JP2014530219A5 - - Google Patents
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- Publication number
- JP2014530219A5 JP2014530219A5 JP2014534512A JP2014534512A JP2014530219A5 JP 2014530219 A5 JP2014530219 A5 JP 2014530219A5 JP 2014534512 A JP2014534512 A JP 2014534512A JP 2014534512 A JP2014534512 A JP 2014534512A JP 2014530219 A5 JP2014530219 A5 JP 2014530219A5
- Authority
- JP
- Japan
- Prior art keywords
- nanoparticles
- nanoparticle
- pharmaceutical composition
- sterol
- quillaja
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002105 nanoparticle Substances 0.000 claims 15
- PIGTXFOGKFOFTO-FVFWYJKVSA-N (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-carboxy-4-formyl-8-hydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound O([C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)C[C@@H](O)[C@]1(CCC(C[C@H]14)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O PIGTXFOGKFOFTO-FVFWYJKVSA-N 0.000 claims 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 229930182558 Sterol Natural products 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 150000003432 sterols Chemical class 0.000 claims 5
- 235000003702 sterols Nutrition 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- 235000012000 cholesterol Nutrition 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 150000003904 phospholipids Chemical class 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- 235000009001 Quillaja saponaria Nutrition 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- 230000005661 hydrophobic surface Effects 0.000 claims 2
- 239000002502 liposome Substances 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 1
- 235000014698 Brassica juncea var multisecta Nutrition 0.000 claims 1
- 241001092142 Molina Species 0.000 claims 1
- 241001092473 Quillaja Species 0.000 claims 1
- 241001454523 Quillaja saponaria Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 244000275904 brauner Senf Species 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 239000000693 micelle Substances 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161542425P | 2011-10-03 | 2011-10-03 | |
| US61/542,425 | 2011-10-03 | ||
| PCT/SE2012/051048 WO2013051994A1 (en) | 2011-10-03 | 2012-10-01 | Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrophobic molecules in fields of medicine including cancer treatment and food related compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530219A JP2014530219A (ja) | 2014-11-17 |
| JP2014530219A5 true JP2014530219A5 (cg-RX-API-DMAC7.html) | 2015-11-19 |
| JP6050822B2 JP6050822B2 (ja) | 2016-12-21 |
Family
ID=47143250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014534512A Active JP6050822B2 (ja) | 2011-10-03 | 2012-10-01 | ナノ粒子、ナノ粒子の調製のための処理、および癌治療および食品関連化合物を含む医療分野における両親媒性分子または疎水性分子ための担体としてのナノ粒子の使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10047116B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2750683B2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6050822B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102090740B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN103857403B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012319239B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2850296C (cg-RX-API-DMAC7.html) |
| DK (2) | DK3311827T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2673957T5 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20180956T1 (cg-RX-API-DMAC7.html) |
| IN (1) | IN2014DN03485A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2750683T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2750683T (cg-RX-API-DMAC7.html) |
| RS (1) | RS57350B1 (cg-RX-API-DMAC7.html) |
| TR (1) | TR201808733T4 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013051994A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201402040B (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3311827T3 (da) | 2011-10-03 | 2023-04-03 | Canqura Oncology Ab | Nanopartikler, fremgangsmåde til fremstilling og anvendelse deraf som bærere for amfipatiske eller hydrofobe molekyler inden for det medicinske område, inklusiv cancerbehandling, samt fødevarerelaterede forbindelser |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
| US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
| US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
| EP2777402A1 (en) | 2013-03-15 | 2014-09-17 | DSM IP Assets B.V. | Solid lipid nanoparticles (I) |
| US9907846B2 (en) | 2013-04-01 | 2018-03-06 | Mx Adjuvac Ab | Nanoparticles, composed of sterol and saponin from Quillaja saponaria Molina for use in pharmaceutical compositions |
| EP3092049A1 (en) | 2014-01-08 | 2016-11-16 | Flodesign Sonics Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| CN104382856B (zh) * | 2014-12-04 | 2017-11-14 | 中国药科大学 | 一种去氧鬼臼毒素长循环脂质体冻干制剂 |
| US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| KR20190127655A (ko) | 2016-10-19 | 2019-11-13 | 프로디자인 소닉스, 인크. | 음향학에 의한 친화성 세포 추출 |
| WO2018237109A1 (en) * | 2017-06-23 | 2018-12-27 | Yale University | Nanomaterials with enhanced drug delivery efficiency |
| JP2021507561A (ja) | 2017-12-14 | 2021-02-22 | フロデザイン ソニックス， インク．Ｆｌｏｄｅｓｉｇｎ Ｓｏｎｉｃｓ， Ｉｎｃ． | 音響トランスデューサドライバ及びコントローラ |
| EP3669890A1 (en) * | 2018-12-18 | 2020-06-24 | Croda International PLC | Filamentous nanoparticles having vaccine adjuvant effect |
| JP7597554B2 (ja) * | 2020-10-30 | 2024-12-10 | 株式会社ニップン | オキシトシン受容体作動性組成物 |
| CN116077639A (zh) * | 2023-01-05 | 2023-05-09 | 国药中生生物技术研究院有限公司 | 雷公藤红素或其可药用衍生物在制备疫苗佐剂中的用途 |
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| DK3311827T3 (da) * | 2011-10-03 | 2023-04-03 | Canqura Oncology Ab | Nanopartikler, fremgangsmåde til fremstilling og anvendelse deraf som bærere for amfipatiske eller hydrofobe molekyler inden for det medicinske område, inklusiv cancerbehandling, samt fødevarerelaterede forbindelser |
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| US9907846B2 (en) | 2013-04-01 | 2018-03-06 | Mx Adjuvac Ab | Nanoparticles, composed of sterol and saponin from Quillaja saponaria Molina for use in pharmaceutical compositions |
| EP3632279B1 (en) | 2017-10-20 | 2024-05-29 | Corelex Shin-Ei Co., Ltd. | Log roll production device |
-
2012
- 2012-10-01 DK DK17207322.3T patent/DK3311827T3/da active
- 2012-10-01 EP EP12781489.5A patent/EP2750683B2/en active Active
- 2012-10-01 ES ES12781489T patent/ES2673957T5/es active Active
- 2012-10-01 EP EP17207322.3A patent/EP3311827B1/en active Active
- 2012-10-01 CN CN201280048961.9A patent/CN103857403B/zh active Active
- 2012-10-01 DK DK12781489.5T patent/DK2750683T4/da active
- 2012-10-01 WO PCT/SE2012/051048 patent/WO2013051994A1/en not_active Ceased
- 2012-10-01 PT PT127814895T patent/PT2750683T/pt unknown
- 2012-10-01 RS RS20180720A patent/RS57350B1/sr unknown
- 2012-10-01 KR KR1020147011942A patent/KR102090740B1/ko active Active
- 2012-10-01 AU AU2012319239A patent/AU2012319239B2/en active Active
- 2012-10-01 US US14/349,142 patent/US10047116B2/en active Active
- 2012-10-01 JP JP2014534512A patent/JP6050822B2/ja active Active
- 2012-10-01 CA CA2850296A patent/CA2850296C/en active Active
- 2012-10-01 HR HRP20180956TT patent/HRP20180956T1/hr unknown
- 2012-10-01 TR TR2018/08733T patent/TR201808733T4/tr unknown
- 2012-10-01 IN IN3485DEN2014 patent/IN2014DN03485A/en unknown
- 2012-10-01 EP EP22214948.6A patent/EP4176871A1/en not_active Withdrawn
- 2012-10-01 PL PL12781489T patent/PL2750683T3/pl unknown
-
2014
- 2014-03-24 ZA ZA2014/02040A patent/ZA201402040B/en unknown
-
2017
- 2017-05-25 US US15/605,595 patent/US10100078B2/en active Active
- 2017-11-16 US US15/815,488 patent/US10487107B2/en active Active
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