aptamer-based sensors

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0232357B1 (en) 1985-08-05 1991-01-30 Rijksuniversiteit Leiden Labelled macromolecules; a process for their preparation and their use for immunological or immunocytochemical assays
US5846713A (en) 1990-06-11 1998-12-08 Nexstar Pharmaceuticals, Inc. High affinity HKGF nucleic acid ligands and inhibitors
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5503978A (en) 1990-06-11 1996-04-02 University Research Corporation Method for identification of high affinity DNA ligands of HIV-1 reverse transcriptase
US5780228A (en) 1990-06-11 1998-07-14 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands to lectins
US6030776A (en) 1990-06-11 2000-02-29 Nexstar Pharmaceuticals, Inc. Parallel SELEX
US5795721A (en) 1990-06-11 1998-08-18 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of ICP4
US5731424A (en) 1990-06-11 1998-03-24 Nexstar Pharmaceuticals, Inc. High affinity TGFβ nucleic acid ligands and inhibitors
US5869641A (en) 1990-06-11 1999-02-09 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of CD4
US6001988A (en) 1990-06-11 1999-12-14 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands to lectins
US6011020A (en) 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
US5861254A (en) 1997-01-31 1999-01-19 Nexstar Pharmaceuticals, Inc. Flow cell SELEX
US5476766A (en) 1990-06-11 1995-12-19 Nexstar Pharmaceuticals, Inc. Ligands of thrombin
US5864026A (en) 1990-06-11 1999-01-26 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue selex
US6028186A (en) 1991-06-10 2000-02-22 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of cytokines
US5451504A (en) * 1991-07-29 1995-09-19 Serex, Inc. Method and device for detecting the presence of analyte in a sample
US5631146A (en) 1995-01-19 1997-05-20 The General Hospital Corporation DNA aptamers and catalysts that bind adenosine or adenosine-5'-phosphates and methods for isolation thereof
US6013443A (en) 1995-05-03 2000-01-11 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: tissue SELEX
US6020130A (en) 1995-06-07 2000-02-01 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands that bind to and inhibit DNA polymerases
DE19622503C2 (de) * 1996-06-05 1998-07-09 Securetec Sicherheitstechnolog Verfahren zum Nachweis von Analyten auf einer Oberfläche
US5792613A (en) 1996-06-12 1998-08-11 The Curators Of The University Of Missouri Method for obtaining RNA aptamers based on shape selection
US6051698A (en) 1997-06-06 2000-04-18 Janjic; Nebojsa Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
FI20022048A0 (fi) * 2002-11-18 2002-11-18 Valtion Teknillinen Ei-kompetetiivinen immunomääritys pienille analyyteille
US7638093B2 (en) * 2004-01-28 2009-12-29 Dnt Scientific Research, Llc Interrupted flow rapid confirmatory immunological testing device and method
DE502004000540D1 (de) * 2004-02-13 2006-06-14 Brahms Ag Verfahren zur Bestimmung der Bildung von Endothelinen zu Zwecken der medizinischen Diagnostik, sowie Antikörper und Kits für die Durchführung eines solchen Verfahrens
EP1733233B1 (en) * 2004-03-30 2012-12-12 GE Healthcare Bio-Sciences Corp. Lateral flow format, materials and methods
EP1787121B1 (en) * 2004-07-29 2010-08-25 Relia Diagnostic Systems, LLC Lateral flow system and assay
US20060127886A1 (en) * 2004-12-15 2006-06-15 Kaylor Rosann M Sample-efficient lateral flow immunoassay
SG169395A1 (en) * 2006-02-09 2011-03-30 Univ South Florida Detection of cancer by elevated levels of bcl-2
JP2009529885A (ja) * 2006-03-17 2009-08-27 バイオマリン ファーマシューティカル インコーポレイテッド リソソーム酵素に対する抗体の検出のためのアッセイ
GB0605965D0 (en) * 2006-03-24 2006-05-03 Univ East Anglia Fluorescence based detection of substances
JP4698559B2 (ja) * 2006-11-24 2011-06-08 Necソフト株式会社 ウサギ由来のIgG抗体に結合性を有する核酸分子
CA2671872A1 (en) * 2006-12-07 2008-06-12 University Of Florida Research Foundation, Inc. Materials and methods for efficient and accurate detection of analytes
JP2009189310A (ja) * 2008-02-15 2009-08-27 Olympus Corp 高親和性核酸フラグメント群の塩基配列決定方法および核酸アプタマーのスクリーニング方法
JP2009195187A (ja) * 2008-02-22 2009-09-03 Olympus Corp 核酸アプタマーのスクリーニング方法
AU2010248380B2 (en) * 2009-05-15 2013-12-19 Nec Solution Innovators, Ltd. Aptamer that recognizes peptide
US9476891B2 (en) * 2009-07-21 2016-10-25 Sekisui Medical Co., Ltd. Insulin assay
JP6041373B2 (ja) * 2010-02-01 2016-12-07 Necソリューションイノベータ株式会社 TNF−αに結合するアプタマー分子

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHO, E. J. et al., Annu. Rev. Anal. Chem., 2009, Vol. 2, pages 241-264 *
JAYASENA, S. D., Clincal Chemistry, Vol. 45, No. 9, pages 1628-1650 *

Also Published As

Publication number Publication date
AU2012325697A1 (en) 2014-05-22
JP2014531031A (ja) 2014-11-20
US20130102003A1 (en) 2013-04-25
EP2769219B1 (en) 2017-08-30
EP2769219A1 (en) 2014-08-27
CA2853103A1 (en) 2013-04-25
HK1201577A1 (en) 2015-09-04
WO2013059805A1 (en) 2013-04-25
CA2853103C (en) 2020-01-07
US20190204309A1 (en) 2019-07-04
JP2017138325A (ja) 2017-08-10
AU2016200720A1 (en) 2016-02-25

Similar Documents

Publication Publication Date Title
AU2012325697B2 (en) Point-of care immunoassay for quantitative small analyte detection
CN110462403B (zh) 用于区分受试者的吸烟状况的诊断测试
US20250020666A1 (en) Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (tbi), using glial fibrillary acidic protein (gfap) and/or ubiquitin carboxy-terminal hydrolase l1 (uch-l1)
CN110249226B (zh) 评估患者样品中gfap状态的改进方法
JP2010518847A5 (https=)
US20220276234A1 (en) Point-of-care immunoassay for quantitative small analyte detection
HK1201577B (en) Point-of care immunoassay for quantitative small analyte detection
JP2025501182A (ja) Tbi(外傷性脳損傷)に対して陰性である、頭部コンピュータ断層撮影(ct)スキャンを受けたことがある又は頭部ctスキャンを受けたことがない対象において亜急性外傷性脳損傷(tbi)を決定するためのバイオマーカーの使用
KR20240139074A (ko) 샘플에서 유비퀴틴 카르복시-말단 히드롤라제 l1 및/또는 신경교 섬유성 산성 단백질의 존재를 검출하거나 또는 그의 양을 측정하기 위한 측면 유동 방법, 검정 및 기기
JP2025503439A (ja) 血液試料におけるuch-l1、gfap及び他のバイオマーカーを決定するためのシステム及び方法
RU2775675C2 (ru) Диагностический тест для распознавания статуса курения субъекта
JP2024544071A (ja) 頭部コンピュータ断層撮影スキャンの結果が外傷性脳損傷(tbi)に関して陰性の対象においてtbiを判定するための1種以上のバイオマーカーの使用
HK40123156A (en) Improved methods of assessing uch-l1 status in patient samples
JP2023552755A (ja) 頭部コンピュータ断層撮影スキャンの結果が外傷性脳損傷(tbi)に関して陰性の対象においてtbiを判定するための1種以上のバイオマーカーの使用
Class et al. Patent application title: IMMUNOASSAYS FOR MEPERIDINE AND METABOLITES Inventors: Ivan Mcconnell (Crumlin, GB) Ivan Mcconnell (Crumlin, GB) Elouard Benchikh (Crumlin, GB) Elouard Benchikh (Crumlin, GB) Philip Lowry (Crumlin, GB) Philip Lowry (Crumlin, GB) Peter Fitzgerald (Crumlin, GB) Peter Fitzgerald (Crumlin, GB)
HK40012576A (en) Improved methods of assessing gfap status in patient samples
HK40021807B (zh) 用心肌肌钙蛋白i和早期生物标记物帮助诊断和评价人受试者中轻度创伤性脑损伤的方法
HK40012577A (zh) 评估患者样品中uch-l1状态的改进方法

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)