JP2014529584A5 - - Google Patents
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- Publication number
- JP2014529584A5 JP2014529584A5 JP2014524097A JP2014524097A JP2014529584A5 JP 2014529584 A5 JP2014529584 A5 JP 2014529584A5 JP 2014524097 A JP2014524097 A JP 2014524097A JP 2014524097 A JP2014524097 A JP 2014524097A JP 2014529584 A5 JP2014529584 A5 JP 2014529584A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- treatment
- administered
- pharmaceutically acceptable
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 27
- 150000003839 salts Chemical class 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 11
- 206010006187 Breast cancer Diseases 0.000 claims description 6
- 208000026310 Breast neoplasm Diseases 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 208000035475 disorder Diseases 0.000 claims description 5
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 5
- 206010059594 Secondary hypogonadism Diseases 0.000 claims description 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 4
- 201000003368 hypogonadotropic hypogonadism Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 3
- 208000002495 Uterine Neoplasms Diseases 0.000 claims description 3
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 208000000509 infertility Diseases 0.000 claims description 3
- 231100000535 infertility Toxicity 0.000 claims description 3
- 230000036512 infertility Effects 0.000 claims description 3
- 206010046766 uterine cancer Diseases 0.000 claims description 3
- 201000005670 Anovulation Diseases 0.000 claims description 2
- 206010002659 Anovulatory cycle Diseases 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
- 206010014733 Endometrial cancer Diseases 0.000 claims description 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims description 2
- 206010064919 Hypospermia Diseases 0.000 claims description 2
- 231100000552 anovulation Toxicity 0.000 claims description 2
- 206010003883 azoospermia Diseases 0.000 claims description 2
- 230000037182 bone density Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 210000003205 muscle Anatomy 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 229960003604 testosterone Drugs 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims 3
- 230000002513 anti-ovulatory effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 16
- 208000001145 Metabolic Syndrome Diseases 0.000 description 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- 206010049287 Lipodystrophy acquired Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 230000001668 ameliorated effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 208000006132 lipodystrophy Diseases 0.000 description 1
- 230000011599 ovarian follicle development Effects 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- GKIRPKYJQBWNGO-QPLCGJKRSA-N zuclomifene Chemical compound C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(/Cl)C1=CC=CC=C1 GKIRPKYJQBWNGO-QPLCGJKRSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161515278P | 2011-08-04 | 2011-08-04 | |
| US61/515,278 | 2011-08-04 | ||
| PCT/US2012/049451 WO2013020017A1 (en) | 2011-08-04 | 2012-08-03 | Trans-clomiphene metabolites and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018186696A Division JP2019023210A (ja) | 2011-08-04 | 2018-10-01 | トランス−クロミフェン代謝物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014529584A JP2014529584A (ja) | 2014-11-13 |
| JP2014529584A5 true JP2014529584A5 (OSRAM) | 2015-07-02 |
| JP6433785B2 JP6433785B2 (ja) | 2018-12-05 |
Family
ID=46724628
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014524097A Expired - Fee Related JP6433785B2 (ja) | 2011-08-04 | 2012-08-03 | トランス−クロミフェン代謝物およびその使用 |
| JP2018186696A Pending JP2019023210A (ja) | 2011-08-04 | 2018-10-01 | トランス−クロミフェン代謝物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018186696A Pending JP2019023210A (ja) | 2011-08-04 | 2018-10-01 | トランス−クロミフェン代謝物およびその使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9981906B2 (OSRAM) |
| EP (2) | EP3351527A1 (OSRAM) |
| JP (2) | JP6433785B2 (OSRAM) |
| KR (1) | KR20140054110A (OSRAM) |
| CN (1) | CN103702975B (OSRAM) |
| AU (2) | AU2012289964B2 (OSRAM) |
| BR (1) | BR112014000908A2 (OSRAM) |
| CA (1) | CA2841572C (OSRAM) |
| CL (1) | CL2014000268A1 (OSRAM) |
| CO (1) | CO6862154A2 (OSRAM) |
| CR (1) | CR20140124A (OSRAM) |
| EA (1) | EA201490416A1 (OSRAM) |
| IL (1) | IL230287B (OSRAM) |
| MX (1) | MX355316B (OSRAM) |
| MY (2) | MY170718A (OSRAM) |
| NI (1) | NI201400008A (OSRAM) |
| PH (1) | PH12014500144A1 (OSRAM) |
| SG (1) | SG10201606425WA (OSRAM) |
| UA (1) | UA113291C2 (OSRAM) |
| WO (1) | WO2013020017A1 (OSRAM) |
| ZA (1) | ZA201400406B (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120284764A1 (en) * | 2011-05-05 | 2012-11-08 | Keith Ball | Method and system for requesting services by a media device |
| UA113291C2 (xx) | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
| BR112014029131B1 (pt) | 2012-05-31 | 2021-03-09 | Allergan Pharmaceuticals International Limited | cápsula de mucoadesivo |
| HK1211852A1 (en) | 2012-11-02 | 2016-06-03 | Repros Therapeutics Inc. | Methods and compositions for treating progesterone-dependent conditions |
| EP2914294A1 (en) | 2012-11-02 | 2015-09-09 | Repros Therapeutics Inc. | Trans-clomiphene for use in cancer therapy |
| US20190008804A1 (en) * | 2016-01-12 | 2019-01-10 | Repros Therapeutics Inc. | Trans-Clomiphene and Progesterone Receptor Antagonist Combination Therapy for Treating Hormone-Dependent Conditions |
| US20190054044A1 (en) * | 2016-02-25 | 2019-02-21 | Aspen Park Pharmaceuticals, Inc. | Oral dosage form of both clomiphene isomers and method of using same to treat secondary hypogonadism and minimize drug side effects in men |
| EP3368506B1 (en) | 2016-04-22 | 2023-09-06 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of enclomiphene citrate having needle shaped crystal habit. |
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| US4820736A (en) * | 1987-03-20 | 1989-04-11 | Yale University | Use of clomiphene to predict fertility in a human female |
| GB8926171D0 (en) | 1989-11-20 | 1990-01-10 | Applied Research Systems | Treatment of infertility |
| JPH04312522A (ja) | 1991-04-08 | 1992-11-04 | Yoshiaki Kawashima | 徐放性錠剤の製造方法 |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
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| DK0660821T3 (da) | 1992-09-15 | 1998-09-21 | Merrell Pharma Inc | Ikke-metaboliserbare clomiphen-analoge til behandling af tamoxifen-resistente tumorer |
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| GB9405304D0 (en) | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
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| WO1997006787A2 (en) | 1995-08-17 | 1997-02-27 | Dyer, Alison, Margaret | Controlled release products |
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| IL120262A (en) | 1996-02-28 | 2001-01-28 | Pfizer | Droloxifene and derivatives thereof for use in increasing serum testosterone levels |
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| IL132120A0 (en) | 1997-04-03 | 2001-03-19 | Guilford Pharm Inc | Biodegradable terephthalate polyester-poly (phosphate) polymers compositions articles and methods for making and using the same |
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| TW201500041A (zh) | 2008-11-07 | 2015-01-01 | Repros Therapeutics Inc | 用於代謝症候群與第２型糖尿病的反式氯米芬 |
| US20100144687A1 (en) | 2008-12-05 | 2010-06-10 | Glaser Rebecca L | Pharmaceutical compositions containing testosterone and an aromatase inhibitor |
| UA113291C2 (xx) | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
| US20140235601A1 (en) | 2011-08-09 | 2014-08-21 | Kenneth W. Adams | Use of Aromatase Inhibitor Or Estrogen Blocker For Increasing Spermatogenesis Or Testosterone Levels In Males |
| US20150031656A1 (en) | 2012-02-29 | 2015-01-29 | Repros Therapeutics Inc. | Combination therapy for treating androgen deficiency |
| CA2880388A1 (en) | 2012-08-21 | 2014-02-27 | Repros Therapeutics Inc. | Trans-clomiphene formulations and uses thereof |
| CN103351304B (zh) | 2013-07-01 | 2015-12-09 | 暨明医药科技（苏州）有限公司 | 一种克罗米芬的合成方法 |
-
2012
- 2012-03-08 UA UAA201402168A patent/UA113291C2/uk unknown
- 2012-08-03 US US14/236,868 patent/US9981906B2/en not_active Expired - Fee Related
- 2012-08-03 WO PCT/US2012/049451 patent/WO2013020017A1/en not_active Ceased
- 2012-08-03 EA EA201490416A patent/EA201490416A1/ru unknown
- 2012-08-03 EP EP18161551.9A patent/EP3351527A1/en not_active Withdrawn
- 2012-08-03 AU AU2012289964A patent/AU2012289964B2/en not_active Ceased
- 2012-08-03 SG SG10201606425WA patent/SG10201606425WA/en unknown
- 2012-08-03 MY MYPI2014000022A patent/MY170718A/en unknown
- 2012-08-03 PH PH1/2014/500144A patent/PH12014500144A1/en unknown
- 2012-08-03 CN CN201280038230.6A patent/CN103702975B/zh not_active Expired - Fee Related
- 2012-08-03 JP JP2014524097A patent/JP6433785B2/ja not_active Expired - Fee Related
- 2012-08-03 MX MX2014000825A patent/MX355316B/es active IP Right Grant
- 2012-08-03 KR KR1020147004588A patent/KR20140054110A/ko not_active Ceased
- 2012-08-03 MY MYPI2017001676A patent/MY191802A/en unknown
- 2012-08-03 CA CA2841572A patent/CA2841572C/en not_active Expired - Fee Related
- 2012-08-03 EP EP12750508.9A patent/EP2744777A1/en not_active Withdrawn
- 2012-08-03 BR BR112014000908A patent/BR112014000908A2/pt active Search and Examination
-
2014
- 2014-01-02 IL IL230287A patent/IL230287B/en active IP Right Grant
- 2014-01-17 ZA ZA2014/00406A patent/ZA201400406B/en unknown
- 2014-01-24 CO CO14014339A patent/CO6862154A2/es unknown
- 2014-01-30 NI NI201400008A patent/NI201400008A/es unknown
- 2014-02-03 CL CL2014000268A patent/CL2014000268A1/es unknown
- 2014-03-13 CR CR20140124A patent/CR20140124A/es unknown
-
2017
- 2017-06-20 AU AU2017204171A patent/AU2017204171A1/en not_active Abandoned
-
2018
- 2018-10-01 JP JP2018186696A patent/JP2019023210A/ja active Pending
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