JP2014528008A - 皮膚外観の清浄化のためのレチナールシクロデキストリンアセタール類およびヘミアセタール類 - Google Patents
皮膚外観の清浄化のためのレチナールシクロデキストリンアセタール類およびヘミアセタール類 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/04—Preparations for care of the skin for chemically tanning the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Abstract
Description
Xは、0(直接結合)、−CH2−CH2−O−、および−CH2−CH2−CH2−O−からなる群から選択され、Xは好ましくは0(直接結合)であり、
Zは、H、−CH2−CH2−OH、−CH2−CH2−CH2−OH、−SO3H、−SO3M、−PO3H2、−PO3M、および−PO3M2からなる群から選択され、Zは好ましくはHであり、
R=レチノイドまたはカロチノイドであり、
Mは、Na、K、Ca、Mg、Ba、Zn、Mn、Cu、Fe、Co、およびNiからなる群から選択される。
n=0、1、2、3、および4、好ましくは、nは、1、2または3であり、
X=Hであり、
Zは、以下の物質からなる群から選択され:H、−CH2−CH2−OH、−CH2−CH2−CH2−OH、−SO3H、−SO3M、−PO3H2、−PO3M、および−PO3M2、好ましくは、ZはHであり、
M=Na、K、Ca、Mg、Ba、Zn、Mn、Cu、Fe、CoおよびNiである。
水 100%(となるように適量添加)
γ−シクロデキストリン 37.00%
レチナール 1.90%
アルガニア・スピノサ(アルガン(Argan))ナッツオイル 3.25%
ペンチレングリコール 2.47%
手順:本組成物を得るため、まず、レチナール、アルガニア・スピノサ(アルガン)ナッツオイル、およびペンチレングリコールを透明な混合物が得られるまで混合する。この混合物にγ−シクロデキストリンおよび水を加え、窒素またはアルゴン雰囲気下で1〜120時間混合する。得られた溶液をその後乾燥し、粉末化する。好ましい乾燥方法は、噴霧乾燥である。乾燥の結果得られる粉末は5%〜15%の水を含む。
水 100%(となるように適量添加)
γ−シクロデキストリン 37.00%
レチナール 1.90%
ペンチレングリコール 5.72%
手順:本組成物を得るため、まず、レチナールおよびペンチレングリコールを透明な混合物が得られるまで混合する。この混合物に、γ−シクロデキストリンおよび水を加え、窒素またはアルゴン雰囲気下で1〜120時間混合する。得られた溶液をその後乾燥し、粉末化する。好ましい乾燥方法は、噴霧乾燥である。乾燥の結果得られる粉末は5%〜15%の水を含む。
水 100%(となるように適量添加)
γ−シクロデキストリン 40.00%
レチナール 2.20%
ルブス・チャマエモルス(chamaemorus)(種子)油 3.50%
ペンチレングリコール 2.13%
ロニセラ・カプリフォリウム(Lonicera Caprifolium)(スイカズラ)花抽出物(および)ロニセラ・ジャポニカ(Lonicera Japonica)(スイカズラ)花抽出物 0.25%
手順:本組成物を得るため、まず、レチナール、ルブス・チャマエモルス(種子)油、およびペンチレングリコールを透明な混合物が得られるまで混合する。この混合物に、γ−シクロデキストリン、水、ロニセラ・カプリフォリウム(スイカズラ)花抽出物(および)ロニセラ・ジャポニカ(スイカズラ)花抽出物を加え、窒素またはアルゴン雰囲気下で1〜120時間混合する。得られた溶液をその後乾燥し、粉末化する。好ましい乾燥方法は、噴霧乾燥である。乾燥の結果得られる粉末は5%〜15%の水を含む。
水 100%(となるように適量添加)
γ−シクロデキストリン 42.00%
レチナール 2.30%
シモンデシア・チネンシス(ホホバ)種子油 3.70%
ペンチレングリコール 2.33%
ロニセラ・カプリフォリウム(スイカズラ)花抽出物(および)ロニセラ・ジャポニカ(スイカズラ)花抽出物 0.25%
手順:本組成物を得るため、まず、レチナール、シモンデシア・チネンシス(ホホバ)種子油、およびペンチレングリコールを透明な混合物が得られるまで混合する。この混合物に、γ−シクロデキストリン、水、ロニセラ・カプリフォリウム(スイカズラ)花抽出物(および)、ロニセラ・ジャポニカ(スイカズラ)花抽出物を加え、窒素またはアルゴン雰囲気下で1〜120時間混合する。得られた溶液をその後乾燥し、粉末化する。好ましい乾燥方法は、「パルス燃焼方式噴霧乾燥」であり、これは、乾燥対象の産物の温度を最低に抑えるように設計された特別な噴霧乾燥技術である。
水 100%(となるように適量添加)
γ−シクロデキストリン 40%
レチナール 2.2%
ルブス・チャマエモルス(クラウドベリー)種子油 3.5%
ペンチレングリコール 2.127%
ロニセラ・カプリフォリウム(スイカズラ)花抽出物/ロニセラ・ジャポニカ(スイカズラ)花抽出物 0.25%
手順:本組成物を得るため、まず、レチナール、ルブス・チャマエモルス(クラウドベリー)種子油、およびペンチレングリコールを透明な混合物が得られるまで混合する。
この混合物に、γ−シクロデキストリン、水、ロニセラ・カプリフォリウム(スイカズラ)花抽出物(および)、ロニセラ・ジャポニカ(スイカズラ)花抽出物を加え、窒素またはアルゴン雰囲気下で1〜120時間混合する。得られた溶液をその後乾燥し、粉末化する。好ましい乾燥方法は、「パルス燃焼方式噴霧乾燥」であり、これは、乾燥対象の産物の温度を最低に抑えるように設計された特別な噴霧乾燥技術である。
水 100%(となるように適量添加)
γ−シクロデキストリン 40%
レチナール 3.913%
ビタミンAプロピオナート 3.913%
ロニセラ・カプリフォリウム(スイカズラ)花抽出物/ロニセラ・ジャポニカ(スイカズラ)花抽出物 0.25%
手順:本組成物を得るため、まず、レチナールおよびビタミンAプロピオナートを透明な混合物が得られるまで混合する。この混合物に、γ−シクロデキストリン、水、ロニセラ・カプリフォリウム(スイカズラ)花抽出物(および)、ロニセラ・ジャポニカ(スイカズラ)花抽出物を加え、窒素またはアルゴン雰囲気下で1〜120時間混合する。得られた溶液をその後乾燥し、粉末化する。好ましい乾燥方法は、「パルス燃焼方式噴霧乾燥」であり、これは、乾燥対象の産物の温度を最低に抑えるように設計された特別な噴霧乾燥技術である。
水 100%(となるように適量添加)
モノステアリン酸グリセリン 4.00%
ステアリン酸 2.20%
セチルアルコール 3.50%
イソプロピルパルミテート 5.00%
メチルパラベン 0.20%
上記実施例1で調製された粉末 7.00%
手順:水、モノステアリン酸グリセリン、ステアリン酸、セチルアルコール、およびイソプロピルパルミテートを65℃まで加熱する。得られた混合物を次にウルトラトゥーラックス(Ultra Turax)、フルエッダイザー(Fluidizer)、または類似のホモジェナイザーを用いてホモジェナイズし、30℃より低い温度まで冷却する。得られた混合物に、実施例1で調製された粉末をメチルパラベンと共に添加し混合する。
水 100%(となるように適量添加)
モノステアリン酸グリセリン 4.00%
ステアリン酸 2.20%
セチルアルコール 3.50%
イソプロピルパルミテート 5.00%
メチルパラベン 0.20%
上記実施例2で調製された粉末 5.00%
手順:水、モノステアリン酸グリセリン、ステアリン酸、セチルアルコール、およびイソプロピルパルミテートを65℃まで加熱する。得られた混合物を次にウルトラトゥーラックス、フルエッダイザー、または類似のホモジェナイザーを用いてホモジェナイズし、30℃より低い温度まで冷却する。得られた混合物に、上記実施例2で調製された粉末をメチルパラベンと共に添加し混合する。
水 100%(となるように適量添加)
モノステアリン酸グリセリン 4.00%
ステアリン酸 2.20%
セチルアルコール 3.50%
イソプロピルパルミテート 5.00%
メチルパラベン 0.20%
上記実施例3で調製された粉末 2.00%
手順:水、モノステアリン酸グリセリン、ステアリン酸、セチルアルコール、およびイソプロピルパルミテートを65℃まで加熱する。得られた混合物を次にウルトラトゥーラックス、フルエッダイザー、または類似のホモジェナイザーを用いてホモジェナイズし、30℃より低い温度まで冷却する。得られた混合物に、上記実施例3で調製された粉末をメチルパラベンと共に添加し混合する。
水 100%(となるように適量添加)
乳化ロウNF 6.00%
エンスリゾール(Ensulizole) 4.00%
オクチノキサート 4.00%
プロピレングリコール 3.00%
グルコノラクトン/安息香酸ナトリウム 1.00%
トリエタノールアミン 0.35%
アンモニウムアクリロイルジメチルタウレート(Ammonium Acryloyldimethyltaurate)/VP共重合体 1.40%
二酸化チタン 0.75%
実施例1で調製された粉末 7.00%
手順:水、乳化ロウNF、エンスリゾール、オクチノキサート、およびプロピレングリコールを80℃まで加熱し混合する。次に、得られた混合物を30℃より低い温度まで冷却する。さらに以下の物質を続けて混合する:グルコノラクトン/安息香酸ナトリウム、トリエタノールアミン、および二酸化チタン。得られた混合物に、上記実施例1で調製された粉末を添加する。
水 100%(となるように適量添加)
乳化ロウNF 6.00%
エンスリゾール 4.00%
オクチノキサート 4.00%
プロピレングリコール 3.00%
グルコノラクトン/安息香酸ナトリウム 1.00%
トリエタノールアミン 0.35%
アンモニウムアクリロイルジメチルタウレート/VP共重合体 1.40%
二酸化チタン 0.75%
実施例2で調製された粉末 4.00%
手順:水、乳化ロウNF、エンスリゾール、オクチノキサート、およびプロピレングリコールを80℃まで加熱し混合する。次に、得られた混合物を30℃より低い温度まで冷却する。さらに以下の物質を続けて混合する:グルコノラクトン/安息香酸ナトリウム、トリエタノールアミン、および二酸化チタン。得られた混合物に、上記実施例2で調製された粉末を添加する。
水 100%(となるように適量添加)
乳化ロウNF 6.00%
エンスリゾール 4.00%
オクチノキサート 4.00%
プロピレングリコール 3.00%
グルコノラクトン/安息香酸ナトリウム 1.00%
トリエタノールアミン 0.35%
アンモニウムアクリロイルジメチルタウレート/VP共重合体 1.40%
二酸化チタン 0.75%
実施例3で調製された粉末 2.00%
手順:水、乳化ロウNF、エンスリゾール、オクチノキサート、およびプロピレングリコールを80℃まで加熱し混合する。次に、得られた混合物を30℃より低い温度まで冷却する。さらに以下の物質を続けて混合する:グルコノラクトン/安息香酸ナトリウム、トリエタノールアミン、および二酸化チタン。得られた混合物に、上記実施例3で調製された粉末を添加する。
水 100%(となるように適量添加)
ヒドロキシプロピルデンプンリン酸 2.00%
キャンデリア/ホホバ/米ぬかポリグリセリル−3エステル類(および)ステアリン酸グリセリル(および)セテアリルアルコール(および)ステアロイル乳酸ナトリウム 7.00%
ペンタステアリン酸ポリグリセリル−10(および)ベヘニルアルコール(および)ステアロイル乳酸ナトリウム 2.00%
グリセリン 5.50%
セチルアルコール 0.80%
ステアリルアルコール 0.80%
ベヘニルアルコール 0.80%
ネオペンタン酸イソステアリル 4.50%
ロニセラ・カプリフォリウム(スイカズラ)花抽出物(および)ロニセラ・ジャポニカ(スイカズラ)花抽出物 1.00%
実施例1で調製された粉末 7.00%
手順:ヒドロキシプロピルデンプンリン酸を水と混合し、80℃まで加熱する。
以下の物質を添加と添加の間に添加し、適度に混合する:キャンデリア/ホホバ/米ぬかポリグリセリル−3エステル類(および)ステアリン酸グリセリル(および)セテアリルアルコール(および)ステアロイル乳酸ナトリウム、ペンタステアリン酸ポリグリセリル−10(および)ベヘニルアルコール(および)ステアロイル乳酸ナトリウム、グリセリン、セチルアルコール、ステアリルアルコール、およびベヘニルアルコール。混合物が均質に混ざったら冷却する。ネオペンタン酸イソステアリル、ロニセラ・カプリフォリウム、(スイカズラ)花抽出物(および)ロニセラ・ジャポニカ(スイカズラ)花抽出物、および実施例1で調製された粉末を添加し、連続的に混合する。
水 100%(となるように適量添加)
ヒドロキシプロピルデンプンリン酸 2.00%
キャンデリア/ホホバ/米ぬかポリグリセリル−3エステル類(および)ステアリン酸グリセリル(および)セテアリルアルコール(および)ステアロイル乳酸ナトリウム 7.00%
ペンタステアリン酸ポリグリセリル−10(および)ベヘニルアルコール(および)ステアロイル乳酸ナトリウム 2.00%
グリセリン 5.50%
セチルアルコール 0.80%
ステアリルアルコール 0.80%
ベヘニルアルコール 0.80%
ネオペンタン酸イソステアリル 4.50%
ロニセラ・カプリフォリウム(スイカズラ)花抽出物(および)ロニセラ・ジャポニカ(スイカズラ)花抽出物 1.00%
実施例2で調製された粉末 4.00%
手順:ヒドロキシプロピルデンプンリン酸を水と混合し、80℃まで加熱する。以下の物質を添加と添加の間に添加し、適度に混合する:キャンデリア/ホホバ/米ぬかポリグリセリル−3エステル類(および)ステアリン酸グリセリル(および)セテアリルアルコール(および)ステアロイル乳酸ナトリウム、ペンタステアリン酸ポリグリセリル−10(および)ベヘニルアルコール(および)ステアロイル乳酸ナトリウム、グリセリン、セチルアルコール、ステアリルアルコール、およびベヘニルアルコール。混合物が均質に混ざったら冷却する。ネオペンタン酸イソステアリル、ロニセラ・カプリフォリウム(スイカズラ)花抽出物(および)ロニセラ・ジャポニカ(スイカズラ)花抽出物、および実施例2で調製された粉末を添加し、連続的に混合する。
水 100%(となるように適量添加)
ヒドロキシプロピルデンプンリン酸 2.00%
キャンデリア/ホホバ/米ぬかポリグリセリル−3エステル類(および)ステアリン酸グリセリル(および)セテアリルアルコール(および)ステアロイル乳酸ナトリウム 7.00%
ペンタステアリン酸ポリグリセリル−10(および)ベヘニルアルコール(および)ステアロイル乳酸ナトリウム 2.00%
グリセリン 5.50%
セチルアルコール 0.80%
ステアリルアルコール G 0.80%
ベヘニルアルコール 0.80%
ネオペンタン酸イソステアリル 4.50%
ロニセラ・カプリフォリウム(スイカズラ)花抽出物(および)ロニセラ・ジャポニカ(スイカズラ)花抽出物 1.00%
実施例3で調製された粉末 3.00%
手順:ヒドロキシプロピルデンプンリン酸を水と混合し、80℃まで加熱する。以下の物質を添加と添加の間に添加し、適度に混合する:キャンデリア/ホホバ/米ぬかポリグリセリル−3エステル類(および)ステアリン酸グリセリル(および)セテアリルアルコール(および)ステアロイル乳酸ナトリウム、ペンタステアリン酸ポリグリセリル−10(および)ベヘニルアルコール(および)ステアロイル乳酸ナトリウム、グリセリン、セチルアルコール、ステアリルアルコール、およびベヘニルアルコール。混合物が均質に混ざったら冷却する。ネオペンタン酸イソステアリル、ロニセラ・カプリフォリウム(スイカズラ)花抽出物(および)ロニセラ・ジャポニカ(スイカズラ)花抽出物、および実施例3で調製された粉末を添加し、連続的に混合する。
水 100%(となるように適量添加)
カーボポール(Carbopol) 0.25%
式(Ia)または(Ib)の化合物を含有する粉末 5%
ロニセラ・カプリフォリウム(スイカズラ)花抽出物/ロニセラ・ジャポニカ(スイカズラ)花抽出物 0.25%
手順:上記成分を記述された順番に添加する。カルボポールが水和されるように一晩おく。次の日に再び混合する
抽出溶媒 レチナール(%)(算出値4.5%)
クロロホルム 0.04
イソプロパノール 1.5
メタノール 4.1
レチナール(コントロール、抽出ステップ無しで直接分析) 98.0(算出値100.0)
Claims (18)
- 請求項1の式(Ia)または式(Ib)の化合物であって、
nは1、2、または3であり、Xは直接結合であることを特徴とする化合物。 - 請求項1の化合物ならびに、
抗酸化物質と、フリーラジカル中和剤と、抗炎症剤と、コラーゲンおよびフィブリンのブースト剤と、4級アンモニウム化合物とからなる群から選択される1つ以上の更なる成分を含む組成物。 - 請求項5の組成物であって、
前記組成物は医薬製剤、栄養補助食品、化粧品、または局所塗布もしくは経口摂取用途のための組成物。 - 請求項5の組成物であって、
前記組成物はさらに以下の成分を1つ以上含む組成物:ロニセラ・カプリフォリウム(スイカズラ)花抽出物およびロニセラ・ジャポニカ(スイカズラ)花抽出物。 - 請求項1の化合物、水、および以下の成分の1つ以上を含む組成物:乳化ロウ、エンスリゾール、オクチノキサート、プロピレングリコール、グルコノラクトン/安息香酸ナトリウム、トリエタノールアミン、アンモニウムアクリロイルジメチルタウレート/VP共重合体、および二酸化チタン。
- 請求項1の化合物、水、および以下の成分の1つ以上を含む組成物:ヒドロキシプロピルデンプンリン酸塩、キャンデリア、ホホバ、米ぬかポリグリセリル−3エステル類、ステアリン酸グリセリル、セテアリルアルコール、ステアロイル乳酸ナトリウム、ペンタステアリン酸ポリグリセリル−10、ベヘニルアルコール、ステアロイル乳酸ナトリウム、グリセリン、セチルアルコール、ステアリルアルコール、ネオペンタン酸イソステアリル、ロニセラ・カプリフォリウム(スイカズラ)花抽出物、およびロニセラ・ジャポニカ(スイカズラ)花抽出物。
- 請求項1の化合物、水、カルボポール、ロニセラ・カプリフォリウム(スイカズラ)花抽出物、およびロニセラ・ジャポニカ(スイカズラ)花抽出物を含む組成物。
- ニキビ、ニキビによる皮膚の美観喪失および皮膚の黒ずみ;ガン、糖尿病、放射線療法、化学療法、および日焼けによる皮膚の黒ずみ;ミトコンドリアおよびDNA機能不全;年齢によるシミ;細胞の抗酸化物質の喪失;コラーゲンの喪失、皮膚従順性の喪失、皮膚柔軟性の喪失、皮膚のシワおよび皮膚の細い線、酸化、放射線による損傷、自由ラジカルによる損傷、紫外線による損傷、を含む老化に伴う皮膚の変化;乾燥皮膚;乾燥症;魚鱗癬;フケ;褐色がかったシミ;角化症;黒皮症;ほくろ;肝斑;シミ、目の下のくま、黒ずんだ皮膚、および斑点を含む、皮膚の色素沈着;脂性肌;いぼ;湿疹;皮膚掻痒症;乾癬;炎症性皮膚病;局所的炎症;荒れた角質;頭皮の乾燥ならびにその組合せからなる群から選択される状態に伴う症状の治療、予防、発生を減らす、または改善する方法であって、前記方法は請求項1の化合物を患者に投与する工程を含む。
- 請求項11の方法であって、
前記状態は、ニキビまたはニキビによる皮膚の美観喪失および皮膚の黒ずみであることを特徴とする方法。 - 請求項11の方法であって、
前記状態が皮膚のシワおよび皮膚の細い線であることを特徴とする方法。 - (i)ポリエンアルデヒドと有機可溶性化液体とを、透明な混合物が得られるまで混合する工程と、
(ii)前記透明な混合物に対して適切なシクロデキストリンおよび水を添加し、窒素またはアルゴン雰囲気下で1〜120時間混合して反応混合物を形成する工程と、
(iii)前記反応混合物を乾燥して粉末化する工程とを含む、請求項1の化合物を作製するプロセス。 - 請求項14のプロセスであって、
前記ポリエンアルデヒドがレチナールであることを特徴とするプロセス。 - 請求項14のプロセスであって、
前記有機可溶性化液体は、トリグリセリド、ポリオール、レチニルプロピオナート、脂肪エステル、またはその組合せからなる群から選択されることを特徴とするプロセス。 - 請求項14のプロセスであって、
前記シクロデキストリンがγ−シクロデキストリンであることを特徴とするプロセス。 - 請求項14のプロセスであって、
前記(ii)の工程において、以下の成分が1つ以上更に添加されることを特徴とする、プロセス:ロニセラ・カプリフォリウム(スイカズラ)花抽出物およびロニセラ・ジャポニカ(スイカズラ)花抽出物。
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PCT/US2012/027826 WO2013036286A2 (en) | 2011-09-07 | 2012-03-06 | Retinal cyclodextrin acetals and hemiacetals for clarifying skin complexion |
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